当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES期刊下所有文献 > MicroRNA29a Reverts the Activated Hepatic Stellate Cells in the Regression of Hepatic Fibrosis through Regulation of ATPase H⁺ Transporting V1 Subunit C1.

MicroRNA29a Reverts the Activated Hepatic Stellate Cells in the Regression of Hepatic Fibrosis through Regulation of ATPase H⁺ Transporting V1 Subunit C1.

Abstract：

:Activated hepatic stellate cells (aHSCs) play a key role in liver fibrosis. During the regression of fibrosis, aHSCs are transformed into inactivated cells (iHSCs), which are quiescent lipid-containing cells and express higher levels of lipid-related genes, such as peroxisome proliferators-activated receptors gamma (PPARγ). Here, we investigated the role of MicroRNA29a (Mir29a) in the resolution of liver fibrosis. Mir29a and lipid-related genes were up-regulated after the recovery of CCl₄-induced liver fibrosis in mice. PPARγ agonist rosiglitazone (RSG) promoted de-differentiation of aHSCs to iHSCs and up-regulated MIR29a expression in a human HSC cell line LX-2. MIR29a mimics in vitro promoted the expression of lipid-related genes, while decreased the expression of fibrosis-related genes. MIR29a inhibitor showed the reverse effects. ATPase H⁺ transporting V1 subunit C1 (Atp6v1c1) was increased in liver fibrosis, while down-regulated after the recovery in mice, and negatively regulated by MIR29a in LX-2 cells. Knockdown of ATP6V1C1 by siRNA decreased alpha-smooth muscle actin (α-SMA) and increased lipid-related genes expression. Simultaneous addition of MIR29a mimics and ATP6V1C1 siRNA further increased RSG promoted expression of lipid-related proteins in vitro. Collectively, MIR29a plays an important role during the trans-differentiation of aHSCs in the resolution of liver fibrosis, in part, through regulation of ATP6V1C1.

journal_name

Int J Mol Sci

journal_title

International journal of molecular sciences

authors

Jing F,Geng Y,Xu XY,Xu HY,Shi JS,Xu ZH

doi

10.3390/ijms20040796

subject

Has Abstract

pub_date

2019-02-13 00:00:00

issue

4

issn

1422-0067

pii

ijms20040796

journal_volume

20

pub_type

杂志文章

相关文献

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES文献大全
  • Biological Activities of Extracts from Loquat (Eriobotrya japonica Lindl.): A Review.

    abstract：:Loquat (Eriobotrya japonica Lindl.) is a subtropical fruit tree with high medicinal value native to China. Different organs of loquat have been used historically as folk medicines and this has been recorded in Chinese history for thousands of years. Research shows that loquat extracts contain many antioxidants, and di...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms17121983

    authors： Liu Y,Zhang W,Xu C,Li X

    更新日期：2016-12-06 00:00:00

  • LGM2605 Reduces Space Radiation-Induced NLRP3 Inflammasome Activation and Damage in In Vitro Lung Vascular Networks.

    abstract：:Updated measurements of charged particle fluxes during the transit from Earth to Mars as well as on site measurements by Curiosity of Martian surface radiation fluxes identified potential health hazards associated with radiation exposure for human space missions. Designing mitigation strategies of radiation risks to a...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms20010176

    authors： Chatterjee S,Pietrofesa RA,Park K,Tao JQ,Carabe-Fernandez A,Berman AT,Koumenis C,Sielecki T,Christofidou-Solomidou M

    更新日期：2019-01-05 00:00:00

  • New Innovations in Wound Healing and Repair.

    abstract：:Wounds are a largely unrecognized, spiraling epidemic that affect millions of people world-wide [...]. ...

    journal_title：International journal of molecular sciences

    pub_type： 社论

    doi：10.3390/ijms20071724

    authors： Cowin AJ

    更新日期：2019-04-08 00:00:00

  • Splice Variants of the RTK Family: Their Role in Tumour Progression and Response to Targeted Therapy.

    abstract：:Receptor tyrosine kinases (RTKs) belong to a family of transmembrane receptors that display tyrosine kinase activity and trigger the activation of downstream signalling pathways mainly involved in cell proliferation and survival. RTK amplification or somatic mutations leading to their constitutive activation and oncog...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms18020383

    authors： Abou-Fayçal C,Hatat AS,Gazzeri S,Eymin B

    更新日期：2017-02-11 00:00:00

  • Biochemical and Behavioral Consequences of Ethanol Intake in a Mouse Model of Metabolic Syndrome.

    abstract：:Ethanol abuse is a common issue in individuals with sedentary lifestyles, unbalanced diets, and metabolic syndrome. Both ethanol abuse and metabolic syndrome have negative impacts on the central nervous system, with effects including cognitive impairment and brain oxidative status deterioration. The combined effects o...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms22020807

    authors： Baliño P,Romero-Cano R,Muriach M

    更新日期：2021-01-15 00:00:00

  • Impact of Methods on the Measurement of mRNA Turnover.

    abstract：:The turnover of the RNA molecules is determined by the rates of transcription and RNA degradation. Several methods have been developed to study RNA turnover since the beginnings of molecular biology. Here we summarize the main methods to measure RNA half-life: transcription inhibition, gene control, and metabolic labe...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms18122723

    authors： Wada T,Becskei A

    更新日期：2017-12-15 00:00:00

  • Molecular cloning and expression analysis of P-selectin from Zebrafish (Danio rerio).

    abstract：:The glycoprotein P-selectin belongs to the selectin family of cell adhesion molecules. In this study, we cloned the full-length cDNA of P-selectin from zebrafish (Danio rerio) by the method of rapid amplification of cDNA ends polymerase chain reaction (RACE-PCR). Zebrafish P-selectin cDNA is 2,800 bp and encodes a put...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms11114618

    authors： Sun G,Pan J,Liu K,Wang X,Wang S

    更新日期：2010-11-17 00:00:00

  • Thermococcus Eurythermalis Endonuclease IV Can Cleave Various Apurinic/Apyrimidinic Site Analogues in ssDNA and dsDNA.

    abstract：:Endonuclease IV (EndoIV) is a DNA damage-specific endonuclease that mainly hydrolyzes the phosphodiester bond located at 5' of an apurinic/apyrimidinic (AP) site in DNA. EndoIV also possesses 3'-exonuclease activity for removing 3'-blocking groups and normal nucleotides. Here, we report that Thermococcus eurythermalis...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms20010069

    authors： Wang WW,Zhou H,Xie JJ,Yi GS,He JH,Wang FP,Xiao X,Liu XP

    更新日期：2018-12-24 00:00:00

  • A Molecular Dynamics Study of Vasoactive Intestinal Peptide Receptor 1 and the Basis of Its Therapeutic Antagonism.

    abstract：:Vasoactive intestinal peptide receptor 1 (VPAC1) is a member of a secretin-like subfamily of G protein-coupled receptors. Its endogenous neuropeptide (VIP), secreted by neurons and immune cells, modulates various physiological functions such as exocrine and endocrine secretions, immune response, smooth muscles relaxat...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms20184348

    authors： Latek D,Langer I,Krzysko K,Charzewski L

    更新日期：2019-09-05 00:00:00

  • The potential of liposomes with carbonic anhydrase IX to deliver anticancer ingredients to cancer cells in vivo.

    abstract：:Drug delivery nanocarriers, especially targeted drug delivery by liposomes are emerging as a class of therapeutics for cancer. Early research results suggest that liposomal therapeutics enhanced efficacy, while simultaneously reducing side effects, owing to properties such as more targeted localization in tumors and a...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms16010230

    authors： Ng HL,Lu A,Lin G,Qin L,Yang Z

    更新日期：2014-12-24 00:00:00

  • Dual Role of Bile Acids on the Biliary Epithelium: Friend or Foe?

    abstract：:Bile acids are a family of amphipathic compounds predominantly known for their role in solubilizing and absorbing hydrophobic compounds (including liposoluble vitamins) in the intestine. Bile acids also are key signaling molecules and inflammatory agents that activate transcriptional factors and cell signaling pathway...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms20081869

    authors： Baiocchi L,Zhou T,Liangpunsakul S,Lenci I,Santopaolo F,Meng F,Kennedy L,Glaser S,Francis H,Alpini G

    更新日期：2019-04-16 00:00:00

  • Endoglin Targeting: Lessons Learned and Questions That Remain.

    abstract：:Approximately 30 years ago, endoglin was identified as a transforming growth factor (TGF)-β coreceptor with a crucial role in developmental biology and tumor angiogenesis. Its selectively high expression on tumor vessels and its correlation with poor survival in cancer patients led to the exploration of endoglin as a ...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms22010147

    authors： Liu Y,Paauwe M,Nixon AB,Hawinkels LJAC

    更新日期：2020-12-25 00:00:00

  • Critical Overview of the Risk Scoring Systems to Predict Non-Responsiveness to Intravenous Immunoglobulin in Kawasaki Syndrome.

    abstract：:Kawasaki syndrome (KS) is the most relevant cause of heart disease in children living in developed countries. Intravenous immunoglobulin (IVIG) has a preventive function in the formation of coronary artery abnormalities and a poor strictly-curative action in established coronary damage. More than two decades ago, the ...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms17030278

    authors： Rigante D,Andreozzi L,Fastiggi M,Bracci B,Natale MF,Esposito S

    更新日期：2016-02-24 00:00:00

  • Carbapenems to Treat Multidrug and Extensively Drug-Resistant Tuberculosis: A Systematic Review.

    abstract：BACKGROUND:Carbapenems (ertapenem, imipenem, meropenem) are used to treat multidrug-resistant (MDR-) and extensively drug-resistant tuberculosis (XDR-TB), even if the published evidence is limited, particularly when it is otherwise difficult to identify the recommended four active drugs to be included in the regimen. N...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms17030373

    authors： Sotgiu G,D'Ambrosio L,Centis R,Tiberi S,Esposito S,Dore S,Spanevello A,Migliori GB

    更新日期：2016-03-12 00:00:00

  • Molecular diagnosis of analbuminemia: a new case caused by a nonsense mutation in the albumin gene.

    abstract：:Analbuminemia is a rare autosomal recessive disorder manifested by the absence, or severe reduction, of circulating serum albumin (ALB). We report here a new case diagnosed in a 45 years old man of Southwestern Asian origin, living in Switzerland, on the basis of his low ALB concentration (0.9 g/L) in the absence of r...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms12117314

    authors： Dagnino M,Caridi G,Haenni U,Duss A,Aregger F,Campagnoli M,Galliano M,Minchiotti L

    更新日期：2011-01-01 00:00:00

  • Recent Advances in Psoriasis Research; the Clue to Mysterious Relation to Gut Microbiome.

    abstract：:Psoriasis is a chronic inflammatory cutaneous disease, characterized by activated plasmacytoid dendritic cells, myeloid dendritic cells, Th17 cells, and hyperproliferating keratinocytes. Recent studies revealed skin-resident cells have pivotal roles in developing psoriatic skin lesions. The balance in effector T cells...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms21072582

    authors： Komine M

    更新日期：2020-04-08 00:00:00

  • Extracellular Vesicle Membrane-Associated Proteins: Emerging Roles in Tumor Angiogenesis and Anti-Angiogenesis Therapy Resistance.

    abstract：:The tumor vasculature is essential for tumor growth and metastasis, and is a prime target of several anti-cancer agents. Increasing evidence indicates that tumor angiogenesis is stimulated by extracellular vesicles (EVs) that are secreted or shed by cancer cells. These EVs encapsulate a variety of biomolecules with an...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms21155418

    authors： Ko SY,Naora H

    更新日期：2020-07-30 00:00:00

  • Gold Nanoparticles in Diagnostics and Therapeutics for Human Cancer.

    abstract：:The application of nanotechnology for the treatment of cancer is mostly based on early tumor detection and diagnosis by nanodevices capable of selective targeting and delivery of chemotherapeutic drugs to the specific tumor site. Due to the remarkable properties of gold nanoparticles, they have long been considered as...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms19071979

    authors： Singh P,Pandit S,Mokkapati VRSS,Garg A,Ravikumar V,Mijakovic I

    更新日期：2018-07-06 00:00:00

  • Newly Developed CK1-Specific Inhibitors Show Specifically Stronger Effects on CK1 Mutants and Colon Cancer Cell Lines.

    abstract：:Protein kinases of the CK1 family can be involved in numerous physiological and pathophysiological processes. Dysregulated expression and/or activity as well as mutation of CK1 isoforms have previously been linked to tumorigenesis. Among all neoplastic diseases, colon and rectal cancer (CRC) represent the fourth leadi...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms20246184

    authors： Liu C,Witt L,Ianes C,Bischof J,Bammert MT,Baier J,Kirschner S,Henne-Bruns D,Xu P,Kornmann M,Peifer C,Knippschild U

    更新日期：2019-12-07 00:00:00

  • Reproduction of Characteristics of Extracellular Matrices in Specific Longitudinal Depth Zone Cartilage within Spherical Organoids in Response to Changes in Osmotic Pressure.

    abstract：:Articular cartilage is compressed with joint-loading and weight-bearing stresses, followed by a bulging of the tissue during times of off-loading. This loading and off-loading causes changes in water content, and thus alterations in osmotic pressure. Another unique characteristic of articular cartilage is that it has ...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms19051507

    authors： Takada E,Mizuno S

    更新日期：2018-05-18 00:00:00

  • Ginsenoside Rb1 Blocks Ritonavir-Induced Oxidative Stress and eNOS Downregulation through Activation of Estrogen Receptor-Beta and Upregulation of SOD in Human Endothelial Cells.

    abstract：:We have previously shown that ritonavir (RTV), a highly active anti-retroviral therapy (HAART) drug, can cause endothelial dysfunction through oxidative stress. Several antioxidants including ginsenoside Rb1, a compound with antioxidant effect, can effectively block this side effect of RTV in endothelial cells. In the...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms20020294

    authors： Lü JM,Jiang J,Jamaluddin MS,Liang Z,Yao Q,Chen C

    更新日期：2019-01-12 00:00:00

  • Isoliquiritigenin Induces Autophagy and Inhibits Ovarian Cancer Cell Growth.

    abstract：:Ovarian cancer is one of the commonest gynecologic malignancies, which has a poor prognosis for patients at the advanced stage. Isoliquiritigenin (ISL), an active flavonoid component of the licorice plant, previously demonstrated antioxidant, anti-inflammatory, and tumor suppressive effects. In this study, we investig...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms18102025

    authors： Chen HY,Huang TC,Shieh TM,Wu CH,Lin LC,Hsia SM

    更新日期：2017-09-21 00:00:00

  • Microglial Pro-Inflammatory and Anti-Inflammatory Phenotypes Are Modulated by Translocator Protein Activation.

    abstract：:A key role of the mitochondrial Translocator Protein 18 KDa (TSPO) in neuroinflammation has been recently proposed. However, little is known about TSPO-activated pathways underlying the modulation of reactive microglia. In the present work, the TSPO activation was explored in an in vitro human primary microglia model ...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms20184467

    authors： Pozzo ED,Tremolanti C,Costa B,Giacomelli C,Milenkovic VM,Bader S,Wetzel CH,Rupprecht R,Taliani S,Settimo FD,Martini C

    更新日期：2019-09-10 00:00:00

  • Correlations of Ion Composition and Power Efficiency in a Reverse Electrodialysis Heat Engine.

    abstract：:The main objective of this study is to explore the influence of ion composition on the trans-membrane potential across the ion exchange membrane (IEM), and thus offers a reference for the deep insight of "reverse electrodialysis heat engine" running in the composite systems. In comparison to the natural system (river ...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms20235860

    authors： Luo F,Wang Y,Sha M,Wei Y

    更新日期：2019-11-22 00:00:00

  • Rethinking the Citric Acid Cycle: Connecting Pyruvate Carboxylase and Citrate Synthase to the Flow of Energy and Material.

    abstract：:In 1937, Sir H. A Krebs first published the Citric Acid Cycle, a unidirectional cycle with carboxylic acids. The original concept of the Citric Acid Cycle from Krebs' 1953 Nobel Prize lecture illustrates the unidirectional degradation of lactic acid to water, carbon dioxide and hydrogen. Here, we add the heart lactate...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms22020604

    authors： Roosterman D,Cottrell GS

    更新日期：2021-01-09 00:00:00

  • Preparation of lung-targeting, emodin-loaded polylactic acid microspheres and their properties.

    abstract：:Emodin (1,3,8-trihydroxy-6-methylanthraquinone) has been identified to have the potential to improve lung fibrosis and lung cancer. To avoid the liver and kidney toxicities and the fast metabolism of emodin, emodin-loaded polylactic acid microspheres (ED-PLA-MS) were prepared and their characteristics were studied. ED...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms15046241

    authors： Chen X,Yang Z,Sun R,Mo Z,Jin G,Wei F,Hu J,Guan W,Zhong N

    更新日期：2014-04-11 00:00:00

  • A Potent Antifungal Agent for Basal Stem Rot Disease Treatment in Oil Palms Based on Chitosan-Dazomet Nanoparticles.

    abstract：:The use of nanotechnology could play a significant role in the agriculture sector, especially in the preparation of new-generation agronanochemicals. Currently, the economically important plant of Malaysia, the oil palm, faces the threat of a devastating disease which is particularly caused by a pathogenic fungus, Gan...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms20092247

    authors： Maluin FN,Hussein MZ,Yusof NA,Fakurazi S,Idris AS,Hilmi NHZ,Jeffery Daim LD

    更新日期：2019-05-07 00:00:00

  • Preparation of Biodegradable and Elastic Poly(ε-caprolactone-co-lactide) Copolymers and Evaluation as a Localized and Sustained Drug Delivery Carrier.

    abstract：:To develop a biodegradable polymer possessing elasticity and flexibility, we synthesized MPEG-b-(PCL-co-PLA) copolymers (PC x L y A), which display specific rates of flexibility and elasticity. We synthesize the PC ...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms18030671

    authors： Park JH,Lee BK,Park SH,Kim MG,Lee JW,Lee HY,Lee HB,Kim JH,Kim MS

    更新日期：2017-03-21 00:00:00

  • In Vitro Feasibility Analysis of a New Sutureless Wound-Closure System Based on a Temperature-Regulated Laser and a Transparent Collagen Membrane for Laser Tissue Soldering (LTS).

    abstract：:For the post-surgical treatment of oral wounds and mucosal defects beyond a certain size, the gold standard is still an autologous skin or mucosal graft in combination with complex suturing techniques. A variety of techniques and biomaterials has been developed for sutureless wound closure including different tissue g...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21197104

    authors： Birkelbach MA,Smeets R,Fiedler I,Kluwe L,Wehner M,Trebst T,Hartjen P

    更新日期：2020-09-26 00:00:00

  • Transient Changes of Metabolism at the Pronuclear Stage in Mice Influences Skeletal Muscle Phenotype in Adulthood.

    abstract：:Skeletal muscle has a remarkable plasticity, and its phenotype is strongly influenced by hormones, transcription factors, and physical activity. However, whether skeletal phenotype can be oriented or not during early embryonic stages has never been investigated. Here, we report that pyruvate as the only source of carb...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21197203

    authors： Bertrand-Gaday C,Letheule M,Blanchet E,Vernus B,Pessemesse L,Bonnet-Garnier A,Bonnieu A,Casas F

    更新日期：2020-09-29 00:00:00