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A Tetra-Panel of Serum Circulating miRNAs for the Diagnosis of the Four Most Prevalent Tumor Types.

Abstract：

:The purpose of this study is to clinically validate a series of circulating miRNAs that distinguish between the 4 most prevalent tumor types (lung cancer (LC); breast cancer (BC); colorectal cancer (CRC); and prostate cancer (PCa)) and healthy donors (HDs). A total of 18 miRNAs and 3 housekeeping miRNA genes were evaluated by qRT-PCR on RNA extracted from serum of cancer patients, 44 LC, 45 BC, 27 CRC, and 40 PCa, and on 45 HDs. The cancer detection performance of the miRNA expression levels was evaluated by studying the area under the curve (AUC) of receiver operating characteristic (ROC) curves at univariate and multivariate levels. miR-21 was significantly overexpressed in all cancer types compared with HDs, with accuracy of 67.5% (p = 0.001) for all 4 tumor types and of 80.8% (p < 0.0001) when PCa cases were removed from the analysis. For each tumor type, a panel of miRNAs was defined that provided cancer-detection accuracies of 91%, 94%, 89%, and 77%, respectively. In conclusion, we have described a series of circulating miRNAs that define different tumor types with a very high diagnostic performance. These panels of miRNAs would constitute the basis of different approaches of cancer-detection systems for which clinical utility should be validated in prospective cohorts.

journal_name

Int J Mol Sci

journal_title

International journal of molecular sciences

authors

Pastor-Navarro B,García-Flores M,Fernández-Serra A,Blanch-Tormo S,Martínez de Juan F,Martínez-Lapiedra C,Maia de Alcantara F,Peñalver JC,Cervera-Deval J,Rubio-Briones J,García-Rupérez J,López-Guerrero JA

doi

10.3390/ijms21082783

subject

Has Abstract

pub_date

2020-04-16 00:00:00

issue

8

issn

1422-0067

pii

ijms21082783

journal_volume

21

pub_type

杂志文章

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