Abstract：
:Substantial efforts are underway for prevention of early stages or recurrence of colorectal cancers (CRC) or new polyp formation by chemoprevention strategies. Several epidemiological, clinical and preclinical studies to date have supported the chemopreventive potentials of several targeted drug classes including non-steroidal anti-inflammatory drugs (NSAIDs) (aspirin, naproxen, sulindac, celecoxib, and licofelone), statins and other natural agents-both individually, and in combinations. Most preclinical trials although were efficacious, only few agents entered clinical trials and have been proven to be potential chemopreventive agents for colon cancer. However, there are limitations for these agents that hinder their approval by the food and drug administration for chemoprevention use in high-risk individuals and in patients with early stages of CRC. In this review, we update the recent advancement in pre-clinical and clinical development of selected anti-inflammatory agents (aspirin, naproxen, sulindac, celecoxib, and licofelone) and their combinations for further development as novel colon cancer chemopreventive drugs. We provide further new perspectives from this old research, and insights into precision medicine strategies to overcome unwanted side-effects and overcoming strategies for colon cancer chemoprevention.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Mohammed A,Yarla NS,Madka V,Rao CVdoi
10.3390/ijms19082332subject
Has Abstractpub_date
2018-08-08 00:00:00issue
8issn
1422-0067pii
ijms19082332journal_volume
19pub_type
杂志文章,评审abstract：:In the first trimester of pregnancy, placental development involves a wide range of cellular processes. These include trophoblast proliferation, fusion, and differentiation, which are dependent on tight cell cycle control. The intrauterine environment affects placental development, which also includes the trophoblast ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21020468
更新日期：2020-01-11 00:00:00
abstract：:The drought is a crucial environmental factor that determines yielding of many crop species, e.g., Fabaceae, which are a source of valuable proteins for food and feed. Herein, we focused on the events accompanying drought-induced activation of flower abscission zone (AZ)-the structure responsible for flower detachment...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20153731
更新日期：2019-07-31 00:00:00
abstract：:We report the characterization of 16 polymorphic microsatellite markers in the golden apple snail, Pomacea canaliculata, a pest registered in the list of "100 of the world's worst invasive alien species". The fast isolation by AFLP (Amplified Fragment Length Polymorphism) of sequences containing repeats (FIASCO) metho...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms12095993
更新日期：2011-01-01 00:00:00
abstract：:Renal fibrosis is the final common pathway of numerous progressive kidney diseases, and transforming growth factor-β (TGF-β) has an important role in tissue fibrosis by up-regulating matrix protein synthesis, inhibiting matrix degradation, and altering cell-cell interaction. Many strategies targeting TGF-β, including ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms19092532
更新日期：2018-08-27 00:00:00
abstract：:Wheat protein is considered a major type of food allergen in many countries including the USA. The mechanisms of allergenicity of wheat proteins are not well understood at present. Both adjuvant-based and adjuvant-free mouse models are reported for this food allergy. However, it is unclear whether the mechanisms under...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21093205
更新日期：2020-05-01 00:00:00
abstract：:Mutations induced by radiation are widely used for developing new varieties of plants. To better understand the frequency and pattern of irradiation-induced chromosomal rearrangements, we irradiated the dry seeds of Chinese Spring (CS)-Dasypyrum villosum nullisomic-tetrasomic (6A/6D) addition (6V) line (2n = 44), WD14...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms161226134
更新日期：2015-12-14 00:00:00
abstract：:Adsorption of precious metals in acidic aqueous solutions using thiourea modified magnetic magnetite nanoparticle (MNP-Tu) was examined. The MNP-Tu was synthesized, characterized and examined as a reusable adsorbent for the recovery of precious metals. The adsorption kinetics were well fitted with pseudo second-order e...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms14059834
更新日期：2013-05-08 00:00:00
abstract：:Protein kinases of the CK1 family can be involved in numerous physiological and pathophysiological processes. Dysregulated expression and/or activity as well as mutation of CK1 isoforms have previously been linked to tumorigenesis. Among all neoplastic diseases, colon and rectal cancer (CRC) represent the fourth leadi...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20246184
更新日期：2019-12-07 00:00:00
abstract：:Sclerotinia sclerotiorum (Ss) is a devastating fungal pathogen that causes Sclerotinia stem rot in rapeseed (Brassica napus), and is also detrimental to mulberry and many other crops. A wild mulberry germplasm, Morus laevigata, showed high resistance to Ss, but the molecular basis for the resistance is largely unknown...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21218358
更新日期：2020-11-07 00:00:00
abstract：:Human endogenous retroviruses (HERVs) are genetic parasites, in-between genetics and environment. Few HERVs retain some coding capability. Sometimes, the host has the advantage of some HERV genes; conversely, HERVs may contribute to pathogenesis. The expression of HERVs depends on several factors, and is regulated epi...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms20153706
更新日期：2019-07-29 00:00:00
abstract：:KRAS oncogenic mutations are widespread in lung cancer and, because direct targeting of KRAS has proven to be challenging, KRAS-driven cancers lack effective therapies. One alternative strategy for developing KRAS targeted therapies is to identify downstream targets involved in promoting important malignant features, ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21165806
更新日期：2020-08-13 00:00:00
abstract：:Lifestyle-related disorders, such as the metabolic syndrome, have become a primary risk factor for the development of liver pathologies that can progress from hepatic steatosis, hepatic insulin resistance, steatohepatitis, fibrosis and cirrhosis, to the most severe condition of hepatocellular carcinoma (HCC). While th...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms19030921
更新日期：2018-03-20 00:00:00
abstract：:Sunflower (Helianthus annuus L.) oil remains under-utilised albeit one of the major seed oils produced world-wide. Moreover, the high oleic sunflower varieties make the oil attractive for applications requiring high temperature processes and those targeting the C=C double bond functionality. Herein an overview of the ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms9081393
更新日期：2008-08-01 00:00:00
abstract：:In 1993, Rosen and collaborators discovered that the gene encoding SOD1 has mutations in amyotrophic lateral sclerosis (ALS) patients; moreover, these mutations are found in the exon regions, suggesting that their toxic effects are the consequence of protein dysfunction with an increase of oxidative stress. While a cl...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms19051345
更新日期：2018-05-03 00:00:00
abstract：:Interferon (IFN)-γ is mainly secreted by CD4+ T helper 1 (Th1), natural killer (NK) and NKT cells after skin injury. Although IFN-γ is well known regarding its inhibitory effects on collagen synthesis by fibroblasts in vitro, information is limited regarding its role in wound healing in vivo. In the present study, we ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20225657
更新日期：2019-11-12 00:00:00
abstract：:Cortisol is a steroid hormone essential to the maintenance of homeostasis that is released in response to stress and low blood glucose concentration. Cortisol is converted from cortisone by 11βhydroxysteroid dehydrogenase type 1 (HSD11B1). It has been reported that too much cortisol or overexpression of HSD11B1 induce...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms18122625
更新日期：2017-12-05 00:00:00
abstract：:Lung cancer is the leading cause of death in the world, and the most common type of lung cancer is non-small-cell lung cancer (NSCLC), accounting for 85% of lung cancer. Patients with NSCLC, when detected, are mostly in a metastatic stage, and over half of patients diagnosed with NSCLC die within one year after diagno...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21124218
更新日期：2020-06-13 00:00:00
abstract：BACKGROUND:Nowadays, the molecular mechanisms governing TSD (temperature-dependent sex determination) or GSD + TE (genotypic sex determination + temperature effects) remain a mystery in fish. METHODS:We developed three all-female families of Nile tilapia (Oreochromis niloticus), and the family with the highest male ra...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19030689
更新日期：2018-02-28 00:00:00
abstract：:This study aimed to determine the effect of selected essential oil compounds (EOCs) on the antibacterial activity of β-lactam antibiotics (βLAs) against methicillin-resistant Staphylococcus aureus (MRSA) strains. The following parameters were studied: antibiotic susceptibility testing, detection of mecA gene and evalu...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21197106
更新日期：2020-09-26 00:00:00
abstract：:Viral persistency in latently infected CD4+ T cells despite antiretroviral therapy (ART) represents a major drawback in the fight against HIV-1. Efforts to purge latent HIV-1 have been attempted using latency reversing agents (LRAs) that activate expression of the quiescent virus. However, initial trials have shown th...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms20184490
更新日期：2019-09-11 00:00:00
abstract：:Several studies indicate that bisphenol A (BPA) and phthalates may have a role in the development of metabolic diseases using different molecular pathways, including epigenetic regulatory mechanisms. However, it is unclear whether exposure to these chemicals modifies serum levels of miRNAs associated with gestational ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20133343
更新日期：2019-07-07 00:00:00
abstract：:Nature has evolved sequence-controlled polymers such as DNA and proteins over its long history [...]. ...
journal_title：International journal of molecular sciences
pub_type： 社论
doi：10.3390/ijms21093276
更新日期：2020-05-06 00:00:00
abstract：:Left ventricular remodeling (LVR) occurring after ST-segment elevation myocardial infarction (STEMI) is frequent and severe. We present a metabolomic approach as an attempt to reveal unknown biomarkers associated with post-STEMI LVR. Out of 192 consecutive patients with successfully revascularized STEMI, 32 presented ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20020289
更新日期：2019-01-12 00:00:00
abstract：:Ly-6/uPAR or three-finger proteins (TFPs) contain a disulfide-stabilized β-structural core and three protruding loops (fingers). In mammals, TFPs have been found in epithelium and the nervous, endocrine, reproductive, and immune systems. Here, using heteronuclear NMR, we determined the three-dimensional (3D) structure...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21197280
更新日期：2020-10-01 00:00:00
abstract：:Oral cancer is a common cancer with poor prognosis. We evaluated the expression of PBK/TOPK (PDZ-binding kinase/T-LAK cell-originated protein kinase) and its prognostic significance in oral cancer. PBK/TOPK expression was measured by immunohistochemical staining of samples from 287 patients with oral cancer. The assoc...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms17071007
更新日期：2016-06-24 00:00:00
abstract：:Brain-derived neurotrophic factor (BDNF), a member of the neurotrophin family, is involved in multiple and fundamental functions of the central and peripheral nervous systems including sensory organs. Despite recent advances in knowledge on the functional significance of BDNF and TrkB in the regulation of the acoustic...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21165787
更新日期：2020-08-12 00:00:00
abstract：:C-type lectin receptors and their adaptor molecules are involved in the recognition of glycosylated self-antigens and pathogens. However, little is known about the species- and organ-specific expression profiles of these molecules. We therefore determined the mRNA expression levels of Dectin-1, MR1, MR2, DC-SIGN, Syk,...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms130810113
更新日期：2012-01-01 00:00:00
abstract：:Wheat amylase trypsin inhibitors (ATIs) represent a common dietary protein component of gluten-containing cereals (wheat, rye, and barley). They act as toll-like receptor 4 ligands, and are largely resistant to intestinal proteases, eliciting a mild inflammatory response within the intestine after oral ingestion. Impo...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21176288
更新日期：2020-08-31 00:00:00
abstract：:Topical or systemic administration of JAK inhibitors has been shown to be a new treatment modality for severe alopecia areata (AA). Some patients show a good response to JAK inhibitors, but frequently relapse after cessation of the treatment. There have been no guidelines about the indications and use of JAK inhibitor...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21145137
更新日期：2020-07-20 00:00:00
abstract：:Protein microarrays are powerful tools that are widely used in systems biology research. For infectious diseases, proteome microarrays assembled from proteins of pathogens will play an increasingly important role in discovery of diagnostic markers, vaccines, and therapeutics. Distinct formats of protein microarrays ha...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms11125165
更新日期：2010-01-01 00:00:00
