Development of lipid-shell and polymer core nanoparticles with water-soluble salidroside for anti-cancer therapy.

Abstract:

:Salidroside (Sal) is a potent antitumor drug with high water-solubility. The clinic application of Sal in cancer therapy has been significantly restricted by poor oral absorption and low tumor cell uptake. To solve this problem, lipid-shell and polymer-core nanoparticles (Sal-LPNPs) loaded with Sal were developed by a double emulsification method. The processing parameters including the polymer types, organic phase, PVA types and amount were systemically investigated. The obtained optimal Sal-LPNPs, composed of PLGA-PEG-PLGA triblock copolymers and lipids, had high entrapment efficiency (65%), submicron size (150 nm) and negatively charged surface (-23 mV). DSC analysis demonstrated the successful encapsulation of Sal into LPNPs. The core-shell structure of Sal-LPNPs was verified by TEM. Sal released slowly from the LPNPs without apparent burst release. MTT assay revealed that 4T1 and PANC-1 cancer cell lines were sensitive to Sal treatment. Sal-LPNPs had significantly higher antitumor activities than free Sal in 4T1 and PANC-1 cells. The data indicate that LPNPs are a promising Sal vehicle for anti-cancer therapy and worthy of further investigation.

journal_name

Int J Mol Sci

authors

Fang DL,Chen Y,Xu B,Ren K,He ZY,He LL,Lei Y,Fan CM,Song XR

doi

10.3390/ijms15033373

subject

Has Abstract

pub_date

2014-02-25 00:00:00

pages

3373-88

issue

3

issn

1422-0067

pii

ijms15033373

journal_volume

15

pub_type

杂志文章
  • Fractalkine/CX3CL1 in Neoplastic Processes.

    abstract::Fractalkine/CX3C chemokine ligand 1 (CX3CL1) is a chemokine involved in the anticancer function of lymphocytes-mainly NK cells, T cells and dendritic cells. Its increased levels in tumors improve the prognosis for cancer patients, although it is also associated with a poorer prognosis in some types of cancers, such as...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审

    doi:10.3390/ijms21103723

    authors: Korbecki J,Simińska D,Kojder K,Grochans S,Gutowska I,Chlubek D,Baranowska-Bosiacka I

    更新日期:2020-05-25 00:00:00

  • Unique Ca2+-Cycling Protein Abundance and Regulation Sustains Local Ca2+ Releases and Spontaneous Firing of Rabbit Sinoatrial Node Cells.

    abstract::Spontaneous beating of the heart pacemaker, the sinoatrial node, is generated by sinoatrial node cells (SANC) and caused by gradual change of the membrane potential called diastolic depolarization (DD). Submembrane local Ca2+ releases (LCR) from sarcoplasmic reticulum (SR) occur during late DD and activate an inward N...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审

    doi:10.3390/ijms19082173

    authors: Vinogradova TM,Tagirova Sirenko S,Lakatta EG

    更新日期:2018-07-25 00:00:00

  • The effect of sericin from various extraction methods on cell viability and collagen production.

    abstract::Silk sericin (SS) can accelerate cell proliferation and attachment; however, SS can be extracted by various methods, which result in SS exhibiting different physical and biological properties. We found that SS produced from various extraction methods has different molecular weights, zeta potential, particle size and a...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms11052200

    authors: Aramwit P,Kanokpanont S,Nakpheng T,Srichana T

    更新日期:2010-05-20 00:00:00

  • Structural Disorder within Paramyxoviral Nucleoproteins and Phosphoproteins in Their Free and Bound Forms: From Predictions to Experimental Assessment.

    abstract::We herein review available computational and experimental data pointing to the abundance of structural disorder within the nucleoprotein (N) and phosphoprotein (P) from three paramyxoviruses, namely the measles (MeV), Nipah (NiV) and Hendra (HeV) viruses. We provide a detailed molecular description of the mechanisms g...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms160715688

    authors: Habchi J,Longhi S

    更新日期:2015-07-10 00:00:00

  • Fabrication of silver nanoparticles dispersed in palm oil using laser ablation.

    abstract::In this study we used a laser ablation technique for preparation of silver nanoparticles. The fabrication process was carried out by ablation of a silver plate immersed in palm oil. A pulsed Nd:YAG laser at a wavelength of 1064 nm was used for ablation of the plate at different times. The palm coconut oil allowed form...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms11114764

    authors: Zamiri R,Zakaria A,Ahangar HA,Sadrolhosseini AR,Mahdi MA

    更新日期:2010-11-22 00:00:00

  • Statin, calcium channel blocker and Beta blocker therapy may decrease the incidence of tuberculosis infection in elderly Taiwanese patients with type 2 diabetes.

    abstract:BACKGROUND:It is well known that diabetes mellitus impairs immunity and therefore is an independent risk factor for tuberculosis. However, the influence of associated metabolic factors, such as hypertension, dyslipidemia and gout has yet to be confirmed. This study aimed to investigate whether the strong association be...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms160511369

    authors: Lee MY,Lin KD,Hsu WH,Chang HL,Yang YH,Hsiao PJ,Shin SJ

    更新日期:2015-05-18 00:00:00

  • Translocator Protein (TSPO) as a Potential Biomarker in Human Cancers.

    abstract::TSPO is a receptor involved in the regulation of cellular proliferation, apoptosis and mitochondrial functions. Previous studies showed that the expression of TSPO protein correlated positively with tumour malignancy and negatively with patient survival. The aim of this study was to determine the transcription of Tspo...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms19082176

    authors: Bhoola NH,Mbita Z,Hull R,Dlamini Z

    更新日期:2018-07-25 00:00:00

  • Mg2+ Is a Missing Link in Plant Cell Ca2+ Signalling and Homeostasis-A Study on Vicia faba Guard Cells.

    abstract::Hyperpolarization-activated calcium channels (HACCs) are found in the plasma membrane and tonoplast of many plant cell types, where they have an important role in Ca2+-dependent signalling. The unusual gating properties of HACCs in plants, i.e., activation by membrane hyperpolarization rather than depolarization, dict...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms21113771

    authors: Lemtiri-Chlieh F,Arold ST,Gehring C

    更新日期:2020-05-27 00:00:00

  • Oxaloacetate Ameliorates Chemical Liver Injury via Oxidative Stress Reduction and Enhancement of Bioenergetic Fluxes.

    abstract::Chemical injury is partly due to free radical lipid peroxidation, which can induce oxidative stress and produce a large number of reactive oxygen species (ROS). Oxaloacetic acid is an important intermediary in the tricarboxylic acid cycle (TCA cycle) and participates in metabolism and energy production. In our study, ...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms19061626

    authors: Kuang Y,Han X,Xu M,Wang Y,Zhao Y,Yang Q

    更新日期:2018-05-31 00:00:00

  • Proneural-Mesenchymal Transition: Phenotypic Plasticity to Acquire Multitherapy Resistance in Glioblastoma.

    abstract::Glioblastoma (GBM) is an extremely aggressive tumor of the central nervous system, with a prognosis of 12-15 months and just 3-5% of survival over 5 years. This is mainly because most patients suffer recurrence after treatment that currently consists in maximal resection followed by radio- and chemotherapy with temozo...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审

    doi:10.3390/ijms20112746

    authors: Fedele M,Cerchia L,Pegoraro S,Sgarra R,Manfioletti G

    更新日期:2019-06-04 00:00:00

  • Inhibition of Colony-Stimulating Factor 1 Receptor by PLX3397 Prevents Amyloid Beta Pathology and Rescues Dopaminergic Signaling in Aging 5xFAD Mice.

    abstract::Alzheimer's disease (AD) is a progressive neurodegenerative disease. In this study, to investigate the effect of microglial elimination on AD progression, we administered PLX3397, a selective colony-stimulating factor 1 receptor inhibitor, to the mouse model of AD (5xFAD mice). Amyloid-beta (Aβ) deposition and amyloid...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms21155553

    authors: Son Y,Jeong YJ,Shin NR,Oh SJ,Nam KR,Choi HD,Choi JY,Lee HJ

    更新日期:2020-08-03 00:00:00

  • Natriuretic Peptide Expression and Function in GH3 Somatolactotropes and Feline Somatotrope Pituitary Tumours.

    abstract::Patients harbouring mutations in genes encoding C-type natriuretic peptide (CNP; NPPC) or its receptor guanylyl cyclase B (GC-B, NPR2) suffer from severe growth phenotypes; loss-of-function mutations cause achondroplasia, whereas gain-of-function mutations cause skeletal overgrowth. Although most of the effects of CNP...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms22031076

    authors: Mirczuk SM,Scudder CJ,Read JE,Crossley VJ,Regan JT,Richardson KM,Simbi B,McArdle CA,Church DB,Fenn J,Kenny PJ,Volk HA,Wheeler-Jones CP,Korbonits M,Niessen SJ,McGonnell IM,Fowkes RC

    更新日期:2021-01-22 00:00:00

  • Discovery of Tricyclic Pyranochromenone as Novel Bruton's Tyrosine Kinase Inhibitors with in Vivo Antirheumatic Activity.

    abstract::Bruton's tyrosine kinase (BTK) is an attractive target for treating patients with B cell malignancies and autoimmune diseases. Many BTK inhibitors have been identified; however, like other kinase inhibitors, they lack diversity in their core structures. Therefore, it is important to secure a novel scaffold that occupi...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms21217919

    authors: Cho H,Lee E,Kwon HA,Seul L,Jeon HJ,Yu JH,Ryu JH,Jeon R

    更新日期:2020-10-25 00:00:00

  • Mechanisms of Iodide⁻Triiodide Exchange Reactions in Ionic Liquids: A Reactive Molecular-Dynamics Exploration.

    abstract::Efficient charge transport has been observed in iodine-doped, iodide-based room-temperature ionic liquids, yielding high ionic conductivity. To elucidate preferred mechanistic pathways for the iodide ( I - )-to-triiodide ( I 3 - ) exchange reactions, we have performed 10 ns reactive molecular-dynamics calculations in ...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms20051123

    authors: Byrne A,Bringa EM,Del Pópolo MG,Kohanoff JJ,Galassi V,English NJ

    更新日期:2019-03-05 00:00:00

  • Genome-Wide Identification and Characterization of the UBP Gene Family in Moso Bamboo (Phyllostachys edulis).

    abstract::The largest group of deubiquitinases-ubiquitin-specific proteases (UBPs)-perform extensive and significant roles in plants, including the regulation of development and stress responses. A comprehensive analysis of UBP genes has been performed in Arabidopsis thaliana, but no systematic study has been conducted in moso ...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms20174309

    authors: Wu R,Shi Y,Zhang Q,Zheng W,Chen S,Du L,Lu C

    更新日期:2019-09-03 00:00:00

  • A Non-Invasive Tool for Real-Time Measurement of Sulfate in Living Cells.

    abstract::Sulfur (S) is an essential element for all forms of life. It is involved in numerous essential processes because S is considered as the primary source of one of the essential amino acids, methionine, which plays an important role in biological events. For the control and regulation of sulfate in a metabolic network th...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms21072572

    authors: Fatima U,Okla MK,Mohsin M,Naz R,Soufan W,Al-Ghamdi AA,Ahmad A

    更新日期:2020-04-07 00:00:00

  • Dinuclear Copper(II) Complexes with Schiff Bases Derived from 2-Hydroxy-5-Methylisophthalaldehyde and Histamine or 2-(2-Aminoethyl)pyridine and Their Application as Magnetic and Fluorescent Materials in Thin Film Deposition.

    abstract::Two Cu(II) complexes, 1 and 2, with tridentate Schiff bases derived from 2-hydroxy-5-methylisophthalaldehyde and histamine HL1 or 2-(2-aminoethyl)pyridine HL2, respectively, were obtained and characterized by X-ray crystallography, spectroscopic (UV-vis, fluorescence, IR, and EPR), magnetic, and thermal methods. Despi...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms21134587

    authors: Barwiolek M,Kaczmarek-Kędziera A,Muziol TM,Jankowska D,Jezierska J,Bieńko A

    更新日期:2020-06-28 00:00:00

  • A Rice B-Box Protein, OsBBX14, Finely Regulates Anthocyanin Biosynthesis in Rice.

    abstract::Anthocyanins are responsible pigments for giving attractive colors of plant organs and nutraceutical benefits of grains. Anthocyanin biosynthesis is known to be regulated by transcription factors and other regulatory proteins. In rice (Oryza sativa), the R2R3 MYB transcription factor (TF) OsC1 and a bHLH TF, OsB2, wer...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms19082190

    authors: Kim DH,Park S,Lee JY,Ha SH,Lee JG,Lim SH

    更新日期:2018-07-27 00:00:00

  • Rat Aquaporin-5 Is pH-Gated Induced by Phosphorylation and Is Implicated in Oxidative Stress.

    abstract::Aquaporin-5 (AQP5) is a membrane water channel widely distributed in human tissues that was found up-regulated in different tumors and considered implicated in carcinogenesis in different organs and systems. Despite its wide distribution pattern and physiological importance, AQP5 short-term regulation was not reported...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms17122090

    authors: Rodrigues C,Mósca AF,Martins AP,Nobre T,Prista C,Antunes F,Cipak Gasparovic A,Soveral G

    更新日期:2016-12-13 00:00:00

  • Brassica Bioactives Could Ameliorate the Chronic Inflammatory Condition of Endometriosis.

    abstract::Endometriosis is a chronic, inflammatory, hormone-dependent disease characterized by histological lesions produced by the presence of endometrial tissue outside the uterine cavity. Despite the fact that an estimated 176 million women are affected worldwide by this gynecological disorder, risk factors that cause endome...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审

    doi:10.3390/ijms21249397

    authors: García-Ibañez P,Yepes-Molina L,Ruiz-Alcaraz AJ,Martínez-Esparza M,Moreno DA,Carvajal M,García-Peñarrubia P

    更新日期:2020-12-10 00:00:00

  • In Vitro Feasibility Analysis of a New Sutureless Wound-Closure System Based on a Temperature-Regulated Laser and a Transparent Collagen Membrane for Laser Tissue Soldering (LTS).

    abstract::For the post-surgical treatment of oral wounds and mucosal defects beyond a certain size, the gold standard is still an autologous skin or mucosal graft in combination with complex suturing techniques. A variety of techniques and biomaterials has been developed for sutureless wound closure including different tissue g...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms21197104

    authors: Birkelbach MA,Smeets R,Fiedler I,Kluwe L,Wehner M,Trebst T,Hartjen P

    更新日期:2020-09-26 00:00:00

  • Genome-Wide Analysis, Expression Profile, and Characterization of the Acid Invertase Gene Family in Pepper.

    abstract::Catalytic decomposition of sucrose by acid invertases (AINVs) under acidic conditions plays an important role in the development of sink organs in plants. To reveal the function of AINVs in the development of pepper fruits, nine AINV genes of pepper were identified. Protein sequencing and phylogenetic analysis reveale...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms20010015

    authors: Shen LB,Qin YL,Qi ZQ,Niu Y,Liu ZJ,Liu WX,He H,Cao ZM,Yang Y

    更新日期:2018-12-20 00:00:00

  • Intrathecal Injection in A Rat Model: A Potential Route to Deliver Human Wharton's Jelly-Derived Mesenchymal Stem Cells into the Brain.

    abstract::Mesenchymal stem cells (MSCs) are considered as promising therapeutic agents for neurodegenerative disorders because they can reduce underlying pathology and also repair damaged tissues. Regarding the delivery of MSCs into the brain, intravenous and intra-arterial routes may be less feasible than intraparenchymal and ...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms21041272

    authors: Kim H,Na DL,Lee NK,Kim AR,Lee S,Jang H

    更新日期:2020-02-13 00:00:00

  • High Expression of microRNA-143 is Associated with Favorable Tumor Immune Microenvironment and Better Survival in Estrogen Receptor Positive Breast Cancer.

    abstract::microRNA-143(miR-143) is a well-known tumor suppressive microRNA that exhibits anti-tumoral function by targeting KRAS signaling pathways in various malignancies. We hypothesized that miR-143 suppresses breast cancer progression by targeting KRAS and its effector molecules. We further hypothesized that high expression...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms21093213

    authors: Tokumaru Y,Asaoka M,Oshi M,Katsuta E,Yan L,Narayanan S,Sugito N,Matsuhashi N,Futamura M,Akao Y,Yoshida K,Takabe K

    更新日期:2020-05-01 00:00:00

  • Neuroprotection by Neurotropin through Crosstalk of Neurotrophic and Innate Immune Receptors in PC12 Cells.

    abstract::Infected or damaged tissues release multiple "alert" molecules such as alarmins and damage-associated molecular patterns (DAMPs) that are recognized by innate immune receptors, and induce tissue inflammation, regeneration, and repair. Recently, an extract from inflamed rabbit skin inoculated with vaccinia virus (Neuro...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms21186456

    authors: Fukuda Y,Nakajima K,Mutoh T

    更新日期:2020-09-04 00:00:00

  • Mutagenic Study of Benzimidazole Derivatives with (+S9) and without (-S9) Metabolic Activation.

    abstract::Benzimidazole derivatives have a diverse range of biological activities, including antiulcer, antihypertensive, antiviral, antifungal, anti-inflammatory, and anticancer. Despite these activities, previous studies have revealed that some of the derivatives can induce mutations. This study aimed to screen for potential ...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms20184324

    authors: Azahar NH,Ab Dullah SS,Abdullah R,Ahmat N,Md Akim A,Ab Hamid H

    更新日期:2019-09-04 00:00:00

  • Inhibition of Porcine Epidemic Diarrhea Virus Replication and Viral 3C-Like Protease by Quercetin.

    abstract::For the last decade, porcine epidemic diarrhea virus (PEDV) variant strains have caused severe damage to the global pig industry. Until now, no effective antivirals have been developed for the therapeutic treatment of PEDV infection. In the present study, we found that quercetin significantly suppressed PEDV infection...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms21218095

    authors: Li Z,Cao H,Cheng Y,Zhang X,Zeng W,Sun Y,Chen S,He Q,Han H

    更新日期:2020-10-30 00:00:00

  • Nerve demyelination increases metabotropic glutamate receptor subtype 5 expression in peripheral painful mononeuropathy.

    abstract::Wallerian degeneration or nerve demyelination, arising from spinal nerve compression, is thought to bring on chronic neuropathic pain. The widely distributed metabotropic glutamate receptor subtype 5 (mGluR5) is involved in modulating nociceptive transmission. The purpose of this study was to investigate the potential...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms16034642

    authors: Ko MH,Hsieh YL,Hsieh ST,Tseng TJ

    更新日期:2015-03-02 00:00:00

  • Homozygous ALOXE3 Nonsense Variant Identified in a Patient with Non-Bullous Congenital Ichthyosiform Erythroderma Complicated by Superimposed Bullous Majocchi's Granuloma: The Consequences of Skin Barrier Dysfunction.

    abstract::Non-bullous congenital ichthyosiform erythroderma (NBCIE) is a hereditary disorder of keratinization caused by pathogenic variants in genes encoding enzymes important to lipid processing and terminal keratinocyte differentiation. Impaired function of these enzymes can cause pathologic epidermal scaling, significantly ...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms160921791

    authors: Wang T,Xu C,Zhou X,Li C,Zhang H,Lian BQ,Lee JJ,Shen J,Liu Y,Lian CG

    更新日期:2015-09-09 00:00:00

  • Berry phenolics of grapevine under challenging environments.

    abstract::Plant phenolics have been for many years a theme of major scientific and applied interest. Grape berry phenolics contribute to organoleptic properties, color and protection against environmental challenges. Climate change has already caused significant warming in most grape-growing areas of the world, and the climatic...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审

    doi:10.3390/ijms140918711

    authors: Teixeira A,Eiras-Dias J,Castellarin SD,Gerós H

    更新日期:2013-09-11 00:00:00