Abstract：
:Oral cancer is a common cancer with poor prognosis. We evaluated the expression of PBK/TOPK (PDZ-binding kinase/T-LAK cell-originated protein kinase) and its prognostic significance in oral cancer. PBK/TOPK expression was measured by immunohistochemical staining of samples from 287 patients with oral cancer. The association between PBK/TOPK expression and clinicopathological features was analyzed. The prognostic value of PBK/TOPK for overall survival was determined by Kaplan-Meier analysis and Cox proportional hazard models. A high PBK/TOPK expression level was correlated with long overall survival. The prognostic role of PBK/TOPK expression was significant in young patients (p < 0.05), patients with smoking habits (p < 0.05), and late stage disease (p < 0.05). Our results suggest that PBK/TOPK expression is enhanced in oral cancer. High PBK/TOPK expression, either alone or in subgroups according to clinicopathological features, may serve as a favorable prognostic marker for patients with oral cancer.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Chang CF,Chen SL,Sung WW,Hsieh MJ,Hsu HT,Chen LH,Chen MK,Ko JL,Chen CJ,Chou MCdoi
10.3390/ijms17071007subject
Has Abstractpub_date
2016-06-24 00:00:00issue
7issn
1422-0067pii
ijms17071007journal_volume
17pub_type
杂志文章abstract：:Larix olgensis Henry is an important coniferous species found in plantation forests in northeastern China, but it is vulnerable to pathogens. Nitric oxide (NO) is an important molecule involved in plant resistance to pathogens. To study the regulatory role of NO at the transcriptional level, we characterized the trans...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms161226117
更新日期：2015-12-02 00:00:00
abstract：:From the stems of Liriodendron tulipifera, seventeen known compounds have been extracted, isolated and purified. By using spectroscopic analysis, the structures of these pure constituents were determined as three lignans, four steroids and ten benzenoids. Identified compounds were screened for antioxidant abilities u...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms14011698
更新日期：2013-01-15 00:00:00
abstract：:Metformin is known to alleviate hepatosteatosis by inducing 5' adenosine monophosphate (AMP)-kinase-independent, sirtuin 1 (SIRT1)-mediated autophagy. Dysfunctional mitophagy in response to glucolipotoxicities might play an important role in hepatosteatosis. Here, we investigated the mechanism by which metformin induc...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms17010122
更新日期：2016-01-16 00:00:00
abstract：:Induced resistance by elicitors is considered to be an eco-friendly strategy to stimulate plant defense against pathogen attack. In this study, we elucidated the effect of salicylic acid (SA) on induced resistance in rubber tree against Phytophthora palmivora and evaluated the possible defense mechanisms that were inv...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19071883
更新日期：2018-06-26 00:00:00
abstract：:Efficient charge transport has been observed in iodine-doped, iodide-based room-temperature ionic liquids, yielding high ionic conductivity. To elucidate preferred mechanistic pathways for the iodide ( I - )-to-triiodide ( I 3 - ) exchange reactions, we have performed 10 ns reactive molecular-dynamics calculations in ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20051123
更新日期：2019-03-05 00:00:00
abstract：:Bacterial pathogens expose on the cell surface a variety of complex carbohydrate molecules. Gram-negative bacteria produce lipopolysaccharides, which are the main components of the outer membrane of bacterial envelopes and play a major role in host-pathogen interactions. B. pertussis, B. parapertussis, B. bronchisepti...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms22031029
更新日期：2021-01-21 00:00:00
abstract：:The silencing of thyroid-related genes presents difficulties in radioiodine therapy for anaplastic thyroid cancers (ATCs). Tunicamycin (TM), an N-linked glycosylation inhibitor, is an anticancer drug. Herein, we investigated TM-induced restoration of responsiveness to radioiodine therapy in radioiodine refractory ATCs...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms22031077
更新日期：2021-01-22 00:00:00
abstract：:The interactions of chemokines with their G protein-coupled receptors promote the migration of leukocytes during normal immune function and as a key aspect of the inflammatory response to tissue injury or infection. This review summarizes the major cellular and biochemical mechanisms by which the interactions of chemo...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms18020342
更新日期：2017-02-07 00:00:00
abstract：:Most cancer therapeutics, such as tubulin-targeting chemotherapy drugs, cause cytotoxic, non-selective effects. These harmful side-effects drastically reduce the cancer patient's quality of life. Recently, researchers have focused their efforts on studying natural health products (NHP's) which have demonstrated the ab...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21228480
更新日期：2020-11-11 00:00:00
abstract：:Opioid analgesics such as morphine have indispensable roles in analgesia. However, morphine use can elicit side effects such as respiratory depression and constipation. It has been reported that G protein-biased agonists as substitutes for classic opioid agonists can alleviate (or even eliminate) these side effects. T...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21134699
更新日期：2020-07-01 00:00:00
abstract：:A distinct G-protein coupled receptor that senses changes in extracellular Zn2+, ZnR/GPR39, was found in cells from tissues in which Zn2+ plays a physiological role. Most prominently, ZnR/GPR39 activity was described in prostate cancer, skin keratinocytes, and colon epithelial cells, where zinc is essential for cell g...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms19020439
更新日期：2018-02-01 00:00:00
abstract：:Antibodies are composed of structurally and functionally independent domains that can be used as building blocks to construct different types of chimeric protein-format molecules. However, the generally used genetic fusion and chemical approaches restrict the types of structures that can be formed and do not give an i...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21030711
更新日期：2020-01-21 00:00:00
abstract：:Acute kidney injury (AKI) in critically ill children and adults is associated with significant short- and long-term morbidity and mortality. As serum creatinine- and urine output-based definitions of AKI have relevant limitations, there is a persistent need for better diagnostics of AKI. Nuclear magnetic resonance (NM...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21041187
更新日期：2020-02-11 00:00:00
abstract：:Proteolipid protein 2 (PLP2), a membrane protein of the endoplasmic reticulum, is related to tumor proliferation and metastasis in some human cancers, but not in gliomas. First, we performed western-blot analysis, real-time quantitative PCR and immunohistochemical stains to detect PLP2 expression in 4 glioma cell line...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19113353
更新日期：2018-10-26 00:00:00
abstract：:Previous studies have shown that germin-like proteins (GLPs) are present ubiquitously in rice and Arabidopsis. However, the understanding regarding their role in development and abiotic/biotic stress resistance remains limited. In the present study, we report genome-wide identification, characterisation, subcellular l...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms17101622
更新日期：2016-09-23 00:00:00
abstract：:Hereditary haemorrhagic telangiectasia (HHT) is an autosomal dominant inherited disease characterised by multisystemic vascular dysplasia. Heritable pulmonary arterial hypertension (HPAH) is a rare but severe complication of HHT. Both diseases can be the result of genetic mutations in ACVLR1 and ENG encoding for prote...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms19103203
更新日期：2018-10-17 00:00:00
abstract：:The epiphyseal plate is a hyaline cartilage plate that sits between the diaphysis and the epiphysis. The objective of this study was to determine the impact of an injury in the growth plate chondrocytes through the study of histological morphology, immunohistochemistry, histomorphometry and Western Blot analyses of th...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms140815767
更新日期：2013-07-29 00:00:00
abstract：:Axitinib is an orally available inhibitor of tyrosine kinases, with high specificity for vascular endothelial growth factor receptors (VEGFRs) 1, 2, and 3. It is approved for the treatment of advanced renal cell carcinoma and is in phase II clinical trials for recurrent glioblastoma (GBM). GBM is a brain tumor peculia...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21041490
更新日期：2020-02-21 00:00:00
abstract：:Chemoresistance is a leading cause of morbidity and mortality in cancer and it continues to be a challenge in cancer treatment. Chemoresistance is influenced by genetic and epigenetic alterations which affect drug uptake, metabolism and export of drugs at the cellular levels. While most research has focused on tumor c...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms18071586
更新日期：2017-07-21 00:00:00
abstract：:Peroxisome proliferator activated receptor α (PPARα) has the most relevant biological functions among PPARs. Activation by drugs and dietary components lead to major metabolic changes, from reduced triglyceridemia to improvement in the metabolic syndrome. Polymorphisms of PPARα are of interest in order to improve our ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms20184378
更新日期：2019-09-06 00:00:00
abstract：:Plants have evolved a sophisticated innate immune system to cope with a diverse range of phytopathogens and insect herbivores. Plasma-membrane-localized pattern recognition receptors (PRRs), such as receptor-like kinases (RLK), recognize special signals, pathogen- or damage-associated molecular patterns (PAMPs or DAMP...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms20184343
更新日期：2019-09-05 00:00:00
abstract：:Neurodegenerative diseases (NDDs) such as Alzheimer's disease, Parkinson's disease and Huntington's disease (HD), amyotrophic lateral sclerosis, and prion diseases are all characterized by the accumulation of protein aggregates (amyloids) into inclusions and/or plaques. The ubiquitous presence of amyloids in NDDs sugg...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms19010325
更新日期：2018-01-22 00:00:00
abstract：:HD-Zip proteins are unique to plants, and contain a homeodomain closely linked to a leucine zipper motif, which are involved in dimerization and DNA binding. Based on homology in the HD-Zip domain, gene structure and the presence of additional motifs, HD-Zips are divided into four families, HD-Zip I⁻IV. Phylogenetic a...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms19124047
更新日期：2018-12-14 00:00:00
abstract：:Cisplatin is one of the most widely used chemical drugs for anticancer treatment. Recent studies have focused on the ability of cisplatin to retain the high mobility group box 1 (HMGB1) protein in cisplatin-DNA adducts, thereby preventing its release from the nucleus. Because HMGB1 is a powerful inflammatory mediator ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms140611224
更新日期：2013-05-27 00:00:00
abstract：:While two mouse NANOS paralogues, NANOS2 and NANOS3, are crucial for maintenance of germ cells by suppression of apoptosis, the mouse NANOS1 paralogue does not seem to regulate these processes. Previously, we described a human NANOS1 p.[(Pro34Thr);(Ser83del)] mutation associated with the absence of germ cells in semin...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21083009
更新日期：2020-04-24 00:00:00
abstract：:The Kv4 family of voltage-gated K⁺ channels underlie the fast transient (A-type) outward K⁺ current. Although A-type currents are critical to determine somato-dendritic integration in central neurons, relatively little is known about the precise subcellular localisation of the underlying channels in hippocampal circui...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20020246
更新日期：2019-01-09 00:00:00
abstract：:The last step in the biosynthesis of flavin adenine dinucleotide (FAD) is considered a target for the design of antimicrobial drugs because it is carried out by two non-homologous proteins in eukaryotic and prokaryotic organisms. Monofunctional FMN: adenylyltransferases (FMNAT) in Eukarya and FMNAT modules of bifuncti...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21103738
更新日期：2020-05-25 00:00:00
abstract：:Cancers can cause some proteins to be aberrantly excreted or released in the urine, which can be used as biomarkers. To screen for potential biomarkers for endometrial cancer (ECa), the urinary proteins from patients who were newly diagnosed with early stage ECa and untreated controls were separated using two-dimensio...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms13089489
更新日期：2012-01-01 00:00:00
abstract：:Reduced forms of ascorbate (AsA) and glutathione (GSH) are among the most important non-enzymatic foliar antioxidants in maize (Zea mays L.). The survey was aimed to evaluate impact of bird cherry-oat aphid (Rhopalosiphum padi L.) or grain aphid (Sitobion avenae F.) herbivory on expression of genes related to ascorbat...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms17030268
更新日期：2016-02-23 00:00:00
abstract：:Hepatic disorders have been increasing in recent years because of high carbohydrate diets. Hepatocytes depend mainly on the basal autophagy to maintain hepatic glucose/lipid homeostasis in mammals. However, the regulatory mechanisms of autophagy in hepatic energy metabolism are still unknown in fish species. According...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21041533
更新日期：2020-02-24 00:00:00
