Special Issue on Basic and Translational Research in Colorectal Cancer.

abstract：:Extensive work on experimental animal models clearly demonstrates that infectious agents can break immunological tolerance to self-antigens and induce autoimmune disorders, mainly systemic lupus erythematosus (SLE). The establishment of a causative link between infections and autoimmunity has been largely studied in a...

journal_title：International journal of molecular sciences

authors： Rigante D,Esposito S

更新日期：2015-07-29 00:00:00

abstract：:Erigeron breviscapus (Vant.) Hand.-Mazz. is a famous traditional Chinese medicine that has positive effects on the treatment of cardiovascular and cerebrovascular diseases. With the increase of market demand (RMB 500 million per year) and the sharp decrease of wild resources, it is an urgent task to cultivate high-qua...

journal_title：International journal of molecular sciences

authors： Chen M,Fan W,Hao B,Zhang W,Yan M,Zhao Y,Liang Y,Liu G,Lu Y,Zhang G,Zhao Z,Hu Y,Yang S

更新日期：2020-02-20 00:00:00

abstract：:The MP2 and DFT/B3LYP methods at 6-311++G(d,p) and aug-cc-pdz basis sets have been used to probe the origin of relative stability preference for eclipsed acetaldehyde over its bisected counterpart. A relative energy stability range of 1.02 to 1.20 kcal/mol, in favor of the eclipsed conformer, was found and discussed. ...

journal_title：International journal of molecular sciences

authors： Osman OI,Alyoubi AO,Elroby SA,Hilal RH,Aziz SG

更新日期：2012-11-20 00:00:00

abstract：:For malignant pleural mesothelioma (MPM) novel therapeutic strategies are urgently needed. In a previous study, we identified 51 putative cancer genes over-expressed in MPM tissues and cell lines. Here, we deepened the study on nine of them (ASS1, EIF4G1, GALNT7, GLUT1, IGF2BP3 (IMP3), ITGA4, RAN, SOD1, and THBS2) to ...

journal_title：International journal of molecular sciences

authors： Dell'Anno I,Barbarino M,Barone E,Giordano A,Luzzi L,Bottaro M,Migliore L,Agostini S,Melani A,Melaiu O,Catalano C,Cipollini M,Silvestri R,Corrado A,Gemignani F,Landi S

更新日期：2020-07-09 00:00:00

abstract：:Pancreatic cancer remains one of the deadliest cancers in the world, as a consequence of late diagnosis, early metastasis and limited response to chemotherapy, under which conditions the potential mechanism of pancreatic cancer progression requires further study. Exosomes are membrane vesicles which are important in t...

journal_title：International journal of molecular sciences

authors： Lan B,Zeng S,Grützmann R,Pilarsky C

更新日期：2019-09-04 00:00:00

abstract：:The life of any living organism can be defined as a hurdle due to different kind of stresses. As with all living organisms, plants are exposed to various abiotic stresses, such as drought, salinity, extreme temperatures and chemical toxicity. These primary stresses are often interconnected, and lead to the overproduct...

journal_title：International journal of molecular sciences

authors： Szarka A,Tomasskovics B,Bánhegyi G

更新日期：2012-01-01 00:00:00

abstract：:Depressive disorders and alcohol use disorders are widespread among the general population and are significant public health and economic burdens. Alcohol use disorders often co-occur with other psychiatric conditions and this dual diagnosis is called comorbidity. Depressive disorders invariably contribute to the deve...

journal_title：International journal of molecular sciences

authors： Shor C,Zuo W,Eloy JD,Ye JH

更新日期：2020-10-30 00:00:00

abstract：:Histone acetylation plays an important role in plant growth and development. Here, we investigated the effect of sodium butyrate (NaB), a histone deacetylase inhibitor, on adventitious shoot formation from protoplast-derived calli and cotyledon explants of tobacco (Nicotiana benthamiana) and tomato (Solanum lycopersic...

journal_title：International journal of molecular sciences

authors： Lee MH,Lee J,Choi SH,Jie EY,Jeong JC,Kim CY,Kim SW

更新日期：2020-11-10 00:00:00

abstract：:Fourier transform infrared (FTIR) microspectroscopy shows potential as a benign, objective and rapid tool to screen pluripotent and multipotent stem cells for clinical use. It offers a new experimental approach that provides a holistic measurement of macromolecular composition such that a signature representing the in...

journal_title：International journal of molecular sciences

authors： Cao J,Ng ES,McNaughton D,Stanley EG,Elefanty AG,Tobin MJ,Heraud P

更新日期：2013-08-26 00:00:00

abstract：:Recent proteome analyses have reported that intrinsically disordered regions (IDRs) of proteins play important roles in biological processes. In higher plants whose genomes have been sequenced, the correlation between IDRs and post-translational modifications (PTMs) has been reported. The genomes of various eukaryotic...

journal_title：International journal of molecular sciences

authors： Kurotani A,Sakurai T

更新日期：2015-08-20 00:00:00

abstract：:The development of new therapeutic options against Clostridioides difficile (C. difficile) infection is a critical public health concern, as the causative bacterium is highly resistant to multiple classes of antibiotics. Antimicrobial host-defense peptides (HDPs) are highly effective at simultaneously modulating the i...

journal_title：International journal of molecular sciences

authors： Oludiran A,Courson DS,Stuart MD,Radwan AR,Poutsma JC,Cotten ML,Purcell EB

更新日期：2019-10-24 00:00:00

abstract：:Topical or systemic administration of JAK inhibitors has been shown to be a new treatment modality for severe alopecia areata (AA). Some patients show a good response to JAK inhibitors, but frequently relapse after cessation of the treatment. There have been no guidelines about the indications and use of JAK inhibitor...

journal_title：International journal of molecular sciences

authors： Kim JE,Lee YJ,Park HR,Lee DG,Jeong KH,Kang H

更新日期：2020-07-20 00:00:00

abstract：:Drought stress is the major abiotic factor threatening maize (Zea mays L.) yield globally. Therefore, revealing the molecular mechanisms fundamental to drought tolerance in maize becomes imperative. Herein, we conducted a comprehensive comparative analysis of two maize inbred lines contrasting in drought stress tolera...

journal_title：International journal of molecular sciences

authors： Zenda T,Liu S,Wang X,Jin H,Liu G,Duan H

更新日期：2018-10-18 00:00:00

abstract：:The cytostatic agent hydroxyurea (HU) has proven to be beneficial for a variety of conditions in the disciplines of oncology, hematology, infectious disease and dermatology. It disrupts the S phase of the cell cycle by inhibiting the ribonucleotide reductase enzyme, thus blocking the transformation of ribonucleotides ...

journal_title：International journal of molecular sciences

authors： Rodríguez-Vázquez L,Martí J

更新日期：2018-12-11 00:00:00

abstract：:We have extracted an extensive collection of recurrent structural motifs (RSMs), which consist of sequentially non-contiguous structural motifs (4-6 residues), each of which appears with very similar conformation in three or more mutually unrelated protein structures. We find that the proteins in our set are covered t...

journal_title：International journal of molecular sciences

authors： Johansson MU,Zoete V,Guex N

更新日期：2013-04-10 00:00:00

abstract：:Leukemia is the most common cancer in children, representing 30% of all childhood cancers. The disease arises from recurrent genetic insults that block differentiation of hematopoietic stem and/or progenitor cells (HSPCs) and drives uncontrolled proliferation and survival of the differentiation-blocked clone. Pediatri...

journal_title：International journal of molecular sciences

authors： Hernández AF,Menéndez P

更新日期：2016-03-29 00:00:00

abstract：:Peroxisome proliferator activated receptor α (PPARα) has the most relevant biological functions among PPARs. Activation by drugs and dietary components lead to major metabolic changes, from reduced triglyceridemia to improvement in the metabolic syndrome. Polymorphisms of PPARα are of interest in order to improve our ...

journal_title：International journal of molecular sciences

authors： Ruscica M,Busnelli M,Runfola E,Corsini A,Sirtori CR

更新日期：2019-09-06 00:00:00

abstract：:Over the past few decades, metal nanoparticles less than 100 nm in diameter have made a substantial impact across diverse biomedical applications, such as diagnostic and medical devices, for personalized healthcare practice. In particular, silver nanoparticles (AgNPs) have great potential in a broad range of applicati...

journal_title：International journal of molecular sciences

authors： Lee SH,Jun BH

更新日期：2019-02-17 00:00:00

abstract：:Alfalfa is an autotetraploid, allogamous and heterozygous forage legume, whose varieties are synthetic populations. Due to the complex nature of the species, information about genetic diversity of germplasm used in any alfalfa breeding program is most beneficial. The genetic diversity of five alfalfa varieties, involv...

journal_title：International journal of molecular sciences

authors： Nagl N,Taski-Ajdukovic K,Barac G,Baburski A,Seccareccia I,Milic D,Katic S

更新日期：2011-01-01 00:00:00

abstract：:The mechanistic target of rapamycin complex 1 (mTORC1) coordinates cellular growth and metabolism with environmental inputs to ensure that cells grow only under favourable conditions. When active, mTORC1 stimulates biosynthetic pathways including protein, lipid and nucleotide synthesis and inhibits cellular catabolism...

journal_title：International journal of molecular sciences

authors： Rabanal-Ruiz Y,Korolchuk VI

更新日期：2018-03-12 00:00:00

abstract：:Extending carbon frameworks via a series of C-C bond forming reactions is essential for the synthesis of natural products, pharmaceutically active compounds, active agrochemical ingredients, and a variety of functional materials. The application of stereoselective C-C bond forming reactions to the one-pot synthesis of...

journal_title：International journal of molecular sciences

authors： Itoh S,Sonoike S,Kitamura M,Aoki S

更新日期：2014-01-29 00:00:00

abstract：:Windup, a progressive increase in spinal response to repetitive stimulations of nociceptive peripheral fibers, is a useful model to study central sensitization to pain. Windup is expressed by neurons in both the dorsal and ventral horn of the spinal cord. In juvenile rats, it has been demonstrated both in vivo and in ...

journal_title：International journal of molecular sciences

authors： Aby F,Bouali-Benazzouz R,Landry M,Fossat P

更新日期：2019-12-05 00:00:00

abstract：:We investigated TLR10 expression in human monocytes, THP-1 cells, cultured in hypoxia (3% O(2)). Levels of both TLR10 mRNA and protein in THP-1 cells cultured in hypoxia were significantly higher than those cultured in normoxia (20% O(2)). We examined intracellular reactive oxygen species (ROS) content in hypoxic cell...

journal_title：International journal of molecular sciences

authors： Kim D,Kim YJ,Koh HS,Jang TY,Park HE,Kim JY

更新日期：2010-09-29 00:00:00

abstract：:Pancreatic cancer (PC) is a highly lethal malignancy due to the cancer routinely being diagnosed late and having a limited response to chemotherapy. Pancreatic ductal adenocarcinoma (PDAC) is the most common form of pancreatic malignant tumor, representing more than 85% of all pancreatic cancers. In the present study,...

journal_title：International journal of molecular sciences

authors： Hsieh MJ,Chiu TJ,Lin YC,Weng CC,Weng YT,Hsiao CC,Cheng KH

更新日期：2020-06-23 00:00:00

abstract：:Proteinuria is a marker of incipient kidney injury in many disorders, including obesity. Previously, we demonstrated that megalin, a receptor endocytotic protein in the proximal tubule, is downregulated in obese mice, which was prevented by inhibition of dipeptidyl protease 4 (DPP4). Obesity is thought to be associate...

journal_title：International journal of molecular sciences

authors： Aroor A,Zuberek M,Duta C,Meuth A,Sowers JR,Whaley-Connell A,Nistala R

更新日期：2016-05-20 00:00:00

abstract：:In this paper, we show a strategy to modify salphen-type Schiff base ligands with naphtol (SYML1) and pyrocathecol (2,3-dihydroxyphenyl) groups (SYML2), or a combination of both (ASYML). Each of these ligands can be used to obtain polynuclear metal complexes following two different strategies. One relies on using meta...

journal_title：International journal of molecular sciences

authors： Gholizadeh Dogaheh S,Barbero S,Barrientos J,Janczak J,Soleimannejad J,Sañudo EC

更新日期：2020-05-18 00:00:00

abstract：:Glial cell line-derived neurotrophic factor (GDNF) was encapsulated into liposomes in order to protect it from enzyme degradation in vivo and promote its permeability across the blood-brain barrier (BBB). In this study, GDNF conventional liposomes (GDNF-L) and GDNF target sterically stabilized liposomes (GDNF-SSL-T) w...

journal_title：International journal of molecular sciences

authors： Wu S,Li G,Li X,Lin C,Yu D,Luan S,Ma C

更新日期：2014-02-27 00:00:00

abstract：:Primary biliary cholangitis (PBC) is an immune-mediated cholestatic disease. Vitamin D receptor (VDR)-dependent signaling constrains an inflammatory response by targeting the miRNA155-SOCS1 (suppressor of cytokine signaling 1) axis. The VDR-miRNA155-SOCS1 pathway was investigated in the context of the autoimmune respo...

journal_title：International journal of molecular sciences

authors： Kempinska-Podhorodecka A,Milkiewicz M,Wasik U,Ligocka J,Zawadzki M,Krawczyk M,Milkiewicz P

更新日期：2017-01-29 00:00:00

abstract：:Mitochondria are involved either directly or indirectly in oncogenesis and the alteration of metabolism in cancer cells. Cancer cells contain large numbers of abnormal mitochondria and produce large amounts of reactive oxygen species (ROS). Oxidative stress is caused by an imbalance between the production of ROS and t...

journal_title：International journal of molecular sciences

authors： Song IS,Kim HK,Jeong SH,Lee SR,Kim N,Rhee BD,Ko KS,Han J

更新日期：2011-01-01 00:00:00

abstract：:The cell membrane is a complex and highly regulated system that is composed of lipid bilayer and proteins. One of the main functions of the cell membrane is the regulation of cell entry. Cell-penetrating peptides (CPPs) are defined as peptides that can cross the plasma membrane and deliver their cargo inside the cell....

journal_title：International journal of molecular sciences

authors： Liu J,Afshar S

更新日期：2020-07-02 00:00:00