Abstract：
:Idiopathic Pulmonary Arterial Hypertension (IPAH) is a deadly and disabling disease characterized by severe vascular remodeling of small pulmonary vessels by fibroblasts, myofibroblasts and vascular smooth muscle cell proliferation. Recent studies suggest that the Natriuretic Peptide Clearance Receptor (NPR-C) signaling pathways may play a crucial role in the development of IPAH. Reduced expression or function of NPR-C signaling in pulmonary artery smooth muscle cells may contribute to the pulmonary vascular remodeling, which is characteristic of this disease. The likely mechanisms may involve an impaired interaction between NPR-C, specific growth factors and other signal transduction pathways including but not limited to Gqα/mitogen-activated protein kinase (MAPK)/PI3K and AKT signaling. The resulting failure of growth suppression in pulmonary artery smooth muscle cells provides critical clues to the cellular pathobiology of IPAH. The reciprocal regulation of NPR-C signaling in models of tissue remodeling may thus provide new insights to our understanding of IPAH.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Egom EEdoi
10.3390/ijms20123063subject
Has Abstractpub_date
2019-06-22 00:00:00issue
12issn
1422-0067pii
ijms20123063journal_volume
20pub_type
杂志文章,评审abstract：:Regulation of synaptically located ionotropic receptors is thought to be the main mechanism by which anaesthetics cause unconsciousness. An alternative explanation, which has received much less attention, is that of primary anaesthetic disruption of brain metabolism via suppression of mitochondrial proteins. In this p...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21134703
更新日期：2020-07-01 00:00:00
abstract：:Synthesis of the CCA end of essential tRNAs is performed either by CCA-adding enzymes or as a collaboration between enzymes restricted to CC- and A-incorporation. While the occurrence of such tRNA nucleotidyltransferases with partial activities seemed to be restricted to Bacteria, the first example of such split CCA-a...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21020462
更新日期：2020-01-10 00:00:00
abstract：:Aluminum-activated malate transporters (ALMTs) play an important role in aluminum tolerance, stomatal opening, and fruit acidity in plants. However, the evolutionary pattern of the ALMT gene family in apples remains relatively unknown. In this study, a total of 25 MdALMT genes were identified from the apple reference ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19092807
更新日期：2018-09-18 00:00:00
abstract：:Milk fat is a key factor affecting milk quality and is also a major trait targeted in dairy cow breeding. To determine how the synthesis and the metabolism of lipids in bovine milk is regulated at the miRNA level, primary mammary epithelial cells (pMEC) derived from two Chinese Holstein dairy cows that produced extrem...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms17020200
更新日期：2016-02-17 00:00:00
abstract：:MicroRNAs are 18-22 nucleotides long, non-coding RNAs that bind transcripts with complementary sequences leading to either mRNA degradation or translational suppression. However, the inherent differences in preferred mode of miRNA regulation among cells of different origin have not been examined. In our previous trans...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms17010072
更新日期：2016-01-08 00:00:00
abstract：:Three quinary polar intermetallic compounds in the (Eu(1-x)Ca(x))9In8(Ge(1-y)Sn(y))8 (x = 0.66, y = 0.03) and the (Eu(1-x)Ca(x))3In(Ge(3-y)Sn(1+y)) (x = 0.66, 0.68; y = 0.13, 0.27) phases have been synthesized using the molten In-metal flux method, and the crystal structures are characterized by powder and single-crys...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
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abstract：:Cholangiocarcinoma (CCA) is the second most common type of liver cancer, and is highly aggressive with very poor prognosis. CCA is classified into intrahepatic cholangiocarcinoma (iCCA) and extra-hepatic cholangiocarcinoma (eCCA), which is further stratified into perihilar (pCCA) and distal (dCCA). Cancer stem cells (...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
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更新日期：2019-08-25 00:00:00
abstract：:Hepatitis C virus (HCV) is an RNA virus that can efficiently establish chronic infection in humans. The overlap between the HCV replication cycle and lipid metabolism is considered to be one of the primary means by which HCV efficiently develops chronic infections. In the blood, HCV is complex with lipoproteins to for...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
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更新日期：2019-04-25 00:00:00
abstract：:2-Bromopropane (2-BP) is used as an alternative to ozone-depleting cleaning solvents. Previously, we reported that 2-BP has cytotoxic effects on mouse blastocysts and is associated with defects in subsequent development. In the present work, we show that 2-BP induces apoptosis in the inner cell mass of mouse blastocys...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms12084991
更新日期：2011-01-01 00:00:00
abstract：:Background-It is recognized that inflammation is an underlying cause of dry eye disease (DED), with cytokine release involved. We systematically reviewed literature with meta-analyses to quantitatively summarize the levels of tear cytokines in DED. Methods-The PubMed, Embase, Web of Science, Ovid, Cochrane, and Scopus...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
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更新日期：2020-04-28 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms19082208
更新日期：2018-07-28 00:00:00
abstract：:RNA binding protein (RBPs) and microRNAs (miRNAs or miRs) are post-transcriptional regulators of gene expression that are implicated in development of cancers. Although their individual roles have been studied, the crosstalk between RBPs and miRNAs is under intense investigation. Here, we show that in breast cancer ce...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms16047112
更新日期：2015-03-30 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms22010337
更新日期：2020-12-30 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20184650
更新日期：2019-09-19 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21218326
更新日期：2020-11-06 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21145058
更新日期：2020-07-17 00:00:00
abstract：:For many years, it was of interest to identify the sequences encoding the two melatonin receptors (MT₁ and MT₂) from various species. After publishing the basic molecular characterization of the human, rat, mouse, sheep, and platypus MT₁, MT₂, or Mel1c receptors, we began cloning the genes from other animals, such as ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19071957
更新日期：2018-07-04 00:00:00
abstract：:Osteoarthritis (OA) affects the integrity of the entire joint including the synovium. The most abundant cells in the synovium are fibroblasts (SF). Excessive mechanical loading might contribute to OA pathogenesis. Here, we investigate the effects of mechanical loading on SF derived from non-OA (N-SF) and OA patients (...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20030585
更新日期：2019-01-30 00:00:00
abstract：:Neurons are particularly susceptible to microtubule (MT) defects and deregulation of the MT cytoskeleton is considered to be a common insult during the pathogenesis of neurodegenerative disorders. Evidence that dysfunctions in the MT system have a direct role in neurodegeneration comes from findings that several forms...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
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更新日期：2020-10-05 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2017-06-17 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2019-11-04 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms160820001
更新日期：2015-08-21 00:00:00
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journal_title：International journal of molecular sciences
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doi：10.3390/ijms15010798
更新日期：2014-01-09 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
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更新日期：2017-09-19 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2019-03-05 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
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更新日期：2019-03-15 00:00:00
abstract：:Wheat protein is considered a major type of food allergen in many countries including the USA. The mechanisms of allergenicity of wheat proteins are not well understood at present. Both adjuvant-based and adjuvant-free mouse models are reported for this food allergy. However, it is unclear whether the mechanisms under...
journal_title：International journal of molecular sciences
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doi：10.3390/ijms21093205
更新日期：2020-05-01 00:00:00
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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更新日期：2020-04-06 00:00:00
abstract：:Previously, we have found that mildronate [3-(2,2,2-trimethylhydrazinium) propionate dihydrate], a small molecule with charged nitrogen and oxygen atoms, protects mitochondrial metabolism that is altered by inhibitors of complex I and has neuroprotective effects in an azidothymidine-neurotoxicity mouse model. In the p...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms11114465
更新日期：2010-11-09 00:00:00
