The Histone Deacetylase Inhibitor BML-210 Influences Gene and Protein Expression in Human Promyelocytic Leukemia NB4 Cells via Epigenetic Reprogramming.

abstract：:In this work, Au-Bi(2)Te(3) nanocomposite thermoelectric film with a hierarchical sub-micron antireflection quasi-periodic structure was synthesized via a low-temperature chemical route using Troides helena (Linnaeus) forewing (T_FW) as the biomimetic template. This method combines chemosynthesis with biomimetic techn...

journal_title：International journal of molecular sciences

authors： Tian J,Zhang W,Zhang Y,Xue R,Wang Y,Zhang Z,Zhang D

更新日期：2015-06-03 00:00:00

abstract：:Vitamin D is a major steroid hormone that is gaining attention as a therapeutic molecule. Due to the general awareness of its importance for the overall well-being, vitamin D deficiency (VDD) is now recognized as a major health issue. The main reason for VDD is minimal exposure to sunlight. The vitamin D receptor (VDR...

journal_title：International journal of molecular sciences

authors： Sirajudeen S,Shah I,Al Menhali A

更新日期：2019-08-05 00:00:00

abstract：:We have reported that conventional protein kinase Cγ (cPKCγ)-modulated neuron-specific autophagy improved the neurological outcome of mice following ischemic stroke through the Akt-mechanistic target of rapamycin (mTOR) pathway. However, its detailed molecular mechanism remains unclear. In this study, prim...

journal_title：International journal of molecular sciences

authors： Hua R,Han S,Zhang N,Dai Q,Liu T,Li J

更新日期：2018-05-06 00:00:00

abstract：:Dysregulation of platelet function can contribute to the disease progression in sepsis. The proteasome represents a critical and vital element of cellular protein metabolism in platelets and its proteolytic activity has been associated with platelet function. However, the role of the platelet proteasome as well as its...

journal_title：International journal of molecular sciences

authors： Grundler Groterhorst K,Mannell H,Pircher J,Kraemer BF

更新日期：2019-11-27 00:00:00

abstract：:Epigenetic factors are essentially involved in carcinogenesis, tumor promotion, and chemoresistance. Two epigenetic key players are miRNAs and histone deacetylases (HDACs). As previously shown by own theoretical databank analysis, the crosstalk between miRNAs and HDACs is relevant in different human chronic diseases a...

journal_title：International journal of molecular sciences

authors： Klieser E,Urbas R,Swierczynski S,Stättner S,Primavesi F,Jäger T,Mayr C,Kiesslich T,Fazio PD,Helm K,Neureiter D

更新日期：2018-09-15 00:00:00

abstract：:Idiopathic pulmonary fibrosis (IPF) is a progressive, fibrotic interstitial pneumonia with high mortality. Melatonin, a hormone predominantly secreted by the pineal gland, has been reported to participate in the process of IPF. However, the mechanisms underlying the effect of melatonin in pulmonary fibrosis have not b...

journal_title：International journal of molecular sciences

authors： Zhao X,Sun J,Su W,Shan H,Zhang B,Wang Y,Shabanova A,Shan H,Liang H

更新日期：2018-04-09 00:00:00

abstract：:Programmed cell death (PCD) is a crucial process required for the normal development and physiology of metazoans. The three major mechanisms that induce PCD are called type I (apoptosis), type II (autophagic cell death), and type III (necrotic cell death). Dysfunctional PCD leads to diseases such as cancer and neurode...

journal_title：International journal of molecular sciences

authors： Shimizu S,Yoshida T,Tsujioka M,Arakawa S

更新日期：2014-02-21 00:00:00

abstract：:Fluorescent silica nanoparticles (FSNPs) can provide high-intensity and photostable fluorescent signals as a probe for biomedical analysis. In this study, FSNPs hybridized with aggregation-induced emission (AIE) luminogens (namely FSNP-SD) were successfully fabricated by a surfactant-free sol-gel method. The FSNP-SD w...

journal_title：International journal of molecular sciences

authors： Xia Y,Li M,Peng T,Zhang W,Xiong J,Hu Q,Song Z,Zheng Q

更新日期：2013-01-07 00:00:00

abstract：:Psoriasis is a chronic inflammatory skin disease characterized by accelerated tumor necrosis factor-α/interleukin-23/interleukin-17 axis, hyperproliferation and abnormal differentiation of epidermal keratinocytes. Psoriasis patients are frequently associated with obesity, diabetes, dyslipidemia, cardiovascular disease...

journal_title：International journal of molecular sciences

authors： Kanda N,Hoashi T,Saeki H

更新日期：2020-07-29 00:00:00

abstract：:The maturation of iPSC-derived cardiomyocytes is still a critical point for their application in cardiovascular research as well as for their clinical use. Although multiple differentiation protocols have been established, researchers failed to generate fully mature cardiomyocytes in vitro possessing identical phenoty...

journal_title：International journal of molecular sciences

authors： Lemcke H,Skorska A,Lang CI,Johann L,David R

更新日期：2020-04-17 00:00:00

abstract：:Bioelectrochemical systems (BES) are groups of bioelectrochemical technologies and platforms that could facilitate versatile environmental and biological applications. The performance of BES is mainly determined by the key process of electron transfer at the bacteria and electrode interface, which is known as extracel...

journal_title：International journal of molecular sciences

authors： Yu YY,Zhai DD,Si RW,Sun JZ,Liu X,Yong YC

更新日期：2017-01-04 00:00:00

abstract：:Neuroblastoma (NB) is an aggressive, relapse-prone infancy tumor of the sympathetic nervous system and is the leading cause of death among preschool age diseases, so the search for novel therapeutic targets is crucial. Golgi phosphoprotein 3 (GOLPH3) has been reported to be involved in the development, and in the DNA ...

journal_title：International journal of molecular sciences

authors： Ognibene M,Podestà M,Garaventa A,Pezzolo A

更新日期：2019-09-25 00:00:00

abstract：:In vitro plant regeneration addresses basic questions of molecular reprogramming in the absence of embryonic positional cues. The process is highly dependent on the genotype and explant characteristics. However, the regulatory mechanisms operating during organ differentiation from in vitro cultures remain largely unkn...

journal_title：International journal of molecular sciences

authors： López-Ruiz BA,Juárez-González VT,Sandoval-Zapotitla E,Dinkova TD

更新日期：2019-04-27 00:00:00

abstract：:Previous studies have demonstrated that microgravity could lead to health risks. The investigation of the molecular mechanisms from the aspect of systems biology has not been performed yet. Here, we integratively analyzed transcriptional and post-transcriptional regulations based on gene and miRNA expression profiles ...

journal_title：International journal of molecular sciences

authors： Yuan M,Liu H,Zhou S,Zhou X,Huang YE,Hou F,Jiang W

更新日期：2020-10-14 00:00:00

abstract：:Serum amyloid A (SAA) promotes endothelial inflammation and dysfunction that is associated with cardiovascular disease and renal pathologies. SAA is an apoprotein for high-density lipoprotein (HDL) and its sequestration to HDL diminishes SAA bioactivity. Herein we investigated the effect of co-supplementing HDL on SAA...

journal_title：International journal of molecular sciences

authors： Cai X,Ahmad G,Hossain F,Liu Y,Wang X,Dennis J,Freedman B,Witting PK

更新日期：2020-02-15 00:00:00

abstract：:Chondrocyte hypertrophy is a hallmark of osteoarthritis (OA) pathology. In the present study, we elucidated the mechanism underlying the relationship between the hypertrophy/apoptotic phenotype and OA pathogenesis in bone marrow-derived mesenchymal stem cells (BM-MSCs) via gene targeting of distal-less homeobox 5 (DLX...

journal_title：International journal of molecular sciences

authors： Twomey-Kozak J,Desai S,Liu W,Li NY,Lemme N,Chen Q,Owens BD,Jayasuriya CT

更新日期：2020-07-08 00:00:00

abstract：:In patients with aortic stenosis (AS), a novel staging classification of extra-valvular left and right heart damage with prognostic relevance was introduced in 2017. The aim of the study was to evaluate the biomarkers of cardiovascular tissue remodelling in relation to this novel staging classification. Patients were ...

journal_title：International journal of molecular sciences

authors： Bäz L,Dannberg G,Grün K,Westphal J,Möbius-Winkler S,Jung C,Pfeil A,Schulze PC,Franz M

更新日期：2020-06-11 00:00:00

abstract：:Synovial sarcoma is a rare but highly malignant and metastatic disease. Despite its relative sensitivity to chemotherapies, the high recurrence and low 5-year survival rate for this disease suggest that new effective therapeutic agents are urgently needed. Marine antimicrobial peptide epinecidin-1 (epi-1), which was i...

journal_title：International journal of molecular sciences

authors： Su BC,Li CC,Horng JL,Chen JY

更新日期：2020-03-19 00:00:00

abstract：:Monoclonal and recombinant antibodies are widely used for the diagnostics and therapy of cancer. They are generated to interact with cell surface proteins which are usually involved in the development and progression of cancer. Carbonic anhydrase XII (CA XII) contributes to the survival of tumors under hypoxic conditi...

journal_title：International journal of molecular sciences

authors： Stravinskiene D,Sliziene A,Baranauskiene L,Petrikaite V,Zvirbliene A

更新日期：2020-12-10 00:00:00

abstract：:The mitochondrial genome of the nematode Romanomermis culicivorax encodes for miniaturized hairpin-like tRNA molecules that lack D- as well as T-arms, strongly deviating from the consensus cloverleaf. The single tRNA nucleotidyltransferase of this organism is fully active on armless tRNAs, while the human counterpart ...

journal_title：International journal of molecular sciences

authors： Hennig O,Philipp S,Bonin S,Rollet K,Kolberg T,Jühling T,Betat H,Sauter C,Mörl M

更新日期：2020-11-28 00:00:00

abstract：:Inflammation is a complex response of the body to exogenous and endogenous insults. Chronic and systemic diseases are attributed to uncontrolled inflammation. Molecules involved in the initiation of inflammation are very well studied while pathways regulating its resolution are insufficiently investigated. Approaches ...

journal_title：International journal of molecular sciences

authors： Buechler C,Pohl R,Aslanidis C

更新日期：2017-02-23 00:00:00

abstract：:Traumatic brain injury (TBI) modelled by lateral fluid percussion-induction (LFPI) in rats is a widely used experimental rodent model to explore and understand the underlying cellular and molecular alterations in the brain caused by TBI in humans. Current improvements in imaging with positron emission tomography (PET)...

journal_title：International journal of molecular sciences

authors： Ghosh KK,Padmanabhan P,Yang CT,Wang Z,Palanivel M,Ng KC,Lu J,Carlstedt-Duke J,Halldin C,Gulyás B

更新日期：2021-01-19 00:00:00

abstract：:Carbonic anhydrase II (CAII) is a zinc-containing metalloenzyme whose aberrant activity is associated with various diseases such as glaucoma, osteoporosis, and different types of tumors; therefore, the development of CAII inhibitors, which can represent promising therapeutic agents for the treatment of these pathologi...

journal_title：International journal of molecular sciences

authors： Poli G,Jha V,Martinelli A,Supuran CT,Tuccinardi T

更新日期：2018-06-23 00:00:00

abstract：:Poly-γ-glutamic acid (γ-PGA)-based nanoparticles draw remarkable attention as drug delivery agents due to their controlled release characteristics, low toxicity, and biocompatibility. 4HGF is an herbal mixture of Phellinus linteus grown on germinated brown rice, Cordyceps militaris grown on germinated soybeans, Polygo...

journal_title：International journal of molecular sciences

authors： Lee HJ,Kwon HK,Kim HS,Kim MI,Park HJ

更新日期：2019-07-13 00:00:00

abstract：:Human bone marrow-derived mesenchymal stromal cells (MSCs) have been investigated in numerous disease settings involving impaired regeneration because of the crucial role they play in tissue maintenance and repair. Considering the number of comorbidities associated with type 2 diabetes mellitus (T2DM), the hypothesis ...

journal_title：International journal of molecular sciences

authors： Cassidy FC,Shortiss C,Murphy CG,Kearns SR,Curtin W,De Buitléir C,O'Brien T,Coleman CM

更新日期：2020-04-02 00:00:00

abstract：:The epithelial sodium channel (ENaC) has a key role in modulating endothelial cell stiffness and this in turn regulates nitric oxide (NO) synthesis. The physiological relevance of endothelial ENaC in pathological conditions where reduced NO bioavailability plays an essential role remains largely unexplored. Renal isch...

journal_title：International journal of molecular sciences

authors： Tarjus A,González-Rivas C,Amador-Martínez I,Bonnard B,López-Marure R,Jaisser F,Barrera-Chimal J

更新日期：2019-06-27 00:00:00

abstract：:Intravenous iron preparations are typically classified as non-dextran-based or dextran/dextran-based complexes. The carbohydrate shell for each of these preparations is unique and is key in determining the various physicochemical properties, the metabolic pathway, and the immunogenicity of the iron-carbohydrate comple...

journal_title：International journal of molecular sciences

authors： Neiser S,Koskenkorva TS,Schwarz K,Wilhelm M,Burckhardt S

更新日期：2016-07-21 00:00:00

abstract：:The application of nanotechnology for the treatment of cancer is mostly based on early tumor detection and diagnosis by nanodevices capable of selective targeting and delivery of chemotherapeutic drugs to the specific tumor site. Due to the remarkable properties of gold nanoparticles, they have long been considered as...

journal_title：International journal of molecular sciences

authors： Singh P,Pandit S,Mokkapati VRSS,Garg A,Ravikumar V,Mijakovic I

更新日期：2018-07-06 00:00:00

abstract：:Saturated aqueous solutions of various common salts were examined for their effect on aqueous aldol reactions catalysted by a highly active C(2)-symmetric diprolinamide organocatalyst developed in our laboratory. With respect to the aldol reaction between cyclohexanone and 4-nitrobenzaldehyde, deionised water was alwa...

journal_title：International journal of molecular sciences

authors： Delaney JP,Henderson LC

更新日期：2011-01-01 00:00:00

abstract：:Protein self-association is a key feature that can modulate the physiological role of proteins or lead to deleterious effects when uncontrolled. Protein oligomerization is a simple way to modify the activity of a protein, as the modulation of binding interfaces allows for self-activation or inhibition, or variation in...

journal_title：International journal of molecular sciences

authors： Gambin Y,Polinkovsky M,Francois B,Giles N,Bhumkar A,Sierecki E

更新日期：2016-04-30 00:00:00