Abstract：
:The interactions of chemokines with their G protein-coupled receptors promote the migration of leukocytes during normal immune function and as a key aspect of the inflammatory response to tissue injury or infection. This review summarizes the major cellular and biochemical mechanisms by which the interactions of chemokines with chemokine receptors are regulated, including: selective and competitive binding interactions; genetic polymorphisms; mRNA splice variation; variation of expression, degradation and localization; down-regulation by atypical (decoy) receptors; interactions with cell-surface glycosaminoglycans; post-translational modifications; oligomerization; alternative signaling responses; and binding to natural or pharmacological inhibitors.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Stone MJ,Hayward JA,Huang C,E Huma Z,Sanchez Jdoi
10.3390/ijms18020342subject
Has Abstractpub_date
2017-02-07 00:00:00issue
2issn
1422-0067pii
ijms18020342journal_volume
18pub_type
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