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Rat Aquaporin-5 Is pH-Gated Induced by Phosphorylation and Is Implicated in Oxidative Stress.

Abstract：

:Aquaporin-5 (AQP5) is a membrane water channel widely distributed in human tissues that was found up-regulated in different tumors and considered implicated in carcinogenesis in different organs and systems. Despite its wide distribution pattern and physiological importance, AQP5 short-term regulation was not reported and mechanisms underlying its involvement in cancer are not well defined. In this work, we expressed rat AQP5 in yeast and investigated mechanisms of gating, as well as AQP5's ability to facilitate H₂O₂ plasma membrane diffusion. We found that AQP5 can be gated by extracellular pH in a phosphorylation-dependent manner, with higher activity at physiological pH 7.4. Moreover, similar to other mammalian AQPs, AQP5 is able to increase extracellular H₂O₂ influx and to affect oxidative cell response with dual effects: whereas in acute oxidative stress conditions AQP5 induces an initial higher sensitivity, in chronic stress AQP5 expressing cells show improved cell survival and resistance. Our findings support the involvement of AQP5 in oxidative stress and suggest AQP5 modulation by phosphorylation as a novel tool for therapeutics.

journal_name

Int J Mol Sci

journal_title

International journal of molecular sciences

authors

Rodrigues C,Mósca AF,Martins AP,Nobre T,Prista C,Antunes F,Cipak Gasparovic A,Soveral G

doi

10.3390/ijms17122090

subject

Has Abstract

pub_date

2016-12-13 00:00:00

issue

12

issn

1422-0067

pii

ijms17122090

journal_volume

17

pub_type

杂志文章

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