Abstract：
:Lung cancer is the leading cause of cancer deaths worldwide. Therefore, for the prevention, diagnosis, prognosis and treatment of lung cancer, efficient preventive strategies and new therapeutic strategies are needed to face these challenges. Natural bioactive compounds and particular flavonoids compounds have been proven to have an important role in lung cancer prevention and of particular interest is the dose used for these studies, to underline the molecular effects and mechanisms at a physiological concentration. The purpose of this review was to summarize the current state of knowledge regarding relevant molecular mechanisms involved in the pharmacological effects, with a special focus on the anti-cancer role, by regulating the coding and non-coding genes. Furthermore, this review focused on the most commonly altered and most clinically relevant oncogenes and tumor suppressor genes and microRNAs in lung cancer. Particular attention was given to the biological effect in tandem with conventional therapy, emphasizing the role in the regulation of drug resistance related mechanisms.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Zanoaga O,Braicu C,Jurj A,Rusu A,Buiga R,Berindan-Neagoe Idoi
10.3390/ijms20174291subject
Has Abstractpub_date
2019-09-02 00:00:00issue
17issn
1422-0067pii
ijms20174291journal_volume
20pub_type
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doi：10.3390/ijms21062008
更新日期：2020-03-16 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 临床试验,杂志文章
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更新日期：2019-12-01 00:00:00
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更新日期：2018-10-16 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21144844
更新日期：2020-07-08 00:00:00
abstract：UNLABELLED:Mycophenolic acid (MPA) is prescribed to maintain allografts in organ-transplanted patients. However, gastrointestinal (GI) complications, particularly diarrhea, are frequently observed as a side effect following MPA therapy. We recently reported that MPA altered the tight junction (TJ)-mediated barrier func...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms17040597
更新日期：2016-04-20 00:00:00
abstract：:In this study, we investigated the anticancer effects of a new benzimidazole derivative, 1-benzyl-2-phenyl -benzimidazole (BPB), in human chondrosarcoma cells. BPB-mediated apoptosis was assessed by the MTT assay and flow cytometry analysis. The in vivo efficacy was examined in a JJ012 xenograft model. Here we found t...
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pub_type： 杂志文章
doi：10.3390/ijms131216472
更新日期：2012-12-04 00:00:00
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms18112325
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