Abstract:
:Erigeron breviscapus (Vant.) Hand.-Mazz. is a famous traditional Chinese medicine that has positive effects on the treatment of cardiovascular and cerebrovascular diseases. With the increase of market demand (RMB 500 million per year) and the sharp decrease of wild resources, it is an urgent task to cultivate high-quality and high-yield varieties of E. breviscapus. However, it is difficult to obtain homozygous lines in breeding due to the self-incompatibility (SI) of E. breviscapus. Here, we first proved that E. breviscapus has sporophyte SI (SSI) characteristics. Characterization of the ARC1 gene in E. breviscapus showed that EbARC1 is a constitutive expression gene located in the nucleus. Overexpression of EbARC1 in Arabidopsis thaliana L. (Col-0) could cause transformation of transgenic lines from self-compatibility (SC) into SI. Yeast two-hybrid (Y2H) and bimolecular fluorescence complementation (BiFC) assays indicated that EbARC1 and EbExo70A1 interact with each other in the nucleus, and the EbARC1-ubox domain and EbExo70A1-N are the key interaction regions, suggesting that EbARC1 may ubiquitinate EbExo70A to regulate SI response. This study of the SSI mechanism in E. breviscapus has laid the foundation for further understanding SSI in Asteraceae and breeding E. breviscapus varieties.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Chen M,Fan W,Hao B,Zhang W,Yan M,Zhao Y,Liang Y,Liu G,Lu Y,Zhang G,Zhao Z,Hu Y,Yang Sdoi
10.3390/ijms21041458subject
Has Abstractpub_date
2020-02-20 00:00:00issue
4issn
1422-0067pii
ijms21041458journal_volume
21pub_type
杂志文章abstract::The purpose of this study is to clinically validate a series of circulating miRNAs that distinguish between the 4 most prevalent tumor types (lung cancer (LC); breast cancer (BC); colorectal cancer (CRC); and prostate cancer (PCa)) and healthy donors (HDs). A total of 18 miRNAs and 3 housekeeping miRNA genes were eval...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21082783
更新日期:2020-04-16 00:00:00
abstract::Mitochondria in neurons contribute to energy supply, the regulation of synaptic transmission, Ca2+ homeostasis, neuronal excitability, and stress adaptation. In recent years, several studies have highlighted that the neurotransmitter serotonin (5-HT) plays an important role in mitochondrial biogenesis in cortical neur...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21249629
更新日期:2020-12-17 00:00:00
abstract::Diabetic nephropathy (DN) is the main cause of end-stage renal disease, which remains incurable. The progression of DN is associated with progressive and irreversible renal fibrosis and also high levels of adenosine. Our aim was to evaluate the effects of ADORA3 antagonism on renal injury in streptozotocin-induced dia...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20184531
更新日期:2019-09-13 00:00:00
abstract::The present editorial aims to summarize the 17 scientific papers that have contributed to this Special Issue focusing on different aspects of basic and translational research in colorectal cancer. ...
journal_title:International journal of molecular sciences
pub_type: 社论
doi:10.3390/ijms20123095
更新日期:2019-06-25 00:00:00
abstract::Brugada syndrome (BrS) is an inherited electrical heart disease associated with a high risk of sudden cardiac death (SCD). The genetic characterization of BrS has always been challenging. Although several cardiac ion channel genes have been associated with BrS, SCN5A is the only gene that presents definitive evidence ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms21228556
更新日期:2020-11-13 00:00:00
abstract::Tackling the first stages of the chondrogenic commitment is essential to drive chondrogenic differentiation to healthy hyaline cartilage and minimize hypertrophy. During chondrogenesis, the extracellular matrix continuously evolves, adapting to the tissue adhesive requirements at each stage. Here, we take advantage of...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21155269
更新日期:2020-07-24 00:00:00
abstract::Cinnamaldehyde, a natural preservative that can non-specifically deactivate foodborne pathogens, was successfully incorporated into fish skin gelatin (FSG) solutions and blow spun into uniform nanofibers. The effects of cinnamaldehyde ratios (5-30%, w/w FSG) on physicochemical properties of fiber-forming emulsions (FF...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms19020618
更新日期:2018-02-22 00:00:00
abstract::The exposure of living organisms to environmental stress triggers defensive responses resulting in the activation of protective processes. Whenever the exposure occurs at low doses, defensive effects overwhelm the adverse effects of the exposure; this adaptive situation is referred to as "hormesis". Environmental, phy...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms21197053
更新日期:2020-09-25 00:00:00
abstract::Triple negative breast cancer (TNBC) is a difficult to treat disease due to the absence of the three unique receptors estrogen, progesterone and herceptin-2 (HER-2). To improve the current therapy and overcome the resistance of TNBC, there is unmet need to develop an effective targeted therapy. In this regard, one of ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms19030838
更新日期:2018-03-13 00:00:00
abstract::Galectins are a family of animal lectins with high affinity for β-galactosides. Galectins are able to bind to bacteria, and a few mammalian galectins are known to kill the bound bacteria. In fish, no galectins with direct bactericidal effect have been reported. In the present study, we identified and characterized a t...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms22010376
更新日期:2020-12-31 00:00:00
abstract::Epilepsy afflicts up to 1.6% of the population and the mechanisms underlying the appearance of seizures are still not understood. In past years, many efforts have been spent trying to understand the mechanisms underlying the excessive and synchronous firing of neurons. Traditionally, attention was pointed towards syna...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms18112269
更新日期:2017-10-28 00:00:00
abstract::3,3'-Diindolylmethane (DIM) is a naturally derived chemopreventive compound. It comes from glucobrassicin, an indole glucosinolate enriched in cruciferous vegetables, and is formed in the acidic environment of the stomach after ingestion. Mouse double minute 2 homolog (MDM2) is an important, multi-functional oncogenic...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21134642
更新日期:2020-06-30 00:00:00
abstract::The rs10830963 variant of the Melatonin Receptor 1B (MTNR1B) gene is associated with the development of gestational diabetes mellitus (GDM). We hypothesized that carrying the rs10830963/G risk allele had effect on antenatal insulin therapy (AIT) initiation in GDM in a body mass index (BMI)-dependent manner. Design: In...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms19123734
更新日期:2018-11-23 00:00:00
abstract::The maintenance of ordinal cell cycle phases is a critical biological process in cancer genesis, which is a crucial target for anti-cancer drugs. As an important natural isoquinoline alkaloid from Chinese herbal medicine, Berberine (BBR) has been reported to possess anti-cancer potentiality to induce cell cycle arrest...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms19020327
更新日期:2018-01-23 00:00:00
abstract::Salidroside (Sal) is a potent antitumor drug with high water-solubility. The clinic application of Sal in cancer therapy has been significantly restricted by poor oral absorption and low tumor cell uptake. To solve this problem, lipid-shell and polymer-core nanoparticles (Sal-LPNPs) loaded with Sal were developed by a...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms15033373
更新日期:2014-02-25 00:00:00
abstract::Adverse experiences and chronic stress are well-known risk factors for the development of major depression, and an impaired stress response regulation is frequently observed in acute depression. Impaired glucocorticoid receptor (GR) signalling plays an important role in these alterations, and a restoration of GR signa...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20030485
更新日期:2019-01-23 00:00:00
abstract::Metronidazole (MD) is known as a periodontitis medicine and has been widely used in antibiotics for resistance to anaerobic bacteria, periodontal disease, and other threats. To treat diseases, drug delivery carriers are needed with a high bioadhesive property and enhanced drug penetration. Poly (acrylic acid) (PAA) hy...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21010187
更新日期:2019-12-26 00:00:00
abstract::Poly(l-lactide-co-glycolide) (PLGA) porous scaffolds were modified with collagen type I (PLGA/coll) or hydroxyapatite (PLGA/HAp) and implanted in rabbits osteochondral defects to check their biocompatibility and bone tissue regeneration potential. The scaffolds were fabricated using solvent casting/particulate leachin...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21207541
更新日期:2020-10-13 00:00:00
abstract::Riboswitches are naturally occurring RNA aptamers that control the expression of essential bacterial genes by binding to specific small molecules. The binding with both high affinity and specificity induces conformational changes. Thus, riboswitches were proposed as a possible molecular target for developing antibioti...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21061926
更新日期:2020-03-11 00:00:00
abstract::NF-E2-related factor 2 (NRF2) is a basic leucine zipper transcription factor, a master regulator of redox homeostasis regulating a variety of genes for antioxidant and detoxification enzymes. NRF2 was, therefore, initially thought to protect the liver from oxidative stress. Recent studies, however, have revealed that ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms21155378
更新日期:2020-07-29 00:00:00
abstract::For the post-surgical treatment of oral wounds and mucosal defects beyond a certain size, the gold standard is still an autologous skin or mucosal graft in combination with complex suturing techniques. A variety of techniques and biomaterials has been developed for sutureless wound closure including different tissue g...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21197104
更新日期:2020-09-26 00:00:00
abstract::The common carp can tolerate extremely low oxygen levels. These fish store zinc in a specific zinc-binding protein presented in digestive tract tissues, and under low oxygen, the stored zinc is released and used as a signal to stimulate erythropoiesis (red blood cell formation). To determine whether the environmental ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms18010138
更新日期:2017-01-11 00:00:00
abstract::High dietary salt intake has been listed among the top ten risk factors for disability-adjusted life years. We discuss the role of endogenous cardiotonic steroids in mediating the dietary salt-induced hypertension and organ damage. ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms20030590
更新日期:2019-01-30 00:00:00
abstract::Administration of antioxidants and anti-inflammatory agents is an effective strategy for preventing ultraviolet (UV) irradiation-induced skin damage. Artocarpus communis possesses several pharmacological activities, such as antioxidant, anticancer and anti-inflammation. However, the photoprotective activity of methan...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms14023860
更新日期:2013-02-12 00:00:00
abstract::MicroRNAs (miRNAs) constitute a large family of noncoding RNAs, approximately 22 nucleotides long, which function as guide molecules in RNA silencing. Targeting most protein-coding transcripts, miRNAs are involved in nearly all developmental and pathophysiological processes in animals. To date, the regulatory roles of...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms21062229
更新日期:2020-03-23 00:00:00
abstract::Antimicrobial peptides (AMPs) are molecules widespread in all branches of the tree of life that participate in host defense and/or microbial competition. Due to their positive charge, hydrophobicity and amphipathicity, they preferentially disrupt negatively charged bacterial membranes. AMPs are considered an important...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21124310
更新日期:2020-06-17 00:00:00
abstract::Long-chain fatty acyl-CoA synthetase (ACSLs) is an essential enzyme for the synthesis of fatty acyl-CoA. ACSL1 plays a key role in the synthesis of triglycerides, phospholipids, and cholesterol esters. BACKGROUND:In the current study, triglyceride content did not increase after overexpression of the ACSL1 gene. METH...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21062044
更新日期:2020-03-17 00:00:00
abstract::Hepatocellular carcinoma (HCC) is a leading cause of cancer-related morbidity and mortality worldwide. Most patients are diagnosed with advanced disease, limiting their options for treatment. While current treatments are adequate for lower staged disease, available systemic treatments are limited, with marginal benefi...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms21186757
更新日期:2020-09-15 00:00:00
abstract::Strigolactones (SLs), a group of plant hormones, induce germination of root-parasitic plants and inhibit shoot branching in many plants. Shoot branching is an important trait that affects the number and quality of flowers and fruits. Root-parasitic plants, such as Phelipanche spp., infect tomato roots and cause econom...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms19092645
更新日期:2018-09-06 00:00:00
abstract::Metastatic spread represents the leading cause of disease-related mortality among cancer patients. Many cancer patients suffer from metastatic relapse years or even decades after radical surgery for the primary tumor. This clinical phenomenon is explained by the early dissemination of cancer cells followed by a long p...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms21197304
更新日期:2020-10-03 00:00:00