Abstract:
:Sirtuins (SIRTs) are class III histone deacetylases (HDACs) that play important roles in aging and a wide range of cellular functions. Sirtuins are crucial to numerous biological processes, including proliferation, DNA repair, mitochondrial energy homeostasis, and antioxidant activity. Mammals have seven different sirtuins, SIRT1-7, and the diverse biological functions of each sirtuin are due to differences in subcellular localization, expression profiles, and cellular substrates. In this review, we summarize research advances into the role of sirtuins in the pathogenesis of various kidney diseases including acute kidney injury, diabetic kidney disease, renal fibrosis, and kidney aging along with the possible underlying molecular mechanisms. The available evidence indicates that sirtuins have great potential as novel therapeutic targets for the prevention and treatment of kidney diseases.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Hong YA,Kim JE,Jo M,Ko GJdoi
10.3390/ijms21186686subject
Has Abstractpub_date
2020-09-12 00:00:00issue
18issn
1422-0067pii
ijms21186686journal_volume
21pub_type
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