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Neurological and Epigenetic Implications of Nutritional Deficiencies on Psychopathology: Conceptualization and Review of Evidence.

Abstract：

:In recent years, a role for epigenetic modifications in the pathophysiology of disease has received significant attention. Many studies are now beginning to explore the gene-environment interactions, which may mediate early-life exposure to risk factors, such as nutritional deficiencies and later development of behavioral problems in children and adults. In this paper, we review the current literature on the role of epigenetics in the development of psychopathology, with a specific focus on the potential for epigenetic modifications to link nutrition and brain development. We propose a conceptual framework whereby epigenetic modifications (e.g., DNA methylation) mediate the link between micro- and macro-nutrient deficiency early in life and brain dysfunction (e.g., structural aberration, neurotransmitter perturbation), which has been linked to development of behavior problems later on in life.

journal_name

Int J Mol Sci

journal_title

International journal of molecular sciences

authors

Liu J,Zhao SR,Reyes T

doi

10.3390/ijms160818129

subject

Has Abstract

pub_date

2015-08-05 00:00:00

pages

18129-48

issue

8

issn

1422-0067

pii

ijms160818129

journal_volume

16

pub_type

杂志文章,评审

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