当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES期刊下所有文献 > P2 Receptors in Cardiac Myocyte Pathophysiology and Mechanotransduction.

P2 Receptors in Cardiac Myocyte Pathophysiology and Mechanotransduction.

Abstract：

:ATP is a major energy source in the mammalian cells, but it is an extracellular chemical messenger acting on P2 purinergic receptors. A line of evidence has shown that ATP is released from many different types of cells including neurons, endothelial cells, and muscle cells. In this review, we described the distribution of P2 receptor subtypes in the cardiac cells and their physiological and pathological roles in the heart. So far, the effects of external application of ATP or its analogues, and those of UTP on cardiac contractility and rhythm have been reported. In addition, specific genetic alterations and pharmacological agonists and antagonists have been adopted to discover specific roles of P2 receptor subtypes including P2X4-, P2X7-, P2Y2- and P2Y6-receptors in cardiac cells under physiological and pathological conditions. Accumulated data suggest that P2X4 receptors may play a beneficial role in cardiac muscle function, and that P2Y2- and P2Y6-receptors can induce cardiac fibrosis. Recent evidence further demonstrates P2Y1 receptor and P2X4 receptor as important mechanical signaling molecules to alter membrane potential and Ca2+ signaling in atrial myocytes and their uneven expression profile between right and left atrium.

journal_name

Int J Mol Sci

journal_title

International journal of molecular sciences

authors

Woo SH,Trinh TN

doi

10.3390/ijms22010251

subject

Has Abstract

pub_date

2020-12-29 00:00:00

issue

1

issn

1422-0067

pii

ijms22010251

journal_volume

22

pub_type

杂志文章,评审

相关文献

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES文献大全
  • Acetaminophen-Induced Rat Hepatotoxicity Based on M1/M2-Macrophage Polarization, in Possible Relation to Damage-Associated Molecular Patterns and Autophagy.

    abstract：:Overdose of acetaminophen (APAP), an antipyretic drug, is an important cause of liver injury. However, the mechanism in the rat model remains undetermined. We analyzed APAP-induced hepatotoxicity using rats based on M1/M2-macrophage functions in relation to damage-associated molecular patterns (DAMPs) and autophagy. L...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21238998

    authors： Tsuji Y,Kuramochi M,Golbar HM,Izawa T,Kuwamura M,Yamate J

    更新日期：2020-11-26 00:00:00

  • Combined Transcriptomics, Proteomics and Bioinformatics Identify Drug Targets in Spinal Cord Injury.

    abstract：:Spinal cord injury (SCI) causes irreversible tissue damage and severe loss of neurological function. Currently, there are no approved treatments and very few therapeutic targets are under investigation. Here, we combined 4 high-throughput transcriptomics and proteomics datasets, 7 days and 8 weeks following clinically...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms19051461

    authors： Tica J,Bradbury EJ,Didangelos A

    更新日期：2018-05-14 00:00:00

  • Human PSC-Derived Hepatocytes Express Low Levels of Viral Pathogen Recognition Receptors, but Are Capable of Mounting an Effective Innate Immune Response.

    abstract：:Hepatocytes are key players in the innate immune response to liver pathogens but are challenging to study because of inaccessibility and a short half-life. Recent advances in in vitro differentiation of hepatocyte-like cells (HLCs) facilitated studies of hepatocyte-pathogen interactions. Here, we aimed to define the a...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21113831

    authors： Fischer L,Lucendo-Villarin B,Hay DC,O'Farrelly C

    更新日期：2020-05-28 00:00:00

  • Norditerpenoids with Selective Anti-Cholinesterase Activity from the Roots of Perovskia atriplicifolia Benth.

    abstract：:Inhibition of cholinesterases remains one of a few available treatment strategies for neurodegenerative dementias such as Alzheimer's disease and related conditions. The current study was inspired by previous data on anticholinesterase properties of diterpenoids from Perovskia atriplicifolia and other Lamiaceae specie...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21124475

    authors： Ślusarczyk S,Senol Deniz FS,Abel R,Pecio Ł,Pérez-Sánchez H,Cerón-Carrasco JP,den-Haan H,Banerjee P,Preissner R,Krzyżak E,Oleszek W,E Orhan I,Matkowski A

    更新日期：2020-06-23 00:00:00

  • Dark Antibacterial Activity of Rose Bengal.

    abstract：:The global spread of bacterial resistance to antibiotics promotes a search for alternative approaches to eradication of pathogenic bacteria. One alternative is using photosensitizers for inhibition of Gram-positive and Gram-negative bacteria under illumination. Due to low penetration of visible light into tissues, app...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms20133196

    authors： Nakonechny F,Barel M,David A,Koretz S,Litvak B,Ragozin E,Etinger A,Livne O,Pinhasi Y,Gellerman G,Nisnevitch M

    更新日期：2019-06-29 00:00:00

  • The MTNR1B rs10830963 Variant in Interaction with Pre-Pregnancy BMI is a Pharmacogenetic Marker for the Initiation of Antenatal Insulin Therapy in Gestational Diabetes Mellitus.

    abstract：:The rs10830963 variant of the Melatonin Receptor 1B (MTNR1B) gene is associated with the development of gestational diabetes mellitus (GDM). We hypothesized that carrying the rs10830963/G risk allele had effect on antenatal insulin therapy (AIT) initiation in GDM in a body mass index (BMI)-dependent manner. Design: In...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms19123734

    authors： Firneisz G,Rosta K,Al-Aissa Z,Hadarits O,Harreiter J,Nádasdi Á,Bancher-Todesca D,Németh L,Igaz P,Rigó J Jr,Sziller I,Kautzky-Willer A,Somogyi A

    更新日期：2018-11-23 00:00:00

  • Special Issue of International Journal of Molecular Sciences (IJMS) "Purinergic P2 Receptors: Structure and Function".

    abstract：:This Special Issue of International Journal of Molecular Sciences (IJMS) contains 7 reviews and 12 original research papers written by a panel of experts who highlight recent advances in molecular structure and cellular function of purinergic P2 receptors[...]. ...

    journal_title：International journal of molecular sciences

    pub_type： 社论

    doi：10.3390/ijms22010383

    authors： Zemkova H

    更新日期：2020-12-31 00:00:00

  • Impaired Photic Entrainment of Spontaneous Locomotor Activity in Mice Overexpressing Human Mutant α-Synuclein.

    abstract：:Parkinson's disease (PD) is characterized by distinct motor and non-motor symptoms. Sleep disorders are the most frequent and challenging non-motor symptoms in PD patients, and there is growing evidence that they are a consequence of disruptions within the circadian system. PD is characterized by a progressive degener...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms19061651

    authors： Pfeffer M,Zimmermann Z,Gispert S,Auburger G,Korf HW,von Gall C

    更新日期：2018-06-03 00:00:00

  • Role of Hedgehog Signaling in Vasculature Development, Differentiation, and Maintenance.

    abstract：:The role of Hedgehog (Hh) signaling in vascular biology has first been highlighted in embryos by Pepicelli et al. in 1998 and Rowitch et al. in 1999. Since then, the proangiogenic role of the Hh ligands has been confirmed in adults, especially under pathologic conditions. More recently, the Hh signaling has been propo...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms20123076

    authors： Chapouly C,Guimbal S,Hollier PL,Renault MA

    更新日期：2019-06-24 00:00:00

  • Overexpression of ThMYC4E Enhances Anthocyanin Biosynthesis in Common Wheat.

    abstract：:The basic helix-loop helix (bHLH) transcription factor has been inferred to play an important role in blue and purple grain traits in common wheat, but to date, its overexpression has not been reported. In this study, the bHLH transcription factor ThMYC4E, the candidate gene controlling the blue grain trait from Th. P...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21010137

    authors： Zhao S,Xi X,Zong Y,Li S,Li Y,Cao D,Liu B

    更新日期：2019-12-24 00:00:00

  • Prognostic Role of Survivin and Macrophage Infiltration Quantified on Protein and mRNA Level in Molecular Subtypes Determined by RT-qPCR of KRT5, KRT20, and ERBB2 in Muscle-Invasive Bladder Cancer Treated by Adjuvant Chemotherapy.

    abstract：OBJECTIVES:Bladder cancer is a heterogeneous malignancy. Therefore, it is difficult to find single predictive markers. Moreover, most studies focus on either the immunohistochemical or molecular assessment of tumor tissues by next-generation sequencing (NGS) or PCR, while a combination of immunohistochemistry (IHC) and...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21197420

    authors： Ecke TH,Kiani A,Schlomm T,Friedersdorff F,Rabien A,Jung K,Kilic E,Boström P,Tervahartiala M,Taimen P,Gleichenhagen J,Johnen G,Brüning T,Koch S,Roggisch J,Wirtz RM

    更新日期：2020-10-08 00:00:00

  • Evidences from a Systematic Review and Meta-Analysis Unveil the Role of MiRNA Polymorphisms in the Predisposition to Female Neoplasms.

    abstract：:Breast (BCa) and gynecological (GCa) cancers constitute a group of female neoplasms that has a worldwide significant contribution to cancer morbidity and mortality. Evidence suggests that polymorphisms influencing miRNA function can provide useful information towards predicting the risk of female neoplasms. Inconsiste...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,meta分析

    doi：10.3390/ijms20205088

    authors： Bastami M,Choupani J,Saadatian Z,Zununi Vahed S,Ouladsahebmadarek E,Mansoori Y,Daraei A,Samadi Kafil H,Yousefi B,Mahdipour M,Masotti A,Nariman-Saleh-Fam Z

    更新日期：2019-10-14 00:00:00

  • Rosmarinic Acid Attenuates Cadmium-Induced Nephrotoxicity via Inhibition of Oxidative Stress, Apoptosis, Inflammation and Fibrosis.

    abstract：:The present investigation was executed to reveal the protective mechanism of rosmarinic acid (RA) against cadmium (Cd)-induced nephrotoxicity. RA exhibited a concentration-dependent anti-apoptotic effect against CdCl2 in isolated mouse proximal tubular epithelial cells. Cd treatment significantly (p < 0.01) imparted o...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms20082027

    authors： Joardar S,Dewanjee S,Bhowmick S,Dua TK,Das S,Saha A,De Feo V

    更新日期：2019-04-24 00:00:00

  • Maintenance of Type 2 Response by CXCR6-Deficient ILC2 in Papain-Induced Lung Inflammation.

    abstract：:Innate lymphoid cells (ILC) are important players of early immune defenses in situations like lymphoid organogenesis or in case of immune response to inflammation, infection and cancer. Th1 and Th2 antagonism is crucial for the regulation of immune responses, however mechanisms are still unclear for ILC functions. ILC...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms20215493

    authors： Meunier S,Chea S,Garrido D,Perchet T,Petit M,Cumano A,Golub R

    更新日期：2019-11-04 00:00:00

  • Polymorphic Forms of Valinomycin Investigated by NMR Crystallography.

    abstract：:A dodecadepsipeptide valinomycin (VLM) has been most recently reported to be a potential anti-coronavirus drug that could be efficiently produced on a large scale. It is thus of importance to study solid-phase forms of VLM in order to be able to ensure its polymorphic purity in drug formulations. The previously availa...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21144907

    authors： Czernek J,Brus J

    更新日期：2020-07-11 00:00:00

  • Transcriptional Analysis of C-Repeat Binding Factors in Fruit of Citrus Species with Differential Sensitivity to Chilling Injury during Postharvest Storage.

    abstract：:Citrus fruit are sensitive to chilling injury (CI) during cold storage, a peel disorder that causes economic losses. C-repeat binding factors (CBFs) are related to cold acclimation and tolerance in different plants. To explore the role of Citrus CBFs in fruit response to cold, an in silico study was performed, reveali...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms22020804

    authors： Salvo M,Rey F,Arruabarrena A,Gambetta G,Rodrigo MJ,Zacarías L,Lado J

    更新日期：2021-01-15 00:00:00

  • Microtubule Dysfunction: A Common Feature of Neurodegenerative Diseases.

    abstract：:Neurons are particularly susceptible to microtubule (MT) defects and deregulation of the MT cytoskeleton is considered to be a common insult during the pathogenesis of neurodegenerative disorders. Evidence that dysfunctions in the MT system have a direct role in neurodegeneration comes from findings that several forms...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms21197354

    authors： Sferra A,Nicita F,Bertini E

    更新日期：2020-10-05 00:00:00

  • Murine Long Noncoding RNA Morrbid Contributes in the Regulation of NRAS Splicing in Hepatocytes In Vitro.

    abstract：:The coupling of alternative splicing with the nonsense-mediated decay (NMD) pathway maintains quality control of the transcriptome in eukaryotes by eliminating transcripts with premature termination codons (PTC) and fine-tunes gene expression. Long noncoding RNA (lncRNA) can regulate multiple cellular processes, inclu...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21165605

    authors： Fefilova A,Melnikov P,Prikazchikova T,Abakumova T,Kurochkin I,Mazin PV,Ziganshin R,Sergeeva O,Zatsepin TS

    更新日期：2020-08-05 00:00:00

  • Constitutive Activation and Inactivation of Mutations Inducing Cell Surface Loss of Receptor and Impairing of Signal Transduction of Agonist-Stimulated Eel Follicle-Stimulating Hormone Receptor.

    abstract：:In the present study, we investigated the signal transduction of mutants of the eel follicle-stimulating hormone receptor (eelFSHR). Specifically, we examined the constitutively activating mutant D540G in the third intracellular loop, and four inactivating mutants (A193V, N195I, R546C, and A548V). To directly assess f...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21197075

    authors： Byambaragchaa M,Kim JS,Park HK,Kim DJ,Hong SM,Kang MH,Min KS

    更新日期：2020-09-25 00:00:00

  • Targeting CD46 Enhances Anti-Tumoral Activity of Adenovirus Type 5 for Bladder Cancer.

    abstract：:CD46 is generally overexpressed in many human cancers, representing a prime target for CD46-binding adenoviruses (Ads). This could help to overcome low anti-tumoral activity by coxsackie-adenoviral receptor (CAR)-targeting cancer gene therapy viruses. However, because of scarce side-by-side information about CAR and C...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms19092694

    authors： Do MH,To PK,Cho YS,Kwon SY,Hwang EC,Choi C,Cho SH,Lee SJ,Hemmi S,Jung C

    更新日期：2018-09-10 00:00:00

  • Application of Chromatographic and Spectroscopic Methods towards the Quality Assessment of Ginger (Zingiber officinale) Rhizomes from Ecological Plantations.

    abstract：:The usefulness of ginger in the food industry and pharmacotherapy is strictly related to its content of various components. The study elucidates the chemical composition of Zingiber officinale rhizomes cultivated on ecological plantations on Shikoku Island (Japan). GC-MS analysis of terpene content, LC-MS determinatio...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms18020452

    authors： Koch W,Kukula-Koch W,Marzec Z,Kasperek E,Wyszogrodzka-Koma L,Szwerc W,Asakawa Y

    更新日期：2017-02-20 00:00:00

  • A Two-in-One Strategy: Target and Nontarget Site Mechanisms Both Play Important Role in IMI-Resistant Weedy Rice.

    abstract：:The introduction of Clearfield technology allows the use of imidazolinone (IMI) herbicides to control weedy rice. Imidazolinone herbicides stop the acetolactate synthase (ALS) enzyme from synthesizing branched-chain amino acids, resulting in the death of the plant. Since the launch of Clearfield technology in Malaysia...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms22030982

    authors： Yean RA,Dilipkumar M,Rahman S,Song BK

    更新日期：2021-01-20 00:00:00

  • Different impacts of cardiovascular risk factors on oxidative stress.

    abstract：:The objective of the study was to evaluate oxidative stress (OS) status in subjects with different cardiovascular risk factors. With this in mind, we have studied three models of high cardiovascular risk: hypertension (HT) with and without metabolic syndrome, familial hypercholesterolemia (FH) and familial combined hy...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms12096146

    authors： Mansego ML,Redon J,Martinez-Hervas S,Real JT,Martinez F,Blesa S,Gonzalez-Albert V,Saez GT,Carmena R,Chaves FJ

    更新日期：2011-01-01 00:00:00

  • Synthesis and biological evaluation of 2-aminobenzamide derivatives as antimicrobial agents: opening/closing pharmacophore site.

    abstract：:A series of new 2-aminobenzamide derivatives (1-10) has been synthesized in good to excellent yields by adopting both conventional and/or a time-efficient microwave assisted methodologies starting from isatoic anhydride (ISA) and characterized on the basis of their physical, spectral and microanalytical data. Selected...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms15035115

    authors： Mabkhot YN,Al-Majid AM,Barakat A,Al-Showiman SS,Al-Har MS,Radi S,Naseer MM,Hadda TB

    更新日期：2014-03-21 00:00:00

  • Guanosine-Mediated Anxiolytic-Like Effect: Interplay with Adenosine A1 and A2A Receptors.

    abstract：:Acute or chronic administration of guanosine (GUO) induces anxiolytic-like effects, for which the adenosine (ADO) system involvement has been postulated yet without a direct experimental evidence. Thus, we aimed to investigate whether adenosine receptors (ARs) are involved in the GUO-mediated anxiolytic-like effect, e...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21239281

    authors： Frinchi M,Verdi V,Plescia F,Ciruela F,Grillo M,Garozzo R,Condorelli DF,Di Iorio P,Caciagli F,Ciccarelli R,Belluardo N,Di Liberto V,Mudò G

    更新日期：2020-12-05 00:00:00

  • Analysis of Orthologous SECONDARY WALL-ASSOCIATED NAC DOMAIN1 (SND1) Promotor Activity in Herbaceous and Woody Angiosperms.

    abstract：:SECONDARY WALL-ASSOCIATED NAC DOMAIN1 (SND1) is a master regulator of fibre secondary wall deposition in Arabidopsis thaliana (Arabidopsis), with homologs in other angiosperms and gymnosperms. However, it is poorly understood to what extent the fibre-specific regulation of the SND1 promoter, and that of its orthologs,...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms20184623

    authors： Tonfack LB,Hussey SG,Veale A,Myburg AA,Mizrachi E

    更新日期：2019-09-18 00:00:00

  • Health Functions and Related Molecular Mechanisms of Tea Components: An Update Review.

    abstract：:Tea is widely consumed all over the world. Generally, tea is divided into six categories: White, green, yellow, oolong, black, and dark teas, based on the fermentation degree. Tea contains abundant phytochemicals, such as polyphenols, pigments, polysaccharides, alkaloids, free amino acids, and saponins. However, the b...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms20246196

    authors： Tang GY,Meng X,Gan RY,Zhao CN,Liu Q,Feng YB,Li S,Wei XL,Atanasov AG,Corke H,Li HB

    更新日期：2019-12-08 00:00:00

  • Radiolabeled 6-(2, 3-Dichlorophenyl)-N4-methylpyrimidine-2, 4-diamine (TH287): A Potential Radiotracer for Measuring and Imaging MTH1.

    abstract：:MTH1 (MutT homolog 1) or NUDT1 (Nudix Hydrolase 1), also known as oxidized purine nucleoside triphosphatase, has potential as a biomarker for monitoring cancer progression and quantifying target engagement for relevant therapies. In this study, we validate one MTH1 inhibitor TH287 as a PET MTH1 radiotracer. TH287 was ...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21228860

    authors： Chen H,Afrin S,Guo Y,Chu W,Benzinger TLS,Rogers BE,Garbow JR,Perlmutter JS,Zhou D,Xu J

    更新日期：2020-11-23 00:00:00

  • The Role of Peroxisome Proliferator-Activated Receptors and Their Transcriptional Coactivators Gene Variations in Human Trainability: A Systematic Review.

    abstract：BACKGROUND:The peroxisome proliferator-activated receptors (PPARA, PPARG, PPARD) and their transcriptional coactivators' (PPARGC1A, PPARGC1B) gene polymorphisms have been associated with muscle morphology, oxygen uptake, power output and endurance performance. The purpose of this review is to determine whether the PPAR...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,meta分析,评审

    doi：10.3390/ijms19051472

    authors： Petr M,Stastny P,Zajac A,Tufano JJ,Maciejewska-Skrendo A

    更新日期：2018-05-15 00:00:00

  • Picropodophyllotoxin, an Epimer of Podophyllotoxin, Causes Apoptosis of Human Esophageal Squamous Cell Carcinoma Cells Through ROS-Mediated JNK/P38 MAPK Pathways.

    abstract：:Esophageal squamous cell carcinoma (ESCC), a major histologic type of esophageal cancer, is one of the frequent causes of cancer-related death worldwide. Picropodophyllotoxin (PPT) is the main component of Podophyllum hexandrum root with antitumor activity via apoptosis-mediated mechanisms in several cancer cells. How...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21134640

    authors： Kwak AW,Yoon G,Lee MH,Cho SS,Shim JH,Chae JI

    更新日期：2020-06-30 00:00:00