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Male reproductive cancers and infertility: a mutual relationship.

Abstract：

:Reproductive dysfunction and malignancies related to the male gender represent a serious health concern, whose incidence has significantly risen over the past years. Prior to treatment, testicular or prostate cancer patients often display poor semen characteristics similar to subfertile or infertile patients. This fact is underscored by cases where the malignancy is often diagnosed in males who undergo a general fertility screening. This review aims to examine the associations between male infertility and reproductive cancers focusing on common etiologies and biological mechanisms underlining these pathologies. Furthermore, we discuss compelling epidemiological data hypothesizing that male reproductive failure may act as a precursor of future andrological malignancies, including testicular or prostate cancer, thus providing a stimulus for a more specific research in male reproductive health and emphasizing the importance of this relation for physicians taking care of male patients with a reproductive disease.

journal_name

Int J Mol Sci

journal_title

International journal of molecular sciences

authors

Tvrda E,Agarwal A,Alkuhaimi N

doi

10.3390/ijms16047230

subject

Has Abstract

pub_date

2015-03-31 00:00:00

pages

7230-60

issue

4

issn

1422-0067

pii

ijms16047230

journal_volume

16

pub_type

杂志文章,评审

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