Abstract：
:Gonadal hormone 17β-estradiol (E2) and its receptors are key regulators of gene transcription by binding to estrogen responsive elements in the genome. Besides the classical genomic action, E2 regulates gene transcription via the modification of epigenetic marks on DNA and histone proteins. Depending on the reaction partner, liganded estrogen receptor (ER) promotes DNA methylation at the promoter or enhancer regions. In addition, ERs are important regulators of passive and active DNA demethylation. Furthermore, ERs cooperating with different histone modifying enzymes and chromatin remodeling complexes alter gene transcription. In this review, we survey the basic mechanisms and interactions between estrogen receptors and DNA methylation, demethylation and histone modification processes as well as chromatin remodeling complexes. The particular relevance of these mechanisms to physiological processes in memory formation, embryonic development, spermatogenesis and aging as well as in pathophysiological changes in carcinogenesis is also discussed.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Kovács T,Szabó-Meleg E,Ábrahám IMdoi
10.3390/ijms21093177subject
Has Abstractpub_date
2020-04-30 00:00:00issue
9issn
1422-0067pii
ijms21093177journal_volume
21pub_type
杂志文章,评审abstract：:Due to the present scenario of climate change, plants have to evolve strategies to survive and perform under a plethora of biotic and abiotic stresses, which restrict plant productivity. Maintenance of plant protein functional conformation and preventing non-native proteins from aggregation, which leads to metabolic d...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
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更新日期：2019-10-25 00:00:00
abstract：:Liposomes have been one of the most exploited drug delivery systems in recent decades. However, their large-scale production with low batch-to-batch differences is a challenge for industry, which ultimately delays the clinical translation of new products. We have investigated the effects of formulation parameters on t...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21051611
更新日期：2020-02-26 00:00:00
abstract：:Thyroid cancer incidence has increased worldwide; however, investigations of thyroid cancer-related factors as potential prognosis markers remain insufficient. Secreted proteins from the cancer secretome are regulators of several molecular mechanisms and are, thereby, ideal candidates for potential markers. We aimed t...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
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更新日期：2020-12-15 00:00:00
abstract：:Acoustic wave biosensors are a real-time, label-free biosensor technology, which have been exploited for the detection of proteins and cells. One of the conventional biosensor approaches involves the immobilization of a monolayer of antibodies onto the surface of the acoustic wave device for the detection of a specifi...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms9020154
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
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更新日期：2017-01-29 00:00:00
abstract：:The worldwide increase in grapevine trunk diseases, mainly esca, represents a major threat for vineyard sustainability. Biocontrol of a pioneer fungus of esca, Phaeomoniella chlamydospora, was investigated here by deciphering the tripartite interaction between this trunk-esca pathogen, grapevine and the biocontrol-oom...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
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更新日期：2020-09-19 00:00:00
abstract：:Glioblastoma (GBM) is an extremely aggressive tumor of the central nervous system, with a prognosis of 12-15 months and just 3-5% of survival over 5 years. This is mainly because most patients suffer recurrence after treatment that currently consists in maximal resection followed by radio- and chemotherapy with temozo...
journal_title：International journal of molecular sciences
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更新日期：2019-06-04 00:00:00
abstract：:This review highlights the added value of PET imaging in Central Nervous System (CNS) tumors, which is a tool that has rapidly evolved from a merely diagnostic setting to multimodal molecular diagnostics and the guidance of targeted therapy. PET is the method of choice for studying target expression and target binding...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
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更新日期：2020-02-04 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
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更新日期：2020-08-26 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19051527
更新日期：2018-05-21 00:00:00
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journal_title：International journal of molecular sciences
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doi：10.3390/ijms20040944
更新日期：2019-02-21 00:00:00
abstract：:Stem cell-based therapy is a promising approach to treat cartilage lesions and clinical benefits have been reported in a number of studies. However, the efficacy of cell injection procedures may be impaired by cell manipulation and damage as well as by cell dissemination to non-target tissues. To overcome such issues,...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19113322
更新日期：2018-10-25 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms15057500
更新日期：2014-04-30 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms19051444
更新日期：2018-05-12 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21020493
更新日期：2020-01-13 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20143603
更新日期：2019-07-23 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21061960
更新日期：2020-03-13 00:00:00
abstract：:Strawberry polyphenols have been extensively studied over the last two decades for their beneficial properties. Recently, their possible use in ameliorating skin conditions has also been proposed; however, their role in preventing UVA-induced damage in cosmetic formulation has not yet been investigated. Skin is consta...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms160817870
更新日期：2015-08-04 00:00:00
abstract：:Deregulated microRNA (miRNA) expression profiles and their contribution to carcinogenesis have been observed in virtually all types of human cancer. However, their role in the pathogenesis of rare mesenchymal gastrointestinal stromal tumors (GISTs) is not well defined, yet. In this study, we aimed to investigate the r...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21145151
更新日期：2020-07-21 00:00:00
abstract：:Runx2 is essential for osteoblast differentiation and chondrocyte maturation. During osteoblast differentiation, Runx2 is weakly expressed in uncommitted mesenchymal cells, and its expression is upregulated in preosteoblasts, reaches the maximal level in immature osteoblasts, and is down-regulated in mature osteoblast...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
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更新日期：2019-04-04 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
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更新日期：2020-02-11 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms16012001
更新日期：2015-01-16 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2017-08-02 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
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更新日期：2020-03-10 00:00:00
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journal_title：International journal of molecular sciences
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doi：10.3390/ijms19041110
更新日期：2018-04-07 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms17101523
更新日期：2016-10-24 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms19072030
更新日期：2018-07-12 00:00:00
abstract：:Antimicrobial lipids such as fatty acids and monoglycerides are promising antibacterial agents that destabilize bacterial cell membranes, causing a wide range of direct and indirect inhibitory effects. The goal of this review is to introduce the latest experimental approaches for characterizing how antimicrobial lipid...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms19041114
更新日期：2018-04-08 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
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更新日期：2020-03-29 00:00:00
abstract：:Particulate matter (PM), a widespread air pollutant, consists of a complex mixture of solid and liquid particles suspended in air. Many diseases have been linked to PM exposure, which induces an imbalance in reactive oxygen species (ROS) generated in cells, and might result in skin diseases (such as aging and atopic d...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20174259
更新日期：2019-08-30 00:00:00
