Abstract:
:Alemtuzumab, a humanized monoclonal antibody targeting the surface molecule CD52, leads to a rapid depletion of immune cells in the innate and adaptive immune system. In phase 2 and 3 trials in multiple sclerosis (MS), infections have been reported more frequently in alemtuzumab than in interferon beta treated patients. Here we report two patients treated with alemtuzumab for MS developing Listeria meningitis few days after the first infusion cycle. Both patients recovered completely after prompt diagnosis and adequate treatment. Physicians and patients should be aware of this serious, but treatable complication.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Rau D,Lang M,Harth A,Naumann M,Weber F,Tumani H,Bayas Adoi
10.3390/ijms160714669subject
Has Abstractpub_date
2015-06-29 00:00:00pages
14669-76issue
7issn
1422-0067pii
ijms160714669journal_volume
16pub_type
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