Abstract：
:Androgens have been known to inhibit cutaneous wound healing in men and male mice. However, in children with major burn injuries, a synthetic androgen was reported clinically to improve wound healing. The aim of this study is to investigate the role of dihydrotestosterone (DHT) as a new therapeutic approach in treating major burn injury. In the present study, mice received systemic androgen treatment post major burn injury. Wound healing rate and body weight were monitored over 21 days. The serum level of inflammatory cytokines/chemokines were measured using multiplex immunoassays. In addition, splenocyte enumeration was performed by flow cytometry. Healing phases of inflammation, re-epithelialization, cell proliferation and collagen deposition were also examined. In results, DHT treated mice lost less weight and displayed accelerated wound healing but has no impact on hypermetabolism. Mice, after burn injury, displayed acute systemic inflammatory responses over 21 days. DHT treatment shortened the systemic inflammatory response with reduced splenic weight and monocyte numbers on day 14 and 21. DHT treatment also reduced wound infiltrating macrophage numbers. In conclusion, DHT treatment facilitates local wound healing by accelerating the resolution of inflammation, but not through alterations of post-burn hypermetabolic response.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Shi H,Lo TH,Ma D,Condor B,Lesmana B,Parungao RJ,Tsai KH,Kim S,Chen HT,Silveira PA,Li Z,Cooper MS,Simanainen U,Handelsman DJ,Maitz PK,Wang Ydoi
10.3390/ijms21176231subject
Has Abstractpub_date
2020-08-28 00:00:00issue
17issn
1422-0067pii
ijms21176231journal_volume
21pub_type
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