Instrumentation on multi-scaled scattering of bio-macromolecular solutions.

abstract：:The majority of the human genome is comprised of non-protein-coding genes, but the relevance of non-coding RNAs in complex diseases has yet to be fully elucidated. One class of non-coding RNAs is long non-coding RNAs or lncRNAs, many of which have been identified to play a range of roles in transcription and translati...

journal_title：International journal of molecular sciences

authors： Wilson C,Kanhere A

更新日期：2021-01-22 00:00:00

abstract：:Frizzled receptors (FZDs) are a family of seven-span transmembrane receptors with hallmarks of G protein-coupled receptors (GPCRs) that serve as receptors for secreted Wingless-type (WNT) ligands in the WNT signaling pathway. Functionally, FZDs play crucial roles in regulating cell polarity, embryonic development, cel...

journal_title：International journal of molecular sciences

authors： Zeng CM,Chen Z,Fu L

更新日期：2018-05-22 00:00:00

abstract：:The dimension of the plants largest organelle-the vacuole-plays a major role in defining cellular elongation rates. The morphology of the vacuole is controlled by the actin cytoskeleton, but molecular players remain largely unknown. Recently, the Networked (NET) family of membrane-associated, actin-binding proteins ha...

journal_title：International journal of molecular sciences

authors： Kaiser S,Eisa A,Kleine-Vehn J,Scheuring D

更新日期：2019-09-25 00:00:00

abstract：:The aim of this study was to develop and evaluate matrix assisted LASER desorption ionization (MALDI) time-of-flight (TOF) mass spectrometry imaging (MSI) of blood smear. Integrated light microscope and MALDI IT-TOF mass spectrometer, together with a matrix sublimation device, were used for analysis of blood smears co...

journal_title：International journal of molecular sciences

authors： Debeljak Ž,Niehoff AC,Bandjak A,Mandić D,Bošnjak B,Heffer M,Mrđenović S,Marković I,Zjalić M,Šerić V

更新日期：2021-01-08 00:00:00

abstract：:This review summarizes available data on argan fruit botany, geographical distribution, traditional uses, environmental interest, socioeconomic role, phytochemistry, as well as health beneficial effects and examination of future prospects. In particular, ethnomedical uses of argan fruits are carried out throughout Mor...

journal_title：International journal of molecular sciences

authors： Khallouki F,Eddouks M,Mourad A,Breuer A,Owen RW

更新日期：2017-10-30 00:00:00

abstract：:Cannabinoid receptors (CB1 and CB2), as part of the endocannabinoid system, play a critical role in numerous human physiological and pathological conditions. Thus, considerable efforts have been made to develop ligands for CB1 and CB2, resulting in hundreds of phyto- and synthetic cannabinoids which have shown varying...

journal_title：International journal of molecular sciences

authors： An D,Peigneur S,Hendrickx LA,Tytgat J

更新日期：2020-07-17 00:00:00

abstract：:Hepatocyte cell death is a key process in the pathogenesis of nonalcoholic steatohepatitis (NASH). However, the factors responsible for and mechanisms underlying NASH-related cell death have not yet been elucidated in detail. We herein investigated the effects of intracellular glyceraldehyde (GA)-derived advanced glyc...

journal_title：International journal of molecular sciences

authors： Sakasai-Sakai A,Takata T,Takeuchi M

更新日期：2020-07-09 00:00:00

abstract：:Homeodomain-interacting protein kinase 2 (HIPK2) is a serine/threonine kinase that phosphorylates and activates the apoptotic program through interaction with diverse downstream targets including tumor suppressor p53. HIPK2 is activated by genotoxic stimuli and modulates cell fate following DNA damage. The DNA damage ...

journal_title：International journal of molecular sciences

authors： Kuwano Y,Nishida K,Akaike Y,Kurokawa K,Nishikawa T,Masuda K,Rokutan K

更新日期：2016-09-27 00:00:00

abstract：:Eosinophilic colitis (EC) is a common cause of haematochezia in infants and young children. The exact pathomechanism is not understood, and the diagnosis is challenging. The role of microRNAs as key class of regulators of mRNA expression and translation in patients with EC has not been explored. Therefore, the aim of ...

journal_title：International journal of molecular sciences

authors： Kiss Z,Béres NJ,Sziksz E,Tél B,Borka K,Arató A,Szabó AJ,Veres G

更新日期：2017-05-12 00:00:00

abstract：:A series of perylene diimide (PDI) derivatives have been investigated at the CAM-B3LYP/6-31G(d) and the TD-B3LYP/6-31+G(d,p) levels to design solar cell acceptors with high performance in areas such as suitable frontier molecular orbital (FMO) energies to match oligo(thienylenevinylene) derivatives and improved charge...

journal_title：International journal of molecular sciences

authors： Lv X,Li Z,Li S,Luan G,Liang D,Tang S,Jin R

更新日期：2016-05-13 00:00:00

abstract：:Vitamin D deficiency is highly prevalent worldwide. It has been associated with heart failure (HF) given its immunoregulatory functions. In-vitro and animal models have shown protective roles through mechanisms involving procollagen-1, JNK2, calcineurin/NFAT, NF-κB, MAPK, Th1, Th2, Th17, cytokines, cholesterol-efflux,...

journal_title：International journal of molecular sciences

authors： Roffe-Vazquez DN,Huerta-Delgado AS,Castillo EC,Villarreal-Calderón JR,Gonzalez-Gil AM,Enriquez C,Garcia-Rivas G,Elizondo-Montemayor L

更新日期：2019-11-19 00:00:00

abstract：:We prepared thermoresponsive hydrogels by mixing poly(N-isopropylacrylamide) (PNIPAAm) derivatives as the main chain components, octa-arm polyethylene glycol (PEG) as a crosslinker, and the Arg-Gly-Asp-Ser (RGDS) peptides as cell adhesion units. Human bone marrow-derived mesenchymal stem cells (hbmMSCs) were cultured ...

journal_title：International journal of molecular sciences

authors： Akimoto AM,Niitsu EH,Nagase K,Okano T,Kanazawa H,Yoshida R

更新日期：2018-04-21 00:00:00

abstract：:Manganese (Mn) is an important trace element present in human body, which acts as an enzyme co-factor or activator in various metabolic reactions. While essential in trace amounts, excess levels of Mn in human brain can produce neurotoxicity, including idiopathic Parkinson's disease (PD)-like extrapyramidal manganism ...

journal_title：International journal of molecular sciences

authors： Bahar E,Lee GH,Bhattarai KR,Lee HY,Choi MK,Rashid HO,Kim JY,Chae HJ,Yoon H

更新日期：2017-01-30 00:00:00

abstract：:Translocator protein 18 kDa (TSPO) is a high affinity cholesterol- and drug-binding protein highly expressed in steroidogenic cells, such as Leydig cells, where it plays a role in cholesterol mitochondrial transport. We have previously shown that TSPO is expressed in postnatal day 3 rat gonocytes, precursors of sperma...

journal_title：International journal of molecular sciences

authors： Manku G,Culty M

更新日期：2016-09-06 00:00:00

abstract：:Bacterial adhesion to the calcium phosphate surface is a serious problem in surgery. To prevent bacterial infection, the development of calcium-phosphate cements (CPCs) with bactericidal properties is indispensable. The aim of this study was to fabricate antibacterial CPCs and evaluate their biological properties. Sil...

journal_title：International journal of molecular sciences

authors： Honda M,Kawanobe Y,Nagata K,Ishii K,Matsumoto M,Aizawa M

更新日期：2020-05-26 00:00:00

abstract：:Polymer-based piezoelectric biomaterials have already proven their relevance for tissue engineering applications. Furthermore, the morphology of the scaffolds plays also an important role in cell proliferation and differentiation. The present work reports on poly(hydroxybutyrate-co-hydroxyvalerate) (PHBV), a biocompat...

journal_title：International journal of molecular sciences

authors： Amaro L,Correia DM,Marques-Almeida T,Martins PM,Pérez L,Vilas JL,Botelho G,Lanceros-Mendez S,Ribeiro C

更新日期：2018-07-24 00:00:00

abstract：:Cationic polymeric nanoparticles (NPs) have the ability to overcome biological membranes, leading to improved efficacy of anticancer drugs. The modulation of the particle-cell interaction is desired to control this effect and avoid toxicity to normal cells. In this study, we explored the surface functionalization of c...

journal_title：International journal of molecular sciences

authors： Dos Santos-Silva AM,de Caland LB,do Nascimento EG,Oliveira ALCSL,de Araújo-Júnior RF,Cornélio AM,Fernandes-Pedrosa MF,da Silva-Júnior AA

更新日期：2019-05-11 00:00:00

abstract：:Determination of the thermal characteristics and temperature-dependent rheological properties of the magnetorheological elastomers (MREs) is of paramount importance particularly with regards to MRE applications. Hitherto, a paucity of temperature dependent analysis has been conducted by MRE researchers. In this study,...

journal_title：International journal of molecular sciences

authors： Yunus NA,Mazlan SA,Ubaidillah.,Abdul Aziz SA,Tan Shilan S,Abdul Wahab NA

更新日期：2019-02-10 00:00:00

abstract：:Understanding molecular interactions and regulatory mechanisms in tumor initiation, progression, and treatment response are key requirements towards advanced cancer diagnosis and novel treatment procedures in personalized medicine. Beyond decoding the gene expression, malfunctioning and cancer-related epigenetic pathw...

journal_title：International journal of molecular sciences

authors： Hausmann M,Ilić N,Pilarczyk G,Lee JH,Logeswaran A,Borroni AP,Krufczik M,Theda F,Waltrich N,Bestvater F,Hildenbrand G,Cremer C,Blank M

更新日期：2017-09-28 00:00:00

abstract：:Wrist osteoarthritis (OA) is one of the most common conditions encountered by hand surgeons with limited efficacy of non-surgical treatments. The purpose of this study is to describe the Platelet-Rich Plasma (PRP) mixed-microfat biological characteristics of an experimental Advanced Therapy Medicinal Product (ATMP) ne...

journal_title：International journal of molecular sciences

authors： Mayoly A,Iniesta A,Curvale C,Kachouh N,Jaloux C,Eraud J,Vogtensperger M,Veran J,Grimaud F,Jouve E,Casanova D,Sabatier F,Legré R,Magalon J

更新日期：2019-03-05 00:00:00

abstract：:Aurora kinases have emerged as attractive targets for the design of anticancer drugs. 3D-QSAR (comparative molecular field analysis (CoMFA) and comparative molecular similarity indices analysis (CoMSIA)) and Surflex-docking studies were performed on a series of pyrrole-indoline-2-ones as Aurora A inhibitors. The CoMFA...

journal_title：International journal of molecular sciences

authors： Ai Y,Wang ST,Sun PH,Song FJ

更新日期：2011-01-01 00:00:00

abstract：:The negative association between psychological stress and male fertility has been known for many years. This study was aimed at (i) identifying spermatogenesis impairment induced by psychological stress in rats and (ii) exploring the role of glucocorticoid receptor (GR) signaling in these adverse effects (if they exis...

journal_title：International journal of molecular sciences

authors： Zou P,Wang X,Yang W,Liu C,Chen Q,Yang H,Zhou N,Zeng Y,Chen H,Zhang G,Liu J,Cao J,Ao L,Sun L

更新日期：2019-09-10 00:00:00

abstract：:Opioid analgesics such as morphine have indispensable roles in analgesia. However, morphine use can elicit side effects such as respiratory depression and constipation. It has been reported that G protein-biased agonists as substitutes for classic opioid agonists can alleviate (or even eliminate) these side effects. T...

journal_title：International journal of molecular sciences

authors： Zhao Z,Huang T,Li J

更新日期：2020-07-01 00:00:00

abstract：:This study aims to determine whether Lactobacillus casei (L. casei) could relieve liver injury in piglets challenged with lipopolysaccharide (LPS). Piglets were randomly allocated into one of the three groups: control, LPS, and L. casei. The control and LPS groups were fed a corn- and soybean meal-based diet, whereas ...

journal_title：International journal of molecular sciences

authors： Zhao D,Wu T,Yi D,Wang L,Li P,Zhang J,Hou Y,Wu G

更新日期：2017-11-26 00:00:00

abstract：:Neuromuscular disorders (NMDs) affect 1 in 3000 people worldwide. There are more than 150 different types of NMDs, where the common feature is the loss of muscle strength. These disorders are classified according to their neuroanatomical location, as motor neuron diseases, peripheral nerve diseases, neuromuscular junc...

journal_title：International journal of molecular sciences

authors： Bachiller S,Alonso-Bellido IM,Real LM,Pérez-Villegas EM,Venero JL,Deierborg T,Armengol JÁ,Ruiz R

更新日期：2020-09-03 00:00:00

abstract：:Phospholipidosis (PLD), the intracellular accumulation of phospholipids, is an adaptive response to toxic stimuli and serves as an important parameter in the biological assessment of compounds. Cationic amphiphilic drugs are the main inducers of PLD and may impair the function of alveolar macrophages. In vivo and in v...

journal_title：International journal of molecular sciences

authors： Öhlinger K,Absenger-Novak M,Meindl C,Ober J,Fröhlich E

更新日期：2020-11-09 00:00:00

abstract：:The protease-cleaved osteopontin (OPN) was proposed to enhance the migration of memory T cells to granulomas in tuberculosis. Various forms of OPN were identified in human monocytic THP-1 cells stimulated by phorbol 12-myristate 13-acetate (PMA). Antibodies O-17, 10A16 and 34E3, which recognize N-terminus, the C-half,...

journal_title：International journal of molecular sciences

authors： Bai G,Motoda H,Ozuru R,Chagan-Yasutan H,Hattori T,Matsuba T

更新日期：2018-01-31 00:00:00

abstract：:Innate lymphoid cells (ILC) are important players of early immune defenses in situations like lymphoid organogenesis or in case of immune response to inflammation, infection and cancer. Th1 and Th2 antagonism is crucial for the regulation of immune responses, however mechanisms are still unclear for ILC functions. ILC...

journal_title：International journal of molecular sciences

authors： Meunier S,Chea S,Garrido D,Perchet T,Petit M,Cumano A,Golub R

更新日期：2019-11-04 00:00:00

abstract：:Human induced pluripotent stem cells (iPSCs) hold enormous promise for regenerative medicine. The major safety concern is the tumorigenicity of transplanted cells derived from iPSCs. A potential solution would be to introduce a suicide gene into iPSCs as a safety switch. The herpes simplex virus type 1 thymidine kinas...

journal_title：International journal of molecular sciences

authors： Iwasawa C,Tamura R,Sugiura Y,Suzuki S,Kuzumaki N,Narita M,Suematsu M,Nakamura M,Yoshida K,Toda M,Okano H,Miyoshi H

更新日期：2019-02-14 00:00:00

abstract：:Glycation is a non-enzymatic post-translational modification of proteins, formed by the reaction of reducing sugars and α-dicarbonyl products of their degradation with amino and guanidino groups of proteins. Resulted early glycation products are readily involved in further transformation, yielding a heterogeneous grou...

journal_title：International journal of molecular sciences

authors： Soboleva A,Vikhnina M,Grishina T,Frolov A

更新日期：2017-11-28 00:00:00