Abstract：
:The mechanistic target of rapamycin complex 1 (mTORC1) coordinates cellular growth and metabolism with environmental inputs to ensure that cells grow only under favourable conditions. When active, mTORC1 stimulates biosynthetic pathways including protein, lipid and nucleotide synthesis and inhibits cellular catabolism through repression of the autophagic pathway, thereby promoting cell growth and proliferation. The recruitment of mTORC1 to the lysosomal surface has been shown to be essential for its activation. This finding has significantly enhanced our knowledge of mTORC1 regulation and has focused the attention of the field on the lysosome as a signalling hub which coordinates several homeostatic pathways. The intriguing localisation of mTORC1 to the cellular organelle that plays a crucial role in catabolism enables mTORC1 to feedback to autophagy and lysosomal biogenesis, thus leading mTORC1 to enact precise spatial and temporal control of cell growth. This review will cover the signalling interactions which take place on the surface of lysosomes and the cross-talk which exists between mTORC1 activity and lysosomal function.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Rabanal-Ruiz Y,Korolchuk VIdoi
10.3390/ijms19030818subject
Has Abstractpub_date
2018-03-12 00:00:00issue
3issn
1422-0067pii
ijms19030818journal_volume
19pub_type
杂志文章,评审abstract：:Osteosarcoma therapy might be moving toward nanotechnology-based drug delivery systems to reduce the cytotoxicity of antineoplastic drugs and improve their pharmacokinetics. In this paper, we present, for the first time, an extensive chemical and in vitro characterization of dual-loaded photo- and chemo-active keratin...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19113670
更新日期：2018-11-20 00:00:00
abstract：:The importance of magnesium (Mg) for plant growth is well-documented. Silicon (Si)-mediated alleviation of mineral deficiencies has been also reported in a number of plant species; however, there is no report on the relevance of Si nutrition in plants grown in Mg-deficient condition. Therefore, in the present work, an...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20040969
更新日期：2019-02-22 00:00:00
abstract：:In plants, microRNAs have been indicated to control various developmental processes, including somatic embryogenesis (SE), which is triggered in the in vitro cultured somatic cells of plants. Although a transcriptomic analysis has indicated that numerous MIRNAs are differentially expressed in the SE of different plant...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20205221
更新日期：2019-10-21 00:00:00
abstract：:Fertilization is a cell biological phenomenon of crucial importance for the birth of new life in a variety of multicellular and sexual reproduction species such as algae, animal and plants. Fertilization involves a sequence of events, in which the female gamete "egg" and the male gamete "spermatozoon (sperm)" develop,...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms16010114
更新日期：2014-12-23 00:00:00
abstract：:The presence of lysine (Lys) or arginine (Arg) and tryptophan (Trp) are important for the antimicrobial effects of cationic peptides. Therefore, we designed and synthesized a series of antimicrobial peptides with various numbers of Lys (or Arg) and Trp repeats [(KW and RW)(n)-NH(2), where n equals 2, 3, 4, or 5]. Anti...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms131115042
更新日期：2012-11-15 00:00:00
abstract：:Bladder cancer is the second most common urological malignancy in the world. In 70% of cases it is initially diagnosed as non-muscle-invasive bladder cancer (NMIBC) and it is amenable to local treatments, with intravesical (IVES) Bacillus-Calmette-Guerin (BCG) immunotherapy being routinely used after transurethral res...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms17071125
更新日期：2016-07-14 00:00:00
abstract：:The protective effects of alpha-1 antitrypsin (AAT) in tacrolimus (TAC)-induced renal injury was evaluated in a rat model. The TAC group rats were subcutaneously injected with 2 mg/kg TAC every day for four weeks. The TAC with AAT group was cotreated with daily subcutaneous injections of TAC and intraperitoneal inject...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21228628
更新日期：2020-11-16 00:00:00
abstract：:Detergent-resistant membranes (DRMs) microdomains, or "raft lipids", are key components of the plasma membrane (PM), being involved in membrane trafficking, signal transduction, cell wall metabolism or endocytosis. Proteins imbibed in these domains play important roles in these cellular functions, but there are few st...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21207694
更新日期：2020-10-17 00:00:00
abstract：:Sugars, which are important signaling molecules, regulate diverse biological processes in plants. However, the convergent regulatory mechanisms governing these physiological activities have not been fully elucidated. MODIFIER OF snc1-1 (MOS1), a modulator of plant immunity, also regulates floral transition, cell cycle...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21197095
更新日期：2020-09-26 00:00:00
abstract：:Post-transcriptional regulatory networks are dependent on the interplay of many RNA-binding proteins having a major role in mRNA processing events in mammals. We have been interested in the concerted action of the two RNA-binding proteins hnRNP A1 and HuR, both stable components of immunoselected hnRNP complexes and h...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms141020256
更新日期：2013-10-11 00:00:00
abstract：:Haemophilus parasuis (H. parasuis) can cause Glässer’s disease in pigs. However, the molecular mechanism of the inflammation response induced by H. parasuis remains unclear. The high-mobility group box 1 (HMGB1) protein is related to the pathogenesis of various infectious pathogens, but little is known abou...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19051307
更新日期：2018-04-27 00:00:00
abstract：:Among natural products under investigation for their additive potential in cancer prevention and treatment, the flavonoid quercetin has received attention for its effects on the cell cycle arrest and apoptosis. In the past, we addressed this issue in K562 cells, a cellular model of the human chronic myeloid leukemia. ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21010032
更新日期：2019-12-19 00:00:00
abstract：:Atrial fibrillation (AF) is a type of sustained arrhythmia in humans often characterized by devastating alterations to the cardiac conduction system as well as the structure of the atria. AF can lead to decreased cardiac function, heart failure, and other complications. Long non-coding RNAs (lncRNAs) have been shown t...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21155424
更新日期：2020-07-30 00:00:00
abstract：:The human DNA2 (DNA replication helicase/nuclease 2) protein is expressed in both the nucleus and mitochondria, where it displays ATPase-dependent nuclease and helicase activities. DNA2 plays an important role in the removing of long flaps in DNA replication and long-patch base excision repair (LP-BER), interacting wi...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms18071562
更新日期：2017-07-18 00:00:00
abstract：:Timely and reliable distinction of sepsis from non-infectious systemic inflammatory response syndrome (SIRS) supports adequate antimicrobial therapy and saves lives but is clinically challenging. Blood transcriptional profiling promises to deliver insights into the pathomechanisms of SIRS and sepsis and to accelerate ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20092290
更新日期：2019-05-09 00:00:00
abstract：:Inflammatory bowel disease (IBD) is a chronic disorder manifested as Crohn's disease (CD) and ulcerative colitis (UC) characterized by intestinal inflammation and involves a dysregulated immune response against commensal microbiota through the activation of CD4 T helper cells. T helper cell differentiation to effector...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21093379
更新日期：2020-05-11 00:00:00
abstract：:Activation of the cannabinoid CB1 receptor induces different cellular signaling cascades through coupling to different effector proteins (G-proteins and β-arrestins), triggering numerous therapeutic effects. Conformational changes and rearrangements at the intracellular domain of this GPCR receptor that accompany liga...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21218111
更新日期：2020-10-30 00:00:00
abstract：:Renal fibrosis is the final common pathway of numerous progressive kidney diseases, and transforming growth factor-β (TGF-β) has an important role in tissue fibrosis by up-regulating matrix protein synthesis, inhibiting matrix degradation, and altering cell-cell interaction. Many strategies targeting TGF-β, including ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms19092532
更新日期：2018-08-27 00:00:00
abstract：:Dysregulation of platelet function can contribute to the disease progression in sepsis. The proteasome represents a critical and vital element of cellular protein metabolism in platelets and its proteolytic activity has been associated with platelet function. However, the role of the platelet proteasome as well as its...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20235961
更新日期：2019-11-27 00:00:00
abstract：:Avascular meniscus tears show poor intrinsic regenerative potential. Thus, lesions within this area predispose the patient to developing knee osteoarthritis. Current research focuses on regenerative approaches using growth factors or mesenchymal stem cells (MSCs) to enhance healing capacity within the avascular menisc...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20051120
更新日期：2019-03-05 00:00:00
abstract：:Agricultural production continues to be constrained by a number of biotic and abiotic factors that can reduce crop yield quantity and quality. Potassium (K) is an essential nutrient that affects most of the biochemical and physiological processes that influence plant growth and metabolism. It also contributes to the s...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms14047370
更新日期：2013-04-02 00:00:00
abstract：:donor⁻acceptorDonor⁻acceptor⁻π⁻acceptor⁻donor (D1-A1-π-A2/A3-D2)-type small molecules, such TPA-MC-2 and TPA-MC-3, were designed and synthesized starting from donor-substituted alkynes (TPA-MC-1) via [2 + 2] cycloaddition-retroelectrocyclization reaction with tetracyanoethylene (TCNE) and 7,7,8,8-tetracyanoquinodimeth...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20071621
更新日期：2019-04-01 00:00:00
abstract：:Sensitive molecular assays are critical for coronavirus disease 2019 (COVID-19) diagnosis. Here, we designed and evaluated two single-tube nested (STN) real-time RT-PCR assays, targeting SARS-CoV-2 RdRp/Hel and N genes. Both STN assays had a low limit of detection and did not cross react with other human coronaviruses...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21165674
更新日期：2020-08-07 00:00:00
abstract：:The extraction and separation conditions of glycyrrhizic acid and glabridin from licorice were investigated. By changing the different extraction solvents, procedures, times and temperature, the optimum extraction condition was established: the used of ethanol/water (30:70, v/v) as an extraction solvent, and 60 min di...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms9040571
更新日期：2008-04-01 00:00:00
abstract：:Emodin, an active constituent of oriental herbs, is widely used to treat allergy, inflammation, and other symptoms. This study provides the scientific basis for the anti-inflammasome effects of emodin on both in vitro and in vivo experimental models. Bone marrow-derived macrophages were used to study the effects of em...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms16048102
更新日期：2015-04-10 00:00:00
abstract：:We examined the effects of gut microbial catabolites of tryptophan on the aryl hydrocarbon receptor (AhR). Using a reporter gene assay, we show that all studied catabolites are low-potency agonists of human AhR. The efficacy of catabolites differed substantially, comprising agonists with no or low (i3-propionate, i3-a...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21072614
更新日期：2020-04-09 00:00:00
abstract：:Protein splicing catalyzed by inteins utilizes many different combinations of amino-acid types at active sites. Inteins have been classified into three classes based on their characteristic sequences. We investigated the structural basis of the protein splicing mechanism of class 3 inteins by determining crystal struc...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21218367
更新日期：2020-11-07 00:00:00
abstract：:Non-communicable diseases (NCDs) have become the largest contributor to worldwide morbidity and mortality. Among them, cancer and cardiovascular diseases (CVDs) are responsible for a 47% of worldwide mortality. In general, preventive approaches modifying lifestyle are more cost-effective than treatments after disease ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms19082305
更新日期：2018-08-06 00:00:00
abstract：:Staphylococcus aureus is able to rapidly develop mechanisms of resistance to various drugs and to form strong biofilms, which makes it necessary to develop new antibacterial drugs. The essential oil of Melaleuca alternifolia is used as an antibacterial, a property believed to be mainly due to the presence of terpinen-...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21124531
更新日期：2020-06-25 00:00:00
abstract：:Combretastatin-4 (CA-4) as a tubulin polymerization inhibitor draws extensive attentions. However, due to its weak stability of cis-olefin and poor metabolic stability, structure modifications on cis-configuration are being performed. In this work, we constructed a series of novel CA-4 analogues with linkers on olefin...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21051817
更新日期：2020-03-06 00:00:00
