The Role of the RNA-Binding Protein Family MEX-3 in Tumorigenesis.

Abstract:

:The muscle excess 3 (MEX-3) protein was first identified in Caenorhabditis elegans (C. elegans), and its respective homologues were also observed in vertebrates, including humans. It is a RNA-binding protein (RBP) with an additional ubiquitin E3 ligase function, which further acts as a post-transcriptional repressor through unknown mechanisms. In humans, MEX-3 proteins post-transcriptionally regulate a number of biological processes, including tumor immunological relevant ones. These have been shown to be involved in various diseases, including tumor diseases of distinct origins. This review provides information on the expression and function of the human MEX-3 family in healthy tissues, as well after malignant transformation. Indeed, the MEX-3 expression was shown to be deregulated in several cancers and to affect tumor biological functions, including apoptosis regulation, antigen processing, and presentation, thereby, contributing to the immune evasion of tumor cells. Furthermore, current research suggests MEX-3 proteins as putative markers for prognosis and as novel targets for the anti-cancer treatment.

journal_name

Int J Mol Sci

authors

Jasinski-Bergner S,Steven A,Seliger B

doi

10.3390/ijms21155209

subject

Has Abstract

pub_date

2020-07-23 00:00:00

issue

15

issn

1422-0067

pii

ijms21155209

journal_volume

21

pub_type

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