Abstract：
:Idiosyncratic drug-induced liver injury (DILI) is an underreported and underestimated adverse drug reaction. Information on the documented hepatotoxicity of drugs has recently been made available by a website that can be accessed in the public domain: LiverTox (http://livertox.nlm.nih.gov). According to critical analysis of the hepatotoxicity of drugs in LiverTox, 53% of drugs had at least one case report of convincing reports of liver injury. Only 48 drugs had more than 50 case reports of DILI. Amoxicillin-clavulanate is the most commonly implicated agent leading to DILI in the prospective series. In a recent prospective study, liver injury due to amoxicillin-clavulanate was found to occur in approximately one out of 2300 users. Drugs with the highest risk of DILI in this study were azathioprine and infliximab.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Björnsson ESdoi
10.3390/ijms17020224subject
Has Abstractpub_date
2016-02-06 00:00:00pages
224issue
2issn
1422-0067pii
ijms17020224journal_volume
17pub_type
杂志文章,评审abstract：:Polyamines (PAs) are natural compounds involved in many growth and developmental processes in plants, and, specifically in fruits, play a vital role regulating its development, ripening and senescence processes. Putrescine (PUT), spermine (SPE), and spermidine (SPD) are prominent PAs applied exogenously to extend shel...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms18081789
更新日期：2017-08-17 00:00:00
abstract：:Sarcopenia is the degenerative loss of skeletal muscle mass and function associated with aging and occurs in the absence of any underlying disease or condition. A comparison of the age-related molecular signaling signatures of different muscles has not previously been reported. In this study, we compared the age-relat...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
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更新日期：2020-04-20 00:00:00
abstract：:Accurate prediction of the potential hepatotoxic nature of new pharmaceuticals remains highly challenging. Therefore, novel in vitro models with improved external validity are needed to investigate hepatic metabolism and timely identify any toxicity of drugs in humans. In this study, we examined the effects of diclofe...
journal_title：International journal of molecular sciences
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更新日期：2016-04-16 00:00:00
abstract：:Glucose variability (GV) has been recognized recently as a promoter of complications and therapeutic targets in diabetes. The aim of this study was to reconstruct and analyze gene networks related to GV in diabetes and its complications. For network analysis, we used the ANDSystem that provides automatic network recon...
journal_title：International journal of molecular sciences
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更新日期：2020-11-18 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2017-04-20 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2020-08-26 00:00:00
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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更新日期：2019-06-10 00:00:00
abstract：:Copy number variants (CNVs) detected by chromosomal microarray analysis (CMA) significantly contribute to understanding the etiology of autism spectrum disorder (ASD) and other related conditions. In recognition of the value of CMA testing and its impact on medical management, CMA is in medical guidelines as a first-t...
journal_title：International journal of molecular sciences
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更新日期：2016-12-09 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
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更新日期：2019-07-12 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
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更新日期：2015-08-05 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2020-01-10 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2018-05-16 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
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更新日期：2015-02-16 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
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更新日期：2019-11-04 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2014-02-28 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
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更新日期：2018-09-21 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2016-01-05 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2018-10-18 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2020-12-14 00:00:00
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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更新日期：2018-02-17 00:00:00
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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更新日期：2017-08-02 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2018-07-28 00:00:00
