Effects of Melatonin and Its Analogues on Pancreatic Inflammation, Enzyme Secretion, and Tumorigenesis.


:Melatonin is an indoleamine produced from the amino acid l-tryptophan, whereas metabolites of melatonin are known as kynuramines. One of the best-known kynuramines is N¹-acetyl-N¹-formyl-5-methoxykynuramine (AFMK). Melatonin has attracted scientific attention as a potent antioxidant and protector of tissue against oxidative stress. l-Tryptophan and kynuramines share common beneficial features with melatonin. Melatonin was originally discovered as a pineal product, has been detected in the gastrointestinal tract, and its receptors have been identified in the pancreas. The role of melatonin in the pancreatic gland is not explained, however several arguments support the opinion that melatonin is probably implicated in the physiology and pathophysiology of the pancreas. (1) Melatonin stimulates pancreatic enzyme secretion through the activation of entero-pancreatic reflex and cholecystokinin (CCK) release. l-Tryptophan and AFMK are less effective than melatonin in the stimulation of pancreatic exocrine function; (2) Melatonin is a successful pancreatic protector, which prevents the pancreas from developing of acute pancreatitis and reduces pancreatic damage. This effect is related to its direct and indirect antioxidant action, to the strengthening of immune defense, and to the modulation of apoptosis. Like melatonin, its precursor and AFMK are able to mimic its protective effect, and it is commonly accepted that all these substances create an antioxidant cascade to intensify the pancreatic protection and acinar cells viability; (3) In pancreatic cancer cells, melatonin and AFMK activated a signal transduction pathway for apoptosis and stimulated heat shock proteins. The role of melatonin and AFMK in pancreatic tumorigenesis remains to be elucidated.


Int J Mol Sci


Jaworek J,Leja-Szpak A,Nawrot-Porąbka K,Szklarczyk J,Kot M,Pierzchalski P,Góralska M,Ceranowicz P,Warzecha Z,Dembinski A,Bonior J




Has Abstract


2017-05-08 00:00:00










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    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Damerau A,Gaber T

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  • Eclipsed acetaldehyde as a precursor for producing vinyl alcohol.

    abstract::The MP2 and DFT/B3LYP methods at 6-311++G(d,p) and aug-cc-pdz basis sets have been used to probe the origin of relative stability preference for eclipsed acetaldehyde over its bisected counterpart. A relative energy stability range of 1.02 to 1.20 kcal/mol, in favor of the eclipsed conformer, was found and discussed. ...

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    authors: Osman OI,Alyoubi AO,Elroby SA,Hilal RH,Aziz SG

    更新日期:2012-11-20 00:00:00

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    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Tonini C,Colardo M,Colella B,Di Bartolomeo S,Berardinelli F,Caretti G,Pallottini V,Segatto M

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  • One Year Follow-Up Risk Assessment in SKH-1 Mice and Wounds Treated with an Argon Plasma Jet.

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    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Schmidt A,Woedtke TV,Stenzel J,Lindner T,Polei S,Vollmar B,Bekeschus S

    更新日期:2017-04-19 00:00:00

  • Virus-Mediated Cell-Cell Fusion.

    abstract::Cell-cell fusion between eukaryotic cells is a general process involved in many physiological and pathological conditions, including infections by bacteria, parasites, and viruses. As obligate intracellular pathogens, viruses use intracellular machineries and pathways for efficient replication in their host target cel...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Leroy H,Han M,Woottum M,Bracq L,Bouchet J,Xie M,Benichou S

    更新日期:2020-12-17 00:00:00

  • Therapeutic Resistance in Acute Myeloid Leukemia: The Role of Non-Coding RNAs.

    abstract::Acute myeloid leukemia (AML) is caused by malignant transformation of hematopoietic stem or progenitor cells and displays the most frequent acute leukemia in adults. Although some patients can be cured with high dose chemotherapy and allogeneic hematopoietic stem cell transplantation, the majority still succumbs to ch...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Zebisch A,Hatzl S,Pichler M,Wölfler A,Sill H

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  • MT-Feeding-Induced Impermanent Sex Reversal in the Orange-Spotted Grouper during Sex Differentiation.

    abstract::In this study, we systematically investigated the process of sex reversal induced by 17-methyltestosterone (MT) feeding and MT-feeding withdrawal at the ovary differentiation stage in orange-spotted groupers, Epinephelus coioides. Gonadal histology showed that MT feeding induced a precocious sex reversal from immature...

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    pub_type: 杂志文章


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  • The Role of miRNAs in Virus-Mediated Oncogenesis.

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    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Vojtechova Z,Tachezy R

    更新日期:2018-04-17 00:00:00

  • Fluorescence Enhancement Effect of TiO2 Nanoparticles and Application for Photodynamic Diagnosis.

    abstract::Photodynamic diagnosis (PDD) can improve diagnostic accuracy by using PDD agents such as 5-aminolevulinic acid (ALA). However, the weakness and photobleaching of fluorescence of PDD agents may lead to insufficient fluorescence visibility for the detection of cancer during resection operations. We focused on the "fluor...

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    authors: Kanehira K,Yano Y,Hasumi H,Fukuhara H,Inoue K,Hanazaki K,Yao M

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  • Effects of OsCDPK1 on the Structure and Physicochemical Properties of Starch in Developing Rice Seeds.

    abstract::Overexpression of a constitutively active truncated form of OsCDPK1 (OEtr) in rice produced smaller seeds, but a double-stranded RNA gene-silenced form of OsCDPK1 (Ri) yielded larger seeds, suggesting that OsCDPK1 plays a functional role in rice seed development. In the study presented here, we propose a model in whic...

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    authors: Jiang JZ,Kuo CH,Chen BH,Chen MK,Lin CS,Ho SL

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    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Soboleva A,Vikhnina M,Grishina T,Frolov A

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  • The voltage-dependent anion channel 1 (AtVDAC1) negatively regulates plant cold responses during germination and seedling development in Arabidopsis and interacts with calcium sensor CBL1.

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    authors: Li ZY,Xu ZS,He GY,Yang GX,Chen M,Li LC,Ma Y

    更新日期:2013-01-04 00:00:00

  • Inhibition of Colony-Stimulating Factor 1 Receptor by PLX3397 Prevents Amyloid Beta Pathology and Rescues Dopaminergic Signaling in Aging 5xFAD Mice.

    abstract::Alzheimer's disease (AD) is a progressive neurodegenerative disease. In this study, to investigate the effect of microglial elimination on AD progression, we administered PLX3397, a selective colony-stimulating factor 1 receptor inhibitor, to the mouse model of AD (5xFAD mice). Amyloid-beta (Aβ) deposition and amyloid...

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    authors: Son Y,Jeong YJ,Shin NR,Oh SJ,Nam KR,Choi HD,Choi JY,Lee HJ

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  • miR-206-3p Inhibits 3T3-L1 Cell Adipogenesis via the c-Met/PI3K/Akt Pathway.

    abstract::MicroRNAs (miRNAs) are important post-transcriptional regulators during adipocyte adipogenesis. MiR-206-3p, a tissue-specific miRNA, is absent in white adipocytes. In this study, we examined the roles of mmu-miR-206-3p in the adipogenic differentiation of 3T3-L1 preadipocytes. The miR-206-3p expression has shown an ap...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Tang R,Ma F,Li W,Ouyang S,Liu Z,Wu J

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  • Comparative Transcriptome Analysis of the Molecular Mechanism of the Hairy Roots of Brassica campestris L. in Response to Cadmium Stress.

    abstract::Brassica campestris L., a hyperaccumulator of cadmium (Cd), is considered a candidate plant for efficient phytoremediation. The hairy roots of Brassica campestris L are chosen here as a model plant system to investigate the response mechanism of Brassica campestris L. to Cd stress. High-throughput sequencing technolog...

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    pub_type: 杂志文章


    authors: Sun Y,Lu Q,Cao Y,Wang M,Cheng X,Yan Q

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    authors: Polasky C,Wendt F,Pries R,Wollenberg B

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    journal_title:International journal of molecular sciences

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    authors: Lkhagvadorj K,Zeng Z,Meyer KF,Verweij LP,Kooistra W,Reinders-Luinge M,Dijkhuizen HW,de Graaf IAM,Plösch T,Hylkema MN

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    authors: Koziróg A,Rajkowska K,Otlewska A,Piotrowska M,Kunicka-Styczyńska A,Brycki B,Nowicka-Krawczyk P,Kościelniak M,Gutarowska B

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  • Anti-Apoptotic Effects of Recombinant Human Hepatocyte Growth Factor on Hepatocytes Were Associated with Intrahepatic Hemorrhage Suppression Indicated by the Preservation of Prothrombin Time.

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    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Motoi S,Toyoda H,Obara T,Ohta E,Arita Y,Negishi K,Moriya K,Kuboi Y,Soejima M,Imai T,Ido A,Tsubouchi H,Kawano T

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    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Mohammadian Gol T,Rodemann HP,Dittmann K

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  • Natural-synthetic hybrid polymers developed via electrospinning: the effect of PET in chitosan/starch system.

    abstract::Chitosan is an amino polysaccharide found in nature, which is biodegradable, nontoxic and biocompatible. It has versatile features and can be used in a variety of applications including films, packaging, and also in medical surgery. Recently a possibility to diversify chitosan properties has emerged by combining it wi...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Espíndola-González A,Martínez-Hernández AL,Fernández-Escobar F,Castaño VM,Brostow W,Datashvili T,Velasco-Santos C

    更新日期:2011-01-01 00:00:00

  • Chirality-Dependent Adsorption between Amphipathic Peptide and POPC Membrane.

    abstract::The interactions between chiral molecules and cell membranes have attracted more and more attention in recent decades, due to their importance in molecular science and medical applications. It is observed that some peptides composed of different chiral amino acids may have distinct interactions with a membrane. How do...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Chen K,Sheng Y,Wang J,Wang W

    更新日期:2019-09-25 00:00:00

  • Bactericidal and Bioresorbable Calcium Phosphate Cements Fabricated by Silver-Containing Tricalcium Phosphate Microspheres.

    abstract::Bacterial adhesion to the calcium phosphate surface is a serious problem in surgery. To prevent bacterial infection, the development of calcium-phosphate cements (CPCs) with bactericidal properties is indispensable. The aim of this study was to fabricate antibacterial CPCs and evaluate their biological properties. Sil...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Honda M,Kawanobe Y,Nagata K,Ishii K,Matsumoto M,Aizawa M

    更新日期:2020-05-26 00:00:00

  • A Proline Derivative-Enriched Fraction from Sideroxylon obtusifolium Protects the Hippocampus from Intracerebroventricular Pilocarpine-Induced Injury Associated with Status Epilepticus in Mice.

    abstract::The N-methyl-(2S,4R)-trans-4-hydroxy-l-proline-enriched fraction (NMP) from Sideroxylon obtusifolium was evaluated as a neuroprotective agent in the intracerebroventricular (icv) pilocarpine (Pilo) model. To this aim, male mice were subdivided into sham (SO, vehicle), Pilo (300 µg/1 µL icv, followed by the vehicle per...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: de Aquino PEA,Rabelo Bezerra J,de Souza Nascimento T,Tavares J,Rosal Lustosa Í,Chaves Filho AJM,Mottin M,Macêdo Gaspar D,Andrade GM,Tavares Neves KR,Biagini G,Silveira ER,de Barros Viana GS

    更新日期:2020-06-11 00:00:00

  • It Is Imperative to Establish a Pellucid Definition of Chimeric RNA and to Clear Up a Lot of Confusion in the Relevant Research.

    abstract::There have been tens of thousands of RNAs deposited in different databases that contain sequences of two genes and are coined chimeric RNAs, or chimeras. However, "chimeric RNA" has never been lucidly defined, partly because "gene" itself is still ill-defined and because the means of production for many RNAs is unclea...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Yuan C,Han Y,Zellmer L,Yang W,Guan Z,Yu W,Huang H,Liao DJ

    更新日期:2017-03-28 00:00:00

  • Current models of mammalian target of rapamycin complex 1 (mTORC1) activation by growth factors and amino acids.

    abstract::Mammalian target of rapamycin (mTOR), which is now referred to as mechanistic target of rapamycin, integrates many signals, including those from growth factors, energy status, stress, and amino acids, to regulate cell growth and proliferation, protein synthesis, protein degradation, and other physiological and biochem...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Zheng X,Liang Y,He Q,Yao R,Bao W,Bao L,Wang Y,Wang Z

    更新日期:2014-11-13 00:00:00

  • Rhodobacter sphaeroides Extract Lycogen™ Attenuates Testosterone-Induced Benign Prostate Hyperplasia in Rats.

    abstract::Benign prostate hyperplasia (BPH) is one of the most common urological problems in mid-aged to elderly men. Risk factors of BPH include family history, obesity, type 2 diabetes, and high oxidative stress. The main medication classes for BPH management are alpha blockers and 5α-reductase inhibitors. However, these conv...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Wang CT,Wang YY,Liu WS,Cheng CM,Chiu KH,Liu LL,Liu XZ,Wen ZH,Chen YH,Chen TM

    更新日期:2018-04-10 00:00:00

  • Functional Analysis of the Ser149/Thr149 Variants of Human Aspartylglucosaminidase and Optimization of the Coding Sequence for Protein Production.

    abstract::Aspartylglucosaminidase (AGA) is a lysosomal hydrolase that participates in the breakdown of glycoproteins. Defects in the AGA gene result in a lysosomal storage disorder, aspartylglucosaminuria (AGU), that manifests mainly as progressive mental retardation. A number of AGU missense mutations have been identified that...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Banning A,König JF,Gray SJ,Tikkanen R

    更新日期:2017-03-26 00:00:00

  • Genetic Dissection of Grain Yield and Agronomic Traits in Maize under Optimum and Low-Nitrogen Stressed Environments.

    abstract::Understanding the genetic basis of maize grain yield and other traits under low-nitrogen (N) stressed environments could improve selection efficiency. In this study, five doubled haploid (DH) populations were evaluated under optimum and N-stressed conditions, during the main rainy season and off-season in Kenya and Rw...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Tadesse Ertiro B,Olsen M,Das B,Gowda M,Labuschagne M

    更新日期:2020-01-15 00:00:00

  • Platelet-Rich Fibrin Facilitates Rabbit Meniscal Repair by Promoting Meniscocytes Proliferation, Migration, and Extracellular Matrix Synthesis.

    abstract::Although platelet-rich fibrin (PRF) has been used in clinical practice for some time, to date, few studies reveal its role as a bioactive scaffold in facilitating meniscal repair. Here, the positive anabolic effects of PRF on meniscocytes harvested from the primary culture of a rabbit meniscus were revealed. The rabbi...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Wong CC,Kuo TF,Yang TL,Tsuang YH,Lin MF,Chang CH,Lin YH,Chan WP

    更新日期:2017-08-07 00:00:00