当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES期刊下所有文献 > ATP Release Channels.

ATP Release Channels.

Abstract：

:Adenosine triphosphate (ATP) has been well established as an important extracellular ligand of autocrine signaling, intercellular communication, and neurotransmission with numerous physiological and pathophysiological roles. In addition to the classical exocytosis, non-vesicular mechanisms of cellular ATP release have been demonstrated in many cell types. Although large and negatively charged ATP molecules cannot diffuse across the lipid bilayer of the plasma membrane, conductive ATP release from the cytosol into the extracellular space is possible through ATP-permeable channels. Such channels must possess two minimum qualifications for ATP permeation: anion permeability and a large ion-conducting pore. Currently, five groups of channels are acknowledged as ATP-release channels: connexin hemichannels, pannexin 1, calcium homeostasis modulator 1 (CALHM1), volume-regulated anion channels (VRACs, also known as volume-sensitive outwardly rectifying (VSOR) anion channels), and maxi-anion channels (MACs). Recently, major breakthroughs have been made in the field by molecular identification of CALHM1 as the action potential-dependent ATP-release channel in taste bud cells, LRRC8s as components of VRACs, and SLCO2A1 as a core subunit of MACs. Here, the function and physiological roles of these five groups of ATP-release channels are summarized, along with a discussion on the future implications of understanding these channels.

journal_name

Int J Mol Sci

journal_title

International journal of molecular sciences

authors

Taruno A

doi

10.3390/ijms19030808

subject

Has Abstract

pub_date

2018-03-11 00:00:00

issue

3

issn

1422-0067

pii

ijms19030808

journal_volume

19

pub_type

杂志文章,评审

相关文献

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES文献大全
  • Proteomics and Metabolomics for Cystic Fibrosis Research.

    abstract：:The aim of this review article is to introduce the reader to the state-of-the-art of the contribution that proteomics and metabolomics sciences are currently providing for cystic fibrosis (CF) research: from the understanding of cystic fibrosis transmembrane conductance regulator (CFTR) biology to biomarker discovery ...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms21155439

    authors： Liessi N,Pedemonte N,Armirotti A,Braccia C

    更新日期：2020-07-30 00:00:00

  • Effects of Selective Substitution of Cysteine Residues on the Conformational Properties of Chlorotoxin Explored by Molecular Dynamics Simulations.

    abstract：:Chlorotoxin (CTX) is a 36⁻amino acid peptide with eight Cys residues that forms four disulfide bonds. It has high affinity for the glioma-specific chloride channel and matrix metalloprotease-2. Structural and binding properties of CTX analogs with various Cys residue substitutions with l-α-aminobutyric acid (Abu) have...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms20061261

    authors： Gregory AJ,Voit-Ostricki L,Lovas S,Watts CR

    更新日期：2019-03-13 00:00:00

  • Hsa-let-7g miRNA targets caspase-3 and inhibits the apoptosis induced by ox-LDL in endothelial cells.

    abstract：:It has been well confirmed ox-LDL plays key roles in the development of atherosclerosis via binding to LOX-1 and inducing apoptosis in vascular endothelial cells. Recent studies have shown ox-LDL can suppress microRNA has-let-7g, which in turn inhibits the ox-LDL induced apoptosis. However, details need to be uncovere...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms141122708

    authors： Zhang Y,Chen N,Zhang J,Tong Y

    更新日期：2013-11-18 00:00:00

  • Competing Endogenous RNA Networks as Biomarkers in Neurodegenerative Diseases.

    abstract：:Protein aggregation is classically considered the main cause of neuronal death in neurodegenerative diseases (NDDs). However, increasing evidence suggests that alteration of RNA metabolism is a key factor in the etiopathogenesis of these complex disorders. Non-coding RNAs are the major contributor to the human transcr...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms21249582

    authors： Moreno-García L,López-Royo T,Calvo AC,Toivonen JM,de la Torre M,Moreno-Martínez L,Molina N,Aparicio P,Zaragoza P,Manzano R,Osta R

    更新日期：2020-12-16 00:00:00

  • Global Analysis of WOX Transcription Factor Gene Family in Brassica napus Reveals Their Stress- and Hormone-Responsive Patterns.

    abstract：:The plant-specific WUSCHEL-related homeobox (WOX) transcription factor gene family is important for plant growth and development but little studied in oil crops. We identified and characterized 58 putative WOX genes in Brassica napus (BnWOXs), which were divided into three major clades and nine subclades based on the ...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms19113470

    authors： Wang MM,Liu MM,Ran F,Guo PC,Ke YZ,Wu YW,Wen J,Li PF,Li JN,Du H

    更新日期：2018-11-05 00:00:00

  • Inhibition of Heme Oxygenase-1 Activity Enhances Wilms Tumor-1-Specific T-Cell Responses in Cancer Immunotherapy.

    abstract：:Wilms tumor protein-1 (WT1) is an attractive target for adoptive T-cell therapy due to its expression in solid tumors and hematologic malignancies. However, T cells recognizing WT1 occur in low frequencies in the peripheral blood of healthy donors, limiting potential therapeutic possibilities. Tin mesoporphyrin (SnMP)...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms20030482

    authors： Schillingmann DA,Riese SB,Vijayan V,Tischer-Zimmermann S,Schmetzer H,Maecker-Kolhoff B,Blasczyk R,Immenschuh S,Eiz-Vesper B

    更新日期：2019-01-23 00:00:00

  • The Ameliorative Effect of Silicon on Maize Plants Grown in Mg-Deficient Conditions.

    abstract：:The importance of magnesium (Mg) for plant growth is well-documented. Silicon (Si)-mediated alleviation of mineral deficiencies has been also reported in a number of plant species; however, there is no report on the relevance of Si nutrition in plants grown in Mg-deficient condition. Therefore, in the present work, an...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms20040969

    authors： Hosseini SA,Naseri Rad S,Ali N,Yvin JC

    更新日期：2019-02-22 00:00:00

  • Facile and Safe Synthesis of Novel Self-Pored Amine-Functionalized Polystyrene with Nanoscale Bicontinuous Morphology.

    abstract：:The chloromethyl-functionalized polystyrene is the most commonly used ammonium cation precursor for making anion exchange resins (AER) and membranes (AEM). However, the chloromethylation of polystyrene or styrene involves highly toxic and carcinogenic raw materials (e.g., chloromethyl ether) and the resultant ammonium...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21249404

    authors： Gui Q,Ouyang Q,Xu C,Ding H,Shi S,Chen X

    更新日期：2020-12-10 00:00:00

  • ERα Mediates Estrogen-Induced Expression of the Breast Cancer Metastasis Suppressor Gene BRMS1.

    abstract：:Recently, estrogen has been reported as putatively inhibiting cancer cell invasion and motility. This information is in direct contrast to the paradigm of estrogen as a tumor promoter. However, data suggests that the effects of estrogen are modulated by the receptor isoform with which it interacts. In order to gain a ...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms17020158

    authors： Ma H,Gollahon LS

    更新日期：2016-01-26 00:00:00

  • LARP6 Meets Collagen mRNA: Specific Regulation of Type I Collagen Expression.

    abstract：:Type I collagen is the most abundant structural protein in all vertebrates, but its constitutive rate of synthesis is low due to long half-life of the protein (60-70 days). However, several hundred fold increased production of type I collagen is often seen in reparative or reactive fibrosis. The mechanism which is res...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms17030419

    authors： Zhang Y,Stefanovic B

    更新日期：2016-03-22 00:00:00

  • Exosomal Expression of CXCR4 Targets Cardioprotective Vesicles to Myocardial Infarction and Improves Outcome after Systemic Administration.

    abstract：:Cell therapy has been evaluated to enhance heart function after injury. Delivered cells mostly act via paracrine mechanisms, including secreted growth factors, cytokines, and vesicles, such as exosomes (Exo). Intramyocardial injection of cardiac-resident progenitor cells (CPC)-derived Exo reduced scarring and improved...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms20030468

    authors： Ciullo A,Biemmi V,Milano G,Bolis S,Cervio E,Fertig ET,Gherghiceanu M,Moccetti T,Camici GG,Vassalli G,Barile L

    更新日期：2019-01-22 00:00:00

  • Supraspliceosomes at defined functional states portray the pre-assembled nature of the pre-mRNA processing machine in the cell nucleus.

    abstract：:When isolated from mammalian cell nuclei, all nuclear pre-mRNAs are packaged in multi-subunit large ribonucleoprotein complexes-supraspliceosomes-composed of four native spliceosomes interconnected by the pre-mRNA. Supraspliceosomes contain all five spliceosomal U snRNPs, together with other splicing factors, and are ...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms150711637

    authors： Kotzer-Nevo H,de Lima Alves F,Rappsilber J,Sperling J,Sperling R

    更新日期：2014-06-30 00:00:00

  • Impact of Pituitary Autoimmunity and Genetic Disorders on Growth Hormone Deficiency in Children and Adults.

    abstract：:Growth hormone (GH), mostly through its peripheral mediator, the insulin-like growth factor 1(IGF1), in addition to carrying out its fundamental action to promote linear bone growth, plays an important role throughout life in the regulation of intermediate metabolism, trophism and function of various organs, especiall...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms21041392

    authors： Bellastella G,Maiorino MI,Longo M,Cirillo P,Scappaticcio L,Vietri MT,Bellastella A,Esposito K,De Bellis A

    更新日期：2020-02-19 00:00:00

  • Early Detection of Pancreatic Intraepithelial Neoplasias (PanINs) in Transgenic Mouse Model by Hyperpolarized 13C Metabolic Magnetic Resonance Spectroscopy.

    abstract：:While pancreatic cancer (PC) survival rates have recently shown modest improvement, the disease remains largely incurable. Early detection of pancreatic cancer may result in improved outcomes and therefore, methods for early detection of cancer, even premalignant lesions, may provide more favorable outcomes. Pancreati...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21103722

    authors： Dutta P,Pando SC,Mascaro M,Riquelme E,Zoltan M,Zacharias NM,Gammon ST,Piwnica-Worms D,Pagel MD,Sen S,Maitra A,Shams S,McAllister F,Bhattacharya PK

    更新日期：2020-05-25 00:00:00

  • Cytomegalovirus (CMV) Pneumonitis: Cell Tropism, Inflammation, and Immunity.

    abstract：:Human cytomegalovirus (HCMV) is an opportunistic pathogen causing disease mainly in immunocompromised patients or after congenital infection. HCMV infection of the respiratory tract leads to pneumonitis in the immunocompromised host, which is often associated with a bad clinical course. The related mouse cytomegalovir...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms20163865

    authors： Fonseca Brito L,Brune W,Stahl FR

    更新日期：2019-08-08 00:00:00

  • Implications of a Soy-Based Diet for Animal Models.

    abstract：:The use of animal models in fundamental or pre-clinical research remains an absolute requirement for understanding human pathologies and developing new drugs. In order to transpose these results into clinical practice, many parameters must be taken into account to limit bias. Attention has recently been focused on the...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms22020774

    authors： Dhot J,Prat V,Ferron M,Aillerie V,Erraud A,Rozec B,Waard M,Gauthier C,Lauzier B

    更新日期：2021-01-14 00:00:00

  • The Non-Coding RNA GAS5 and Its Role in Tumor Therapy-Induced Resistance.

    abstract：:The growth arrest-specific transcript 5 (GAS5) is a >200-nt lncRNA molecule that regulates several cellular functions, including proliferation, apoptosis, invasion and metastasis, across different types of human cancers. Here, we reviewed the current literature on the expression of GAS5 in leukemia, cervical, breast, ...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms21207633

    authors： Lambrou GI,Hatziagapiou K,Zaravinos A

    更新日期：2020-10-15 00:00:00

  • Expression of Salivary and Serum Malondialdehyde and Lipid Profile of Patients with Periodontitis and Coronary Heart Disease.

    abstract：:Malondialdehyde (MAA) within a lipid pathway has been demonstrated to possess an important role in endothelial function that undergoes periodontitis and coronary heart disease (CHD) development. This study evaluated the impact of periodontitis, CHD, or a combination of both diseases (periodontitis + CHD) on salivary a...

    journal_title：International journal of molecular sciences

    pub_type： 临床试验,杂志文章

    doi：10.3390/ijms20236061

    authors： Isola G,Polizzi A,Santonocito S,Alibrandi A,Ferlito S

    更新日期：2019-12-01 00:00:00

  • Functionalized Polymeric Materials with Bio-Derived Antimicrobial Peptides for "Active" Packaging.

    abstract：:Food packaging is not only a simple protective barrier, but a real "active" component, which is expected to preserve food quality, safety and shelf-life. Therefore, the materials used for packaging production should show peculiar features and properties. Specifically, antimicrobial packaging has recently gained great ...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms20030601

    authors： Agrillo B,Balestrieri M,Gogliettino M,Palmieri G,Moretta R,Proroga YTR,Rea I,Cornacchia A,Capuano F,Smaldone G,De Stefano L

    更新日期：2019-01-30 00:00:00

  • Function and Clinical Implications of Long Non-Coding RNAs in Melanoma.

    abstract：:Metastatic melanoma is the most deadly type of skin cancer. Despite the success of immunotherapy and targeted agents, the majority of patients experience disease recurrence upon treatment and die due to their disease. Long non-coding RNAs (lncRNAs) are a new subclass of non-protein coding RNAs involved in (epigenetic)...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms18040715

    authors： Richtig G,Ehall B,Richtig E,Aigelsreiter A,Gutschner T,Pichler M

    更新日期：2017-03-28 00:00:00

  • Systemically Administered, Target Organ-Specific Therapies for Regenerative Medicine.

    abstract：:Growth factors and other agents that could potentially enhance tissue regeneration have been identified, but their therapeutic value in clinical medicine has been limited for reasons such as difficulty to maintain bioactivity of locally applied therapeutics in the protease-rich environment of regenerating tissues. Alt...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms161023556

    authors： Järvinen TA,May U,Prince S

    更新日期：2015-09-30 00:00:00

  • Transport of glial cell line-derived neurotrophic factor into liposomes across the blood-brain barrier: in vitro and in vivo studies.

    abstract：:Glial cell line-derived neurotrophic factor (GDNF) was encapsulated into liposomes in order to protect it from enzyme degradation in vivo and promote its permeability across the blood-brain barrier (BBB). In this study, GDNF conventional liposomes (GDNF-L) and GDNF target sterically stabilized liposomes (GDNF-SSL-T) w...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms15033612

    authors： Wu S,Li G,Li X,Lin C,Yu D,Luan S,Ma C

    更新日期：2014-02-27 00:00:00

  • OsMKK3, a Stress-Responsive Protein Kinase, Positively Regulates Rice Resistance to Nilaparvata lugens via Phytohormone Dynamics.

    abstract：:Plants undergo several but very precise molecular, physiological, and biochemical modulations in response to biotic stresses. Mitogen-activated protein kinase (MAPK) cascades orchestrate multiple cellular processes including plant growth and development as well as plant responses against abiotic and biotic stresses. H...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms20123023

    authors： Zhou S,Chen M,Zhang Y,Gao Q,Noman A,Wang Q,Li H,Chen L,Zhou P,Lu J,Lou Y

    更新日期：2019-06-20 00:00:00

  • Integrins and Cell Metabolism: An Intimate Relationship Impacting Cancer.

    abstract：:Integrins are important regulators of cell survival, proliferation, adhesion and migration. Once activated, integrins establish a regulated link between the extracellular matrix and the cytoskeleton. Integrins have well-established functions in cancer, such as in controlling cell survival by engagement of many specifi...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms18010189

    authors： Ata R,Antonescu CN

    更新日期：2017-01-18 00:00:00

  • Inhibition of Calcium/Calmodulin-Dependent Protein Kinase Kinase β Is Detrimental in Hypoxia⁻Ischemia Neonatal Brain Injury.

    abstract：:Neonatal hypoxia-ischemia (HI) is a major cause of death and disability in neonates. HI leads to a dramatic rise in intracellular calcium levels, which was originally thought to be detrimental to the brain. However, it has been increasingly recognized that this calcium signaling may also play an important protective r...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms20092063

    authors： Min JW,Bu F,Qi L,Munshi Y,Kim GS,Marrelli SP,McCullough LD,Li J

    更新日期：2019-04-26 00:00:00

  • Orofacial Manifestations and Temporomandibular Disorders of Systemic Scleroderma: An Observational Study.

    abstract：:Scleroderma is a disorder involving oral and facial tissues, with skin hardening, thin lips, deep wrinkles, xerostomia, tongue rigidity, and microstomia. The aim of this study was to investigate the prevalence of oral manifestations and temporomandibular disorders (TMD) in Systemic Sclerosis (SSc) patients compared wi...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,随机对照试验

    doi：10.3390/ijms17071189

    authors： Crincoli V,Fatone L,Fanelli M,Rotolo RP,Chialà A,Favia G,Lapadula G

    更新日期：2016-07-22 00:00:00

  • Dual Effect of Soloxolone Methyl on LPS-Induced Inflammation In Vitro and In Vivo.

    abstract：:Plant-extracted triterpenoids belong to a class of bioactive compounds with pleotropic functions, including antioxidant, anti-cancer, and anti-inflammatory effects. In this work, we investigated the anti-inflammatory and anti-oxidative activities of a semisynthetic derivative of 18βH-glycyrrhetinic acid (18βH-GA), sol...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21217876

    authors： Markov AV,Sen'kova AV,Babich VO,Odarenko KV,Talyshev VA,Salomatina OV,Salakhutdinov NF,Zenkova MA,Logashenko EB

    更新日期：2020-10-23 00:00:00

  • Endothelial nitric oxide synthase (eNOS) 4b/a gene polymorphisms and coronary artery disease: evidence from a meta-analysis.

    abstract：:A variety of studies have suggested that the 4b/a polymorphism in the endothelial nitric oxide synthase (eNOS) was associated with coronary artery disease (CAD) risk. However, the data remain conflicting. The aim of the present meta-analysis was to estimate the overall association between risk of CAD and eNOS 4b/a pol...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,meta分析

    doi：10.3390/ijms15057987

    authors： Yang Y,Du K,Liu Z,Lu X

    更新日期：2014-05-07 00:00:00

  • The Autophagy Status of Cancer Stem Cells in Gliobastoma Multiforme: From Cancer Promotion to Therapeutic Strategies.

    abstract：:Glioblastoma multiforme (GBM) is the most common and aggressive primary brain tumor featuring rapid cell proliferation, treatment resistance, and tumor relapse. This is largely due to the coexistence of heterogeneous tumor cell populations with different grades of differentiation, and in particular, to a small subset ...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms20153824

    authors： Ryskalin L,Gaglione A,Limanaqi F,Biagioni F,Familiari P,Frati A,Esposito V,Fornai F

    更新日期：2019-08-05 00:00:00

  • Applications and mechanisms of ionic liquids in whole-cell biotransformation.

    abstract：:Ionic liquids (ILs), entirely composed of cations and anions, are liquid solvents at room temperature. They are interesting due to their low vapor pressure, high polarity and thermostability, and also for the possibility to fine-tune their physicochemical properties through modification of the chemical structures of t...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms150712196

    authors： Fan LL,Li HJ,Chen QH

    更新日期：2014-07-09 00:00:00