Abstract：
:To develop a biodegradable polymer possessing elasticity and flexibility, we synthesized MPEG-b-(PCL-co-PLA) copolymers (PC x L y A), which display specific rates of flexibility and elasticity. We synthesize the PC x L y A copolymers by ring-opening polymerization of ε-caprolactone and l-lactide. PC x L y A copolymers of various compositions were synthesized with 500,000 molecular weight. The PC x L y A copolymers mechanical properties were dependent on the mole ratio of the ε-caprolactone and l-lactide components. Cyclic tensile tests were carried out to investigate the resistance to creep of PC x L y A specimens after up to 20 deformation cycles to 50% elongation. After in vivo implantation, the PC x L y A implants exhibited biocompatibility, and gradually biodegraded over an eight-week experimental period. Immunohistochemical characterization showed that the PC x L y A implants provoked in vivo inflammation, which gradually decreased over time. The copolymer was used as a drug carrier for locally implantable drugs, the hydrophobic drug dexamethasone (Dex), and the water-soluble drug dexamethasone 21-phosphate disodium salt (Dex(p)). We monitored drug-loaded PC x L y A films for in vitro and in vivo drug release over 40 days and observed real-time sustained release of near-infrared (NIR) fluorescence over an extended period from hydrophobic IR-780- and hydrophilic IR-783-loaded PC x L y A implanted in live animals. Finally, we confirmed that PC x L y A films are usable as biodegradable, elastic drug carriers.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Park JH,Lee BK,Park SH,Kim MG,Lee JW,Lee HY,Lee HB,Kim JH,Kim MSdoi
10.3390/ijms18030671subject
Has Abstractpub_date
2017-03-21 00:00:00issue
3issn
1422-0067pii
ijms18030671journal_volume
18pub_type
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