Abstract：
:CD155 is an adhesion molecule belonging to the Nectin/Nectin-like family often overexpressed on tumor cells and involved in many different processes such as cell adhesion, migration and proliferation. In contrast to these pro-tumorigenic functions, CD155 is also a ligand for the activating receptor DNAM-1 expressed on cytotoxic lymphocytes including Natural Killer (NK) cells and involved in anti-tumor immune response. However, during tumor progression inhibitory receptors for CD155 are up-regulated on the surface of effector cells, contributing to an impairment of their cytotoxic capacity. In this review we will focus on the roles of CD155 as a ligand for the activating receptor DNAM-1 regulating immune surveillance against cancer and as pro-oncogenic molecule favoring tumor proliferation, invasion and immune evasion. A deeper understanding of the multiple roles played by CD155 in cancer development contributes to improving anti-tumor strategies aimed to potentiate immune response against cancer.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Molfetta R,Zitti B,Lecce M,Milito ND,Stabile H,Fionda C,Cippitelli M,Gismondi A,Santoni A,Paolini Rdoi
10.3390/ijms21030922subject
Has Abstractpub_date
2020-01-30 00:00:00issue
3issn
1422-0067pii
ijms21030922journal_volume
21pub_type
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