Abstract：
:Bile acids are a family of amphipathic compounds predominantly known for their role in solubilizing and absorbing hydrophobic compounds (including liposoluble vitamins) in the intestine. Bile acids also are key signaling molecules and inflammatory agents that activate transcriptional factors and cell signaling pathways that regulate lipid, glucose, and energy metabolism in various human disorders, including chronic liver diseases. However, in the last decade increased awareness has been founded on the physiological and chemical heterogeneity of this category of compounds and their possible beneficial or injurious effects on the biliary tree. In this review, we provide an update on the current understanding of the molecular mechanism involving bile acid and biliary epithelium. The last achievements of the research in this field are summarized, focusing on the molecular aspects and the elements with relevance regarding human liver diseases.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Baiocchi L,Zhou T,Liangpunsakul S,Lenci I,Santopaolo F,Meng F,Kennedy L,Glaser S,Francis H,Alpini Gdoi
10.3390/ijms20081869subject
Has Abstractpub_date
2019-04-16 00:00:00issue
8issn
1422-0067pii
ijms20081869journal_volume
20pub_type
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journal_title：International journal of molecular sciences
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