Abstract：
:The circadian clock has a critical role in many physiological functions of skeletal muscle and is essential to fully understand the precise underlying mechanisms involved in these complex interactions. The importance of circadian expression for structure, function and metabolism of skeletal muscle is clear when observing the muscle phenotype in models of molecular clock disruption. Presently, the maintenance of circadian rhythms is emerging as an important new factor in human health, with disruptions linked to ageing, as well as to the development of many chronic diseases, including sarcopenia. Therefore, the aim of this review is to present the latest findings demonstrating how circadian rhythms in skeletal muscle are important for maintenance of the cellular physiology, metabolism and function of skeletal muscle. Moreover, we will present the current knowledge about the tissue-specific functions of the molecular clock in skeletal muscle.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Vitale JA,Bonato M,La Torre A,Banfi Gdoi
10.3390/ijms20174318subject
Has Abstractpub_date
2019-09-03 00:00:00issue
17issn
1422-0067pii
ijms20174318journal_volume
20pub_type
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