Abstract：
:In our study, poly(dl-lactide-co-glycolide) (PLGA) nanoparticles loaded with perphenazine (PPH) and chlorpromazine hydrochloride (CPZ-HCl) were formulated by emulsion solvent evaporation technique. The effect of various processing variables, including PLGA concentration, theoretical drug loading, poly(vinyl alcohol) (PVA) concentration and the power of sonication were assessed systematically to obtain higher encapsulation efficiency and to minimize the nanoparticles size. By the optimization formulation process, the nanoparticles were obtained in submicron size from 325.5 ± 32.4 to 374.3 ± 10.1 nm for nanoparticles loaded with PPH and CPZ-HCl, respectively. Nanoparticles observed by scanning electron microscopy (SEM) presented smooth surface and spherical shape. The encapsulation efficiency of nanoparticles loaded with PPH and CPZ-HCl were 83.9% and 71.0%, respectively. The drug loading were 51.1% and 39.4% for PPH and CPZ-HCl, respectively. Lyophilized nanoparticles with different PLGA concentration 0.8%, 1.3% and 1.6% (w/v) in formulation process were evaluated for in vitro release in phosphate buffered saline (pH = 7.4) by using dialysis bags. The release profile for both drugs have shown that the rate of PPH and CPZ-HCl release were dependent on a size and amount of drugs in the nanoparticles.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Halayqa M,Domańska Udoi
10.3390/ijms151223909subject
Has Abstractpub_date
2014-12-22 00:00:00pages
23909-23issue
12issn
1422-0067pii
ijms151223909journal_volume
15pub_type
杂志文章abstract：:Clinical applications of camptothecin (CPT) have been heavily hindered due to its non-targeted toxicity, active lactone ring instability, and poor water solubility. Targeted drug delivery systems may offer the possibility to overcome the above issues as reported. In this research, a series of prostate-specific membran...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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更新日期：2019-10-30 00:00:00
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更新日期：2014-09-26 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2012-10-16 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2020-06-25 00:00:00
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更新日期：2019-05-23 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2018-09-17 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2018-01-25 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2009-03-01 00:00:00
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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更新日期：2017-02-20 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2019-06-27 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2019-01-15 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
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更新日期：2017-05-08 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
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更新日期：2016-07-15 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2009-06-19 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
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更新日期：2020-09-19 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2019-04-22 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21228750
更新日期：2020-11-19 00:00:00
