Abstract:
:Systemic sclerosis is a rare chronic heterogenous disease that involves inflammation and vasculopathy, and converges in end-stage development of multisystem tissue fibrosis. The loss of tight spatial distribution and temporal expression of proteins in the extracellular matrix (ECM) leads to progressive organ stiffening, which is a hallmark of fibrotic disease. A group of nonstructural matrix proteins, known as matricellular proteins (MCPs) are implicated in dysregulated processes that drive fibrosis such as ECM remodeling and various cellular behaviors. Accordingly, MCPs have been described in the context of fibrosis in sclerosis (SSc) as predictive disease biomarkers and regulators of ECM synthesis, with promising therapeutic potential. In this present review, an informative summary of major MCPs is presented highlighting their clear correlations to SSc- fibrosis.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Feng D,Gerarduzzi Cdoi
10.3390/ijms21134776subject
Has Abstractpub_date
2020-07-06 00:00:00issue
13issn
1422-0067pii
ijms21134776journal_volume
21pub_type
杂志文章,评审abstract::Doxorubicin (DOX) is an anthracycline drug with a wide spectrum of antineoplastic activities. However, it causes cardiac cytotoxicity, and this limits its clinical applications. MicroRNA-21 (miR-21) plays a vital role in regulating cell proliferation and apoptosis. While miR-21 is preferentially expressed in adult car...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms160714511
更新日期:2015-06-26 00:00:00
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journal_title:International journal of molecular sciences
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journal_title:International journal of molecular sciences
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abstract::Genetically modified vaccinia viruses (VACVs) have been shown to possess profound oncolytic capabilities. However, tumor cell resistance to VACVs may endanger broad clinical success. Using cell mass assays, viral replication studies, and fluorescence microscopy, we investigated primary resistance phenomena of cell lin...
journal_title:International journal of molecular sciences
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abstract::B cells, plasma cells and antibodies may play a key role in the pathogenesis of multiple sclerosis (MS). This notion is supported by various immunological changes observed in MS patients, such as activation and pro-inflammatory differentiation of peripheral blood B cells, the persistence of clonally expanded plasma ce...
journal_title:International journal of molecular sciences
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journal_title:International journal of molecular sciences
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abstract::Barley (Hordeum vulgare L.) is an important cereal crop grown for both the feed and malting industries. The allelic dwarfing gene sdw1/denso has been used throughout the world to develop commercial barley varieties. Proteomic analysis offers a new approach to identify a broad spectrum of genes that are expressed in th...
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abstract::Acidovorax citrulli (A. citrulli) strains cause bacterial fruit blotch (BFB) in cucurbit crops and affect melon significantly. Numerous strains of the bacterium have been isolated from melon hosts globally. Strains that are aggressively virulent towards melon and diagnostic markers for detecting such strains are yet t...
journal_title:International journal of molecular sciences
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journal_title:International journal of molecular sciences
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journal_title:International journal of molecular sciences
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更新日期:2018-11-28 00:00:00
abstract:BACKGROUND:The determinants that mediate the interactions between microRNAs and the gut microbiome impacting on obesity are scarcely understood. Thus, the aim of this study was to investigate possible interactions between circulating microRNAs and gut microbiota composition in obesity. METHOD:The sample comprised 78 s...
journal_title:International journal of molecular sciences
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abstract::Mathematical optimization framework allows the identification of certain nodes within a signaling network. In this work, we analyzed the complex extracellular-signal-regulated kinase 1 and 2 (ERK1/2) cascade in cardiomyocytes using the framework to find efficient adjustment screws for this cascade that is important fo...
journal_title:International journal of molecular sciences
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更新日期:2019-05-02 00:00:00
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journal_title:International journal of molecular sciences
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journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21082914
更新日期:2020-04-21 00:00:00
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journal_title:International journal of molecular sciences
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doi:10.3390/ijms18081743
更新日期:2017-08-11 00:00:00
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journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20081821
更新日期:2019-04-12 00:00:00
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journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms17030373
更新日期:2016-03-12 00:00:00
abstract::Maize (Zea mays L.) is a host to numerous pathogenic species that impose serious diseases to its ear and foliage, negatively affecting the yield and the quality of the maize crop. A considerable amount of research has been carried out to elucidate mechanisms of maize-pathogen interactions with a major goal to identify...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms161226106
更新日期:2015-11-30 00:00:00
abstract::Ganoderma lucidum polysaccharide (GLP) is a biologically active substance reported to possess anti-tumor ability. Nonetheless, the mechanisms of GLP-stimulated apoptosis are still unclear. This study aims to determine the inhibitory and apoptosis-inducing effects of GLP on HCT-116 cells. We found that GLP reduced cell...
journal_title:International journal of molecular sciences
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doi:10.3390/ijms15059103
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journal_title:International journal of molecular sciences
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更新日期:2020-08-26 00:00:00
abstract::There is a growing body of evidence showing the importance of physical activity against acute ischemic events in various organs. Ischemia/reperfusion injury (I/R) is characterized by tissue damage as a result of restriction and subsequent restoration of blood supply to an organ. Oxidative stress due to increased react...
journal_title:International journal of molecular sciences
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journal_title:International journal of molecular sciences
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doi:10.3390/ijms20215354
更新日期:2019-10-28 00:00:00
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journal_title:International journal of molecular sciences
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更新日期:2017-07-24 00:00:00
abstract::Cisplatin is one of the most widely used chemical drugs for anticancer treatment. Recent studies have focused on the ability of cisplatin to retain the high mobility group box 1 (HMGB1) protein in cisplatin-DNA adducts, thereby preventing its release from the nucleus. Because HMGB1 is a powerful inflammatory mediator ...
journal_title:International journal of molecular sciences
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doi:10.3390/ijms140611224
更新日期:2013-05-27 00:00:00
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journal_title:International journal of molecular sciences
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doi:10.3390/ijms19030808
更新日期:2018-03-11 00:00:00
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journal_title:International journal of molecular sciences
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doi:10.3390/ijms21218111
更新日期:2020-10-30 00:00:00
abstract::Activated carbon honeycomb-monoliths with different textural properties were prepared by chemical activation of African palm shells with H(3)PO(4), ZnCl(2) and CaCl(2) aqueous solutions of various concentrations. The adsorbents obtained were characterized by N(2) adsorption at 77 K, and their carbon dioxide adsorption...
journal_title:International journal of molecular sciences
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doi:10.3390/ijms13078388
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journal_title:International journal of molecular sciences
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更新日期:2019-08-26 00:00:00
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journal_title:International journal of molecular sciences
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doi:10.3390/ijms11020492
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journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms18061329
更新日期:2017-06-21 00:00:00