Abstract：
:The growth arrest-specific transcript 5 (GAS5) is a >200-nt lncRNA molecule that regulates several cellular functions, including proliferation, apoptosis, invasion and metastasis, across different types of human cancers. Here, we reviewed the current literature on the expression of GAS5 in leukemia, cervical, breast, ovarian, prostate, urinary bladder, lung, gastric, colorectal, liver, osteosarcoma and brain cancers, as well as its interaction with various miRNAs and its effect on therapy-related resistance in these malignancies. The general consensus is that GAS5 acts as a tumor suppressor across different tumor types and that its up-regulation results in tumor sensitization to chemotherapy or radiotherapy. GAS5 seems to play a previously unappreciated, but significant role in tumor therapy-induced resistance.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Lambrou GI,Hatziagapiou K,Zaravinos Adoi
10.3390/ijms21207633subject
Has Abstractpub_date
2020-10-15 00:00:00issue
20issn
1422-0067pii
ijms21207633journal_volume
21pub_type
杂志文章,评审abstract：:As one of the major abiotic stresses, salinity stress may affect the physiology and biochemical components of Apocynum venetum L. To systematically evaluate the quality of Apocyni Veneti Folium (AVF) from the perspective of physiological and the wide variety of bioactive components response to various concentrations o...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19103042
更新日期：2018-10-05 00:00:00
abstract：:Akt acts as a pivotal regulator in the PI3K/Akt signaling pathway and represents a potential drug target for cancer therapy. To search for new inhibitors of Akt kinase, we performed a structure-based virtual screening using the DOCK 4.0 program and the X-ray crystal structure of human Akt kinase. From the virtual scre...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms16023202
更新日期：2015-02-02 00:00:00
abstract：:MET-amplified gastric cancer cells are extremely sensitive to MET inhibition in vitro, whereas clinical efficacy of MET inhibitors is disappointing. The compensatory activation of other oncogenic growth factor receptors may serve as an underlying mechanism of resistance. In this study, we analyzed the role of HER rece...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms22010082
更新日期：2020-12-23 00:00:00
abstract：:Dietary NaCl depletion increases Na+ and Cl- absorption in the colon, but the mechanisms are not fully understood. So far, we reported that the expression of claudin-7 (CLDN7), a tight junction (TJ) protein, was upregulated in the mice fed with NaCl-depleted diets, but the regulatory mechanism has not been clarified. ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21041442
更新日期：2020-02-20 00:00:00
abstract：:Metformin is a biguanide drug that has been used to treat type 2 diabetes mellitus for more than 60 years. The United Kingdom Prospective Diabetic Study (UKPDS) has shown metformin to improve mortality rates in diabetes patients, and recent studies suggest metformin has additional effects in treating cancer, obesity, ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms19102863
更新日期：2018-09-21 00:00:00
abstract：:Circular dichroism (CD) is a useful technique for monitoring changes in the conformation of antimicrobial peptides or gelatin. In this study, interactions between cationic peptides and gelatin were observed without affecting the triple helical content of the gelatin, which was more strongly affected by anionic surfact...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms13033229
更新日期：2012-01-01 00:00:00
abstract：:The endocannabinoid system is a component of the neuroprotective mechanisms that an organism displays after traumatic brain injury (TBI). A diurnal variation in several components of this system has been reported. This variation may influence the recovery and survival rate after TBI. We have previously reported that t...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms141223341
更新日期：2013-11-27 00:00:00
abstract：:Amaranthus spinosus Linn. (Family: Amaranthaceae) has been shown to be useful in preventing and mitigating adverse pathophysiological conditions and complex diseases. However, only limited information is available on the anticancer potential of this plant. In this study, we examined the antiproliferative and pro-apopt...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms17101604
更新日期：2016-09-22 00:00:00
abstract：:The objective of this study was to investigate the underlying mechanisms behind the radiation-sensitising effects of the antennapedia proteins (ANTP)-smacN7 fusion protein on tumour cells. ANTP-SmacN7 fusion proteins were synthesised, and the ability of this fusion protein to penetrate cells was observed. Effects of r...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms141224087
更新日期：2013-12-11 00:00:00
abstract：:The role of kisspeptin in stimulating hypothalamic GnRH is undisputed. However, the role of kisspeptin signaling in testicular function is less clear. The testes are essential for male reproduction through their functions of spermatogenesis and steroidogenesis. Our review focused on the current literature investigatin...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21082958
更新日期：2020-04-22 00:00:00
abstract：:(1) Background: TP53 deficiency remains a major adverse event in Multiple Myeloma (MM) despite therapeutic progresses. As it is not possible to target TP53 deficiency with pharmacological agents, we explored the possibility of activating another p53 family member, p73, which has not been well studied in myeloma. (2) M...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19010040
更新日期：2017-12-23 00:00:00
abstract：:Gelam honey exerts anti-inflammatory and antioxidant activities and is thought to have potent effects in reducing infections and healing wounds. The aim of this study was to investigate the effects of intravenously-injected Gelam honey in protecting organs from lethal doses of lipopolysaccharide (LPS). Six groups of r...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms13056370
更新日期：2012-01-01 00:00:00
abstract：:Stem cell-derived hepatocytes represent promising models to study human liver biology and disease. This concise review discusses the recent progresses in the field, with a focus on human liver disease, drug metabolism and virus infection. ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms141122011
更新日期：2013-11-06 00:00:00
abstract：:This narrative review aims to summarize the current controversy on the balance between ethanol and phytochemicals in wine, focusing on light drinking and oral cancer. Extensive literature search included PUBMED and EMBASE databases to identify in human studies and systematic reviews (up to March 2015), which contribut...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms160817029
更新日期：2015-07-27 00:00:00
abstract：:For bone regeneration, a biocompatible thermo-gelling hydrogel, hyaluronic acid-g-chitosan-g-poly(N-isopropylacrylamide) (HA-CPN) was used as a three-dimensional organic gel matrix for entrapping rabbit adipose-derived stem cells (rASCs). Biphasic calcium phosphate (BCP) ceramic microparticles were embedded within the...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19092537
更新日期：2018-08-27 00:00:00
abstract：:The interactions of plants with environment and insects are bi-directional and dynamic. Consequently, a myriad of mechanisms has evolved to engage organisms in different types of interactions. These interactions can be mediated by allelochemicals known as volatile organic compounds (VOCs) which include volatile terpen...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21197382
更新日期：2020-10-06 00:00:00
abstract：:MicroRNAs (miRNAs) are important post-transcriptional regulators during adipocyte adipogenesis. MiR-206-3p, a tissue-specific miRNA, is absent in white adipocytes. In this study, we examined the roles of mmu-miR-206-3p in the adipogenic differentiation of 3T3-L1 preadipocytes. The miR-206-3p expression has shown an ap...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms18071510
更新日期：2017-07-14 00:00:00
abstract：:Activated hepatic stellate cells (aHSCs) play a key role in liver fibrosis. During the regression of fibrosis, aHSCs are transformed into inactivated cells (iHSCs), which are quiescent lipid-containing cells and express higher levels of lipid-related genes, such as peroxisome proliferators-activated receptors gamma (P...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20040796
更新日期：2019-02-13 00:00:00
abstract：:Rhodobactersphaeroides has two chemotaxis clusters, an Escherichia coli-like cluster with membrane-spanning chemoreceptors and a less-understood cytoplasmic cluster. The cytoplasmic CheA is split into CheA4, a kinase, and CheA3, a His-domain phosphorylated by CheA4 and a phosphatase domain, which together phosphorylat...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20205095
更新日期：2019-10-14 00:00:00
abstract：:Advanced preservation injury (PI) after intestinal transplantation has deleterious short- and long-term effects and constitutes a major research topic. Logistics and costs favor rodent studies, whereas clinical translation mandates studies in larger animals or using human material. Despite diverging reports, no direct...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20133135
更新日期：2019-06-27 00:00:00
abstract：:O-mannosylation is implicated in protein quality control in Saccharomyces cerevisiae due to the attachment of mannose to serine and threonine residues of un- or misfolded proteins in the endoplasmic reticulum (ER). This process also designated as unfolded protein O-mannosylation (UPOM) that ends futile folding cycles ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20246220
更新日期：2019-12-10 00:00:00
abstract：:High-density genetic linkage maps of crop species are particularly useful in detecting qualitative and quantitative trait loci for important agronomic traits and in improving the power of classical approaches to identify candidate genes. The aim of this study was to develop a high-density genetic linkage map in a duru...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms18061329
更新日期：2017-06-21 00:00:00
abstract：:The role of E-cadherin in Hereditary Diffuse Gastric Cancer (HDGC) is unequivocal. Germline alterations in its encoding gene (CDH1) are causative of HDGC and occur in about 40% of patients. Importantly, while in most cases CDH1 alterations result in the complete loss of E-cadherin associated with a well-established cl...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms18122687
更新日期：2017-12-12 00:00:00
abstract：:Some studies have ascribed a protective effect against neurodegenerative diseases to the β-carbolines harman (H) and norharman (NH), which occur mostly in coffee and coffee substitutes. We determined the concentrations of β-carbolines and undesirable compounds (such as acrylamide) in roasted coffee substitute ingredie...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21155245
更新日期：2020-07-24 00:00:00
abstract：:The emergence of multidrug-resistant bacteria is a major global health concern. The search for new therapies has brought bacteriophages into the spotlight, and new phages are being described as possible therapeutic agents. Among the bacteria that are most extensively resistant to current antibiotics is Klebsiella pneu...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21093160
更新日期：2020-04-30 00:00:00
abstract：:Background: Gastric glands grow and cells reach differentiation at weaning in rats. By considering that early weaning (EW) can affect the timing of development, we aimed to compare molecular and cellular markers of differentiation in pups and adults. Methods: Wistar rats were separated into suckling-control (S) and EW...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21010196
更新日期：2019-12-27 00:00:00
abstract：:Cisplatin is the first-line treatment for different types of solid tumors, such as ovarian, testicular, bladder, cervical, head and neck, lung, and esophageal cancers. The main problem related to its clinical use is the onset of drug resistance. In the last decades, among the studied molecular mechanisms of cisplatin ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21030937
更新日期：2020-01-31 00:00:00
abstract：:Sex reversal has been used as a breeding strategy by salmonid fish to produce genetically and phenotypically single sex populations. Production of all-female fish has great importance for the creation of monosex female triploids of salmonid fish, which are valued for their sterility, lack of female maturation, and lar...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms22020964
更新日期：2021-01-19 00:00:00
abstract：:Overabundance of extracellular matrix resulting from hyperproliferation of keloid fibroblasts (KFs) and dysregulation of apoptosis represents the main pathophysiology underlying keloids. High-mobility group box 1 (HMGB1) plays important roles in the regulation of cellular death. Suppression of HMGB1 inhibits autophagy...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20174134
更新日期：2019-08-24 00:00:00
abstract：:The muscle excess 3 (MEX-3) protein was first identified in Caenorhabditis elegans (C. elegans), and its respective homologues were also observed in vertebrates, including humans. It is a RNA-binding protein (RBP) with an additional ubiquitin E3 ligase function, which further acts as a post-transcriptional repressor t...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21155209
更新日期：2020-07-23 00:00:00
