Abstract:
:The tumor vasculature is essential for tumor growth and metastasis, and is a prime target of several anti-cancer agents. Increasing evidence indicates that tumor angiogenesis is stimulated by extracellular vesicles (EVs) that are secreted or shed by cancer cells. These EVs encapsulate a variety of biomolecules with angiogenic properties, and have been largely thought to stimulate vessel formation by transferring this luminal cargo into endothelial cells. However, recent studies have revealed that EVs can also signal to recipient cells via proteins on the vesicular surface. This review discusses and integrates emerging insights into the diverse mechanisms by which proteins associate with the EV membrane, the biological functions of EV membrane-associated proteins in tumor angiogenesis, and the clinical significance of these proteins in anti-angiogenic therapy.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Ko SY,Naora Hdoi
10.3390/ijms21155418subject
Has Abstractpub_date
2020-07-30 00:00:00issue
15issn
1422-0067pii
ijms21155418journal_volume
21pub_type
杂志文章,评审abstract::Dendritic cells (DCs) are heterogeneous groups of innate immune cells, which orchestrate immune responses by presenting antigens to cognate T cells and stimulating other types of immune cells. Although the term 'DCs' generally represent highly mixed subsets with functional heterogeneity, the classical definition of DC...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms19010042
更新日期:2017-12-23 00:00:00
abstract::Melatonin (MT; N-acetyl-5-methoxytryptamine) is a pleiotropic signaling molecule that has been demonstrated to play an important role in plant growth, development, and regulation of environmental stress responses. Studies have been conducted on the role of the exogenous application of MT in a few species, but the pote...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20051176
更新日期:2019-03-07 00:00:00
abstract::The terpolymerization of carbon dioxide (CO₂), propylene oxide (PO), and cyclohexene oxide (CHO) were performed by both random polymerization and block polymerization to synthesize the random poly (propylene cyclohexene carbonate) (PPCHC), di-block polymers of poly (propylene carbonate⁻cyclohexyl carbonate) (PPC-PCHC)...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms19123723
更新日期:2018-11-23 00:00:00
abstract::In order to determine the effect of different gelation temperatures (80 °C and 90 °C) on the structural arrangements in 1,3-β-d-glucan (curdlan) matrices, spectroscopic and microscopic approaches were chosen. Attenuated total reflection Fourier transform infrared spectroscopy (ATR FT-IR) and Raman spectroscopy are wel...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21176154
更新日期:2020-08-26 00:00:00
abstract::Graphene oxide (GO) is a bidimensional novel material that exhibits high biocompatibility and angiogenic properties, mostly related to the intracellular formation of reactive oxygen species (ROS). In this work, we set up an experimental methodology for the fabrication of GO@peptide hybrids by the immobilization, via i...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21155571
更新日期:2020-08-04 00:00:00
abstract::Pollination is a crucial stage in plant reproductive process. The self-compatibility (SC) and self-incompatibility (SI) mechanisms determined the plant genetic diversity and species survival. D. chrysanthum is a highly valued ornamental and traditional herbal orchid in Asia but has been declared endangered. The sexual...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms18122496
更新日期:2017-11-23 00:00:00
abstract::Diabetic retinopathy is a common complication of diabetes and remains the leading cause of blindness among the working-age population. For decades, diabetic retinopathy was considered only a microvascular complication, but the retinal microvasculature is intimately associated with and governed by neurons and glia, whi...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms19040942
更新日期:2018-03-22 00:00:00
abstract::Transcription control plays a crucial role in establishing a unique gene expression signature for each of the hundreds of mammalian cell types. Though gene expression data have been widely used to infer cellular regulatory networks, existing methods mainly infer correlations rather than causality. We developed statist...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms19113609
更新日期:2018-11-15 00:00:00
abstract::Tight regulation of inflammation is very important to guarantee a balanced immune response without developing chronic inflammation. One of the major mediators of the resolution of inflammation is the transcription factor: the nuclear factor erythroid 2-like 2 (Nrf2). Stabilized following oxidative stress, Nrf2 induces...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms18122772
更新日期:2017-12-20 00:00:00
abstract::Mitochondria in neurons contribute to energy supply, the regulation of synaptic transmission, Ca2+ homeostasis, neuronal excitability, and stress adaptation. In recent years, several studies have highlighted that the neurotransmitter serotonin (5-HT) plays an important role in mitochondrial biogenesis in cortical neur...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21249629
更新日期:2020-12-17 00:00:00
abstract::Chitosan is a versatile compound with multiple biotechnological applications. This polymer inhibits clinically important human fungal pathogens under the same carbon and nitrogen status as in blood. Chitosan permeabilises their high-fluidity plasma membrane and increases production of intracellular oxygen species (ROS...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms20020332
更新日期:2019-01-15 00:00:00
abstract::Stimulation of thermogenesis in brown adipose tissue (BAT) could have far-reaching health benefits in combatting obesity and obesity-related complications. Apolipoprotein A-IV (ApoA-IV), produced by the gut and the brain in the presence of dietary lipids, is a well-known short-term satiating protein. While our previou...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms22031221
更新日期:2021-01-27 00:00:00
abstract::The often observed scarcity of physical-chemical and well as toxicological data hampers the assessment of potentially hazardous chemicals released to the environment. In such cases Quantitative Structure-Activity Relationships/Quantitative Structure-Property Relationships (QSAR/QSPR) constitute an obvious alternative ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms10041628
更新日期:2009-04-17 00:00:00
abstract::The development of neural circuits is a complex process that relies on the proper navigation of axons through their environment to their appropriate targets. While axon-environment and axon-target interactions have long been known as essential for circuit formation, communication between axons themselves has only more...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms21145170
更新日期:2020-07-21 00:00:00
abstract::The insulin signaling (IIS) pathway plays an important role in the metabolism, growth, development, reproduction, and longevity of an organism. As a key member of the IIS pathway, insulin-like growth factor binding proteins (IGFBPs) are widely distributed a family in invertebrates and vertebrates that are critical in ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms22031056
更新日期:2021-01-21 00:00:00
abstract::Obesity and diabetes are the most prevailing health concerns worldwide and their incidence is increasing at a high rate, resulting in enormous social costs. Obesity is a complex disease commonly accompanied by insulin resistance and increases in oxidative stress and inflammatory marker expression, leading to augmented...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms17040569
更新日期:2016-04-15 00:00:00
abstract::Wallerian degeneration or nerve demyelination, arising from spinal nerve compression, is thought to bring on chronic neuropathic pain. The widely distributed metabotropic glutamate receptor subtype 5 (mGluR5) is involved in modulating nociceptive transmission. The purpose of this study was to investigate the potential...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms16034642
更新日期:2015-03-02 00:00:00
abstract::VDACs (voltage-dependent anion-selective channels) are pore-forming proteins of the outer mitochondrial membrane, whose permeability is primarily due to VDACs' presence. In higher eukaryotes, three isoforms are raised during the evolution: they have the same exon-intron organization, and the proteins show the same cha...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21197388
更新日期:2020-10-07 00:00:00
abstract::Extracellular vesicles (EVs) are a heterogeneous group of particles, between 15 nanometers and 10 microns in diameter, released by almost all cell types in physiological and pathological conditions, including tumors. EVs have recently emerged as particularly interesting informative vehicles, so that they could be cons...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms18061183
更新日期:2017-06-02 00:00:00
abstract::Recent studies have shown that dexmedetomidine exerts an anti-inflammatory effect by reducing serum levels of inflammatory factors, however, the up-stream mechanism is still unknown. The transcription factor NF-κB enters the nucleus and promotes the transcription of its target genes, including those encoding the pro-i...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms15034049
更新日期:2014-03-06 00:00:00
abstract::Articular cartilage is a structure lack of vascular distribution. Once the cartilage is injured or diseased, it is unable to regenerate by itself. Surgical treatments do not effectively heal defects in articular cartilage. Tissue engineering is the most potential solution to this problem. In this study, methoxy poly(e...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms19041125
更新日期:2018-04-09 00:00:00
abstract::The establishment of a proangiogenic phenotype and epithelial-to-mesenchymal transition (EMT) are considered as critical events that promote the induction of invasive growth in epithelial tumors, and stimulation of lymphangiogenesis is believed to confer the capacity for early dissemination to cancer cells. Recent res...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21186515
更新日期:2020-09-06 00:00:00
abstract::The consumption of polyphenols has frequently been associated with low incidence of degenerative diseases. Most of these natural antioxidants come from fruits, vegetables, spices, grains and herbs. For this reason, there has been increasing interest in identifying plant extract compounds. Polymeric tannins and monomer...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms151120382
更新日期:2014-11-06 00:00:00
abstract::The adhesion behavior of human tissue cells changes in vitro, when gravity forces affecting these cells are modified. To understand the mechanisms underlying these changes, proteins involved in cell-cell or cell-extracellular matrix adhesion, their expression, accumulation, localization, and posttranslational modifica...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21051749
更新日期:2020-03-04 00:00:00
abstract::Cypermethrin is one of the most highly effective synthetic pyrethroid insecticides. The toxicity of cypermethrin to the reproductive and nervous systems has been well studied. However, little is known about the toxic effect of cypermethrin on immune cells such as macrophages. Here, we investigated the cytotoxicity of ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms17060885
更新日期:2016-06-17 00:00:00
abstract::The availability of osteoinductive biomaterials has encouraged new therapies in bone regeneration and has potentially triggered paradigmatic shifts in the development of new implants in orthopedics and dentistry. Among several available synthetic biomaterials, bioceramics have gained attention for their ability to ind...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20174080
更新日期:2019-08-21 00:00:00
abstract::Saturated aqueous solutions of various common salts were examined for their effect on aqueous aldol reactions catalysted by a highly active C(2)-symmetric diprolinamide organocatalyst developed in our laboratory. With respect to the aldol reaction between cyclohexanone and 4-nitrobenzaldehyde, deionised water was alwa...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms12129083
更新日期:2011-01-01 00:00:00
abstract::Although the application of cardioprotective ischaemia/reperfusion (I/R) stimuli after myocardial infarction (MI) is a promising concept for salvaging the myocardium, translation to a clinical scenario has not fulfilled expectations. We have previously shown that in pigs, ischaemic postconditioning (IPostC) reduces my...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20020344
更新日期:2019-01-15 00:00:00
abstract::Tear stability decreases with increasing age and the same signs of instability are exacerbated with dry eye. Meibum lipid compositional changes with age provide insights into the biomolecules responsible for tear film instability. Meibum was collected from 69 normal donors ranging in age from 0.6 to 68 years of age. I...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms18091862
更新日期:2017-08-28 00:00:00
abstract::Influenza is a respiratory disease induced by infection by the influenza virus, which is a member of Orthomyxoviridae family. This infectious disease has serious impacts on public health systems and results in considerable mortality and economic costs throughout the world. Based on several experimental studies, massiv...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms19072065
更新日期:2018-07-16 00:00:00