当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES期刊下所有文献 > Resistin stimulates expression of chemokine genes in chondrocytes via combinatorial regulation of C/EBPβ and NF-κB.

Resistin stimulates expression of chemokine genes in chondrocytes via combinatorial regulation of C/EBPβ and NF-κB.

Abstract：

:To further investigate the regulation role of two chemokine genes CCL3 and CCL4 in chondrocytes in response to resistin, human primary chondrocytes and T/C-28a2 cells were cultured. The function of resistin on the chemokine genes, and the expression of C/EBPβ, NF-κB isoforms were tested using qPCR. The methods used to investigate timed co-regulation of C/EBPβ and NF-κB were NF-κB inhibitor (IKK-NBD) and C/EBPβ inhibitor (SB303580) treatments, and subcellular localization, with or without resistin stimulation. Results showed that resistin could increase the up-regulation of chemokine genes independently. Resistin increased the expression of C/EBPβ and NF-κB isoforms. C/EBPβ regulated basal activity and steadily increased over time up to 24h with resistin. NF-κB was up-regulated upon induction with resistin, peaking at 4 h. C/EBPβ and NF-κB co-enhanced the chemokines expression; inhibition of their activity was additive. The timing of activation in chondrocytes was confirmed by subcellular localization of C/EBPβ and c-rel. Chondrocytes react to resistin in a non-restricted cell-specific manner, utilizing C/EBPβ and NF-κB in a combinatorial regulation of chemokine gene expression. The activity of C/EBPβ is augmented by a transient increase in activity of NF-κB, and both transcription factors act independently on the chemokine genes, CCL3 and CCL4. Thus, resistin stimulates CCL3 and CCL4 through combinatorial regulation of C/EBPβ and NF-κB in chondrocytes.

journal_name

Int J Mol Sci

journal_title

International journal of molecular sciences

authors

Zhang Z,Zhang Z,Kang Y,Hou C,Duan X,Sheng P,Sandell LJ,Liao W

doi

10.3390/ijms151017242

subject

Has Abstract

pub_date

2014-09-26 00:00:00

pages

17242-55

issue

10

issn

1422-0067

pii

ijms151017242

journal_volume

15

pub_type

杂志文章

相关文献

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES文献大全
  • Insights into the Antimicrobial Mechanism of Action of Human RNase6: Structural Determinants for Bacterial Cell Agglutination and Membrane Permeation.

    abstract：:Human Ribonuclease 6 is a secreted protein belonging to the ribonuclease A (RNaseA) superfamily, a vertebrate specific family suggested to arise with an ancestral host defense role. Tissue distribution analysis revealed its expression in innate cell types, showing abundance in monocytes and neutrophils. Recent evidenc...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms17040552

    authors： Pulido D,Arranz-Trullén J,Prats-Ejarque G,Velázquez D,Torrent M,Moussaoui M,Boix E

    更新日期：2016-04-13 00:00:00

  • Genetic Overlap between General Cognitive Function and Schizophrenia: A Review of Cognitive GWASs.

    abstract：:General cognitive (intelligence) function is substantially heritable, and is a major determinant of economic and health-related life outcomes. Cognitive impairments and intelligence decline are core features of schizophrenia which are evident before the onset of the illness. Genetic overlaps between cognitive impairme...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms19123822

    authors： Ohi K,Sumiyoshi C,Fujino H,Yasuda Y,Yamamori H,Fujimoto M,Shiino T,Sumiyoshi T,Hashimoto R

    更新日期：2018-11-30 00:00:00

  • Oral Administration of Lactobacillus Casei Expressing Flagellin A Protein Confers Effective Protection against Aeromonas Veronii in Common Carp, Cyprinus Carpio.

    abstract：:Aeromonas veronii is a pathogen capable of infecting humans, livestock and aquatic animals, resulting in serious economic losses. In this study, two recombinant Lactobacillus casei expressing flagellin A (FlaA) of A. veronii, Lc-pPG-1-FlaA (surface-displayed) and Lc-pPG-2-FlaA (secretory) were constructed. The immune ...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21010033

    authors： Tian JX,Kang YH,Chu GS,Liu HJ,Kong YD,Zhao LH,Kong YX,Shan XF,Wang GQ

    更新日期：2019-12-19 00:00:00

  • Characterization of the Copper Transporters from Lotus spp. and Their Involvement under Flooding Conditions.

    abstract：:Forage legumes are an important livestock nutritional resource, which includes essential metals, such as copper. Particularly, the high prevalence of hypocuprosis causes important economic losses to Argentinian cattle agrosystems. Copper deficiency in cattle is partially due to its low content in forage produced by na...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms20133136

    authors： Escaray FJ,Antonelli CJ,Copello GJ,Puig S,Peñarrubia L,Ruiz OA,Perea-García A

    更新日期：2019-06-27 00:00:00

  • Deciphering the Role of B Cells in Multiple Sclerosis-Towards Specific Targeting of Pathogenic Function.

    abstract：:B cells, plasma cells and antibodies may play a key role in the pathogenesis of multiple sclerosis (MS). This notion is supported by various immunological changes observed in MS patients, such as activation and pro-inflammatory differentiation of peripheral blood B cells, the persistence of clonally expanded plasma ce...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms18102048

    authors： Lehmann-Horn K,Kinzel S,Weber MS

    更新日期：2017-09-23 00:00:00

  • Current status in the therapy of liver diseases.

    abstract：:Hepatic diseases, like viral hepatitis, autoimmune hepatitis, hereditary hemochromatosis, non-alcoholic fatty liver disease (NAFLD) and Wilson's disease, play an important role in the development of liver cirrhosis and, hence, hepatocellular carcinoma. In this review, the current treatment options and the molecular me...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms15057500

    authors： Uhl P,Fricker G,Haberkorn U,Mier W

    更新日期：2014-04-30 00:00:00

  • Small molecule membrane transporters in the mammalian podocyte: a pathogenic and therapeutic target.

    abstract：:The intriguingly complex glomerular podocyte has been a recent object of intense study. Researchers have sought to understand its role in the pathogenesis of common proteinuric diseases such as minimal change disease and focal segmental glomerular sclerosis. In particular, considerable effort has been directed towards...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms151121366

    authors： Zennaro C,Artero M,Di Maso V,Carraro M

    更新日期：2014-11-18 00:00:00

  • Proteasome-Rich PaCS as an Oncofetal UPS Structure Handling Cytosolic Polyubiquitinated Proteins. In Vivo Occurrence, in Vitro Induction, and Biological Role.

    abstract：:In this article, we outline and discuss available information on the cellular site and mechanism of proteasome interaction with cytosolic polyubiquitinated proteins and heat-shock molecules. The particulate cytoplasmic structure (PaCS) formed by barrel-like particles, closely reproducing in vivo the high-resolution st...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms19092767

    authors： Solcia E,Necchi V,Sommi P,Ricci V

    更新日期：2018-09-14 00:00:00

  • NADPH Oxidases and Mitochondria in Vascular Senescence.

    abstract：:Aging is the major risk factor in the development of cardiovascular diseases (CVDs), including hypertension, atherosclerosis, and myocardial infarction. Oxidative stress caused by overproduction of reactive oxygen species (ROS) and/or by reduced expression of antioxidant enzymes is a major contributor to the progressi...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms19051327

    authors： Salazar G

    更新日期：2018-04-29 00:00:00

  • A Review on Ubiquitination of Neurotrophin Receptors: Facts and Perspectives.

    abstract：:Ubiquitination is a reversible post-translational modification involved in a plethora of different physiological functions. Among the substrates that are ubiquitinated, neurotrophin receptors (TrkA, TrkB, TrkC, and p75NTR) have been studied recently. TrkA is the most studied receptor in terms of its ubiquitination, an...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms18030630

    authors： Sánchez-Sánchez J,Arévalo JC

    更新日期：2017-03-14 00:00:00

  • Proteomic Profiling of Colon Cancer Tissues: Discovery of New Candidate Biomarkers.

    abstract：:Colon cancer is an aggressive tumor form with a poor prognosis. This study reports a comparative proteomic analysis performed by using two-dimensional differential in-gel electrophoresis (2D-DIGE) between 26 pooled colon cancer surgical tissues and adjacent non-tumoral tissues, to identify potential target proteins co...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21093096

    authors： Buttacavoli M,Albanese NN,Roz E,Pucci-Minafra I,Feo S,Cancemi P

    更新日期：2020-04-28 00:00:00

  • Hypoxia Inducible Factor 1 (HIF-1) Recruits Macrophage to Activate Pancreatic Stellate Cells in Pancreatic Ductal Adenocarcinoma.

    abstract：:Hypoxia inducible factor 1 (HIF-1) is a transcription factor composed of two subunits, namely, HIF-1α and HIF-1β, in which HIF-1β is constitutively expressed. HIF-1 upregulates several hypoxia-responsive proteins, including angiogenesis factors, glycolysis solution enzymes, and cell survival proteins. HIF-1 is also as...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms17060799

    authors： Li N,Li Y,Li Z,Huang C,Yang Y,Lang M,Cao J,Jiang W,Xu Y,Dong J,Ren H

    更新日期：2016-06-03 00:00:00

  • D-(+)-galactose-conjugated single-walled carbon nanotubes as new chemical probes for electrochemical biosensors for the cancer marker galectin-3.

    abstract：:D-(+)-Galactose-conjugated single-walled carbon nanotubes (SWCNTs) were synthesized for use as biosensors to detect the cancer marker galectin-3. To investigate the binding of galectin-3 to the d-(+)-galactose-conjugated SWCNTs, an electrochemical biosensor was fabricated by using molybdenum electrodes. The binding af...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms12052946

    authors： Park YK,Bold B,Lee WK,Jeon MH,An KH,Jeong SY,Shim YK

    更新日期：2011-01-01 00:00:00

  • High-Capacity Adenoviral Vectors: Expanding the Scope of Gene Therapy.

    abstract：:The adaptation of adenoviruses as gene delivery tools has resulted in the development of high-capacity adenoviral vectors (HC-AdVs), also known, helper-dependent or "gutless". Compared with earlier generations (E1/E3-deleted vectors), HC-AdVs retain relevant features such as genetic stability, remarkable efficacy of i...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms21103643

    authors： Ricobaraza A,Gonzalez-Aparicio M,Mora-Jimenez L,Lumbreras S,Hernandez-Alcoceba R

    更新日期：2020-05-21 00:00:00

  • Activation of Matrix Hyaluronan-Mediated CD44 Signaling, Epigenetic Regulation and Chemoresistance in Head and Neck Cancer Stem Cells.

    abstract：:Head and neck squamous cell carcinoma (HNSCC) is a solid tumor composed by a genotypically and phenotypically heterogeneous population of neoplastic cells types. High recurrence rate and regional metastases lead to major morbidity and mortality. Recently, many studies have focused on cellular and molecular mechanisms ...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms18091849

    authors： Bourguignon LYW,Earle C,Shiina M

    更新日期：2017-08-24 00:00:00

  • Structural Requirements of Benzofuran Derivatives Dehydro-δ- and Dehydro-ε-Viniferin for Antimicrobial Activity Against the Foodborne Pathogen Listeria monocytogenes.

    abstract：:In a recent study, we investigated the antimicrobial activity of a collection of resveratrol-derived monomers and dimers against a series of foodborne pathogens. Out of the tested molecules, dehydro-δ-viniferin and dehydro-ε-viniferin emerged as the most promising derivatives. To define the structural elements essenti...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21062168

    authors： Catinella G,Mattio LM,Musso L,Arioli S,Mora D,Beretta GL,Zaffaroni N,Pinto A,Dallavalle S

    更新日期：2020-03-21 00:00:00

  • Profiling the proteome of exhaled breath condensate in healthy smokers and COPD patients by LC-MS/MS.

    abstract：:Three pools of exhaled breath condensate (EBC) from non-smokers plus healthy smokers (NS + HS, n = 45); chronic obstructive pulmonary disease (COPD) without emphysema (COPD, n = 15) and subjects with pulmonary emphysema associated with α(1)-antitrypsin deficiency (AATD, n = 23) were used for an exploratory proteomic ...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms131113894

    authors： Fumagalli M,Ferrari F,Luisetti M,Stolk J,Hiemstra PS,Capuano D,Viglio S,Fregonese L,Cerveri I,Corana F,Tinelli C,Iadarola P

    更新日期：2012-10-29 00:00:00

  • Low-Cost Cellulase-Hemicellulase Mixture Secreted by Trichoderma harzianum EM0925 with Complete Saccharification Efficacy of Lignocellulose.

    abstract：:Fermentable sugars are important intermediate products in the conversion of lignocellulosic biomass to biofuels and other value-added bio-products. The main bottlenecks limiting the production of fermentable sugars from lignocellulosic biomass are the high cost and the low saccharification efficiency of degradation en...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21020371

    authors： Zhang Y,Yang J,Luo L,Wang E,Wang R,Liu L,Liu J,Yuan H

    更新日期：2020-01-07 00:00:00

  • Antioxidant properties of aminoethylcysteine ketimine decarboxylated dimer: a review.

    abstract：:Aminoethylcysteine ketimine decarboxylated dimer is a natural sulfur-containing compound detected in human plasma and urine, in mammalian brain and in many common edible vegetables. Over the past decade many studies have been undertaken to identify its metabolic role. Attention has been focused on its antioxidant prop...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms12053072

    authors： Macone A,Fontana M,Barba M,Botta B,Nardini M,Ghirga F,Calcaterra A,Pecci L,Matarese RM

    更新日期：2011-01-01 00:00:00

  • NECTIN4 Expression in Extramammary Paget's Disease: Implication of a New Therapeutic Target.

    abstract：:Extramammary Paget's disease (EMPD) is a rare skin cancer arising in the anogenital area. Most EMPD tumors remain dormant as in situ lesions, but the outcomes of patients with metastatic EMPD are poor because of the lack of effective systemic therapies. Nectin cell adhesion molecule 4 (NECTIN4) has attracted attention...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21165891

    authors： Murata M,Ito T,Tanaka Y,Kaku-Ito Y,Furue M

    更新日期：2020-08-16 00:00:00

  • SLC9A3 Protein Is Critical for Acrosomal Formation in Postmeiotic Male Germ Cells.

    abstract：:Solute carrier family 9 isoform 3 (SLC9A3), a Na⁺/H⁺ exchanger, regulates the transepithelial absorption of Na⁺ and water and is primarily expressed on the apical membranes of the intestinal epithelium, renal proximal tubule, epididymis, and vas deferens. Loss of the Slc9a3 allele in mice enhances intestinal fluid and...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms19010103

    authors： Wang YY,Chiang HS,Cheng CY,Wu YN,Lin YC,Liu HC,Tsai WK,Chen YL,Lin YH

    更新日期：2017-12-29 00:00:00

  • Revealing and Harnessing Tumour-Associated Microglia/Macrophage Heterogeneity in Glioblastoma.

    abstract：:Abstract: Cancer heterogeneity and progression are subject to complex interactions between neoplastic cells and their microenvironment, including the immune system. Although glioblastomas (GBMs) are classified as 'cold tumours' with very little lymphocyte infiltration, they can contain up to 30-40% of tumour-associate...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms21030689

    authors： Pires-Afonso Y,Niclou SP,Michelucci A

    更新日期：2020-01-21 00:00:00

  • The self-assembled behavior of DNA bases on the interface.

    abstract：:A successful example of self-assembly in a biological system is that DNA can be an excellent agent to self-assemble into desirable two and three-dimensional nanostructures in a well-ordered manner by specific hydrogen bonding interactions between the DNA bases. The self-assembly of DNA bases have played a significant ...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms15021901

    authors： Liu L,Xia D,Klausen LH,Dong M

    更新日期：2014-01-27 00:00:00

  • Physicochemical and Antimicrobial Characterization of Beeswax-Starch Food-Grade Nanoemulsions Incorporating Natural Antimicrobials.

    abstract：:Nanoemulsions are feasible delivery systems of lipophilic compounds, showing potential as edible coatings with enhanced functional properties. The aim of this work was to study the effect of emulsifier type (stearic acid (SA), Tween 80 (T80) or Tween 80/Span 60 (T80/S60)) and emulsification process (homogenization, ul...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms18122712

    authors： Arredondo-Ochoa T,García-Almendárez BE,Escamilla-García M,Martín-Belloso O,Rossi-Márquez G,Medina-Torres L,Regalado-González C

    更新日期：2017-12-15 00:00:00

  • Biochemical properties and possible roles of ectophosphatase activities in fungi.

    abstract：:Ectophosphatases are surface membrane-bound proteins whose active sites face the extracellular medium. These enzymes have been reported in several microorganisms including a large number of medically relevant fungal species. An effective technique for identifying ectophosphatases is performing phosphatase activity ass...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms15022289

    authors： Freitas-Mesquita AL,Meyer-Fernandes JR

    更新日期：2014-02-06 00:00:00

  • Hormonal Responses to Plasmodiophora brassicae Infection in Brassica napus Cultivars Differing in Their Pathogen Resistance.

    abstract：:Hormonal dynamics after Plasmodiophora brassicae infection were compared in two Brassica napus cultivars-more resistant SY Alister and more sensitive Hornet, in order to elucidate responses associated with efficient defense. Both cultivars responded to infection by the early transient elevation of active cytokinins (p...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms19124024

    authors： Prerostova S,Dobrev PI,Konradyova V,Knirsch V,Gaudinova A,Kramna B,Kazda J,Ludwig-Müller J,Vankova R

    更新日期：2018-12-13 00:00:00

  • Improving protein crystal quality by the without-oil microbatch method: crystallization and preliminary X-ray diffraction analysis of glutathione synthetase from Pseudoalteromonas haloplanktis.

    abstract：:Glutathione synthetases catalyze the ATP-dependent synthesis of glutathione from l-γ-glutamyl- l-cysteine and glycine. Although these enzymes have been sequenced and characterized from a variety of biological sources, their exact catalytic mechanism is not fully understood and nothing is known about their adaptation a...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms12096312

    authors： Merlino A,Russo Krauss I,Albino A,Pica A,Vergara A,Masullo M,De Vendittis E,Sica F

    更新日期：2011-01-01 00:00:00

  • Norditerpenoids with Selective Anti-Cholinesterase Activity from the Roots of Perovskia atriplicifolia Benth.

    abstract：:Inhibition of cholinesterases remains one of a few available treatment strategies for neurodegenerative dementias such as Alzheimer's disease and related conditions. The current study was inspired by previous data on anticholinesterase properties of diterpenoids from Perovskia atriplicifolia and other Lamiaceae specie...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21124475

    authors： Ślusarczyk S,Senol Deniz FS,Abel R,Pecio Ł,Pérez-Sánchez H,Cerón-Carrasco JP,den-Haan H,Banerjee P,Preissner R,Krzyżak E,Oleszek W,E Orhan I,Matkowski A

    更新日期：2020-06-23 00:00:00

  • Eicosanoids in Skin Wound Healing.

    abstract：:Wound healing is an important process in the human body to protect against external threats. A dysregulation at any stage of the wound healing process may result in the development of various intractable ulcers or excessive scar formation. Numerous factors such as growth factors, cytokines, and chemokines are involved...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms21228435

    authors： Yasukawa K,Okuno T,Yokomizo T

    更新日期：2020-11-10 00:00:00

  • Quorum sensing in the squid-Vibrio symbiosis.

    abstract：:Quorum sensing is an intercellular form of communication that bacteria use to coordinate group behaviors such as biofilm formation and the production of antibiotics and virulence factors. The term quorum sensing was originally coined to describe the mechanism underlying the onset of luminescence production in cultures...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms140816386

    authors： Verma SC,Miyashiro T

    更新日期：2013-08-07 00:00:00