Abstract：
:Almost all tumors are composed of a heterogeneous cell population, making them difficult to treat. A small cancer stem cell population with a low proliferation rate and a high tumorigenic potential is thought to be responsible for cancer development, metastasis and resistance to therapy. Stem cells were reported to be involved in both normal development and carcinogenesis, some molecular mechanisms being common in both processes. No less controversial, stem cells are considered to be important in treatment of malignant diseases both as targets and drug carriers. The efforts to understand the role of different signalling in cancer stem cells requires in depth knowledge about the mechanisms that control their self-renewal, differentiation and malignant potential. The aim of this paper is to discuss insights into cancer stem cells historical background and to provide a brief review of the new therapeutic strategies for targeting cancer stem cells.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Ciurea ME,Georgescu AM,Purcaru SO,Artene SA,Emami GH,Boldeanu MV,Tache DE,Dricu Adoi
10.3390/ijms15058169subject
Has Abstractpub_date
2014-05-09 00:00:00pages
8169-85issue
5issn
1422-0067pii
ijms15058169journal_volume
15pub_type
杂志文章,评审abstract：:Homeodomain-interacting protein kinase 2 (HIPK2) is a serine/threonine kinase that phosphorylates and activates the apoptotic program through interaction with diverse downstream targets including tumor suppressor p53. HIPK2 is activated by genotoxic stimuli and modulates cell fate following DNA damage. The DNA damage ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms17101638
更新日期：2016-09-27 00:00:00
abstract：:Passage of apolipoprotein B-containing lipoproteins (apoB-LPs), i.e., triglyceride-rich lipoproteins (TRLs), intermediate-density lipoproteins (IDLs), and low-density lipoproteins (LDLs), through the endothelial monolayer occurs in normal and atherosclerotic arteries. Among these lipoproteins, TRLs and IDLs are apoE-r...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19113593
更新日期：2018-11-14 00:00:00
abstract：:Acute liver failure (ALF) leads to neurological symptoms defined as hepatic encephalopathy (HE). Although accumulation of ammonia and neuroinflammation are generally accepted as main contributors to HE pathomechanism, a buildup of bile acids (BA) in the blood is a frequent component of liver injury in HE patients. Rec...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21207750
更新日期：2020-10-20 00:00:00
abstract：:Salinity is one of the most important abiotic stresses threatening plant growth and agricultural productivity worldwide. In green alga Chlamydomonas reinhardtii, physiological evidence indicates that saline stress increases intracellular peroxide levels and inhibits photosynthetic-electron flow. However, understanding...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19113359
更新日期：2018-10-26 00:00:00
abstract：:Separation of polyphenolic phytochemical compounds from their mixtures with sugars is necessary to produce an added-value sugar-reduced extract with high biological activity from fruit juice processing industry waste streams. The separation characteristics of a binary mixture of rutin and glucose using a Pellicon-2 re...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms11020672
更新日期：2010-02-09 00:00:00
abstract：:Timely and reliable distinction of sepsis from non-infectious systemic inflammatory response syndrome (SIRS) supports adequate antimicrobial therapy and saves lives but is clinically challenging. Blood transcriptional profiling promises to deliver insights into the pathomechanisms of SIRS and sepsis and to accelerate ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20092290
更新日期：2019-05-09 00:00:00
abstract：:The usefulness of ginger in the food industry and pharmacotherapy is strictly related to its content of various components. The study elucidates the chemical composition of Zingiber officinale rhizomes cultivated on ecological plantations on Shikoku Island (Japan). GC-MS analysis of terpene content, LC-MS determinatio...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms18020452
更新日期：2017-02-20 00:00:00
abstract：:Marine environments harbor a wide range of microorganisms from the three domains of life. These microorganisms have great potential to enable discovery of new enzymes and bioactive compounds for industrial use. However, only ~1% of microorganisms from the environment can currently be identified through cultured isolat...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms161226101
更新日期：2015-11-27 00:00:00
abstract：:Metabolic reprogramming that favors high glycolytic flux with lactate production in normoxia is among cancer hallmarks. Lactate is an essential oncometabolite regulating cellular redox homeostasis, energy substrate partitioning, and intracellular signaling. Moreover, malignant phenotype's chief characteristics are dep...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21249676
更新日期：2020-12-18 00:00:00
abstract：:Recent evidence suggests that autophagy impairment is implicated in the epileptogenic mechanisms downstream of mTOR hyperactivation. This holds true for a variety of genetic and acquired epileptic syndromes besides malformations of cortical development which are classically known as mTORopathies. Autophagy suppression...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21051642
更新日期：2020-02-28 00:00:00
abstract：:Schizophrenia and autism spectrum disorder (ASD) are multi-factorial and multi-symptomatic psychiatric disorders, each affecting 0.5%-1% of the population worldwide. Both are characterized by impairments in cognitive functions, emotions and behaviour, and they undermine basic human processes of perception and judgment...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms17060856
更新日期：2016-06-01 00:00:00
abstract：:The objective of our study was to evaluate whether feeding pseudopurpurin affects bone mineral density and bone geometry architecture in rats. Pseudopurpurin was extracted, analyzed and purified using an HLPC-ESI-MS. Rats were given 0% and 0.5% pseudopurpurin powder in their diet. Femurs of rats were examined at 0.5, ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms13033431
更新日期：2012-01-01 00:00:00
abstract：:The cell membrane is a complex and highly regulated system that is composed of lipid bilayer and proteins. One of the main functions of the cell membrane is the regulation of cell entry. Cell-penetrating peptides (CPPs) are defined as peptides that can cross the plasma membrane and deliver their cargo inside the cell....
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21134719
更新日期：2020-07-02 00:00:00
abstract：:Metabolic syndrome (MetS) is a predictor of cardiovascular diseases, commonly associated with oxidative stress and inflammation. However, the pathogenic mechanisms are not yet fully elucidated. The aim of the study is to evaluate the oxidative status and inflammation in the heart of obese Zucker rats (OZRs) and lean Z...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21062035
更新日期：2020-03-16 00:00:00
abstract：:Suboptimal early-life conditions affect the developing kidney, resulting in long-term programming effects, namely renal programming. Adverse renal programming increases the risk for developing hypertension and kidney disease in adulthood. Conversely, reprogramming is a strategy aimed at reversing the programming proce...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms19061744
更新日期：2018-06-12 00:00:00
abstract：BACKGROUND:Nowadays, the molecular mechanisms governing TSD (temperature-dependent sex determination) or GSD + TE (genotypic sex determination + temperature effects) remain a mystery in fish. METHODS:We developed three all-female families of Nile tilapia (Oreochromis niloticus), and the family with the highest male ra...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19030689
更新日期：2018-02-28 00:00:00
abstract：:Transcription control plays a crucial role in establishing a unique gene expression signature for each of the hundreds of mammalian cell types. Though gene expression data have been widely used to infer cellular regulatory networks, existing methods mainly infer correlations rather than causality. We developed statist...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19113609
更新日期：2018-11-15 00:00:00
abstract：:Parkinson's disease (PD) is caused by the loss of dopaminergic (DA) neurons in the midbrain substantia nigra (SN). Neuroinflammation, which is marked by microglial activation, plays a very important role in the pathogenesis of PD. Pro-inflammatory mediators produced by activated microglia could damage DA neurons. Henc...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19010012
更新日期：2017-12-21 00:00:00
abstract：:Histone acetylation plays an important role in plant growth and development. Here, we investigated the effect of sodium butyrate (NaB), a histone deacetylase inhibitor, on adventitious shoot formation from protoplast-derived calli and cotyledon explants of tobacco (Nicotiana benthamiana) and tomato (Solanum lycopersic...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21228451
更新日期：2020-11-10 00:00:00
abstract：:Recovered blood supply after cerebral ischemia for a certain period of time fails to restore brain function, with more severe dysfunctional problems developing, called cerebral ischemia-reperfusion injury (CIR). CIR involves several extremely complex pathophysiological processes in which the interactions between key f...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms18071599
更新日期：2017-07-24 00:00:00
abstract：:The frequency and volume of Asian sand dust (ASD) (Kosa) are increasing in Japan, and it has been reported that ASD may cause adverse respiratory effects. The pulmonary toxicity of ASD has been previously analyzed in mice exposed to ASD particles by intratracheal instillation. To study the pulmonary toxicity induced b...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19020416
更新日期：2018-01-31 00:00:00
abstract：:Well-run screening programs for cervical cancer in the population at risk have been shown to result in a sharp decrease in the incidence and mortality of cervical cancer in a number of large populations. Expression patterns of a recently identified biomarker family, microRNA, appear to be characteristic of tumor type ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms15010758
更新日期：2014-01-08 00:00:00
abstract：:Understanding disease pathology often does not require an overall proteomic analysis of clinical samples but rather the analysis of different, often rare, subpopulations of cells in a heterogeneous mixture of cell types. For the isolation of pre-specified cellular subtypes, fluorescence activated cell sorting (FACS) i...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21186557
更新日期：2020-09-08 00:00:00
abstract：:Dihydroxyacetone (DHA) kinase from Citrobacter freundii provides an easy entry for the preparation of DHA phosphate; a very important C3 building block in nature. To modify the phosphoryl donor specificity of this enzyme from ATP to inorganic polyphosphate (poly-P); a directed evolution program has been initiated. In ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms161126073
更新日期：2015-11-24 00:00:00
abstract：:MicroRNAs (miRNAs) are small noncoding RNAs that have emerged as new potential epigenetic biomarkers. Here, we evaluate the efficacy of six circulating miRNA previously described in the literature as biomarkers for the diagnosis of temporal lobe epilepsy (TLE) and/or as predictive biomarkers to antiepileptic drug resp...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms22020702
更新日期：2021-01-12 00:00:00
abstract：:Streptococcus mutans (S. mutans) is widely regarded as the main cause of human dental caries via three main virulence factors: adhesion, acidogenicity, and aciduricity. Citric acid is one of the antibiotic agents that can inhibit the virulence capabilities of S. mutans. A full understanding of the acidic resistance me...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21249481
更新日期：2020-12-13 00:00:00
abstract：:The 18 kDa translocator protein (TSPO) is an evolutionary conserved cholesterol binding protein localized in the outer mitochondrial membrane. It has been implicated in the regulation of various cellular processes including oxidative stress, proliferation, apoptosis, and steroid hormone biosynthesis. Since the express...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20133359
更新日期：2019-07-09 00:00:00
abstract：:Benzo[a]pyrene (BaP) is a well-known carcinogen formed during the cooking process. Although BaP exposure has been implicated as one of the risk factors for lung cancer in animals and humans, there are only limited data on BaP-induced gastrointestinal cancer. Therefore, this study investigated the protective effects of...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20225533
更新日期：2019-11-06 00:00:00
abstract：:In inflammatory bowel diseases (IBD), the therapeutic benefit and mucosal healing from specific probiotics may relate to the modulation of dendritic cells (DCs). Herein, we assessed the immunomodulatory effects of four probiotic strains including Lactobacillus salivarius, Bifidobacterium bifidum, Bacillus coagulans an...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21176266
更新日期：2020-08-29 00:00:00
abstract：:Benzimidazole derivatives have a diverse range of biological activities, including antiulcer, antihypertensive, antiviral, antifungal, anti-inflammatory, and anticancer. Despite these activities, previous studies have revealed that some of the derivatives can induce mutations. This study aimed to screen for potential ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20184324
更新日期：2019-09-04 00:00:00
