Abstract：
:Matrix metalloproteinases (MMPs) play an important role in the degradation of extracellular matrix components crucial for tumor growth, invasion and metastasis. MMPs are controlled by natural inhibitors called tissue inhibitors of metalloproteinases (TIMPs). We and others have demonstrated that MMPs and TIMPs are especially important in the process of tumor invasion, progression and the metastasis of colorectal cancer (CRC). It has been proposed that MMPs and TIMPs might play a part not only in tumor invasion and initiation of metastasis but also in carcinogenesis from colorectal adenomas. Several recent studies demonstrated that high preoperative serum or plasma MMP-2, MMP-9 and TIMP-1 antigen levels are strong predictive factors for poor prognosis in patients with CRC and their determination might be useful for identification of patients with higher risk for cancer recurrence. MMP-9 and TIMP-1 have significant potential tumor marker impact in CRC. Their diagnostic sensitivity is consistently higher than those of conventional biomarkers. The pharmacological targeting of CRC by the development of a new generation of selective inhibitors of MMPs, that is highly specific for certain MMPs, is a promising and challenging area for the future.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Herszényi L,Hritz I,Lakatos G,Varga MZ,Tulassay Zdoi
10.3390/ijms131013240subject
Has Abstractpub_date
2012-10-16 00:00:00pages
13240-63issue
10issn
1422-0067pii
ijms131013240journal_volume
13pub_type
杂志文章,评审abstract：:Increasing photosynthetic ability as a whole is essential for acquiring higher crop yields. Nonleaf green organs (NLGOs) make important contributions to photosynthate formation, especially under stress conditions. However, there is little information on the pod wall in legume forage related to seed development and yie...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21124457
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abstract：:Tanshinone IIA (Tan-IIA) is an extract from the widely used traditional Chinese medicine (TCM) Danshen (Salvia miltiorrhiza), and has been found to attenuate the proliferation of bladder cancer (BCa) cells (The IC50 were: 5637, 2.6 μg/mL; BFTC, 2 μg/mL; T24, 2.7 μg/mL, respectively.). However, the mechanism of the eff...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
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更新日期：2017-07-25 00:00:00
abstract：:Evodiamine (Evo), a major alkaloid compound isolated from the dry unripened fruit of Evodia fructus, has a wide range of pharmacological activities. The present study sought to explore the neuroprotective effects of Evo in l-glutamate (l-Glu)-induced apoptosis of HT22 cells, and in a d-galactose and aluminum trichlori...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
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更新日期：2018-05-21 00:00:00
abstract：:Protein arginine deimination leading to the non-coded amino acid citrulline remains a key question in the field of post-translational modifications ever since its discovery by Rogers and Simmonds in 1958. Citrullination is catalyzed by a family of enzymes called peptidyl arginine deiminases (PADIs). Initially, increas...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
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更新日期：2020-02-17 00:00:00
abstract：:Background: To evaluate the distribution of the transforming growth factor-beta induced (TGFBI) corneal dystrophies in a multi-ethnic population in Singapore, and to present the different phenotypes with the same genotype. Methods: This study included 32 patients. Slit lamp biomicroscopy was performed for each patient...
journal_title：International journal of molecular sciences
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更新日期：2021-01-27 00:00:00
abstract：:Herein, we propose newly designed and synthesized gold nanopeanuts (Au NPes) as supports for cisplatin (cPt) immobilization, dedicated to combined glioblastoma nano-chemo-radiotherapy. Au NPes offer a large active surface, which can be used for drugs immobilization. Transmission electron microscopy (TEM) revealed that...
journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
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更新日期：2015-06-19 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2008-01-01 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2014-09-25 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2018-04-08 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2021-01-19 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2020-04-28 00:00:00
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journal_title：International journal of molecular sciences
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doi：10.3390/ijms161226214
更新日期：2015-12-16 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21124310
更新日期：2020-06-17 00:00:00
abstract：:The circadian clock has a critical role in many physiological functions of skeletal muscle and is essential to fully understand the precise underlying mechanisms involved in these complex interactions. The importance of circadian expression for structure, function and metabolism of skeletal muscle is clear when observ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms20174318
更新日期：2019-09-03 00:00:00
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journal_title：International journal of molecular sciences
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doi：10.3390/ijms161125963
更新日期：2015-11-04 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21176070
更新日期：2020-08-23 00:00:00
abstract：:Mammalian aquaporins (AQPs) are transmembrane channels expressed in a large variety of cells and tissues throughout the body. They are known as water channels, but they also facilitate the transport of small solutes, gasses, and monovalent cations. To date, 13 different AQPs, encoded by the genes AQP0-AQP12, have been...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms20082039
更新日期：2019-04-25 00:00:00
abstract：:Recent evidence suggests that autophagy impairment is implicated in the epileptogenic mechanisms downstream of mTOR hyperactivation. This holds true for a variety of genetic and acquired epileptic syndromes besides malformations of cortical development which are classically known as mTORopathies. Autophagy suppression...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
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更新日期：2020-02-28 00:00:00
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journal_title：International journal of molecular sciences
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doi：10.3390/ijms160510016
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
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更新日期：2020-03-18 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
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更新日期：2019-06-18 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2020-10-01 00:00:00
abstract：:Live-cell microscopy is now routinely used to monitor the activities of the genetically encoded biosensor proteins that are designed to directly measure specific cell signaling events inside cells, tissues, or organisms. Most fluorescent biosensor proteins rely on Förster resonance energy transfer (FRET) to report con...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms131114385
更新日期：2012-11-07 00:00:00
abstract：:Grass carp reovirus (GCRV) causes huge economic loss to the grass carp cultivation industry but the mechanism remains largely unknown. In this study, we investigated the global and complement gene-specific DNA methylation in grass carp after GCRV infection aimed to uncover the mechanism underlying GCRV infection. The ...
journal_title：International journal of molecular sciences
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更新日期：2018-04-07 00:00:00
abstract：:Glioblastoma multiforme (GBM) is the most common type of primary and malignant tumor occurring in the adult central nervous system. GBM often invades surrounding regions of the brain during its early stages, making successful treatment difficult. Osthole, an active constituent isolated from the dried C. monnieri fruit...
journal_title：International journal of molecular sciences
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更新日期：2014-03-04 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2017-05-19 00:00:00
abstract：:Bladder cancer is the second most common urological malignancy in the world. In 70% of cases it is initially diagnosed as non-muscle-invasive bladder cancer (NMIBC) and it is amenable to local treatments, with intravesical (IVES) Bacillus-Calmette-Guerin (BCG) immunotherapy being routinely used after transurethral res...
journal_title：International journal of molecular sciences
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更新日期：2016-07-14 00:00:00
