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Exposure to Engineered Nanomaterials: Impact on DNA Repair Pathways.

Abstract：

:Some engineered nanomaterials (ENMs) may have the potential to cause damage to the genetic material in living systems. The mechanistic machinery functioning at the cellular/molecular level, in the form of DNA repair processes, has evolved to help circumvent DNA damage caused by exposure to a variety of foreign substances. Recent studies have contributed to our understanding of the various DNA damage repair pathways involved in the processing of DNA damage. However, the vast array of ENMs may present a relatively new challenge to the integrity of the human genome; therefore, the potential hazard posed by some ENMs necessitates the evaluation and understanding of ENM-induced DNA damage repair pathways. This review focuses on recent studies highlighting the differential regulation of DNA repair pathways, in response to a variety of ENMs, and discusses the various factors that dictate aberrant repair processes, including intracellular signalling, spatial interactions and ENM-specific responses.

journal_name

Int J Mol Sci

journal_title

International journal of molecular sciences

authors

Singh N,Nelson BC,Scanlan LD,Coskun E,Jaruga P,Doak SH

doi

10.3390/ijms18071515

subject

Has Abstract

pub_date

2017-07-13 00:00:00

issue

7

issn

1422-0067

pii

ijms18071515

journal_volume

18

pub_type

杂志文章,评审

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