Abstract：
:NF-E2-related factor 2 (NRF2) is a basic leucine zipper transcription factor, a master regulator of redox homeostasis regulating a variety of genes for antioxidant and detoxification enzymes. NRF2 was, therefore, initially thought to protect the liver from oxidative stress. Recent studies, however, have revealed that mutations in NRF2 cause aberrant accumulation of NRF2 in the nucleus and exert the upregulation of NRF2 target genes. Moreover, among all molecular changes in hepatocellular carcinoma (HCC), NRF2 activation has been revealed as a more prominent pathway contributing to the progression of precancerous lesions to malignancy. Nevertheless, how its activation leads to poor prognosis in HCC patients remains unclear. In this review, we provide an overview of how aberrant activation of NRF2 triggers HCC development. We also summarize the emerging roles of other NRF family members in liver cancer development.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Haque E,Karim MR,Salam Teeli A,Śmiech M,Leszczynski P,Winiarczyk D,Parvanov ED,Atanasov AG,Taniguchi Hdoi
10.3390/ijms21155378subject
Has Abstractpub_date
2020-07-29 00:00:00issue
15issn
1422-0067pii
ijms21155378journal_volume
21pub_type
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