Abstract：
:Impairment of skeletal muscle function causes disabilities in elderly people. Therefore, in an aged society, prevention and treatment of sarcopenia are important for expanding healthy life expectancy. In addition to aging, adipose tissue disfunction and inflammation also contribute to the pathogenesis of sarcopenia by causing the combined state called 'sarcopenic obesity'. Muscle quality as well as muscle mass contributes to muscle strength and physical performance. Mitochondria in the skeletal muscles affect muscle quality by regulating the production of energy and reactive oxygen species. A certain portion of the mitochondrial respiratory chain complexes form a higher-order structure called a "supercomplex", which plays important roles in efficient energy production, stabilization of respiratory chain complex I, and prevention of reactive oxygen species (ROS) generation. Several molecules including phospholipids, proteins, and certain chemicals are known to promote or stabilize mitochondrial respiratory chain supercomplex assembly directly or indirectly. In this article, we review the distinct mechanisms underlying the promotion or stabilization of mitochondrial respiratory chain supercomplex assembly by supercomplex assembly factors. Further, we introduce regulatory pathways of mitochondrial respiratory chain supercomplex assembly and discuss the roles of supercomplex assembly factors and regulatory pathways in skeletal muscles and adipose tissues, believing that this will lead to discovery of potential targets for prevention and treatment of muscle disorders such as sarcopenia.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Azuma K,Ikeda K,Inoue Sdoi
10.3390/ijms21093182subject
Has Abstractpub_date
2020-04-30 00:00:00issue
9issn
1422-0067pii
ijms21093182journal_volume
21pub_type
杂志文章,评审abstract：:Lysophosphatidic acid (LPA) is a small lysophospholipid molecule that activates multiple cellular functions through pathways with G-protein-coupled receptors. So far, six LPA receptors (LPAR1 to LPAR6) have been discovered and each one of them can connect to the downstream cell message-transmitting network. A previous...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21082837
更新日期：2020-04-18 00:00:00
abstract：:Complex neurodevelopmental syndromes frequently have an unknown etiology, in which genetic factors play a pathogenic role. This study utilizes whole-exome sequencing (WES) to examine four members of a family with a son presenting, since birth, with epileptic-like crises, combined with cerebral palsy, severe neuromotor...
journal_title：International journal of molecular sciences
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更新日期：2020-06-23 00:00:00
abstract：BACKGROUND:Epstein-Barr Virus (EBV) positive and microsatellite unstable (MSI-high) gastric cancer (GC) are molecular subgroups with distinctive molecular profiles. We explored the transcriptomic differences between EBV+ and MSI-high GCs, and the expression of current GC immunotherapy targets such as PD-1, PD-L1, CTLA4...
journal_title：International journal of molecular sciences
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更新日期：2018-07-17 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms18112442
更新日期：2017-11-17 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
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更新日期：2010-06-09 00:00:00
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更新日期：2020-11-15 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2020-11-11 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2020-12-30 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
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更新日期：2020-07-06 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2018-04-09 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms161226214
更新日期：2015-12-16 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19010126
更新日期：2018-01-02 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21249679
更新日期：2020-12-18 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19124067
更新日期：2018-12-15 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
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更新日期：2020-03-20 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21093268
更新日期：2020-05-05 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21228628
更新日期：2020-11-16 00:00:00
abstract：:Prodrug activator gene therapy mediated by murine leukemia virus (MLV)-based retroviral replicating vectors (RRV) was previously shown to be highly effective in killing glioma cells both in culture and in vivo. To avoid receptor interference and enable dual vector co-infection with MLV-RRV, we have developed another R...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21041433
更新日期：2020-02-20 00:00:00
abstract：:Small noncoding RNAs that are 19-23 nucleotides long, known as microRNAs (miRNAs), are involved in almost all biological mechanisms during carcinogenesis. Recent studies show that miRNAs released from live cells are detectable in body fluids and may be taken up by other cells to confer cell-cell communication. These r...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms140714785
更新日期：2013-07-16 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2017-08-07 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
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更新日期：2013-05-10 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2020-03-30 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
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更新日期：2020-08-15 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms151222743
更新日期：2014-12-09 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2019-07-12 00:00:00
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journal_title：International journal of molecular sciences
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doi：10.3390/ijms20225796
更新日期：2019-11-18 00:00:00
abstract：:Organ replacement is an option to mitigate irreversible organ damage. This procedure has achieved a considerable degree of acceptance. However, several factors significantly limit its effectiveness. Among them, the initial inflammatory graft reaction due to ischemia-reperfusion injury (IRI) has a fundamental influence...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms19010102
更新日期：2018-01-04 00:00:00
abstract：:Chitin synthase synthesizes chitin, which is critical for the arthropod exoskeleton. In this study, we cloned the cDNA sequences of a chitin synthase 1 gene, PcCHS1, in the citrus red mite, Panonychus citri (McGregor), which is one of the most economically important pests of citrus worldwide. The full-length cDNA of P...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms15033711
更新日期：2014-02-28 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
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更新日期：2014-09-09 00:00:00
abstract：:We report molecular dynamics simulations of confined liquid crystals using the Gay-Berne-Kihara model. Upon isobaric cooling, the standard sequence of isotropic-nematic-smectic A phase transitions is found. Upon further cooling a reentrant nematic phase occurs. We investigate the temperature dependence of the self-dif...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms13067854
更新日期：2012-01-01 00:00:00
