Abstract:
:(1) Background: TP53 deficiency remains a major adverse event in Multiple Myeloma (MM) despite therapeutic progresses. As it is not possible to target TP53 deficiency with pharmacological agents, we explored the possibility of activating another p53 family member, p73, which has not been well studied in myeloma. (2) Methods: Using human myeloma cell lines (HMCLs) with normal or abnormal TP53 status, we assessed TP73 methylation and expression. (3) Results: Using microarray data, we reported that TP73 is weakly expressed in 47 HMCLs and mostly in TP53 wild type (TP53wt) HMCLs (p = 0.0029). Q-RT-PCR assays showed that TP73 was expressed in 57% of TP53wt HMCLs (4 out of 7) and 11% of TP53 abnormal (TP53abn) HMCLs (2 out of 18) (p = 0.0463). We showed that TP73 is silenced by methylation in TP53abn HMCLs and that decitabine increased its expression, which, however, remained insufficient for significant protein expression. Alkylating drugs increased expression of TP73 only in TP53wt HMCLs but failed to synergize with decitabine in TP53abn HMCLs. (4) Conclusions: Decitabine and melphalan does not appear as a promising combination for inducing p73 and bypassing p53 deficiency in myeloma cells.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Gillardin PS,Descamps G,Maiga S,Tessoulin B,Djamai H,Lucani B,Chiron D,Moreau P,Le Gouill S,Amiot M,Pellat-Deceunynck C,Moreau-Aubry Adoi
10.3390/ijms19010040subject
Has Abstractpub_date
2017-12-23 00:00:00issue
1issn
1422-0067pii
ijms19010040journal_volume
19pub_type
杂志文章abstract::The lignin-carbohydrate complex (LCC) was isolated from milled wood lignin of 2- and 24-month-old crude bamboo (Neosinocalamus affinis) culms using acetic acid (AcOH) and then characterized. The results have shown that the LCC preparation from 2-month-old bamboo (L₂) exhibited a slightly lower molecular weight than th...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms19010001
更新日期:2017-12-21 00:00:00
abstract::Post-transcriptional regulatory networks are dependent on the interplay of many RNA-binding proteins having a major role in mRNA processing events in mammals. We have been interested in the concerted action of the two RNA-binding proteins hnRNP A1 and HuR, both stable components of immunoselected hnRNP complexes and h...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms141020256
更新日期:2013-10-11 00:00:00
abstract::Fatty acid (FA) profiles in the plasma of patients with metabolic syndrome and chronic kidney disease (CKD) seem to be identical despite their different etiology (dietary mistakes vs. cachexia). The aim of this study was to compare both profiles and to highlight the differences that could influence the improvement of ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20071719
更新日期:2019-04-06 00:00:00
abstract::Several studies have demonstrated that basic fibroblast growth factor (bFGF) can induce neural differentiation of mesenchymal stem cells. In this study, we investigated the neural differentiation of muscle-derived stem cells (MDSCs) following treatment with bFGF and ethosuximide, a small molecule used as an anticonvul...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms14046614
更新日期:2013-03-25 00:00:00
abstract::In patients with aortic stenosis (AS), a novel staging classification of extra-valvular left and right heart damage with prognostic relevance was introduced in 2017. The aim of the study was to evaluate the biomarkers of cardiovascular tissue remodelling in relation to this novel staging classification. Patients were ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21114174
更新日期:2020-06-11 00:00:00
abstract::Sirtuins (SIRTs) are class III histone deacetylases (HDACs) that play important roles in aging and a wide range of cellular functions. Sirtuins are crucial to numerous biological processes, including proliferation, DNA repair, mitochondrial energy homeostasis, and antioxidant activity. Mammals have seven different sir...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms21186686
更新日期:2020-09-12 00:00:00
abstract::This pilot study aims to investigate whether salivary small extracellular vesicle (sEV)-associated microRNAs could act as potential biomarkers for periodontal disease status. Twenty-nine participants (10 who were healthy, nine with gingivitis, 10 with stage III/IV periodontitis) were recruited and unstimulated whole s...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21082809
更新日期:2020-04-17 00:00:00
abstract::The molecular mechanism regulating embryo development under reduced oxygen tension remains elusive. This study aimed to identify the molecular mechanism impacting embryo development under low oxygen conditions. Buffalo embryos were cultured under 5% or 20% oxygen and were evaluated according to their morphological par...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21061996
更新日期:2020-03-14 00:00:00
abstract::Biotic stresses do damage to the growth and development of plants, and yield losses for some crops. Confronted with microbial infections, plants have evolved multiple defense mechanisms, which play important roles in the never-ending molecular arms race of plant⁻pathogen interactions. The complicated defense systems i...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms20020335
更新日期:2019-01-15 00:00:00
abstract::Hybrid magnetorheological elastomers (hMREs) were manufactured based on silicone rubber, silicone oil, carbonyl iron microparticles, graphene nanoparticles and cotton fabric. Using the hMREs, flat capacitors (FCs) were made. Using the installation described in this paper, the electrical capacitance and the coefficient...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20174201
更新日期:2019-08-27 00:00:00
abstract::This study aimed to elucidate the mechanisms explaining the persistence of anemia and resistance to recombinant human erythropoietin (rHuEPO) therapy in a rat model of chronic kidney disease (CKD)-associated anemia with formation of anti-rHuEPO antibodies. The remnant kidney rat model of CKD induced by 5/6 nephrectomy...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms17010028
更新日期:2015-12-25 00:00:00
abstract::Reproductive dysfunction and malignancies related to the male gender represent a serious health concern, whose incidence has significantly risen over the past years. Prior to treatment, testicular or prostate cancer patients often display poor semen characteristics similar to subfertile or infertile patients. This fac...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms16047230
更新日期:2015-03-31 00:00:00
abstract::Metastatic castration-resistant prostate cancer is commonly treated with chemotherapy, whose effect is less than satisfactory. This raised the need for novel agents for the treatment of prostate cancer. In the present study, five phthalimide-based curcumin derivatives were synthesized and completely characterized to a...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20010028
更新日期:2018-12-21 00:00:00
abstract::Hepatic disorders have been increasing in recent years because of high carbohydrate diets. Hepatocytes depend mainly on the basal autophagy to maintain hepatic glucose/lipid homeostasis in mammals. However, the regulatory mechanisms of autophagy in hepatic energy metabolism are still unknown in fish species. According...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21041533
更新日期:2020-02-24 00:00:00
abstract::High-dose human recombinant erythropoietin (rEPO) is a promising potential neuroprotective treatment in preterm and full-term neonates with hypoxic-ischemic encephalopathy (HIE). There are limited data on the pharmacokinetics of high-dose rEPO in neonates. We examined the effects of body weight, gestation age, global ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21093042
更新日期:2020-04-25 00:00:00
abstract::Magnetic biomimetic scaffolds of poly(L-lactide) (PLLA) and nanoparticles of magnetite (nFe3O4) are prepared in a wide ratio of compositions by lyophilization for bone regeneration. The magnetic properties, cytotoxicity, and the in vitro degradation of these porous materials are closely studied. The addition of magnet...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20194664
更新日期:2019-09-20 00:00:00
abstract::Targeting cancer cells using chimeric-antigen-receptor (CAR-)T cells has propelled adoptive T-cell therapy (ATT) to the next level. A plentitude of durable complete responses using CD19-specific CAR-T cells in patients suffering from various lymphoid malignancies resulted in the approval by the food and drug administr...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms20235942
更新日期:2019-11-26 00:00:00
abstract::A specific oligodeoxynucleotide (ODN), ODN MT01, was found to have positive effects on the proliferation and activation of the osteoblast-like cell line MG 63. In this study, the detailed signaling pathways in which ODN MT01 promoted the differentiation of osteoblasts were systematically examined. ODN MT01 enhanced th...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms13077902
更新日期:2012-01-01 00:00:00
abstract::Osteochondrosis is a failure of the endochondral ossification that affects developing joints in humans and several animal species. It is a localized idiopathic joint disorder characterized by focal chondronecrosis and growing cartilage retention, which can lead to the formation of fissures, subchondral bone cysts, or ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20246179
更新日期:2019-12-07 00:00:00
abstract::Understanding molecular interactions and regulatory mechanisms in tumor initiation, progression, and treatment response are key requirements towards advanced cancer diagnosis and novel treatment procedures in personalized medicine. Beyond decoding the gene expression, malfunctioning and cancer-related epigenetic pathw...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms18102066
更新日期:2017-09-28 00:00:00
abstract::Overexpression of Sonic Hedgehog signaling (Shh) pathway molecules is associated with invasiveness and recurrence in breast carcinoma. Therefore, inhibition of the Shh pathway downstream molecule Glioma-associated Oncogene Homolog (Gli) was investigated for its ability to reduce progression and invasiveness of patient...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms19051375
更新日期:2018-05-05 00:00:00
abstract::Wintersweet (Chimonanthus praecox) is a well-known traditional fragrant plant and a winter-flowering deciduous shrub that originated in China. The five different developmental stages of wintersweet, namely, flower-bud period (FB), displayed petal stage (DP), open flower stage (OF), later blooming period (LB), and wilt...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms19103278
更新日期:2018-10-22 00:00:00
abstract::Defensins are small and rather ubiquitous cysteine-rich anti-microbial peptides. These proteins may act against pathogenic microorganisms either directly (by binding and disrupting membranes) or indirectly (as signaling molecules that participate in the organization of the cellular defense). Even though defensins are ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21249380
更新日期:2020-12-09 00:00:00
abstract::Bombyx mori doublesex (Bmdsx) functions as a double-switch gene in the final step of the sex-determination cascade in the silkworm Bombyx mori. The P-element somatic inhibitor (PSI) protein in B. mori interacts with Bmdsx pre-mRNA in CE1 as an exonic splicing silencer to promote male-specific splicing of Bmdsx. Howeve...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20092361
更新日期:2019-05-13 00:00:00
abstract::It is an important but also a challenging analytical problem to understand the chemical composition and structure of prebiotic organic matter that is present in extraterrestrial materials. Its formation, evolution and content in the building blocks ("seeds") for more complex molecules, such as proteins and DNA, are ke...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms17040439
更新日期:2016-03-24 00:00:00
abstract::Photosystems of higher plants alleviate heat-induced damage in the presence of light under moderate stressed conditions; however, in the absence of light (i.e., in the dark), the same plants are damaged more easily. (Yamauchi and Kimura, 2011) We demonstrate that regulating photochemical energy transfer in heat-treate...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms151223042
更新日期:2014-12-11 00:00:00
abstract::The intriguingly complex glomerular podocyte has been a recent object of intense study. Researchers have sought to understand its role in the pathogenesis of common proteinuric diseases such as minimal change disease and focal segmental glomerular sclerosis. In particular, considerable effort has been directed towards...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms151121366
更新日期:2014-11-18 00:00:00
abstract::Complex neuropsychiatric-cardiac syndromes can be genetically determined. For the first time, the authors present a syndromal form of short QT syndrome in a 34-year-old German male patient with extracardiac features with predominant psychiatric manifestation, namely a severe form of secondary high-functioning autism s...
journal_title:International journal of molecular sciences
pub_type:
doi:10.3390/ijms21228611
更新日期:2020-11-15 00:00:00
abstract::Though Cnidium officinale Makino (COM) was known to have anti-angiogenic, anti-oxidant, neuroprotective, and anti-cancer effects, the underlying anticancer mechanism of COM using endoplasmic reticulum (ER) stress and miRNA remained unclear until now. Thus, in the current study, the inhibitory mechanism of COM in lymph...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms19030865
更新日期:2018-03-15 00:00:00
abstract::Acute or chronic administration of guanosine (GUO) induces anxiolytic-like effects, for which the adenosine (ADO) system involvement has been postulated yet without a direct experimental evidence. Thus, we aimed to investigate whether adenosine receptors (ARs) are involved in the GUO-mediated anxiolytic-like effect, e...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21239281
更新日期:2020-12-05 00:00:00