Abstract:
:Updated measurements of charged particle fluxes during the transit from Earth to Mars as well as on site measurements by Curiosity of Martian surface radiation fluxes identified potential health hazards associated with radiation exposure for human space missions. Designing mitigation strategies of radiation risks to astronauts is critical. We investigated radiation-induced endothelial cell damage and its mitigation by LGM2605, a radioprotector with antioxidant and free radical scavenging properties. We used an in vitro model of lung vascular networks (flow-adapted endothelial cells; FAECs), exposed to gamma rays, low/higher linear energy transfer (LET) protons (3⁻4 or 8⁻10 keV/µm, respectively), and mixed field radiation sources (gamma and protons), given at mission-relevant doses (0.25 gray (Gy)⁻1 Gy). We evaluated endothelial inflammatory phenotype, NLRP3 inflammasome activation, and oxidative cell injury. LGM2605 (100 µM) was added 30 min post radiation exposure and gene expression changes evaluated 24 h later. Radiation induced a robust increase in mRNA levels of antioxidant enzymes post 0.25 Gy and 0.5 Gy gamma radiation, which was significantly decreased by LGM2605. Intercellular cell adhesion molecule-1 (ICAM-1) and NOD-like receptor protein 3 (NLRP3) induction by individual or mixed-field exposures were also significantly blunted by LGM2605. We conclude that LGM2605 is a likely candidate to reduce tissue damage from space-relevant radiation exposure.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Chatterjee S,Pietrofesa RA,Park K,Tao JQ,Carabe-Fernandez A,Berman AT,Koumenis C,Sielecki T,Christofidou-Solomidou Mdoi
10.3390/ijms20010176subject
Has Abstractpub_date
2019-01-05 00:00:00issue
1issn
1422-0067pii
ijms20010176journal_volume
20pub_type
杂志文章abstract::We previously discovered a novel sirtuin (SIRT) inhibitor, MHY2256, that exerts anticancer activity through p53 acetylation in MCF-7 human breast cancer cells. We investigated the anticancer activity of MHY2256 against hormone-related cancer, an endometrial cancer with a poor prognosis. The IC50 values of MHY2256 were...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms19092743
更新日期:2018-09-13 00:00:00
abstract::The insect midgut secretes a semi-permeable, acellular peritrophic membrane (PM) that maintains intestinal structure, promotes digestion, and protects the midgut from food particles and pathogenic microorganisms. Peritrophin is an important PM protein (PMP) in the PM. Here, we identified 11 peritrophins with 1-16 chit...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21217973
更新日期:2020-10-27 00:00:00
abstract::The current work reports the synthesis, spectroscopic studies, antiradical and antiproliferative properties of four ruthenium(III) complexes of heterocyclic tridentate Schiff base bearing a simple 2',4'-dihydroxyacetophenone functionality and ethylenediamine as the bridging ligand with RCHO moiety. The reaction of the...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms17010060
更新日期:2016-01-04 00:00:00
abstract::Biologically active chemical compounds may provide remedies for several diseases. Meanwhile, Machine Learning techniques applied to Drug Discovery, which are cheaper and faster than wet-lab experiments, have the capability to more effectively identify molecules with the expected pharmacological activity. Therefore, it...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20092175
更新日期:2019-05-02 00:00:00
abstract::Morquio B disease (MBD) is an autosomal recessive GLB1-gene-related lysosomal storage disease, presenting with a peculiar type of dysostosis multiplex which is also observed in GALNS-related Morquio A disease. MBD may present as pure skeletal phenotype (pure MBD) or in combination with the neuronopathic manifestations...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms21239121
更新日期:2020-11-30 00:00:00
abstract::Drought adversely affects crop production across the globe. The root system immensely contributes to water management and the adaptability of plants to drought stress. In this study, drought-induced phenotypic and transcriptomic responses of two contrasting chickpea (Cicer arietinum L.) genotypes were compared at the ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21051781
更新日期:2020-03-05 00:00:00
abstract::Lymphoma, a group of widely prevalent hematological malignancies of lymphocyte origin, has become the focus of significant clinical research due to their high propensity for refractory/relapsed (R/R) disease, leading to poor prognostic outcomes. The complex molecular circuitry in lymphomas, especially in the aggressiv...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms21030904
更新日期:2020-01-30 00:00:00
abstract::In order to use cyanobacteria for the biological production of hydrogen, it is important to thoroughly study the function and the regulation of the hydrogen-production machine in order to better understand its role in the global cell metabolism and identify bottlenecks limiting H2 production. Most of the recent advanc...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms151119938
更新日期:2014-10-31 00:00:00
abstract::Bombyx mori doublesex (Bmdsx) functions as a double-switch gene in the final step of the sex-determination cascade in the silkworm Bombyx mori. The P-element somatic inhibitor (PSI) protein in B. mori interacts with Bmdsx pre-mRNA in CE1 as an exonic splicing silencer to promote male-specific splicing of Bmdsx. Howeve...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20092361
更新日期:2019-05-13 00:00:00
abstract::Parkinson's disease (PD) is characterized by distinct motor and non-motor symptoms. Sleep disorders are the most frequent and challenging non-motor symptoms in PD patients, and there is growing evidence that they are a consequence of disruptions within the circadian system. PD is characterized by a progressive degener...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms19061651
更新日期:2018-06-03 00:00:00
abstract::Deregulation of the cholesterol pathway is an anomaly observed in human diseases, many of which have in common neurological involvement and unknown pathogenesis. In this study we have used Mevalonate Kinase Deficiency (MKD) as a disease-model in order to investigate the link between the deregulation of the mevalonate ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms17030365
更新日期:2016-03-11 00:00:00
abstract::The survival kinase protein kinase B (Akt) participates in the regulation of essential subcellular processes, e.g., proliferation, growth, survival, and apoptosis, and has a documented role in promoting resistance against genotoxic stress including radiotherapy, presumably by influencing the DNA damage response and DN...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms19082233
更新日期:2018-07-31 00:00:00
abstract::Development of stimuli-responsive supramolecular micelles that enable high levels of well-controlled drug release in cancer cells remains a grand challenge. Here, we encapsulated the antitumor drug doxorubicin (DOX) and pro-photosensitizer 5-aminolevulinic acid (5-ALA) within adenine-functionalized supramolecular mice...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms22010154
更新日期:2020-12-25 00:00:00
abstract::MCP-1-induced protein (MCPIP, also known as Zc3h12a or Regnase-1), a newly identified suppressor of cytokine signaling, is expressed in endothelial cells (ECs). To investigate the role of endothelial MCPIP in vascular homeostasis and function, we deleted the MCPIP gene specifically in ECs using the Cre-LoxP system. EC...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20010172
更新日期:2019-01-05 00:00:00
abstract::Transcription factors (TFs) play essential roles in the transcriptional regulation of functional genes, and are involved in diverse physiological processes in living organisms. The fruit fly Drosophila melanogaster, a simple and easily manipulated organismal model, has been extensively applied to study the biological ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms19113691
更新日期:2018-11-21 00:00:00
abstract::Poly-γ-glutamic acid (γ-PGA)-based nanoparticles draw remarkable attention as drug delivery agents due to their controlled release characteristics, low toxicity, and biocompatibility. 4HGF is an herbal mixture of Phellinus linteus grown on germinated brown rice, Cordyceps militaris grown on germinated soybeans, Polygo...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20143447
更新日期:2019-07-13 00:00:00
abstract::Genetic analysis of "InochinoIchi," an exceptionally large grain rice variety, was conducted through five continuous backcrosses with Koshihikari as a recurrent parent using the large grain F3 plant in Koshihikari × Inochinoichi as a nonrecurrent parent. Thorough the F2 and all BCnF2 generations, large, medium, and sm...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20215442
更新日期:2019-10-31 00:00:00
abstract::Autophagy is an important process by which pathogens and damaged or unused organelles are eliminated. The role of autophagy in development and the immune response to pathogens is well established. Autophagy-related protein 8 (Atg8) is involved in the formation of the autophagosome and, with the help of the serine prot...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21082944
更新日期:2020-04-22 00:00:00
abstract::Thlaspi arvense is a well-known annual farmland weed with worldwide distribution, which can be found from sea level to above 4000 m high on the Qinghai-Tibetan Plateau (QTP). In this paper, a phylogeographic history of T. arvense including 19 populations from China was inferred by using three chloroplast (cp) DNA segm...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms160613339
更新日期:2015-06-11 00:00:00
abstract::An imbalance of excitatory and inhibitory neurotransmission leading to over excitation plays a crucial role in generating seizures, while enhancing GABAergic mechanisms are critical in terminating seizures. In recent years, it has been reported in many studies that astrocytes are deeply involved in synaptic transmissi...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms20122964
更新日期:2019-06-18 00:00:00
abstract::The purpose of this study was to investigate the feasibility and advantages of constructing a novel tissue engineering bone, using β-tricalcium phosphate (β-TCP) and rat bone marrow mesenchymal stem cells (MSCs), modified with human bone morphogenetic protein 2 gene (hBMP2) and human vascular endothelial growth factor...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms12031744
更新日期:2011-01-01 00:00:00
abstract::Infectious diseases caused by parasites are a major threat for the entire mankind, especially in the tropics. More than 1 billion people world-wide are directly exposed to tropical parasites such as the causative agents of trypanosomiasis, leishmaniasis, schistosomiasis, lymphatic filariasis and onchocerciasis, which ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms14023395
更新日期:2013-02-06 00:00:00
abstract::Ischemia-reperfusion injury (IRI) is a major cause of graft loss and dysfunction in clinical transplantation and organ resection. [...]. ...
journal_title:International journal of molecular sciences
pub_type: 社论
doi:10.3390/ijms19124093
更新日期:2018-12-18 00:00:00
abstract::In our study, poly(dl-lactide-co-glycolide) (PLGA) nanoparticles loaded with perphenazine (PPH) and chlorpromazine hydrochloride (CPZ-HCl) were formulated by emulsion solvent evaporation technique. The effect of various processing variables, including PLGA concentration, theoretical drug loading, poly(vinyl alcohol) (...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms151223909
更新日期:2014-12-22 00:00:00
abstract::Extracellular vesicles (EVs) are a heterogeneous group of particles, between 15 nanometers and 10 microns in diameter, released by almost all cell types in physiological and pathological conditions, including tumors. EVs have recently emerged as particularly interesting informative vehicles, so that they could be cons...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms18061183
更新日期:2017-06-02 00:00:00
abstract::Long non-coding RNAs (lncRNAs) play crucial roles in diverse biological processes and human complex diseases. Distinguishing lncRNAs from protein-coding transcripts is a fundamental step for analyzing the lncRNA functional mechanism. However, the experimental identification of lncRNAs is expensive and time-consuming. ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21155222
更新日期:2020-07-23 00:00:00
abstract::Factor binding IST-1 (FBI-1) plays an important role in oncogenic transformation and tumorigenesis. As FBI-1 is over-expressed in multiple human cancers, the regulation of itself would provide new effective options for cancer intervention. In this work, we aimed to study the role that EPAS-1 plays in regulating FBI-1....
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms150915689
更新日期:2014-09-04 00:00:00
abstract::Cardiovascular disease is the leading cause of morbidity and mortality in the Western and developing world, and the incidence of cardiovascular disease is increasing with the longer lifespan afforded by our modern lifestyle. Vascular diseases including coronary heart disease, high blood pressure, and stroke comprise t...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms21124525
更新日期:2020-06-25 00:00:00
abstract::Humans are exposed to phthalates released from plastics, cosmetics, or food on a daily basis. Phthalates have low acute liver toxicity, but their chronic exposures could induce molecular and cellular effects linked to adverse health outcomes, such as liver tumor promotion or chronic liver diseases. The alternation of ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21176069
更新日期:2020-08-23 00:00:00
abstract::RNAi technology has significant potential as a future therapeutic and could theoretically be used to knock down disease-specific RNAs. However, due to frequent off-target effects, low efficiency, and limited accessibility of nuclear transcripts, the clinical application of the technology remains challenging. In this s...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21238904
更新日期:2020-11-24 00:00:00