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Adult Renal Stem/Progenitor Cells Can Modulate T Regulatory Cells and Double Negative T Cells.

Abstract：

:Adult Renal Stem/Progenitor Cells (ARPCs) have been recently identified in the human kidney and several studies show their active role in kidney repair processes during acute or chronic injury. However, little is known about their immunomodulatory properties and their capacity to regulate specific T cell subpopulations. We co-cultured ARPCs activated by triggering Toll-Like Receptor 2 (TLR2) with human peripheral blood mononuclear cells for 5 days and 15 days and studied their immunomodulatory capacity on T cell subpopulations. We found that activated-ARPCs were able to decrease T cell proliferation but did not affect CD8+ and CD4+ T cells. Instead, Tregs and CD3+ CD4- CD8- double-negative (DN) T cells decreased after 5 days and increased after 15 days of co-culture. In addition, we found that PAI1, MCP1, GM-CSF, and CXCL1 were significantly expressed by TLR2-activated ARPCs alone and were up-regulated in T cells co-cultured with activated ARPCs. The exogenous cocktail of cytokines was able to reproduce the immunomodulatory effects of the co-culture with activated ARPCs. These data showed that ARPCs can regulate immune response by inducing Tregs and DN T cells cell modulation, which are involved in the balance between immune tolerance and autoimmunity.

journal_name

Int J Mol Sci

journal_title

International journal of molecular sciences

authors

Curci C,Picerno A,Chaoul N,Stasi A,De Palma G,Franzin R,Pontrelli P,Castellano G,Pertosa GB,Macchia L,Di Lorenzo VF,Sabbà C,Gallone A,Gesualdo L,Sallustio F

doi

10.3390/ijms22010274

subject

Has Abstract

pub_date

2020-12-29 00:00:00

issue

1

issn

1422-0067

pii

ijms22010274

journal_volume

22

pub_type

杂志文章

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