Abstract：
:To increase the efficiency of therapy via enhancing its selectivity, the usage of gold nanorods (GNR) as a factor sensitizing cancer cells to radiation was proposed. Due to gold nanoparticles' characteristics, the smaller doses of radiation would be sufficient in the treatment, protecting the healthy tissue around the tumor. The aim of this study was to investigate the effect of gold nanorods on cancer and normal prostate cells and the role of nanorods in the cell response to ionizing radiation. The effect was evaluated by measuring the toxicity, cell cycle, cell granularity, reactive oxygen species (ROS) level, and survival fractions. Nanorods showed a strong toxicity dependent on the concentration and incubation time toward all used cell lines. A slight effect of nanorods on the cycle distribution was observed. The results demonstrated that the administration of nanorods at higher concentrations resulted in an increased level of generated radicals. The results of cellular proliferation after irradiation are ambiguous; however, there are noticeable differences after the application of nanorods before irradiation. The obtained results lead to the conclusion that nanorods affect the physiology of both normal and cancer cells. Nanorods might become a potential tool used to increase the effectiveness of radiation treatment.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Musielak M,Boś-Liedke A,Piotrowski I,Kozak M,Suchorska Wdoi
10.3390/ijms22010016subject
Has Abstractpub_date
2020-12-22 00:00:00issue
1issn
1422-0067pii
ijms22010016journal_volume
22pub_type
杂志文章abstract：:Phenolic compounds are responsible of the nutritional and sensory quality of extra-virgin olive oil (EVOO). The composition of phenolic compounds in EVOO is related to the initial content of phenolic compounds in the olive-fruit tissues and the activity of enzymes acting on these compounds during the industrial proces...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms17030337
更新日期：2016-03-04 00:00:00
abstract：:This study investigated the effect of casein phosphopeptide-amorphous calcium phosphate (CPP-ACP)-modified glass ionomer cement (GIC) on shear bond strength (SBS) and remineralisation of artificial "caries-affected" dentine. Human dentine slices were demineralised and allocated to three groups: group 1, conventional G...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms18081723
更新日期：2017-08-07 00:00:00
abstract：:Agricultural production continues to be constrained by a number of biotic and abiotic factors that can reduce crop yield quantity and quality. Potassium (K) is an essential nutrient that affects most of the biochemical and physiological processes that influence plant growth and metabolism. It also contributes to the s...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms14047370
更新日期：2013-04-02 00:00:00
abstract：:It is widely accepted that chronic inflammation initiates and promotes carcinogenesis and tumor progression in various cell types. However, this paradigm has not been comprehensively investigated in melanoma. To investigate the effects of chronic inflammation on the progression of melanoma, we established a murine inf...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20010169
更新日期：2019-01-04 00:00:00
abstract：:The objective of this study was to determine the effects of feeding protein-iron complex (PIC) on productive performance and indicators of iron metabolism, hematology parameters, antioxidant and immune status during first 35 days of a calf's life. Preparation of the complex involved enzymatic hydrolysis of milk casein...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms18071501
更新日期：2017-07-12 00:00:00
abstract：:In modern societies, high fructose intake from sugar-sweetened beverages has contributed to obesity development. In the diet, sucrose and high fructose corn syrup are the main sources of fructose and can be metabolized in the intestine and transported into the systemic circulation. The liver can metabolize around 70% ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms20112787
更新日期：2019-06-07 00:00:00
abstract：:Rhodobactersphaeroides has two chemotaxis clusters, an Escherichia coli-like cluster with membrane-spanning chemoreceptors and a less-understood cytoplasmic cluster. The cytoplasmic CheA is split into CheA4, a kinase, and CheA3, a His-domain phosphorylated by CheA4 and a phosphatase domain, which together phosphorylat...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20205095
更新日期：2019-10-14 00:00:00
abstract：:Bisphenol A (BPA) is a widespread pollutant threatening the ecosystem and human health. An effective BPA degrader YC-JY1 was isolated and identified as Sphingobium sp. The optimal temperature and pH for the degradation of BPA by strain YC-JY1 were 30 °C and 6.5, respectively. The biodegradation pathway was proposed ba...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21103588
更新日期：2020-05-19 00:00:00
abstract：:The application of nanotechnology for the treatment of cancer is mostly based on early tumor detection and diagnosis by nanodevices capable of selective targeting and delivery of chemotherapeutic drugs to the specific tumor site. Due to the remarkable properties of gold nanoparticles, they have long been considered as...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms19071979
更新日期：2018-07-06 00:00:00
abstract：:Determination of the thermal characteristics and temperature-dependent rheological properties of the magnetorheological elastomers (MREs) is of paramount importance particularly with regards to MRE applications. Hitherto, a paucity of temperature dependent analysis has been conducted by MRE researchers. In this study,...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20030746
更新日期：2019-02-10 00:00:00
abstract：:Lung squamous cell carcinoma (LUSC) is often diagnosed at the advanced stage with poor prognosis. The mechanisms of its pathogenesis and prognosis require urgent elucidation. This study was performed to screen potential biomarkers related to the occurrence, development and prognosis of LUSC to reveal unknown physiolog...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21082994
更新日期：2020-04-23 00:00:00
abstract：:Esophageal adenocarcinoma (EAC) is a highly lethal cancer type with an overall poor survival rate. Twenty to thirty percent of EAC overexpress the human epidermal growth factor receptor 2 (Her2), a transmembrane receptor tyrosine kinase promoting cell growth and proliferation. Patients with Her2 overexpressing breast ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19103069
更新日期：2018-10-08 00:00:00
abstract：:The cluster Re6Se8I63- has been shown to induce preferential cell death of a hepatic carcinoma cell line, thus becoming a promising anti-cancer drug. Whether this cluster induces acute hemolysis or if it interacts with albumin remains unclear. The effect of acute exposure of human red blood cells to different concentr...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms16011728
更新日期：2015-01-13 00:00:00
abstract：:Growing evidence suggests that inflammatory responses, in both the brain and peripheral tissues, contribute to disease pathology in Huntington's disease (HD), an inherited, progressive neurodegenerative disorder typically affecting adults in their 30-40 s. Hence, studies of inflammation-related markers in peripheral f...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21176363
更新日期：2020-09-02 00:00:00
abstract：:Sjögren's syndrome (SS) is a chronic autoimmune disease characterized by lymphocytic infiltration of salivary and lacrimal glands resulting in diminished production of saliva and tears. The pathophysiology of SS has not yet been fully deciphered. Classically it has been postulated that sicca symptoms in SS patients ar...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms19113392
更新日期：2018-10-30 00:00:00
abstract：:Shared metabolomic patterns at delivery have been suggested to underlie the mother-to-child transmission of adverse metabolic health. This study aimed to investigate whether mothers with gestational diabetes mellitus (GDM) and their offspring show similar metabolomic patterns several years postpartum. Targeted metabol...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21249647
更新日期：2020-12-17 00:00:00
abstract：:Although not a disease itself, aging represents a risk factor for many aging-related illnesses, including cancer. Numerous causes underlie the increased incidence of malignancies in the elderly, for example, genomic instability and epigenetic alterations that occur at cellular level, which also involve the immune cell...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms19123774
更新日期：2018-11-27 00:00:00
abstract：:Given their extremely small size and light weight, carbon nanotubes (CNTs) can be readily inhaled by human lungs resulting in increased rates of pulmonary disorders, particularly fibrosis. Although the fibrogenic potential of CNTs is well established, there is a lack of consensus regarding the contribution of physicoc...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms15057444
更新日期：2014-04-29 00:00:00
abstract：:Thrombospondin-1 (TSP-1) is a potent endogenous inhibitor of both physiological and pathological angiogenesis, widely studied as a target in drug development for treating cancer. Several studies performed in the cardiovascular field on TSP-1 are contradictory, the role of TSP-1 in the physiopathology of cardiovascular...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms18020348
更新日期：2017-02-07 00:00:00
abstract：:Glioblastoma multiforme (GBM) is the most common and aggressive primary brain tumor featuring rapid cell proliferation, treatment resistance, and tumor relapse. This is largely due to the coexistence of heterogeneous tumor cell populations with different grades of differentiation, and in particular, to a small subset ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms20153824
更新日期：2019-08-05 00:00:00
abstract：:Idiopathic Pulmonary Arterial Hypertension (IPAH) is a deadly and disabling disease characterized by severe vascular remodeling of small pulmonary vessels by fibroblasts, myofibroblasts and vascular smooth muscle cell proliferation. Recent studies suggest that the Natriuretic Peptide Clearance Receptor (NPR-C) signali...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms20123063
更新日期：2019-06-22 00:00:00
abstract：:Carbonic anhydrases (CAs) are a family of enzymes involved in the pH regulation of metabolically active cells/tissues. Upregulation of the CAIX/XII isoforms is associated with hypoxic tumours and clinically linked with malignant progression, treatment resistance and poor prognosis. The elucidation of the crystal struc...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms20236080
更新日期：2019-12-02 00:00:00
abstract：:Five 6,6'-dimethyl-2,2'-bipyridine ligands bearing N-arylmethaniminyl substituents in the 4- and 4'-positions were prepared by Schiff base condensation in which the aryl group is Ph (1), 4-tolyl (2), 4- t BuC6H4 (3), 4-MeOC6H4 (4), and 4-Me2NC6H4 (5). The homoleptic copper(I...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21051735
更新日期：2020-03-03 00:00:00
abstract：:Hepatocyte differentiation, proliferation, and apoptosis are affected by growth factors produced in liver. Insulin-like growth factor 1 and 2 (IGF1 and IGF2) act in response to growth hormone (GH). Other IGF family components include at least six binding proteins (IGFBP1 to 6), manifested by both IGFs develop due to i...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms19051308
更新日期：2018-04-27 00:00:00
abstract：:Lysozyme is widely used as a model protein in studies of structure-function relationships. Recently, lysozyme has gained attention for use in accelerating the degradation of secondary sludge, which mainly consists of bacteria. However, a high-throughput screening system for lysozyme engineering has not been reported. ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21228668
更新日期：2020-11-17 00:00:00
abstract：:Pulses are the main source of protein and minerals in the vegetarian diet. These are primarily cultivated on marginal lands with few inputs in several resource-poor countries of the world, including several in South Asia. Their cultivation in resource-scarce conditions exposes them to various abiotic and biotic stress...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms20122971
更新日期：2019-06-18 00:00:00
abstract：:In this paper, we used a Genotyping-by-Sequencing (GBS) approach to find and genotype more than 4000 genome-wide SNPs (Single Nucleotide Polymorphisms) from striped killifish exposed to a variety of polychlorinated biphenyls (PCBs) and other aromatic pollutants in New Bedford Harbor (NBH, Massachusetts, USA). The aims...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20051129
更新日期：2019-03-05 00:00:00
abstract：:Preimplantation embryo manipulations during standard assisted reproductive technologies (ART) have significant repercussions on offspring. However, few studies to date have investigated the potential long-term outcomes associated with the vitrification procedure. Here, we performed an experiment to unravel the particu...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21228642
更新日期：2020-11-16 00:00:00
abstract：:Synovial sarcoma is a rare but highly malignant and metastatic disease. Despite its relative sensitivity to chemotherapies, the high recurrence and low 5-year survival rate for this disease suggest that new effective therapeutic agents are urgently needed. Marine antimicrobial peptide epinecidin-1 (epi-1), which was i...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21062109
更新日期：2020-03-19 00:00:00
abstract：:This study aimed to investigate the effects of cyclopamine, a specific inhibitor of Hedgehog signaling pathways, on the chondrogenic differentiation of mesenchymal stem cells (MSCs). During culture, the experimental groups were treated with cyclopamine and their cell proliferation status was assessed using the MTT tes...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms14035966
更新日期：2013-03-14 00:00:00
