Abstract:
:The muscle excess 3 (MEX-3) protein was first identified in Caenorhabditis elegans (C. elegans), and its respective homologues were also observed in vertebrates, including humans. It is a RNA-binding protein (RBP) with an additional ubiquitin E3 ligase function, which further acts as a post-transcriptional repressor through unknown mechanisms. In humans, MEX-3 proteins post-transcriptionally regulate a number of biological processes, including tumor immunological relevant ones. These have been shown to be involved in various diseases, including tumor diseases of distinct origins. This review provides information on the expression and function of the human MEX-3 family in healthy tissues, as well after malignant transformation. Indeed, the MEX-3 expression was shown to be deregulated in several cancers and to affect tumor biological functions, including apoptosis regulation, antigen processing, and presentation, thereby, contributing to the immune evasion of tumor cells. Furthermore, current research suggests MEX-3 proteins as putative markers for prognosis and as novel targets for the anti-cancer treatment.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Jasinski-Bergner S,Steven A,Seliger Bdoi
10.3390/ijms21155209subject
Has Abstractpub_date
2020-07-23 00:00:00issue
15issn
1422-0067pii
ijms21155209journal_volume
21pub_type
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journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
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