Abstract:
:Abiotic stresses are major constraints limiting crop growth and production. Heat shock factors (Hsfs) play significant roles in mediating plant resistance to various environmental stresses, including heat, drought and salinity. In this study, we explored the biological functions and underlying mechanisms of wheat TaHsfA6f in plant tolerance to various abiotic stresses. Gene expression profiles showed that TaHsfA6f has relatively high expression levels in wheat leaves at the reproductive stage. Transcript levels of TaHsfA6f were substantially up-regulated by heat, dehydration, salinity, low temperature, and multiple phytohormones, but was not induced by brassinosteroids (BR). Subcellular localization analyses revealed that TaHsfA6f is localized to the nucleus. Overexpression of the TaHsfA6f gene in Arabidopsis results in improved tolerance to heat, drought and salt stresses, enhanced sensitivity to exogenous abscisic acid (ABA), and increased accumulation of ABA. Furthermore, RNA-sequencing data demonstrated that TaHsfA6f functions through up-regulation of a number of genes involved in ABA metabolism and signaling, and other stress-associated genes. Collectively, these results provide evidence that TaHsfA6f participates in the regulation of multiple abiotic stresses, and that TaHsfA6f could serve as a valuable gene for genetic modification of crop abiotic stress tolerance.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Bi H,Zhao Y,Li H,Liu Wdoi
10.3390/ijms21093121subject
Has Abstractpub_date
2020-04-28 00:00:00issue
9issn
1422-0067pii
ijms21093121journal_volume
21pub_type
杂志文章abstract::Hepatic disorders have been increasing in recent years because of high carbohydrate diets. Hepatocytes depend mainly on the basal autophagy to maintain hepatic glucose/lipid homeostasis in mammals. However, the regulatory mechanisms of autophagy in hepatic energy metabolism are still unknown in fish species. According...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21041533
更新日期:2020-02-24 00:00:00
abstract::Nano Ag has excellent antibacterial properties and is widely used in various antibacterial materials, such as antibacterial medicine and medical devices, food packaging materials and antibacterial textiles. Despite the many benefits of nano-Ag, more and more research indicates that it may have potential biotoxic effec...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21051618
更新日期:2020-02-27 00:00:00
abstract::Soil salinity is a key problem for crop production worldwide. High salt concentration in soil negatively modulates plant growth and development. In roots, salinity affects the growth and development of both primary and lateral roots. The phytohormone auxin regulates various developmental processes during the plant's l...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21249528
更新日期:2020-12-15 00:00:00
abstract::In this study, drug nanocarriers were designed using linear copolymers with different contents of cholinium-based ionic liquid units, i.e., [2-(methacryloyloxy)ethyl]trimethylammonium chloride (TMAMA/Cl: 25, 50, and 75 mol%). The amphiphilicity of the copolymers was evaluated on the basis of their critical micelle con...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms22010284
更新日期:2020-12-30 00:00:00
abstract::Melatonin is produced by the pineal gland. It can be regarded as an anticancer agent and used for combined therapy, owing to its oncostatic, antioxidant, and immunoregulatory activities. Retinoic acid is widely used for the treatment of acute promyelocytic leukemia; however, it has adverse effects on the human organis...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms19102873
更新日期:2018-09-21 00:00:00
abstract::Synthesis of the CCA end of essential tRNAs is performed either by CCA-adding enzymes or as a collaboration between enzymes restricted to CC- and A-incorporation. While the occurrence of such tRNA nucleotidyltransferases with partial activities seemed to be restricted to Bacteria, the first example of such split CCA-a...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21020462
更新日期:2020-01-10 00:00:00
abstract::Endoglucanases (EGLs) are important components of multienzyme cocktails used in the production of a wide variety of fine and bulk chemicals from lignocellulosic feedstocks. However, a low thermostability and the loss of catalytic performance of EGLs at industrially required temperatures limit their commercial applicat...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20071602
更新日期:2019-03-30 00:00:00
abstract::Signaling by transforming growth factor (TGF)-β plays an important role in development, including in palatogenesis. The dynamic morphological process of palatal fusion occurs to achieve separation of the nasal and oral cavities. Critically and specifically important in palatal fusion are the medial edge epithelial (ME...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms19113638
更新日期:2018-11-19 00:00:00
abstract::MicroRNAs (miRNAs) are important post-transcriptional regulators during adipocyte adipogenesis. MiR-206-3p, a tissue-specific miRNA, is absent in white adipocytes. In this study, we examined the roles of mmu-miR-206-3p in the adipogenic differentiation of 3T3-L1 preadipocytes. The miR-206-3p expression has shown an ap...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms18071510
更新日期:2017-07-14 00:00:00
abstract::The present editorial aims to summarize the 17 scientific papers that have contributed to this Special Issue focusing on different aspects of basic and translational research in colorectal cancer. ...
journal_title:International journal of molecular sciences
pub_type: 社论
doi:10.3390/ijms20123095
更新日期:2019-06-25 00:00:00
abstract::Cystic fibrosis is an inherited multi-organ disorder caused by mutations in the CFTR gene. Patients with this disease exhibit characteristic abnormalities in the levels of unsaturated fatty acids in blood and tissue. Recent studies have uncovered an underlying biochemical mechanism for some of these changes, namely in...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms150916083
更新日期:2014-09-11 00:00:00
abstract::There have been no major improvements in the overall survival of ovarian cancer patients in recent decades. Even though more accurate surgery and more effective treatments are available, the mortality rate remains high. Given the differences in origin and the heterogeneity of these tumors, research to elucidate the si...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms18081658
更新日期:2017-07-30 00:00:00
abstract::The development of atherosclerosis is a multi-step process, at least in part controlled by the vascular endothelium function. Observations in humans and experimental models of atherosclerosis have identified monocyte recruitment as an early event in atherogenesis. Chronic inflammation is associated with ageing and its...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms140612696
更新日期:2013-06-17 00:00:00
abstract::Recent data show that cardiac hypertrophy contributes substantially to the overall heart failure burden. Mitochondrial dysfunction is a common feature of cardiac hypertrophy. Recent studies have reported that isosteviol inhibits myocardial ischemia-reperfusion injury in guinea pigs and H9c2 cells. This work investigat...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21020682
更新日期:2020-01-20 00:00:00
abstract::Adverse experiences and chronic stress are well-known risk factors for the development of major depression, and an impaired stress response regulation is frequently observed in acute depression. Impaired glucocorticoid receptor (GR) signalling plays an important role in these alterations, and a restoration of GR signa...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20030485
更新日期:2019-01-23 00:00:00
abstract::Non-alcoholic fatty liver disease (NAFLD) is the most common liver disorder worldwide. Several lines of evidence have indicated a pathogenic role of insulin resistance, and a strong association with type 2 diabetes (T2MD) and metabolic syndrome. Importantly, NAFLD appears to enhance the risk for T2MD, as well as worse...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms141122933
更新日期:2013-11-20 00:00:00
abstract::The physicochemical properties and antioxidant activity of a molecule could be improved by the substitution of an oxygen atom in a molecule with selenium. We synthesized selenoflavanones and flavanones to evaluate their neuroprotective effects. The selenoflavanones showed improved physicochemical properties, suggestiv...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms161226188
更新日期:2015-12-10 00:00:00
abstract::In recent years, ongoing interest in ischemic brain injury research has provided data showing that ischemic episodes are involved in the development of Alzheimer's disease-like neuropathology. Brain ischemia is the second naturally occurring neuropathology, such as Alzheimer's disease, which causes the death of neuron...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms19124002
更新日期:2018-12-12 00:00:00
abstract::Prenatal smoke exposure (PreSE) is a risk factor for nicotine dependence, which is further enhanced by postnatal smoke exposure (PostSE). One susceptibility gene to nicotine dependence is Cytochrome P450 (CYP) 2A6, an enzyme responsible for the conversion of nicotine to cotinine in the liver. Higher CYP2A6 activity is...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms22010164
更新日期:2020-12-26 00:00:00
abstract::Eukaryotic cells express a large variety of RNA binding proteins (RBPs), with diverse affinities and specificities towards target RNAs. These proteins play a crucial role in almost every aspect of RNA biogenesis, expression and function. The heterogeneous nuclear ribonucleoproteins (hnRNPs) are a complex and diverse f...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms140918999
更新日期:2013-09-16 00:00:00
abstract::Bone is a peculiar tissue subjected to a continuous process of self-renewal essential to assure the integrity of the skeleton and to explicate the endocrine functions. The study of bone diseases characterized by increased or reduced bone mass due to osteoclast alterations has been essential to understand the great rol...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms20184502
更新日期:2019-09-11 00:00:00
abstract::Long-standing efforts to identify the multifaceted roles of histone deacetylase inhibitors (HDACis) have positioned these agents as promising drug candidates in combatting cancer, autoimmune, neurodegenerative, and infectious diseases. The same has also encouraged the evaluation of multiple HDACi candidates in preclin...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms20092241
更新日期:2019-05-07 00:00:00
abstract::In mammals, leptin has been demonstrated to perform important roles in many physiological activities and to influence development, growth, metabolism and reproduction. However, in fish, its function is still unclear. Duplicate leptin genes, leptin-a and leptin-b, have been identified in the orange-spotted grouper. In ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms150711996
更新日期:2014-07-07 00:00:00
abstract::Several research disciplines require fast, reliable and highly automated determination of pharmaceutically active compounds and their enantiomers in complex biological matrices. To address some of the challenges of Capillary Electrophoresis (CE), such as low concentration sensitivity and performance degradation linked...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21186852
更新日期:2020-09-18 00:00:00
abstract::The objective of this study was to determine the effects of feeding protein-iron complex (PIC) on productive performance and indicators of iron metabolism, hematology parameters, antioxidant and immune status during first 35 days of a calf's life. Preparation of the complex involved enzymatic hydrolysis of milk casein...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms18071501
更新日期:2017-07-12 00:00:00
abstract::Naturally existing Chlorogenic acid (CGA) is an antioxidant-rich compound reported to act a chemopreventive agent by scavenging free radicals and suppressing cancer-causing mechanisms. Conversely, the compound's poor thermal and pH (neutral and basic) stability, poor solubility, and low cellular permeability have been...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20194667
更新日期:2019-09-20 00:00:00
abstract::Endocannabinoids are key-players of female fertility and potential biomarkers of reproductive dysfunctions. Here, we investigated localization and expression of cannabinoid receptor type-1 and -2 (CB1R and CB2R), G-protein coupled receptor 55 (GPR55), and transient receptor potential vanilloid type 1 channel (TRPV1) i...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20122866
更新日期:2019-06-12 00:00:00
abstract::Plastid-nucleus-located WHIRLY1 protein plays a role in regulating leaf senescence and is believed to associate with the increase of reactive oxygen species delivered from redox state of the photosynthetic electron transport chain. In order to make sure whether WHIRLY1 plays a role in photosynthesis, in this study, th...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms18112352
更新日期:2017-11-07 00:00:00
abstract::The local anesthetic lidocaine, which has been used extensively during liposuction, has been reported to have cytotoxic effects and therefore would be unsuitable for use in autologous lipotransfer. We evaluated the effect of lidocaine on the distribution, number, and viability of adipose-derived stem cells (ASCs), pre...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21082869
更新日期:2020-04-20 00:00:00
abstract::Stable five-coordinate Pt(II) complexes have been highlighted as a promising and original platform for the development of new cytotoxic drugs. Their interaction with proteins has been scarcely studied. Here, the reactivity of the five-coordinate Pt(II) compound [Pt(I)(Me) (dmphen)(olefin)] (Me = methyl, dmphen = 2,9-d...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20030520
更新日期:2019-01-26 00:00:00