Abstract:
:Mitochondria have emerged as key players regarding cellular homeostasis not only due to their contribution regarding energy production through oxidative phosphorylation, but also due to their involvement in signaling, ion regulation, and programmed cell death. Indeed, current knowledge supports the notion that mitochondrial dysfunction is a hallmark in the pathogenesis of various diseases. Mitochondrial biogenesis and function require the coordinated action of two genomes: nuclear and mitochondrial. Unfortunately, both intrinsic and environmental genotoxic insults constantly threaten the integrity of nuclear as well as mitochondrial DNA. Despite the extensive research that has been made regarding nuclear genome instability, the importance of mitochondrial genome integrity has only recently begun to be elucidated. The specific architecture and repair mechanisms of mitochondrial DNA, as well as the dynamic behavior that mitochondria exert regarding fusion, fission, and autophagy participate in mitochondrial genome stability, and therefore, cell homeostasis.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Vasileiou PVS,Mourouzis I,Pantos Cdoi
10.3390/ijms18081821subject
Has Abstractpub_date
2017-08-22 00:00:00issue
8issn
1422-0067pii
ijms18081821journal_volume
18pub_type
杂志文章,评审abstract::Lung cancer is the leading cause of cancer deaths worldwide. Therefore, for the prevention, diagnosis, prognosis and treatment of lung cancer, efficient preventive strategies and new therapeutic strategies are needed to face these challenges. Natural bioactive compounds and particular flavonoids compounds have been pr...
journal_title:International journal of molecular sciences
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更新日期:2019-09-02 00:00:00
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journal_title:International journal of molecular sciences
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abstract::Alemtuzumab, a humanized monoclonal antibody targeting the surface molecule CD52, leads to a rapid depletion of immune cells in the innate and adaptive immune system. In phase 2 and 3 trials in multiple sclerosis (MS), infections have been reported more frequently in alemtuzumab than in interferon beta treated patient...
journal_title:International journal of molecular sciences
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journal_title:International journal of molecular sciences
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abstract::The role of dynamic processes on self-assembled structures of 4'-([2,2':6', 2''-terpyridin]-4'-yl)-[1,1'-biphenyl]-4-carboxylic acid (l) molecules on Au(III) has been studied by scanning tunneling microscopy. The as-deposited monolayer is closed-packed and periodic in a short-range due to dipole forces. A thermal anne...
journal_title:International journal of molecular sciences
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journal_title:International journal of molecular sciences
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abstract::Humans are exposed to phthalates released from plastics, cosmetics, or food on a daily basis. Phthalates have low acute liver toxicity, but their chronic exposures could induce molecular and cellular effects linked to adverse health outcomes, such as liver tumor promotion or chronic liver diseases. The alternation of ...
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更新日期:2017-05-03 00:00:00
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journal_title:International journal of molecular sciences
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journal_title:International journal of molecular sciences
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更新日期:2015-07-08 00:00:00
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journal_title:International journal of molecular sciences
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更新日期:2019-03-31 00:00:00
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journal_title:International journal of molecular sciences
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更新日期:2010-07-09 00:00:00
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journal_title:International journal of molecular sciences
pub_type: 杂志文章
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更新日期:2019-03-27 00:00:00
abstract::Aegilops geniculata Roth has been used as a donor of disease-resistance genes, to enrich the gene pool for wheat (Triticum aestivum) improvement through distant hybridization. In this study, the wheat-Ae. geniculata alien disomic substitution line W16998 was obtained from the BC1F8 progeny of a cross between the commo...
journal_title:International journal of molecular sciences
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journal_title:International journal of molecular sciences
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更新日期:2019-12-12 00:00:00
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journal_title:International journal of molecular sciences
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journal_title:International journal of molecular sciences
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journal_title:International journal of molecular sciences
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abstract::Adenylyl cyclase (AC) is a key enzyme that synthesizes cyclic AMP (cAMP) at the onset of the signaling pathway to activate sperm motility. Here, we showed that both transmembrane AC (tmAC) and soluble AC (sAC) are distinctly involved in the regulation of sperm motility in the ascidian Ciona intestinalis. A tmAC inhibi...
journal_title:International journal of molecular sciences
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更新日期:2014-07-28 00:00:00
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abstract::Psoralea corylifolia L., (P. corylifolia), which is used for treating vitiligo in clinic, shows inhibitory and activating effects on tyrosinase, a rate-limiting enzyme of melanogenesis. This study aimed to determine the active ingredients in the ethenal extracts of P. corylifolia on tyrosinase activity. The spectrum-e...
journal_title:International journal of molecular sciences
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更新日期:2018-11-02 00:00:00
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