EPAS-1 mediates SP-1-dependent FBI-1 expression and regulates tumor cell survival and proliferation.

abstract：:Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignancies, and thus better understanding of its molecular pathology is crucial for us to devise more effective treatment of this deadly disease. As cancer cell line remains a convenient starting point for discovery and proof-of-concept studies, here ...

journal_title：International journal of molecular sciences

authors： Shen Y,Pu K,Zheng K,Ma X,Qin J,Jiang L,Li J

更新日期：2019-09-10 00:00:00

abstract：:The phenol-degrading efficiency of Pseudochrobactrum sp. was enhanced by ultraviolet (UV) irradiation. First, a bacterial strain, Pseudochrobactrum sp. XF1, was isolated from the activated sludge in a coking plant. It was subjected to mutation by UV radiation for 120 s and a mutant strain with higher phenol-degrading ...

journal_title：International journal of molecular sciences

authors： Mao Z,Yu C,Xin L

更新日期：2015-04-01 00:00:00

abstract：:Poly(ADP-ribose)polymerase-1 (PARP1) is a nuclear protein implicated in DNA repair, recombination, replication, and chromatin remodeling. The aim of this study was to evaluate possible differences between PARP1(-/-) and wild-type mice regarding induction and repair of DNA lesions in irradiated male germ cells. Comet a...

journal_title：International journal of molecular sciences

authors： Villani P,Fresegna AM,Ranaldi R,Eleuteri P,Paris L,Pacchierotti F,Cordelli E

更新日期：2013-09-04 00:00:00

abstract：:Neuromuscular disorders (NMDs) affect 1 in 3000 people worldwide. There are more than 150 different types of NMDs, where the common feature is the loss of muscle strength. These disorders are classified according to their neuroanatomical location, as motor neuron diseases, peripheral nerve diseases, neuromuscular junc...

journal_title：International journal of molecular sciences

authors： Bachiller S,Alonso-Bellido IM,Real LM,Pérez-Villegas EM,Venero JL,Deierborg T,Armengol JÁ,Ruiz R

更新日期：2020-09-03 00:00:00

abstract：:Crude glycerol from the biodiesel manufacturing process is being produced in increasing quantities due to the expanding number of biodiesel plants. It has been previously shown that, in batch mode, semi-anaerobic fermentation of crude glycerol by Enterobacter aerogenes can produce biohydrogen and bioethanol simultaneo...

journal_title：International journal of molecular sciences

authors： Jitrwung R,Yargeau V

更新日期：2015-05-11 00:00:00

abstract：:Diabetes mellitus (DM) is a risk factor for hepatocellular carcinoma (HCC). The purpose of this study was to investigate the impact of the disorder of glucose metabolism on the recurrence of HCC after curative treatment. Two hundred and eleven patients with HCC who received curative treatment in our hospital from 2006...

journal_title：International journal of molecular sciences

authors： Imai K,Takai K,Hanai T,Suetsugu A,Shiraki M,Shimizu M

更新日期：2019-01-30 00:00:00

abstract：:Thymidylate synthase (TYMS) is an essential enzyme for the de novo synthesis of deoxythymidine monophosphate (dTMP) and has been a primary target for cancer chemotherapy. Although the physical structure of TYMS and the molecular mechanisms of TYMS catalyzing the conversion of deoxyuridine monophosphate (dUMP) to dTMP ...

journal_title：International journal of molecular sciences

authors： Xie D,Wang L,Xiao Q,Wu X,Zhang L,Yang Q,Wang L

更新日期：2018-05-07 00:00:00

abstract：:The purpose of this study was to investigate the inhibitory activities of ethanolic extracts from Antrodia cinnamomea (EEAC) on lung cancer. Cell proliferation and cell cycle distribution were analyzed using (3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) (MTT) assay and flow cytometry, respectively. Wo...

journal_title：International journal of molecular sciences

authors： Wu CH,Liu FC,Pan CH,Lai MT,Lan SJ,Wu CH,Sheu MJ

更新日期：2018-03-09 00:00:00

abstract：:Proteomic analyses are rapid and powerful tools that are used to increase the understanding of cancer pathogenesis, discover cancer biomarkers and predictive markers, and select and monitor novel targets for cancer therapy. Feline injection-site sarcomas (FISS) are aggressive skin tumours with high recurrence rates, d...

journal_title：International journal of molecular sciences

authors： Zabielska-Koczywąs K,Michalak K,Wojtalewicz A,Winiarczyk M,Adaszek Ł,Winiarczyk S,Lechowski R

更新日期：2018-02-14 00:00:00

abstract：:Osteoarthritis (OA) affects the integrity of the entire joint including the synovium. The most abundant cells in the synovium are fibroblasts (SF). Excessive mechanical loading might contribute to OA pathogenesis. Here, we investigate the effects of mechanical loading on SF derived from non-OA (N-SF) and OA patients (...

journal_title：International journal of molecular sciences

authors： Schröder A,Nazet U,Muschter D,Grässel S,Proff P,Kirschneck C

更新日期：2019-01-30 00:00:00

abstract：:The aim of this study was to explore the optimal therapeutic dose and time window of picroside II for treating cerebral ischemic injury in rats according to the orthogonal test. The middle cerebral artery occlusion (MCAO) models were established by intraluminally inserting a thread into middle cerebral artery (MCA) fr...

journal_title：International journal of molecular sciences

authors： Pei H,Su X,Zhao L,Li H,Guo Y,Zhang M,Xin H

更新日期：2012-01-01 00:00:00

abstract：:Acute erythroleukemia (AEL) is a rare disease typically associated with a poor prognosis. The median survival ranges between 3-9 months from initial diagnosis. Hypomethylating agents (HMAs) have been shown to prolong survival in patients with myelodysplastic syndromes (MDS) and AML, but there is limited data of their ...

journal_title：International journal of molecular sciences

authors： Almeida AM,Prebet T,Itzykson R,Ramos F,Al-Ali H,Shammo J,Pinto R,Maurillo L,Wetzel J,Musto P,Van De Loosdrecht AA,Costa MJ,Esteves S,Burgstaller S,Stauder R,Autzinger EM,Lang A,Krippl P,Geissler D,Falantes JF,Pedr

更新日期：2017-04-14 00:00:00

abstract：:Aqueous solutions of ethoxylated alcohols which form lyotropic liquid crystals at high concentrations (40-80%) were selected as model lubricating substances. Microscopic studies under polarized light and viscosity measurements were carried out in order to confirm the presence of liquid crystalline structures in the ca...

journal_title：International journal of molecular sciences

authors： Sulek MW,Bak A

更新日期：2010-01-12 00:00:00

abstract：:Metabolic syndrome (MetS) is a predictor of cardiovascular diseases, commonly associated with oxidative stress and inflammation. However, the pathogenic mechanisms are not yet fully elucidated. The aim of the study is to evaluate the oxidative status and inflammation in the heart of obese Zucker rats (OZRs) and lean Z...

journal_title：International journal of molecular sciences

authors： Martinelli I,Tomassoni D,Moruzzi M,Roy P,Cifani C,Amenta F,Tayebati SK

更新日期：2020-03-16 00:00:00

abstract：:In advanced cirrhosis, the TNFα-mediated intestinal inflammation and bacteria dysbiosis are involved in the development of inflammation and vasoconstriction-related renal dysfunction. In colitis and acute kidney injury models, activation of SIRT1 attenuates the TNFα-mediated intestinal and renal abnormalities. This st...

journal_title：International journal of molecular sciences

authors： Chou YT,Liu TT,Yang UC,Huang CC,Liu CW,Huang SF,Li TH,Liu HM,Lin MW,Yang YY,Lee TY,Huang YH,Hou MC,Lin HC

更新日期：2021-01-27 00:00:00

abstract：:This Special Issue of International Journal of Molecular Sciences (IJMS) contains 7 reviews and 12 original research papers written by a panel of experts who highlight recent advances in molecular structure and cellular function of purinergic P2 receptors[...]. ...

journal_title：International journal of molecular sciences

authors： Zemkova H

更新日期：2020-12-31 00:00:00

abstract：:C-type lectin receptors and their adaptor molecules are involved in the recognition of glycosylated self-antigens and pathogens. However, little is known about the species- and organ-specific expression profiles of these molecules. We therefore determined the mRNA expression levels of Dectin-1, MR1, MR2, DC-SIGN, Syk,...

journal_title：International journal of molecular sciences

authors： Lech M,Susanti HE,Römmele C,Gröbmayr R,Günthner R,Anders HJ

更新日期：2012-01-01 00:00:00

abstract：:Methyl jasmonate (MeJA), synthesized in the jasmonic acid (JA) pathway, has been found to upregulate glucosinolate (GS) biosynthesis in plant species of the Brassicaceae family. Exogenous application of MeJA has shown to increase tissue GS concentrations and the formation of myrosinase-mediated GS hydrolysis products ...

journal_title：International journal of molecular sciences

authors： Chiu YC,Juvik JA,Ku KM

更新日期：2018-04-02 00:00:00

abstract：:Autophagy (cellular self-consumption) is a crucial adaptation mechanism during cellular stress conditions. This study aimed to examine how this important process is regulated in human periodontal ligament (PDL) fibroblasts by mechanical and inflammatory stress conditions and whether the mammalian target of rapamycin (...

journal_title：International journal of molecular sciences

authors： Blawat K,Mayr A,Hardt M,Kirschneck C,Nokhbehsaim M,Behl C,Deschner J,Jäger A,Memmert S

更新日期：2020-12-11 00:00:00

abstract：:Renal fibrosis is the final common pathway of numerous progressive kidney diseases, and transforming growth factor-β (TGF-β) has an important role in tissue fibrosis by up-regulating matrix protein synthesis, inhibiting matrix degradation, and altering cell-cell interaction. Many strategies targeting TGF-β, including ...

journal_title：International journal of molecular sciences

authors： Isaka Y

更新日期：2018-08-27 00:00:00

abstract：:Psm ES4326/AvrRpt2 (AvrRpt2) was widely used as the reaction system of hypersensitive response (HR) in Arabidopsis. The study showed that in npr1 (GFP-ATG8a), AvrRpt2 was more effective at inducing the production of autophagosome and autophagy flux than that in GFP-ATG8a. The mRNA expression of ATG1, ATG6 and ATG8a we...

journal_title：International journal of molecular sciences

authors： Gong W,Li B,Zhang B,Chen W

更新日期：2020-07-21 00:00:00

abstract：:Treatment with 1-methylcyclopropylene (1-MCP) is an effective technique to preserve fruits, but inappropriate treatment with 1-MCP causes a ripening disorder (rubbery texture) in papaya fruit. In this study, a combined metabolomic and transcriptomic analysis was conducted to reveal the possible mechanism of the ripeni...

journal_title：International journal of molecular sciences

authors： Zheng S,Hao Y,Fan S,Cai J,Chen W,Li X,Zhu X

更新日期：2021-01-18 00:00:00

abstract：:Osteoporosis is a progressive skeletal disease characterized by decreased bone mass and degraded bone microstructure, which leads to increased bone fragility and risks of bone fracture. Osteoporosis is generally age related and has become a major disease of the world. Uncovering the molecular mechanisms underlying ost...

journal_title：International journal of molecular sciences

authors： Hu L,Yin C,Zhao F,Ali A,Ma J,Qian A

更新日期：2018-01-25 00:00:00

abstract：:An ongoing challenge in functional epigenomics is to develop tools for precise manipulation of epigenetic marks. These tools would allow moving from correlation-based to causal-based findings, a necessary step to reach conclusions on mechanistic principles. In this review, we describe and discuss the advantages and li...

journal_title：International journal of molecular sciences

authors： Fal K,Tomkova D,Vachon G,Chabouté ME,Berr A,Carles CC

更新日期：2021-01-06 00:00:00

abstract：:Recent studies have shown that free fatty acids are associated with chronic inflammation, which may be involved in vascular injury. The intake of eicosapentaenoic acid (EPA) can decrease cardiovascular disease risks, but the protective mechanisms of EPA on endothelial cells remain unclear. In this study, primary human...

journal_title：International journal of molecular sciences

authors： Lee CH,Lee SD,Ou HC,Lai SC,Cheng YJ

更新日期：2014-06-10 00:00:00

abstract：:Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors that govern the expression of genes responsible for energy metabolism, cellular development, and differentiation. Their crucial biological roles dictate the significance of PPAR-targeting synthetic ligands in medical research and drug discovery....

journal_title：International journal of molecular sciences

authors： Cheng HS,Tan WR,Low ZS,Marvalim C,Lee JYH,Tan NS

更新日期：2019-10-11 00:00:00

abstract：:Biomarkers for the early detection of pancreatic cancer are urgently needed. The aim of this pilot study was to evaluate changes in serum N-glycoproteins and their glycosylation status prior to clinical presentation of pancreatic cancer that may be potential biomarkers. Prediagnosis serum samples pooled according to f...

journal_title：International journal of molecular sciences

authors： Krishnan S,Whitwell HJ,Cuenco J,Gentry-Maharaj A,Menon U,Pereira SP,Gaspari M,Timms JF

更新日期：2017-12-09 00:00:00

abstract：:Mature mRNA is generated by the 3' end cleavage and polyadenylation of its precursor pre-mRNA. Eukaryotic genes frequently have multiple polyadenylation sites, resulting in mRNA isoforms with different 3'-UTR lengths that often encode different C-terminal amino acid sequences. It is well-known that this form of post-t...

journal_title：International journal of molecular sciences

authors： Ikeda T,Saito-Takatsuji H,Yoshitomi Y,Yonekura H

更新日期：2020-09-04 00:00:00

abstract：:Marek's Disease (MD) is a highly contagious pathogenic and oncogenic disease primarily affecting chickens. Chicken Lines 63 and 72, as well as their recombinant congenic strains (RCS) with varied susceptibility to MD, are ideal models to study the complex mechanisms of genetic resistance to MD. In this study, we inves...

journal_title：International journal of molecular sciences

authors： Xu L,He Y,Ding Y,Sun G,Carrillo JA,Li Y,Ghaly MM,Ma L,Zhang H,Liu GE,Song J

更新日期：2017-05-09 00:00:00

abstract：:Nanosilver plays an important role in nanoscience and nanotechnology, and is becoming increasingly used for applications in nanomedicine. Nanosilver ranges from 1 to 100 nanometers in diameter. Smaller particles more readily enter cells and interact with the cellular components. The exposure dose, particle size, coati...

journal_title：International journal of molecular sciences

authors： Cameron SJ,Hosseinian F,Willmore WG

更新日期：2018-07-12 00:00:00