The Role of Sirtuins in Kidney Diseases.

Abstract:

:Sirtuins (SIRTs) are class III histone deacetylases (HDACs) that play important roles in aging and a wide range of cellular functions. Sirtuins are crucial to numerous biological processes, including proliferation, DNA repair, mitochondrial energy homeostasis, and antioxidant activity. Mammals have seven different sirtuins, SIRT1-7, and the diverse biological functions of each sirtuin are due to differences in subcellular localization, expression profiles, and cellular substrates. In this review, we summarize research advances into the role of sirtuins in the pathogenesis of various kidney diseases including acute kidney injury, diabetic kidney disease, renal fibrosis, and kidney aging along with the possible underlying molecular mechanisms. The available evidence indicates that sirtuins have great potential as novel therapeutic targets for the prevention and treatment of kidney diseases.

journal_name

Int J Mol Sci

authors

Hong YA,Kim JE,Jo M,Ko GJ

doi

10.3390/ijms21186686

subject

Has Abstract

pub_date

2020-09-12 00:00:00

issue

18

issn

1422-0067

pii

ijms21186686

journal_volume

21

pub_type

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