Bone Control of Muscle Function.

Abstract:

:Bone and muscle represent a single functional system and are tightly connected to each other. Indeed, diseases characterized by alterations of muscle physiology have effects on bone remodeling and structure and vice versa. Muscle influence on bone has been deeply studied, and recent studies identified irisin as new molecule involved in this crosstalk. Muscle regulation by bone needs to be extensively investigated since in the last few years osteocalcin was recognized as a key molecule in the bone-muscle interaction. Osteocalcin can exist in two forms with different degrees of carboxylation. The undercarboxylated form of osteocalcin is a hormone released by the bone matrix during the osteoclast bone resorption and can bind its G-protein coupled receptor GPRC6A expressed in the muscle, thus regulating its function. Recently, this hormone was described as an antiaging molecule for its ability to regulate bone, muscle and cognitive functions. Indeed, the features of this bone-related hormone were used to test a new therapeutic approach for sarcopenia, since injection of osteocalcin in older mice induces the acquirement of physical abilities of younger animals. Even if this approach should be tested in humans, osteocalcin represents the most surprising molecule in endocrine regulation by the skeleton.

journal_name

Int J Mol Sci

authors

Battafarano G,Rossi M,Marampon F,Minisola S,Del Fattore A

doi

10.3390/ijms21041178

subject

Has Abstract

pub_date

2020-02-11 00:00:00

issue

4

issn

1422-0067

pii

ijms21041178

journal_volume

21

pub_type

杂志文章,评审
  • The interplay between QSAR/QSPR studies and partial order ranking and formal concept analyses.

    abstract::The often observed scarcity of physical-chemical and well as toxicological data hampers the assessment of potentially hazardous chemicals released to the environment. In such cases Quantitative Structure-Activity Relationships/Quantitative Structure-Property Relationships (QSAR/QSPR) constitute an obvious alternative ...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审

    doi:10.3390/ijms10041628

    authors: Carlsen L

    更新日期:2009-04-17 00:00:00

  • Cooperative Binding of KaiB to the KaiC Hexamer Ensures Accurate Circadian Clock Oscillation in Cyanobacteria.

    abstract::The central oscillator generating cyanobacterial circadian rhythms comprises KaiA, KaiB, and KaiC proteins. Their interactions cause KaiC phosphorylation and dephosphorylation cycles over approximately 24 h. KaiB interacts with phosphorylated KaiC in competition with SasA, an output protein harboring a KaiB-homologous...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms20184550

    authors: Murakami R,Yunoki Y,Ishii K,Terauchi K,Uchiyama S,Yagi H,Kato K

    更新日期:2019-09-13 00:00:00

  • Methyl Donor Deficiency during Gestation and Lactation in the Rat Affects the Expression of Neuropeptides and Related Receptors in the Hypothalamus.

    abstract::The micronutrients vitamins B9 and B12 act as methyl donors in the one-carbon metabolism involved in transmethylation reactions which critically influence epigenetic mechanisms and gene expression. Both vitamins are essential for proper development, and their deficiency during pregnancy has been associated with a wide...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms20205097

    authors: Saber Cherif L,Pourié G,Geoffroy A,Julien A,Helle D,Robert A,Umoret R,Guéant JL,Bossenmeyer-Pourié C,Daval JL

    更新日期:2019-10-14 00:00:00

  • Various Mechanisms Involve the Nuclear Factor (Erythroid-Derived 2)-Like (NRF2) to Achieve Cytoprotection in Long-Term Cisplatin-Treated Urothelial Carcinoma Cell Lines.

    abstract::Therapeutic efficacy of cisplatin-based chemotherapy for advanced-stage urothelial carcinoma (UC) is limited by drug resistance. The nuclear factor (erythroid-derived 2)-like 2 (NRF2) pathway is a major regulator of cytoprotective responses. We investigated its involvement in cisplatin resistance in long-term cisplati...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms18081680

    authors: Skowron MA,Niegisch G,Albrecht P,van Koeveringe G,Romano A,Albers P,Schulz WA,Hoffmann MJ

    更新日期:2017-08-02 00:00:00

  • DNA Repair Deficient Chinese Hamster Ovary Cells Exhibiting Differential Sensitivity to Charged Particle Radiation under Aerobic and Hypoxic Conditions.

    abstract::It has been well established that hypoxia significantly increases both cellular and tumor resistance to ionizing radiation. Hypoxia associated radiation resistance has been known for some time but there has been limited success in sensitizing cells to radiation under hypoxic conditions. These studies show that, when i...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms19082228

    authors: Cartwright IM,Su C,Haskins JS,Salinas VA,Sunada S,Yu H,Uesaka M,Hirakawa H,Chen DJ,Fujimori A,Kato TA

    更新日期:2018-07-30 00:00:00

  • Sweet Immunity: Inulin Boosts Resistance of Lettuce (Lactuca sativa) against Grey Mold (Botrytis cinerea) in an Ethylene-Dependent Manner.

    abstract::The concept of "Sweet Immunity" postulates that sugar metabolism and signaling influence plant immune networks. In this study, we tested the potential of commercially available inulin-type fructans to limit disease symptoms caused by Botrytis cinerea in lettuce. Spraying mature lettuce leaves, with inulin-type fructan...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms20051052

    authors: Tarkowski ŁP,Van de Poel B,Höfte M,Van den Ende W

    更新日期:2019-02-28 00:00:00

  • Immunotherapies and Future Combination Strategies for Head and Neck Squamous Cell Carcinoma.

    abstract::Head and neck squamous cell carcinoma (HNSCC) is often diagnosed at an advanced stage and has a dismal prognosis. Nearly 10 years after the approval of cetuximab, anti-PD1/PD-L1 checkpoint inhibitors are the first drugs that have shown any survival benefit for the treatment on platinum-refractory recurrent/metastatic ...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审

    doi:10.3390/ijms20215399

    authors: Cristina V,Herrera-Gómez RG,Szturz P,Espeli V,Siano M

    更新日期:2019-10-30 00:00:00

  • Phenotypic Screen with the Human Secretome Identifies FGF16 as Inducing Proliferation of iPSC-Derived Cardiac Progenitor Cells.

    abstract::Paracrine factors can induce cardiac regeneration and repair post myocardial infarction by stimulating proliferation of cardiac cells and inducing the anti-fibrotic, antiapoptotic, and immunomodulatory effects of angiogenesis. Here, we screened a human secretome library, consisting of 923 growth factors, cytokines, an...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms20236037

    authors: Jennbacken K,Wågberg F,Karlsson U,Eriksson J,Magnusson L,Chimienti M,Ricchiuto P,Bernström J,Ding M,Ross-Thriepland D,Xue Y,Peiris D,Aastrup T,Tegel H,Hober S,Sivertsson Å,Uhlén M,Strömstedt PE,Davies R,Holmberg Sch

    更新日期:2019-11-30 00:00:00

  • Reply to the Letter to the Editor by Li et al.: Bioinformatics Analysis in Mice with Diet-Induced Nonalcoholic Steatohepatitis Treated with Astaxanthin and Vitamin E.

    abstract::n/a. ...

    journal_title:International journal of molecular sciences

    pub_type: 评论,杂志文章

    doi:10.3390/ijms18050994

    authors: Kobori M,Takahashi Y,Sakurai M,Ni Y,Chen G,Nagashimada M,Kaneko S,Ota T

    更新日期:2017-05-05 00:00:00

  • Resveratrol induces the expression of interleukin-10 and brain-derived neurotrophic factor in BV2 microglia under hypoxia.

    abstract::Microglia are the resident macrophages of the central nervous system (CNS) and play an important role in neuronal recovery by scavenging damaged neurons. However, overactivation of microglia leads to neuronal death that is associated with CNS disorders. Therefore, regulation of microglial activation has been suggested...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms150915512

    authors: Song J,Cheon SY,Jung W,Lee WT,Lee JE

    更新日期:2014-09-02 00:00:00

  • Fluid Shear Stress Induces EMT of Circulating Tumor Cells via JNK Signaling in Favor of Their Survival during Hematogenous Dissemination.

    abstract::Tumor cells metastasize to distal organs mainly through hematogenous dissemination, where they experience considerable levels of fluid shear stress. Epithelial-mesenchymal transition (EMT) plays a critical role in tumor metastasis. However, how fluid shear stress influences the EMT phenotype of circulating tumor cells...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms21218115

    authors: Xin Y,Li K,Yang M,Tan Y

    更新日期:2020-10-30 00:00:00

  • Detection of Bacterial Pathogens from Broncho-Alveolar Lavage by Next-Generation Sequencing.

    abstract::The applications of whole-metagenome shotgun sequencing (WMGS) in routine clinical analysis are still limited. A combination of a DNA extraction procedure, sequencing, and bioinformatics tools is essential for the removal of human DNA and for improving bacterial species identification in a timely manner. We tackled th...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms18092011

    authors: Leo S,Gaïa N,Ruppé E,Emonet S,Girard M,Lazarevic V,Schrenzel J

    更新日期:2017-09-20 00:00:00

  • Applications and mechanisms of ionic liquids in whole-cell biotransformation.

    abstract::Ionic liquids (ILs), entirely composed of cations and anions, are liquid solvents at room temperature. They are interesting due to their low vapor pressure, high polarity and thermostability, and also for the possibility to fine-tune their physicochemical properties through modification of the chemical structures of t...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审

    doi:10.3390/ijms150712196

    authors: Fan LL,Li HJ,Chen QH

    更新日期:2014-07-09 00:00:00

  • The Autophagy Status of Cancer Stem Cells in Gliobastoma Multiforme: From Cancer Promotion to Therapeutic Strategies.

    abstract::Glioblastoma multiforme (GBM) is the most common and aggressive primary brain tumor featuring rapid cell proliferation, treatment resistance, and tumor relapse. This is largely due to the coexistence of heterogeneous tumor cell populations with different grades of differentiation, and in particular, to a small subset ...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审

    doi:10.3390/ijms20153824

    authors: Ryskalin L,Gaglione A,Limanaqi F,Biagioni F,Familiari P,Frati A,Esposito V,Fornai F

    更新日期:2019-08-05 00:00:00

  • Identification of Salt Stress Responding Genes Using Transcriptome Analysis in Green Alga Chlamydomonas reinhardtii.

    abstract::Salinity is one of the most important abiotic stresses threatening plant growth and agricultural productivity worldwide. In green alga Chlamydomonas reinhardtii, physiological evidence indicates that saline stress increases intracellular peroxide levels and inhibits photosynthetic-electron flow. However, understanding...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms19113359

    authors: Wang N,Qian Z,Luo M,Fan S,Zhang X,Zhang L

    更新日期:2018-10-26 00:00:00

  • Nutrition and Psoriasis.

    abstract::Psoriasis is a chronic inflammatory skin disease characterized by accelerated tumor necrosis factor-α/interleukin-23/interleukin-17 axis, hyperproliferation and abnormal differentiation of epidermal keratinocytes. Psoriasis patients are frequently associated with obesity, diabetes, dyslipidemia, cardiovascular disease...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审

    doi:10.3390/ijms21155405

    authors: Kanda N,Hoashi T,Saeki H

    更新日期:2020-07-29 00:00:00

  • Cholesterol, Oxysterols and LXRs in Breast Cancer Pathophysiology.

    abstract::Breast cancer is the most frequent cancer among women. In 2018, it is estimated that 627,000 women died from breast cancer. This is approximately 15% of all cancer deaths among women (WHO 2018). Breast cancer is a multifactorial chronic disease. While important progress has been made to treat patients, many questions ...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审

    doi:10.3390/ijms21041356

    authors: Nazih H,Bard JM

    更新日期:2020-02-17 00:00:00

  • A labile pool of IQGAP1 disassembles endothelial adherens junctions.

    abstract::Adhesion molecules are known to play an important role in endothelial activation and angiogenesis. Here we determined the functional role of IQGAP1 in the regulation of endothelial adherens junctions. VE-cadherin is found to be associated with actin filaments and thus stable, but IQGAP1 at intercellular junctions is n...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms140713377

    authors: Yuan Z,Zhang W,Tan W

    更新日期:2013-06-27 00:00:00

  • Problems Associated with Deprescribing of Proton Pump Inhibitors.

    abstract::Proton pump inhibitors (PPIs) are recommended as a first-line treatment for gastroesophageal reflux disease (GERD) and other acid related disorders. In recent years, concerns have been raised about the increasing prevalence of patients on long-term PPI therapy and inappropriate PPI use. It is well known that short-ter...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审

    doi:10.3390/ijms20215469

    authors: Helgadottir H,Bjornsson ES

    更新日期:2019-11-02 00:00:00

  • Autophagy Deficiency in Renal Proximal Tubular Cells Leads to an Increase in Cellular Injury and Apoptosis under Normal Fed Conditions.

    abstract::Renal proximal tubular epithelial cells are significantly damaged during acute kidney injury. Renal proximal tubular cell-specific autophagy-deficient mice show increased sensitivity against renal injury, while showing few pathological defects under normal fed conditions. Considering that autophagy protects the proxim...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms21010155

    authors: Suzuki C,Tanida I,Oliva Trejo JA,Kakuta S,Uchiyama Y

    更新日期:2019-12-25 00:00:00

  • Renal Protective Effects of Low Molecular Weight of Inonotus obliquus Polysaccharide (LIOP) on HFD/STZ-Induced Nephropathy in Mice.

    abstract::Diabetic nephropathy (DN) is the leading cause of end-stage renal disease in diabetes mellitus. Oxidative stress, insulin resistance and pro-inflammatory cytokines have been shown to play an important role in pathogeneses of renal damage on type 2 diabetes mellitus (DM). Inonotus obliquus (IO) is a white rot fungus th...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms17091535

    authors: Chou YJ,Kan WC,Chang CM,Peng YJ,Wang HY,Yu WC,Cheng YH,Jhang YR,Liu HW,Chuu JJ

    更新日期:2016-09-13 00:00:00

  • Bioinformatics Approaches for Fetal DNA Fraction Estimation in Noninvasive Prenatal Testing.

    abstract::The discovery of cell-free fetal DNA molecules in plasma of pregnant women has created a paradigm shift in noninvasive prenatal testing (NIPT). Circulating cell-free DNA in maternal plasma has been increasingly recognized as an important proxy to detect fetal abnormalities in a noninvasive manner. A variety of approac...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审

    doi:10.3390/ijms18020453

    authors: Peng XL,Jiang P

    更新日期:2017-02-20 00:00:00

  • MicroRNA29a Reverts the Activated Hepatic Stellate Cells in the Regression of Hepatic Fibrosis through Regulation of ATPase H⁺ Transporting V1 Subunit C1.

    abstract::Activated hepatic stellate cells (aHSCs) play a key role in liver fibrosis. During the regression of fibrosis, aHSCs are transformed into inactivated cells (iHSCs), which are quiescent lipid-containing cells and express higher levels of lipid-related genes, such as peroxisome proliferators-activated receptors gamma (P...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms20040796

    authors: Jing F,Geng Y,Xu XY,Xu HY,Shi JS,Xu ZH

    更新日期:2019-02-13 00:00:00

  • Photo-Responsive Supramolecular Micelles for Controlled Drug Release and Improved Chemotherapy.

    abstract::Development of stimuli-responsive supramolecular micelles that enable high levels of well-controlled drug release in cancer cells remains a grand challenge. Here, we encapsulated the antitumor drug doxorubicin (DOX) and pro-photosensitizer 5-aminolevulinic acid (5-ALA) within adenine-functionalized supramolecular mice...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms22010154

    authors: Ilhami FB,Peng KC,Chang YS,Alemayehu YA,Tsai HC,Lai JY,Chiao YH,Kao CY,Cheng CC

    更新日期:2020-12-25 00:00:00

  • Environmental risk factors for multiple sclerosis: a review with a focus on molecular mechanisms.

    abstract::Multiple sclerosis (MS) is a chronic disabling disease of the central nervous system commonly affecting young adults. Pathologically, there are patches of inflammation (plaques) with demyelination of axons and oligodendrocyte loss. There is a global latitude gradient in MS prevalence, and incidence of MS is increasing...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审

    doi:10.3390/ijms130911718

    authors: O'Gorman C,Lucas R,Taylor B

    更新日期:2012-01-01 00:00:00

  • In vitro corrosion and cytocompatibility properties of nano-whisker hydroxyapatite coating on magnesium alloy for bone tissue engineering applications.

    abstract::We report here the successful fabrication of nano-whisker hydroxyapatite (nHA) coatings on Mg alloy by using a simple one-step hydrothermal process in aqueous solution. The nHA coating shows uniform structure and high crystallinity. Results indicate that nHA coating is promising for improving the in vitro corrosion an...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms16036113

    authors: Yang H,Yan X,Ling M,Xiong Z,Ou C,Lu W

    更新日期:2015-03-17 00:00:00

  • The Salt Sensitivity Induced by Disruption of Cell Wall-Associated Kinase 1 (SlWAK1) Tomato Gene Is Linked to Altered Osmotic and Metabolic Homeostasis.

    abstract::Tomato cell wall-associated kinase 1 (SlWAK1) has only been studied in biotic stress response and hence its function in abiotic stress remains unknown. In a screening under salinity of an insertional mutant collection of tomato (Solanum lycopersicum L.), a mutant exhibiting lower degree of leaf chlorosis than wild typ...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms21176308

    authors: Meco V,Egea I,Ortíz-Atienza A,Drevensek S,Esch E,Yuste-Lisbona FJ,Barneche F,Vriezen W,Bolarin MC,Lozano R,Flores FB

    更新日期:2020-08-31 00:00:00

  • Recent Advances in SELEX Technology and Aptamer Applications in Biomedicine.

    abstract::Aptamers are short DNA/RNA oligonucleotides capable of binding to target molecules with high affinity and specificity. The process of selecting an aptamer is called Systematic Evolution of Ligands by Exponential Enrichment (SELEX). Thanks to the inherit merits, aptamers have been used in a wide range of applications, ...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审

    doi:10.3390/ijms18102142

    authors: Zhuo Z,Yu Y,Wang M,Li J,Zhang Z,Liu J,Wu X,Lu A,Zhang G,Zhang B

    更新日期:2017-10-14 00:00:00

  • Capsaicin-Cyclodextrin Complex Enhances Mepivacaine Targeting and Improves Local Anesthesia in Inflamed Tissues.

    abstract::Acidic environments, such as in inflamed tissues, favor the charged form of local anesthetics (LA). Hence, these drugs show less cell permeation and diminished potency. Since the analgesic capsaicin (CAP) triggers opening of the TRPV1 receptor pore, its combination with LAs could result in better uptake and improved a...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms21165741

    authors: Couto VM,Oliveira-Nascimento L,Cabeça LF,Geraldes DC,Costa JSR,Riske KA,Franz-Montan M,Yokaychiya F,Franco MKKD,Paula E

    更新日期:2020-08-10 00:00:00

  • Symmetrical Modification of Minimized Dermaseptins to Extend the Spectrum of Antimicrobials with Endotoxin Neutralization Potency.

    abstract::Antimicrobial peptides (AMPs) have emerged as a promising class of antimicrobial agents that could potentially address the global antibiotic resistance. Generating mirror-like peptides by minimizing dermaseptin family sequences is an effective strategy for designing AMPs. However, the previous research still had some ...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms20061417

    authors: Shao C,Li W,Tan P,Shan A,Dou X,Ma D,Liu C

    更新日期:2019-03-20 00:00:00