Bioinformatics Approaches for Fetal DNA Fraction Estimation in Noninvasive Prenatal Testing.

abstract：:Naturally existing Chlorogenic acid (CGA) is an antioxidant-rich compound reported to act a chemopreventive agent by scavenging free radicals and suppressing cancer-causing mechanisms. Conversely, the compound's poor thermal and pH (neutral and basic) stability, poor solubility, and low cellular permeability have been...

journal_title：International journal of molecular sciences

authors： Kavi Rajan R,Hussein MZ,Fakurazi S,Yusoff K,Masarudin MJ

更新日期：2019-09-20 00:00:00

abstract：:The floral development in an important legume crop yellow lupine (Lupinus luteus L., Taper cv.) is often affected by the abscission of flowers leading to significant economic losses. Small non-coding RNAs (sncRNAs), which have a proven effect on almost all developmental processes in other plants, might be of key playe...

journal_title：International journal of molecular sciences

authors： Glazińska P,Kulasek M,Glinkowski W,Wojciechowski W,Kosiński J

更新日期：2019-10-16 00:00:00

abstract：:Three quinary polar intermetallic compounds in the (Eu(1-x)Ca(x))9In8(Ge(1-y)Sn(y))8 (x = 0.66, y = 0.03) and the (Eu(1-x)Ca(x))3In(Ge(3-y)Sn(1+y)) (x = 0.66, 0.68; y = 0.13, 0.27) phases have been synthesized using the molten In-metal flux method, and the crystal structures are characterized by powder and single-crys...

journal_title：International journal of molecular sciences

authors： Woo H,Jang E,Kim J,Lee Y,Kim J,You TS

更新日期：2015-04-22 00:00:00

abstract：:Chronic immune response to bone implant may lead to delayed healing and its failure. Thus, newly developed biomaterials should be characterized by high biocompatibility. Moreover, it is well known that macrophages play a crucial role in the controlling of biomaterial-induced inflammatory response. Immune cells synthes...

journal_title：International journal of molecular sciences

authors： Kazimierczak P,Koziol M,Przekora A

更新日期：2021-01-23 00:00:00

abstract：BACKGROUND:Epstein-Barr Virus (EBV) positive and microsatellite unstable (MSI-high) gastric cancer (GC) are molecular subgroups with distinctive molecular profiles. We explored the transcriptomic differences between EBV+ and MSI-high GCs, and the expression of current GC immunotherapy targets such as PD-1, PD-L1, CTLA4...

journal_title：International journal of molecular sciences

authors： Gullo I,Carvalho J,Martins D,Lemos D,Monteiro AR,Ferreira M,Das K,Tan P,Oliveira C,Carneiro F,Oliveira P

更新日期：2018-07-17 00:00:00

abstract：:Molecular Dynamics is a method of choice for membrane simulations and the rising of coarse-grained forcefields has opened the way to longer simulations with reduced calculations times. Here, we present an elastic network, SAHBNET (Surface Accessibility Hydrogen-Bonds elastic NETwork), that will maintain the structure ...

journal_title：International journal of molecular sciences

authors： Dony N,Crowet JM,Joris B,Brasseur R,Lins L

更新日期：2013-05-30 00:00:00

abstract：:Epigenetic modifications have emerged into one of the cancer hallmarks, replacing the concept of malignant pathologies as being solely genetic-based conditions. The epigenetic landscape is responsible for normal development but also for the heterogeneity among tissues in terms of gene expression patterns. Dysregulatio...

journal_title：International journal of molecular sciences

authors： Irimie AI,Ciocan C,Gulei D,Mehterov N,Atanasov AG,Dudea D,Berindan-Neagoe I

更新日期：2018-02-27 00:00:00

abstract：:The aim of this review article is to introduce the reader to the state-of-the-art of the contribution that proteomics and metabolomics sciences are currently providing for cystic fibrosis (CF) research: from the understanding of cystic fibrosis transmembrane conductance regulator (CFTR) biology to biomarker discovery ...

journal_title：International journal of molecular sciences

authors： Liessi N,Pedemonte N,Armirotti A,Braccia C

更新日期：2020-07-30 00:00:00

abstract：:In advanced cirrhosis, the TNFα-mediated intestinal inflammation and bacteria dysbiosis are involved in the development of inflammation and vasoconstriction-related renal dysfunction. In colitis and acute kidney injury models, activation of SIRT1 attenuates the TNFα-mediated intestinal and renal abnormalities. This st...

journal_title：International journal of molecular sciences

authors： Chou YT,Liu TT,Yang UC,Huang CC,Liu CW,Huang SF,Li TH,Liu HM,Lin MW,Yang YY,Lee TY,Huang YH,Hou MC,Lin HC

更新日期：2021-01-27 00:00:00

abstract：:The world faces the serious problem of aging. In this study, we aimed to investigate the effect of chlorogenic acid (CGA) on vascular senescence. C57/BL6 female mice that were 14 ± 3 months old were infused with either Angiotensin II (AngII) or saline subcutaneously for two weeks. These mice were administered CGA of 2...

journal_title：International journal of molecular sciences

authors： Hada Y,Uchida HA,Otaka N,Onishi Y,Okamoto S,Nishiwaki M,Takemoto R,Takeuchi H,Wada J

更新日期：2020-06-25 00:00:00

abstract：:A major hallmark of diabetes is a constant high blood glucose level (hyperglycaemia), resulting in endothelial dysfunction. Transient or prolonged hyperglycemia can cause diabetic vasculopathy, a secondary systemic damage. C-Peptide is a product of cleavage of proinsulin by a serine protease that occurs within the pan...

journal_title：International journal of molecular sciences

authors： Souto SB,Campos JR,Fangueiro JF,Silva AM,Cicero N,Lucarini M,Durazzo A,Santini A,Souto EB

更新日期：2020-01-18 00:00:00

abstract：BACKGROUND:The determinants that mediate the interactions between microRNAs and the gut microbiome impacting on obesity are scarcely understood. Thus, the aim of this study was to investigate possible interactions between circulating microRNAs and gut microbiota composition in obesity. METHOD:The sample comprised 78 s...

journal_title：International journal of molecular sciences

authors： Assmann TS,Cuevas-Sierra A,Riezu-Boj JI,Milagro FI,Martínez JA

更新日期：2020-12-14 00:00:00

abstract：:Amyloid A (AA) amyloidosis is a condition in which amyloid fibrils characterized by a linear morphology and a cross-β structure accumulate and are deposited extracellularly in organs, resulting in chronic inflammatory diseases and infections. The incidence of AA amyloidosis is high in humans and several animal species...

journal_title：International journal of molecular sciences

authors： Lin X,Watanabe K,Kuragano M,Tokuraku K

更新日期：2021-01-21 00:00:00

abstract：:Single nucleotide polymorphisms (SNPs) are currently the marker of choice in a variety of genetic studies. Using the high resolution melting (HRM) genotyping approach, 101 gene-based SNP markers were developed for Apostichopus japonicus, a sea cucumber species with economic significance for the aquaculture industry in...

journal_title：International journal of molecular sciences

authors： Du H,Bao Z,Yan J,Tian M,Mu X,Wang S,Lu W

更新日期：2012-01-01 00:00:00

abstract：:Broad Copy Number Gains (BCNGs) are copy-number increases of chromosomes or large segments of chromosomal arms. Publicly-available single-nucleotide polymorphism (SNP) array and RNA-Seq data of colon adenocarcinoma (COAD) samples from The Cancer Genome Atlas (TCGA) consortium allowed us to design better control groups...

journal_title：International journal of molecular sciences

authors： Condorelli DF,Privitera AP,Barresi V

更新日期：2019-09-19 00:00:00

abstract：:The insulin-like growth factor (IGF) pathway plays an important role in several brain tumor entities. However, the lack of inhibitors crossing the blood-brain barrier remains a significant obstacle for clinical translation. Here, we targeted the IGF pathway using ceritinib, an off-target inhibitor of the IGF1 receptor...

journal_title：International journal of molecular sciences

authors： Russo A,Paret C,Alt F,Burhenne J,Fresnais M,Wagner W,Glaser M,Bender H,Huprich S,Harter PN,Filipski K,Lehmann N,Backes N,Roth L,Seidmann L,Sommer C,Brockmann MA,Pietsch T,Neu MA,Wingerter A,Faber J

更新日期：2019-08-30 00:00:00

abstract：:Endonuclease IV (EndoIV) is a DNA damage-specific endonuclease that mainly hydrolyzes the phosphodiester bond located at 5' of an apurinic/apyrimidinic (AP) site in DNA. EndoIV also possesses 3'-exonuclease activity for removing 3'-blocking groups and normal nucleotides. Here, we report that Thermococcus eurythermalis...

journal_title：International journal of molecular sciences

authors： Wang WW,Zhou H,Xie JJ,Yi GS,He JH,Wang FP,Xiao X,Liu XP

更新日期：2018-12-24 00:00:00

abstract：:L-3,4-dihydroxyphenylalanine (L-DOPA) has been successfully used in the treatment of Parkinson's disease (PD) for more than 50 years. It fulfilled the criteria to cross the blood-brain barrier and counteract the biochemical defect of dopamine (DA). It remarkably worked after some adjustments in line with the initial h...

journal_title：International journal of molecular sciences

authors： Chagraoui A,Boulain M,Juvin L,Anouar Y,Barrière G,Deurwaerdère P

更新日期：2019-12-31 00:00:00

abstract：:The ocular surface has the challenging responsibility of maintaining a clear moist refractive surface while protecting the eye from exogenous pathogens and the environment. Homeostasis of the ocular surface, including its innate immune components, is altered in ocular surface disease states. In this review, we focus o...

journal_title：International journal of molecular sciences

authors： Eshac Y,Redfern RL,Aakalu VK

更新日期：2021-01-13 00:00:00

abstract：:Supercritical fluid extraction (SFE) was used in the analysis of bacterial respiratory quinone (RQ), bacterial phospholipid fatty acid (PLFA), and archaeal phospholipid ether lipid (PLEL) from anaerobically digested sludge. Bacterial RQ were determined using ultra performance liquid chromatography (UPLC). Determinatio...

journal_title：International journal of molecular sciences

authors： Hanif M,Atsuta Y,Fujie K,Daimon H

更新日期：2012-01-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is a leading cause of cancer-related morbidity and mortality worldwide. Most patients are diagnosed with advanced disease, limiting their options for treatment. While current treatments are adequate for lower staged disease, available systemic treatments are limited, with marginal benefi...

journal_title：International journal of molecular sciences

authors： Patel K,Lamm R,Altshuler P,Dang H,Shah AP

更新日期：2020-09-15 00:00:00

abstract：:Hypoxia inducible factor 1 (HIF-1) is a transcription factor composed of two subunits, namely, HIF-1α and HIF-1β, in which HIF-1β is constitutively expressed. HIF-1 upregulates several hypoxia-responsive proteins, including angiogenesis factors, glycolysis solution enzymes, and cell survival proteins. HIF-1 is also as...

journal_title：International journal of molecular sciences

authors： Li N,Li Y,Li Z,Huang C,Yang Y,Lang M,Cao J,Jiang W,Xu Y,Dong J,Ren H

更新日期：2016-06-03 00:00:00

abstract：:Microglia constitute the resident immunocompetent cells of the central nervous system. Although much work has focused on their ability to mount an inflammatory response in reaction to pathology, recent studies have delved into their role in maintaining homeostasis in the healthy brain. It is important to note that the...

journal_title：International journal of molecular sciences

authors： Nissen JC

更新日期：2017-03-04 00:00:00

abstract：:Idiopathic pulmonary fibrosis (IPF) is a chronic disease characterized by fibroblasts activation, ECM accumulation, and diffused alveolar inflammation. The role of inflammation in IPF is still controversial and its involvement may follow nontraditional mechanisms. It is seen that a pathological microenvironment may af...

journal_title：International journal of molecular sciences

authors： Bonifazi M,Di Vincenzo M,Caffarini M,Mei F,Salati M,Zuccatosta L,Refai M,Mattioli-Belmonte M,Gasparini S,Orciani M

更新日期：2020-10-30 00:00:00

abstract：:The plant-specific WUSCHEL-related homeobox (WOX) transcription factor gene family is important for plant growth and development but little studied in oil crops. We identified and characterized 58 putative WOX genes in Brassica napus (BnWOXs), which were divided into three major clades and nine subclades based on the ...

journal_title：International journal of molecular sciences

authors： Wang MM,Liu MM,Ran F,Guo PC,Ke YZ,Wu YW,Wen J,Li PF,Li JN,Du H

更新日期：2018-11-05 00:00:00

abstract：:Oral squamous cell carcinoma (OSCC) is one of the most common cancers worldwide. In China, its 5-year survival rate is roughly 50%, owing to acquired chemotherapeutic resistance and metastasis of the disease. Accumulating evidence demonstrates that aspirin (ASA) acts as a preventive or therapeutic agent in multiple ca...

journal_title：International journal of molecular sciences

authors： Zhang X,Feng H,Li Z,Guo J,Li M

更新日期：2018-07-12 00:00:00

abstract：:Present day awareness of biofilm colonization on polymeric surfaces has prompted the scientific community to develop an ever-increasing number of new materials with anti-biofilm features. However, compared to the large amount of work put into discovering potent biofilm inhibitors, only a small number of papers deal wi...

journal_title：International journal of molecular sciences

authors： Cattò C,Cappitelli F

更新日期：2019-08-03 00:00:00

abstract：:The MP2 and DFT/B3LYP methods at 6-311++G(d,p) and aug-cc-pdz basis sets have been used to probe the origin of relative stability preference for eclipsed acetaldehyde over its bisected counterpart. A relative energy stability range of 1.02 to 1.20 kcal/mol, in favor of the eclipsed conformer, was found and discussed. ...

journal_title：International journal of molecular sciences

authors： Osman OI,Alyoubi AO,Elroby SA,Hilal RH,Aziz SG

更新日期：2012-11-20 00:00:00

abstract：:Rice (Oryza sativa L.) is a widely cultivated food crop around the world, especially in Asia. However, rice seedlings often suffer from cold stress, which affects their growth and yield. Here, RNA-seq analysis and Meta-QTLs mapping were performed to understand the molecular mechanisms underlying cold tolerance in the ...

journal_title：International journal of molecular sciences

authors： Kong W,Zhang C,Qiang Y,Zhong H,Zhao G,Li Y

更新日期：2020-06-29 00:00:00

abstract：:The translation of metallothioneins (MTs) is one of the defense strategies by which organisms protect themselves from metal-induced toxicity. MTs belong to a family of proteins comprising MT-1, MT-2, MT-3, and MT-4 classes, with multiple isoforms within each class. The main aim of this study was to determine the behav...

journal_title：International journal of molecular sciences

authors： Merlos Rodrigo MA,Molina-López J,Jimenez Jimenez AM,Planells Del Pozo E,Adam P,Eckschlager T,Zitka O,Richtera L,Adam V

更新日期：2017-03-11 00:00:00