Abstract：
:Cancer vaccines may be harnessed to incite immunity against poorly immunogenic tumors, however they have failed in therapeutic settings. Poor antigenicity coupled with systemic and intratumoral immune suppression have been significant drawbacks. RNA encoding for tumor associated or specific epitopes can serve as a more immunogenic and expeditious trigger of anti-tumor immunity. RNA stimulates innate immunity through toll like receptor stimulation producing type I interferon, and it mediates potent adaptive responses. Since RNA is inherently unstable, delivery systems have been developed to protect and deliver it to intended targets in vivo. In this review, we discuss liposomes as RNA delivery vehicles and their role as cancer vaccines.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Sayour EJ,Mendez-Gomez HR,Mitchell DAdoi
10.3390/ijms19102890subject
Has Abstractpub_date
2018-09-23 00:00:00issue
10issn
1422-0067pii
ijms19102890journal_volume
19pub_type
杂志文章,评审abstract：:Research on the supramolecular buildup of eumelanin has gained high momentum in the last years. Several new aspects regarding the involved structures and mechanisms have been established, which has led to a better understanding of the entire process. This review intends to provide a clearly laid-out summary of previou...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms18091901
更新日期：2017-09-06 00:00:00
abstract：:Fetal programming implies that the maternal diet during pregnancy affects the long-term health of offspring. Although maternal diet influences metabolic disorders and non-alcoholic fatty liver disease in offspring, the hepatic mechanisms related to metabolites are still unknown. Here, we investigated the maternal diet...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21239060
更新日期：2020-11-28 00:00:00
abstract：:Adlay (Coix larchryma-jobi L.) was the commonly used Traditional Chinese Medicine (TCM) with high content of seed storage protein. The hydrolyzed bioactive oligopeptides of adlay have been proven to be anti-hypertensive effective components. However, the structures and anti-hypertensive mechanism of bioactive oligopep...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms17122099
更新日期：2016-12-14 00:00:00
abstract：:A series of novel purpurinimides with long wavelength absorption were designed and synthesized to develop novel and potential photosensitizers. These compounds were investigated through reduction, oxidation, rearrangement reaction and amidation reactions of methyl pheophorbide a. They demonstrated a considerable batho...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms15058091
更新日期：2014-05-08 00:00:00
abstract：:We have originally reported that colony-forming units granulocyte/macrophage (CFU-GM) formation is an in vitro feature of chronic myelomonocytic leukemia (CMML) and a strong predictor for short survival. Elucidation of the molecular basis underlying this in vitro phenomenon could be helpful to define molecular feature...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21176057
更新日期：2020-08-22 00:00:00
abstract：:Pyrroloquinoline quinone (PQQ) is a novel stimulator of mitochondrial biogenesis and cellular energy metabolism. This is the first study investigating regulatory mechanisms and metabolic responses underlying PQQ's action in palmitate-exposed L6 myotubes. Particularly, we assessed alterations in lipid content and compo...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21218382
更新日期：2020-11-08 00:00:00
abstract：:Gelam honey exerts anti-inflammatory and antioxidant activities and is thought to have potent effects in reducing infections and healing wounds. The aim of this study was to investigate the effects of intravenously-injected Gelam honey in protecting organs from lethal doses of lipopolysaccharide (LPS). Six groups of r...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms13056370
更新日期：2012-01-01 00:00:00
abstract：:Type 2 innate lymphoid cells (ILC2s) and their adaptive counterpart type 2 T helper (TH2) cells respond to interleukin-33 (IL-33) by producing IL-5, which is a crucial cytokine for eosinophil development in the bone marrow. The aim of this study was to determine if bone marrow ILC2s, TH cells, and eosinophils are loca...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21113751
更新日期：2020-05-26 00:00:00
abstract：:We have previously reported that adipose tissue-derived stem cells (ASCs) cultured at high cell density can induce cancer cell death through the expression of type I interferons and tumor necrosis factor (TNF)-related apoptosis-inducing ligands (TRAIL). Here, we investigated whether TRAIL-expressing ASCs induced by M1...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21113887
更新日期：2020-05-29 00:00:00
abstract：:MicroRNAs (miRNAs) play important roles in the progression of human cancer. Although previous reports have shown that miR-145-5p is down-regulated in esophageal squamous cell carcinoma (ESCC), the roles and mechanisms of down-regulation of miR-145-5p in ESCC are still largely unknown. Using microRNA microarray and Gen...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms18091833
更新日期：2017-08-23 00:00:00
abstract：:Hedgehog (Hh) proteins are prototypical morphogens known to regulate epithelial/mesenchymal interactions during embryonic development. In addition to its pivotal role in embryogenesis, the Hh signaling pathway may be recapitulated in post-natal life in a number of physiological and pathological conditions, including i...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms20215270
更新日期：2019-10-24 00:00:00
abstract：BACKGROUND:Fisetin (3,7,3',4'-tetrahydroxyflavone) is a dietary flavonol and exhibits antioxidant, anti-inflammatory, and neuroprotective activities. However, high concentration of fisetin is reported to produce reactive oxygen species (ROS), induce endoplasmic reticulum (ER) stress and cause cytotoxicity in cancer cel...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms18040852
更新日期：2017-04-17 00:00:00
abstract：:Mammalian aquaporins (AQPs) are transmembrane channels expressed in a large variety of cells and tissues throughout the body. They are known as water channels, but they also facilitate the transport of small solutes, gasses, and monovalent cations. To date, 13 different AQPs, encoded by the genes AQP0-AQP12, have been...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms20082039
更新日期：2019-04-25 00:00:00
abstract：:We have previously shown that neural precursor cell-expressed developmentally downregulated gene 4-2 (Nedd4-2) isoforms with a C2 domain are closely related to ubiquitination of epithelial sodium channel (ENaC), resulting in salt-sensitive hypertension by Nedd4-2 C2 targeting in mice. The sodium voltage-gated channel ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms18061268
更新日期：2017-06-14 00:00:00
abstract：:Heme oxygenase 1 (HO-1) and carbon monoxide were shown to normalize oxidative stress and inflammatory reactions induced by neuropathic pain in the central nervous system, but their effects in the locus coeruleus (LC) of animals with peripheral inflammation and their interaction with nitric oxide are unknown. In wild-t...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20092211
更新日期：2019-05-05 00:00:00
abstract：:Lung squamous cell carcinoma (LUSC) is often diagnosed at the advanced stage with poor prognosis. The mechanisms of its pathogenesis and prognosis require urgent elucidation. This study was performed to screen potential biomarkers related to the occurrence, development and prognosis of LUSC to reveal unknown physiolog...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21082994
更新日期：2020-04-23 00:00:00
abstract：:Wounding is a serious environmental stress in plants. Oxylipins such as jasmonic acid play an important role in defense against wounding. Mechanisms to adapt to wounding have been investigated in vascular plants; however, those mechanisms in nonvascular plants remain elusive. To examine the response to wounding in Phy...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21041417
更新日期：2020-02-19 00:00:00
abstract：:Cotton is one of the most economically important crops in the world, and it is exposed to various abiotic stresses during its lifecycle, especially salt stress. However, the molecular mechanisms underlying cotton tolerance to salt stress are still not fully understood due to the complex nature of salt response. Theref...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20215244
更新日期：2019-10-23 00:00:00
abstract：:We previously demonstrated that clinical administration of mobilized CD133+ bone marrow stem cells (BMSC) accelerates hepatic regeneration. Here, we investigated the potential of platelets to modulate CD133+BMSC homing to hepatic endothelial cells and sequestration to warm ischemic livers. Modulatory effects of platel...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21176431
更新日期：2020-09-03 00:00:00
abstract：:Phenolic compounds are responsible of the nutritional and sensory quality of extra-virgin olive oil (EVOO). The composition of phenolic compounds in EVOO is related to the initial content of phenolic compounds in the olive-fruit tissues and the activity of enzymes acting on these compounds during the industrial proces...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms17030337
更新日期：2016-03-04 00:00:00
abstract：:Arterial wall remodeling underlies increased pulmonary vascular resistance and right heart failure in pulmonary arterial hypertension (PAH). None of the established vasodilator drug therapies for PAH prevents or reverse established arterial wall thickening, stiffening, and hypercontractility. Therefore, new approaches...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21239222
更新日期：2020-12-03 00:00:00
abstract：:Speckle-type BTB/POZ protein (SPOP) is a substrate recognition receptor of the cullin-3 (CUL3)/RING type ubiquitin E3 complex. To date, approximately 30 proteins have been identified as ubiquitinated substrates of the CUL3/SPOP complex. Pathologically, missense mutations in the substrate-binding domain of SPOP have be...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21197293
更新日期：2020-10-02 00:00:00
abstract：:Soluble receptors are widely understood to be freestanding moieties formed via cleavage from their membrane-bound counterparts. They have unique structures, are found among various receptor families, and have intriguing mechanisms of generation and release. Soluble receptors' ability to exhibit pleiotropic action by r...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms22031108
更新日期：2021-01-23 00:00:00
abstract：:In many social anxiety disorder (SAD) patients, the efficacy of antidepressant therapy is unsatisfactory. Here, we investigated whether mice deficient for the lysosomal glycoprotein acid sphingomyelinase (ASM-/-) represent an appropriate tool to study antidepressant-resistant social fear. We also investigated whether ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21218220
更新日期：2020-11-03 00:00:00
abstract：:Alfalfa is an autotetraploid, allogamous and heterozygous forage legume, whose varieties are synthetic populations. Due to the complex nature of the species, information about genetic diversity of germplasm used in any alfalfa breeding program is most beneficial. The genetic diversity of five alfalfa varieties, involv...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms12085449
更新日期：2011-01-01 00:00:00
abstract：:The application of combined nitrogen, especially nitrate, to soybean plants is known to strongly inhibit nodule formation, growth and nitrogen fixation. In the present study, we measured the effects of supplying 5 mM nitrate on the growth of nodules, primary root, and lateral roots under light at 28 °C or dark at 18 °...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms15034464
更新日期：2014-03-13 00:00:00
abstract：:Gaucher disease (GD) is an autosomal recessive lysosomal storage disorder caused by mutations in the acid β-glucosidase gene (GBA1). Besides causing GD, GBA1 mutations constitute the main genetic risk factor for developing Parkinson's disease. The molecular basis of neurological manifestations in GD remain elusive. Ho...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21093268
更新日期：2020-05-05 00:00:00
abstract：:Bladder cancer (BC) remains the most common malignancy of urinary tract. Sex-related differences in BC epidemiology, diagnosis, therapy, and outcomes have been reported. Throughout the recent years, extensive research has been devoted to genetic and molecular alterations in BC. Apart from the molecular background, ano...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21124488
更新日期：2020-06-24 00:00:00
abstract：:The 18 kDa translocator protein (TSPO) is an evolutionary conserved cholesterol binding protein localized in the outer mitochondrial membrane. It has been implicated in the regulation of various cellular processes including oxidative stress, proliferation, apoptosis, and steroid hormone biosynthesis. Since the express...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20133359
更新日期：2019-07-09 00:00:00
abstract：:Ectophosphatases are surface membrane-bound proteins whose active sites face the extracellular medium. These enzymes have been reported in several microorganisms including a large number of medically relevant fungal species. An effective technique for identifying ectophosphatases is performing phosphatase activity ass...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms15022289
更新日期：2014-02-06 00:00:00
