Clinical Outcomes of 217 Patients with Acute Erythroleukemia According to Treatment Type and Line: A Retrospective Multinational Study.

Abstract:

:Acute erythroleukemia (AEL) is a rare disease typically associated with a poor prognosis. The median survival ranges between 3-9 months from initial diagnosis. Hypomethylating agents (HMAs) have been shown to prolong survival in patients with myelodysplastic syndromes (MDS) and AML, but there is limited data of their efficacy in AEL. We collected data from 210 AEL patients treated at 28 international sites. Overall survival (OS) and PFS were estimated using the Kaplan-Meier method and the log-rank test was used for subgroup comparisons. Survival between treatment groups was compared using the Cox proportional hazards regression model. Eighty-eight patients were treated with HMAs, 44 front line, and 122 with intensive chemotherapy (ICT). ICT led to a higher overall response rate (complete or partial) compared to first-line HMA (72% vs. 46.2%, respectively; p ≤ 0.001), but similar progression-free survival (8.0 vs. 9.4 months; p = 0.342). Overall survival was similar for ICT vs. HMAs (10.5 vs. 13.7 months; p = 0.564), but patients with high-risk cytogenetics treated with HMA first-line lived longer (7.5 for ICT vs. 13.3 months; p = 0.039). Our results support the therapeutic value of HMA in AEL.

journal_name

Int J Mol Sci

authors

Almeida AM,Prebet T,Itzykson R,Ramos F,Al-Ali H,Shammo J,Pinto R,Maurillo L,Wetzel J,Musto P,Van De Loosdrecht AA,Costa MJ,Esteves S,Burgstaller S,Stauder R,Autzinger EM,Lang A,Krippl P,Geissler D,Falantes JF,Pedr

doi

10.3390/ijms18040837

subject

Has Abstract

pub_date

2017-04-14 00:00:00

issue

4

issn

1422-0067

pii

ijms18040837

journal_volume

18

pub_type

杂志文章,多中心研究
  • Enhancing the Thermo-Stability and Anti-Bacterium Activity of Lysozyme by Immobilization on Chitosan Nanoparticles.

    abstract::The recent emergence of antibiotic-resistant bacteria requires the development of new antibiotics or new agents capable of enhancing antibiotic activity. Lysozyme degrades bacterial cell wall without involving antibiotic resistance and has become a new antibacterial strategy. However, direct use of native, active prot...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms21051635

    authors: Wang Y,Li S,Jin M,Han Q,Liu S,Chen X,Han Y

    更新日期:2020-02-27 00:00:00

  • USP19-Mediated Deubiquitination Facilitates the Stabilization of HRD1 Ubiquitin Ligase.

    abstract::In the endoplasmic reticulum (ER), misfolded and unfolded proteins are eliminated by a process called ER-associated protein degradation (ERAD) in order to maintain cell homeostasis. In the ERAD pathway, several ER-localized E3 ubiquitin ligases target ERAD substrate proteins for ubiquitination and subsequent proteasom...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms17111829

    authors: Harada K,Kato M,Nakamura N

    更新日期:2016-11-02 00:00:00

  • Leukocyte Immunoglobulin-Like Receptors A2 and A6 are Expressed in Avian Macrophages and Modulate Cytokine Production by Activating Multiple Signaling Pathways.

    abstract::The activating leukocyte immunoglobulin-like receptors (LILRAs) play an important role in innate immunity. However, most of the LILRA members have not been characterized in avian species including chickens. The present study is the first attempt at cloning, structural analysis and functional characterization of two LI...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms19092710

    authors: Truong AD,Rengaraj D,Hong Y,Tran HTT,Dang HV,Nguyen VK,Lillehoj HS,Hong YH

    更新日期:2018-09-11 00:00:00

  • The Constipation-Relieving Property of d-Tagatose by Modulating the Composition of Gut Microbiota.

    abstract::d-tagatose, a monosaccharide as well as a dietary supplement, has been reported as having a wide range of applicability in the food industry, however, the prebiotic activity, anticonstipation effects, and related mechanisms are still unclear. In this study, using the loperamide-induced constipation Kunming mice as the...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms20225721

    authors: Liang YX,Wen P,Wang Y,OuYang DM,Wang D,Chen YZ,Song Y,Deng J,Sun YM,Wang H

    更新日期:2019-11-14 00:00:00

  • First Insights into Human Fingertip Regeneration by Echo-Doppler Imaging and Wound Microenvironment Assessment.

    abstract::Fingertip response to trauma represents a fascinating example of tissue regeneration. Regeneration derives from proliferative mesenchymal cells (blastema) that subsequently differentiate into soft and skeletal tissues. Clinically, conservative treatment of the amputated fingertip under occlusive dressing can shift the...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms18051054

    authors: Jafari P,Muller C,Grognuz A,Applegate LA,Raffoul W,di Summa PG,Durand S

    更新日期:2017-05-13 00:00:00

  • High PD-L1 Expression Predicts for Worse Outcome of Leukemia Patients with Concomitant NPM1 and FLT3 Mutations.

    abstract::Compared to solid tumors, the role of PD-L1 in hematological malignancies is less explored, and the knowledge in this area is mostly limited to lymphomas. However, several studies indicated that PD-L1 is also overexpressed in myeloid malignancies. Successful treatment of the acute myeloid leukemia (AML) is likely asso...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms20112823

    authors: Brodská B,Otevřelová P,Šálek C,Fuchs O,Gašová Z,Kuželová K

    更新日期:2019-06-10 00:00:00

  • Protein Deimination Signatures in Plasma and Plasma-EVs and Protein Deimination in the Brain Vasculature in a Rat Model of Pre-Motor Parkinson's Disease.

    abstract::The identification of biomarkers for early diagnosis of Parkinson's disease (PD) is of pivotal importance for improving approaches for clinical intervention. The use of translatable animal models of pre-motor PD therefore offers optimal opportunities for novel biomarker discovery in vivo. Peptidylarginine deiminases (...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms21082743

    authors: Sancandi M,Uysal-Onganer P,Kraev I,Mercer A,Lange S

    更新日期:2020-04-15 00:00:00

  • DNA sequence analysis of South African Helicobacter pylori Vacuolating Cytotoxin Gene (vacA).

    abstract::Sequence diversity and population structures can vary widely among pathogenic bacteria species. In some species, all isolates are highly similar, whereas in others most of the isolates are distinguished easily. H. pylori is known for its wide genetic diversity amongst the various strains most especially in the genes i...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms12117459

    authors: Tanih NF,Ndip LM,Ndip RN

    更新日期:2011-01-01 00:00:00

  • Sex Differences in a Rodent Model of HIV-1-Associated Neuropathic Pain.

    abstract::Worldwide, women account for approximately 51% of human immunodeficiency virus-1 (HIV) seropositive individuals. The prevalence of neuropathic pain among individuals with HIV and a lack of preclinical data characterizing sex differences prompted us to address this knowledge gap. C57BL/6 male and female mice received m...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms20051196

    authors: Guindon J,Blanton H,Brauman S,Donckels K,Narasimhan M,Benamar K

    更新日期:2019-03-09 00:00:00

  • Calcium Signaling in Aging and Neurodegenerative Diseases 2019.

    abstract::The European Calcium Society (ECS) workshop, which is held every 2 years, is a dedicated meeting of scientists interested in the elucidation of the action of calcium binding, calcium signaling and the study of proteins and organelles, such as mitochondria and endoplasmic reticulum, thereby involved, either in health a...

    journal_title:International journal of molecular sciences

    pub_type:

    doi:10.3390/ijms21031125

    authors: Cortes L,Malva J,Rego AC,Pereira CF

    更新日期:2020-02-07 00:00:00

  • The Effect of the acetone extract of Arctotis arctotoides (Asteraceae) on the growth and ultrastructure of some opportunistic fungi associated with HIV/AIDS.

    abstract::In this study, the effect of the acetone extract of Arctotis arctotoides (L.f.) O. Hoffm. (Asteraceae) on the growth and ultrastructure of some opportunistic fungi associated with HIV/AIDS was analyzed by means of scanning electron microscope (SEM). Remarkable morphological alterations in the fungal mycelia which were...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms12129226

    authors: Otang WM,Grierson DS,Ndip RN

    更新日期:2011-01-01 00:00:00

  • Identifying Common Features in the Activation of Melanocortin-2 Receptors: Studies on the Xenopus tropicalis Melanocortin-2 Receptor.

    abstract::The interaction between the pituitary hormone, adrenocorticotropin (ACTH), and melanocortin-2 receptor (MC2R) orthologs involves the H6 F7 R8 W9 and R/K15 K16 R17 R18 motifs in ACTH making contact with corresponding contact sites on MC2R. Earlier studies have localized the common HFRW binding site of all melanocortin ...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms20174166

    authors: Davis PE,Wilkinson EC,Dores RM

    更新日期:2019-08-26 00:00:00

  • Primary study for the therapeutic dose and time window of picroside II in treating cerebral ischemic injury in rats.

    abstract::The aim of this study was to explore the optimal therapeutic dose and time window of picroside II for treating cerebral ischemic injury in rats according to the orthogonal test. The middle cerebral artery occlusion (MCAO) models were established by intraluminally inserting a thread into middle cerebral artery (MCA) fr...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms13032551

    authors: Pei H,Su X,Zhao L,Li H,Guo Y,Zhang M,Xin H

    更新日期:2012-01-01 00:00:00

  • Acquiring chondrocyte phenotype from human mesenchymal stem cells under inflammatory conditions.

    abstract::An inflammatory milieu breaks down the cartilage matrix and induces chondrocyte apoptosis, resulting in cartilage destruction in patients with cartilage degenerative diseases, such as rheumatoid arthritis or osteoarthritis. Because of the limited regenerative ability of chondrocytes, defects in cartilage are irreversi...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审

    doi:10.3390/ijms151121270

    authors: Kondo M,Yamaoka K,Tanaka Y

    更新日期:2014-11-17 00:00:00

  • Alterations in Cellular Iron Metabolism Provide More Therapeutic Opportunities for Cancer.

    abstract::Iron is an essential element for the growth and proliferation of cells. Cellular iron uptake, storage, utilization and export are tightly regulated to maintain iron homeostasis. However, cellular iron metabolism pathways are disturbed in most cancer cells. To maintain rapid growth and proliferation, cancer cells acqui...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审

    doi:10.3390/ijms19051545

    authors: Zhou L,Zhao B,Zhang L,Wang S,Dong D,Lv H,Shang P

    更新日期:2018-05-22 00:00:00

  • Parkin Coordinates Platelet Stress Response in Diabetes Mellitus: A Big Role in a Small Cell.

    abstract::Increased platelet activation and apoptosis are characteristic of diabetic (DM) platelets, where a Parkin-dependent mitophagy serves a major endogenous protective role. We now demonstrate that Parkin is highly expressed in both healthy platelets and diabetic platelets, compared to other mitochondria-enriched tissues s...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms21165869

    authors: Lee SH,Du J,Hwa J,Kim WH

    更新日期:2020-08-15 00:00:00

  • Nephrocalcinosis: A Review of Monogenic Causes and Insights They Provide into This Heterogeneous Condition.

    abstract::The abnormal deposition of calcium within renal parenchyma, termed nephrocalcinosis, frequently occurs as a result of impaired renal calcium handling. It is closely associated with renal stone formation (nephrolithiasis) as elevated urinary calcium levels (hypercalciuria) are a key common pathological feature underlyi...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审

    doi:10.3390/ijms21010369

    authors: Dickson FJ,Sayer JA

    更新日期:2020-01-06 00:00:00

  • PD-1 and PD-L1 Expression on Circulating Lymphocytes as a Marker of Epstein-Barr Virus Reactivation-Associated Proliferative Glomerulonephritis.

    abstract::Alterations to the programmed cell death protein-1 (PD-1) pathway were previously shown to be involved in a poorer prognosis for patients with proliferative glomerulonephritis (PGN). Here, we investigated the association between several infectious agents and the expression of PD-1 and its ligand (PD-L1) on T and B lym...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms21218001

    authors: Grywalska E,Smarz-Widelska I,Korona-Głowniak I,Mertowski S,Gosik K,Hymos A,Ludian J,Niedźwiedzka-Rystwej P,Roliński J,Załuska W

    更新日期:2020-10-27 00:00:00

  • The Emerging Role of Exosomes in Diagnosis, Prognosis, and Therapy in Head and Neck Cancer.

    abstract::Exosomes, the smallest group of extracellular vesicles, carry proteins, miRNA, mRNA, DNA, and lipids, which they efficiently deliver to recipient cells, generating a communication network. Exosomes strongly contribute to the immune suppressive tumor microenvironment of head and neck squamous cell carcinomas (HNSCC). I...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审

    doi:10.3390/ijms21114072

    authors: Hofmann L,Ludwig S,Vahl JM,Brunner C,Hoffmann TK,Theodoraki MN

    更新日期:2020-06-06 00:00:00

  • Modeling human liver biology using stem cell-derived hepatocytes.

    abstract::Stem cell-derived hepatocytes represent promising models to study human liver biology and disease. This concise review discusses the recent progresses in the field, with a focus on human liver disease, drug metabolism and virus infection. ...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审

    doi:10.3390/ijms141122011

    authors: Sun P,Zhou X,Farnworth SL,Patel AH,Hay DC

    更新日期:2013-11-06 00:00:00

  • Chemopreventive Agent 3,3'-Diindolylmethane Inhibits MDM2 in Colorectal Cancer Cells.

    abstract::3,3'-Diindolylmethane (DIM) is a naturally derived chemopreventive compound. It comes from glucobrassicin, an indole glucosinolate enriched in cruciferous vegetables, and is formed in the acidic environment of the stomach after ingestion. Mouse double minute 2 homolog (MDM2) is an important, multi-functional oncogenic...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms21134642

    authors: Gao X,Liu J,Cho KB,Kedika S,Guo B

    更新日期:2020-06-30 00:00:00

  • Effects of calorie restriction and IGF-1 receptor blockade on the progression of 22Rv1 prostate cancer xenografts.

    abstract::Calorie restriction (CR) inhibits prostate cancer progression, partially through modulation of the IGF axis. IGF-1 receptor (IGF-1R) blockade reduces prostate cancer xenograft growth. We hypothesized that combining calorie restriction with IGF-1R blockade would have an additive effect on prostate cancer growth. Severe...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms140713782

    authors: Galet C,Gray A,Said JW,Castor B,Wan J,Beltran PJ,Calzone FJ,Elashoff D,Cohen P,Aronson WJ

    更新日期:2013-07-03 00:00:00

  • At-Hook Motif Nuclear Localised Protein 18 as a Novel Modulator of Root System Architecture.

    abstract::The At-Hook Motif Nuclear Localized Protein (AHL) gene family encodes embryophyte-specific nuclear proteins with DNA binding activity. They modulate gene expression and affect various developmental processes in plants. We identify AHL18 (At3G60870) as a developmental modulator of root system architecture and growth. A...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms21051886

    authors: Širl M,Šnajdrová T,Gutiérrez-Alanís D,Dubrovsky JG,Vielle-Calzada JP,Kulich I,Soukup A

    更新日期:2020-03-10 00:00:00

  • Neuroinflammation and Oxidative Stress in Psychosis and Psychosis Risk.

    abstract::Although our understanding of psychotic disorders has advanced substantially in the past few decades, very little has changed in the standard of care for these illnesses since the development of atypical anti-psychotics in the 1990s. Here, we integrate new insights into the pathophysiology with the increasing interest...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审

    doi:10.3390/ijms18030651

    authors: Barron H,Hafizi S,Andreazza AC,Mizrahi R

    更新日期:2017-03-17 00:00:00

  • Effects of estradiol and methoxychlor on Leydig cell regeneration in the adult rat testis.

    abstract::The objective of the present study is to determine whether methoxychlor (MXC) exposure in adulthood affects rat Leydig cell regeneration and to compare its effects with estradiol (E2). Adult 90-day-old male Sprague-Dawley rats received ethane dimethane sulfonate (EDS) to eliminate the adult Leydig cell population. Sub...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms15057812

    authors: Chen B,Chen D,Jiang Z,Li J,Liu S,Dong Y,Yao W,Akingbemi B,Ge R,Li X

    更新日期:2014-05-06 00:00:00

  • Investigating ionic effects applied to water based organocatalysed aldol reactions.

    abstract::Saturated aqueous solutions of various common salts were examined for their effect on aqueous aldol reactions catalysted by a highly active C(2)-symmetric diprolinamide organocatalyst developed in our laboratory. With respect to the aldol reaction between cyclohexanone and 4-nitrobenzaldehyde, deionised water was alwa...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms12129083

    authors: Delaney JP,Henderson LC

    更新日期:2011-01-01 00:00:00

  • Epidermal growth factor stimulates extracellular-signal regulated kinase phosphorylation of a novel site on cytoplasmic Dynein intermediate chain 2.

    abstract::Extracellular-signal regulated kinase (ERK) signaling is required for a multitude of physiological and patho-physiological processes. However, the identities of the proteins that ERK phosphorylates to elicit these responses are incompletely known. Using an affinity purification methodology of general utility, here we ...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms14023595

    authors: Pullikuth AK,Ozdemir A,Cardenas D,Bailey E,Sherman NE,Pfister KK,Catling AD

    更新日期:2013-02-07 00:00:00

  • Polygonatum odoratum Polysaccharides Modulate Gut Microbiota and Mitigate Experimentally Induced Obesity in Rats.

    abstract::Increasing evidence suggests that the gut microbiota plays vital roles in metabolic diseases. Polygonatum odoratum extract alleviates hyperglycemia and hyperlipidemia, but the underlying mechanism remains unclear. This study investigated the effects of P. odoratum polysaccharides (POPs) on high-fat diet (HFD)-induced ...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms19113587

    authors: Wang Y,Fei Y,Liu L,Xiao Y,Pang Y,Kang J,Wang Z

    更新日期:2018-11-13 00:00:00

  • Quantitative Structure-Activity Relationships Study on the Rate Constants of Polychlorinated Dibenzo-p-Dioxins with OH Radical.

    abstract::The OH-initiated reaction rate constants (kOH) are of great importance to measure atmospheric behaviors of polychlorinated dibenzo-p-dioxins (PCDDs) in the environment. The rate constants of 75 PCDDs with the OH radical at 298.15 K have been calculated using high level molecular orbital theory, and the rate constants ...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms160818812

    authors: Qi C,Zhang C,Sun X

    更新日期:2015-08-12 00:00:00

  • Advances and Future Applications of Augmented Peripheral Nerve Regeneration.

    abstract::Peripheral nerve injuries remain a significant source of long lasting morbidity, disability, and economic costs. Much research continues to be performed in areas related to improving the surgical outcomes of peripheral nerve repair. In this review, the physiology of peripheral nerve regeneration and the multitude of e...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审

    doi:10.3390/ijms17091494

    authors: Jones S,Eisenberg HM,Jia X

    更新日期:2016-09-07 00:00:00